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Phase I COVID-19 Vaccines

This site presents COVID-19 vaccines that are currently in Phase I clinical trials as of November 28, 2020.

Existing vaccines in Phase I clinical trial include:

  1. AdimrSC-2f
    • Clinical trial ID:
      • Phase I: NCT04522089
        • Age subgroups: 20-60 years
        • Location: Taiwan
    • Type: Subunit vaccine
    • Manufacturer: Adimmune Corporation
  2. ARCoV
    • Clinical trial ID:
    • Type: mRNA vaccine
    • Manufacturer: Academy of Military Sciences, Walvax Biotech.
    • Publications:
      • Zhang et al. A Thermostable mRNA Vaccine against COVID-19. Cell. 2020; 182(5); 1271-1283. [PubMed: 32795413].
    • VIOLIN: 5783
    • VO: VO_0005161
  3. bacTRL-Spike vaccine
    • Clinical trial ID:
      • Phase I: NCT04334980
        • Age subgroups: 18-59 years
        • Location: Australia
    • Type: DNA vaccine
    • Manufacturer: Symvivo
  4. ChulaCov19
    • Clinical trial ID:
      • Phase I: NCT04566276
        • Age subgroups:
          • Phase I: 18-55 years; 65-75 years
          • Phase II: 18-55 years; 65-75 years
        • Location: Australia
    • Type: mRNA vaccine
    • Manufacturer: Chulalongkorn University
  5. CORVax12
    • Clinical trial ID:
      • Phase I: NCT04627675
        • Age subgroups: 18-50 years; 60 years and older
        • Location: USA
    • Type: DNA vaccine
    • Manufacturer: Providence Health & Services; OncoSec Medical Inc.
  6. COVAC1
    • Clinical trial ID:
    • Type: RNA vaccine
    • Manufacturer: Imperial College London; Morningside Ventures
    • Publications:
      • McKay et al. Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice. Nat Commun. 2020; 11(1); 3523. [PubMed: 32647131].
    • VIOLIN: 5779
    • VO: VO_0005156
  7. Covigenix
    • Clinical trial ID:
      • Phase I: NCT04591184
        • Age subgroups: 18-54 years; 65-84 years
        • Location: Canada
    • Type: DNA vaccine
    • Manufacturer: Entos Pharmaceuticals
  8. COVI-VAC
    • Clinical trial ID:
      • Phase I: NCT04619628
        • Age subgroups: 18-30 years
        • Location: UK
    • Type: Live, attenuated vaccine
    • Manufacturer: Codagenix, Inc.
  9. GRAd-CoV2
    • Clinical trial ID:
      • Phase I: NCT04528641
        • Age subgroups: 18-55 years; 65-85 years
        • Location: Italy
    • Type: Recombinant vector vaccine
    • Manufacturer: ReiThera
    • VIOLIN: 5787
    • VO: VO_0005169
  10. hAd5-COVID-19
    • Clinical trial ID:
      • Phase I: NCT04591717
        • Age subgroups: 18-55 years
        • Location: USA
    • Type: Recombinant vector vaccine
    • Manufacturer: ImmunityBio, Inc.; NantKwest Inc.
  11. MVA-SARS-2-S
    • Clinical trial ID:
      • Phase I: NCT04569383
        • Age subgroups: 18-55 years
        • Location: Germany
    • Type: Recombinant vector vaccine
    • Manufacturer: Universitätsklinikum Hamburg-Eppendorf; Ludwig-Maximilians - University of Munich
  12. MVC-COV1901
    • Clinical trial ID:
      • Phase I: NCT04487210
        • Age subgroups: 20-49 years
        • Location: Taiwan
    • Type: Subunit vaccine
    • Manufacturer: Medigen; Dynavax
  13. Recombinant SARS-CoV-2 vaccine (Sf9 cell)
    • Clinical trial ID:
      • Phase I: ChiCTR2000037518
        • Age subgroups: 18-55 years; 56 years and above
        • Location: China
    • Type: Subunit vaccine
    • Manufacturer: Sichuan University
  14. Recombinant spike protein with Advax™ adjuvant
    • Clinical trial ID:
      • Phase I: NCT04453852
        • Age subgroups: 18-65 years
        • Location: Australia
    • Type: Subunit vaccine
    • Manufacturer: Vaxine
  15. Soberana 01
    • Clinical trial ID:
      • Phase I: IFV/COR/04
        • Age subgroups: 19-59 years; 60-80 years
        • Location: Cuba
      • Phase I: IFV/COR/05
        • Age subgroups: 19-59 years
        • Location: Cuba
    • Type: Subunit vaccine
    • Manufacturer: Instituto Finlay de Vacunas, Cuba
  16. Soberana 02
    • Clinical trial ID:
      • Phase I: IFV/COR/06
        • Age subgroups: 19-59 years
        • Location: Cuba
    • Type: Subunit vaccine
    • Manufacturer: Instituto Finlay de Vacunas, Cuba
  17. SCB-2019
    • Clinical trial ID:
      • Phase I: NCT04405908
        • Age subgroups: 18-54 years; 55-75 years
        • Location: Australia
    • Type: Subunit vaccine
    • Manufacturer: Clover Biopharmaceuticals; GSK; Dynavax
  18. TMV-083
    • Clinical trial ID:
      • Phase I: NCT04497298
        • Age subgroups: 18-55 years
        • Location: Belgium, France
    • Type: Recombinant vector vaccine
    • Manufacturer: Merck; Themis Bioscience; Institut Pasteur
  19. UB-612
    • Clinical trial ID:
      • Phase I: NCT04545749
        • Age subgroups: 20-55 years
        • Location: Taiwan
    • Type: Subunit vaccine
    • Manufacturer: COVAXX; United Biomedical Inc. Asia
  20. UQ-1-SARS-CoV-2-Sclamp
    • Clinical trial ID:
    • Type: Subunit vaccine
    • Manufacturer: University of Queensland; CSL
  21. V590
    • Clinical trial ID:
      • Phase I: NCT04569786
        • Age subgroups: 18-54 years; 55 years and above
        • Location: USA
    • Type: Recombinant vector vaccine
    • Manufacturer: Merck
  22. VXA-CoV2-1
    • Clinical trial ID:
      • Phase I: NCT04563702
        • Age subgroups: 18-54 years
        • Location: USA
    • Type: Recombinant vector vaccine
    • Manufacturer: Vaxart

Provenance: All data in Cov19VaxKB originates from manual curation of reliable resources.

Note: The page was updated on November 28, 2020. We plan to update this page on a weekly or even a daily basis. Please provide us with any new information that you believe would be useful if included on the website.