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Phase I COVID-19 Vaccines

This site presents COVID-19 vaccines that are currently in Phase I clinical trials as of November 28, 2020.

Existing vaccines in Phase I clinical trial include:

1. AdimrSC-2f
• Clinical trial ID:
• Phase I: NCT04522089
• Age subgroups: 20-60 years
• Location: Taiwan
• Type: Subunit vaccine
• Manufacturer: Adimmune Corporation
2. ARCoV
• Clinical trial ID:
• Phase I: ChiCTR2000034112
• Age subgroups: 18-59 years; 60 years and above
• Location: China
• Phase I: ChiCTR2000039212
• Age subgroups: 18-59 years
• Location: China
• Type: mRNA vaccine
• Manufacturer: Academy of Military Sciences, Walvax Biotech.
• Publications:
• Zhang et al. A Thermostable mRNA Vaccine against COVID-19. Cell. 2020; 182(5); 1271-1283. [PubMed: 32795413].
• VIOLIN: 5783
• VO: VO_0005161
3. bacTRL-Spike vaccine
• Clinical trial ID:
• Phase I: NCT04334980
• Age subgroups: 18-59 years
• Location: Australia
• Type: DNA vaccine
• Manufacturer: Symvivo
4. ChulaCov19
• Clinical trial ID:
• Phase I: NCT04566276
• Age subgroups:
• Phase I: 18-55 years; 65-75 years
• Phase II: 18-55 years; 65-75 years
• Location: Australia
• Type: mRNA vaccine
• Manufacturer: Chulalongkorn University
5. CORVax12
• Clinical trial ID:
• Phase I: NCT04627675
• Age subgroups: 18-50 years; 60 years and older
• Location: USA
• Type: DNA vaccine
• Manufacturer: Providence Health & Services; OncoSec Medical Inc.
6. COVAC1
• Clinical trial ID:
• Phase I: ISRCTN17072692
• Age subgroups: 18-75 years
• Location: UK
• Type: RNA vaccine
• Manufacturer: Imperial College London; Morningside Ventures
• Publications:
• McKay et al. Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice. Nat Commun. 2020; 11(1); 3523. [PubMed: 32647131].
• VIOLIN: 5779
• VO: VO_0005156
7. Covigenix
• Clinical trial ID:
• Phase I: NCT04591184
• Age subgroups: 18-54 years; 65-84 years
• Location: Canada
• Type: DNA vaccine
• Manufacturer: Entos Pharmaceuticals
8. COVI-VAC
• Clinical trial ID:
• Phase I: NCT04619628
• Age subgroups: 18-30 years
• Location: UK
• Type: Live, attenuated vaccine
• Manufacturer: Codagenix, Inc.
9. GRAd-CoV2
• Clinical trial ID:
• Phase I: NCT04528641
• Age subgroups: 18-55 years; 65-85 years
• Location: Italy
• Type: Recombinant vector vaccine
• Manufacturer: ReiThera
• VIOLIN: 5787
• VO: VO_0005169
10. hAd5-COVID-19
• Clinical trial ID:
• Phase I: NCT04591717
• Age subgroups: 18-55 years
• Location: USA
• Type: Recombinant vector vaccine
• Manufacturer: ImmunityBio, Inc.; NantKwest Inc.
11. MVA-SARS-2-S
• Clinical trial ID:
• Phase I: NCT04569383
• Age subgroups: 18-55 years
• Location: Germany
• Type: Recombinant vector vaccine
• Manufacturer: Universitätsklinikum Hamburg-Eppendorf; Ludwig-Maximilians - University of Munich
12. MVC-COV1901
• Clinical trial ID:
• Phase I: NCT04487210
• Age subgroups: 20-49 years
• Location: Taiwan
• Type: Subunit vaccine
• Manufacturer: Medigen; Dynavax
13. Recombinant SARS-CoV-2 vaccine (Sf9 cell)
• Clinical trial ID:
• Phase I: ChiCTR2000037518
• Age subgroups: 18-55 years; 56 years and above
• Location: China
• Type: Subunit vaccine
• Manufacturer: Sichuan University
14. Recombinant spike protein with Advax™ adjuvant
• Clinical trial ID:
• Phase I: NCT04453852
• Age subgroups: 18-65 years
• Location: Australia
• Type: Subunit vaccine
• Manufacturer: Vaxine
15. Soberana 01
• Clinical trial ID:
• Phase I: IFV/COR/04
• Age subgroups: 19-59 years; 60-80 years
• Location: Cuba
• Phase I: IFV/COR/05
• Age subgroups: 19-59 years
• Location: Cuba
• Type: Subunit vaccine
• Manufacturer: Instituto Finlay de Vacunas, Cuba
16. Soberana 02
• Clinical trial ID:
• Phase I: IFV/COR/06
• Age subgroups: 19-59 years
• Location: Cuba
• Type: Subunit vaccine
• Manufacturer: Instituto Finlay de Vacunas, Cuba
17. SCB-2019
• Clinical trial ID:
• Phase I: NCT04405908
• Age subgroups: 18-54 years; 55-75 years
• Location: Australia
• Type: Subunit vaccine
• Manufacturer: Clover Biopharmaceuticals; GSK; Dynavax
18. TMV-083
• Clinical trial ID:
• Phase I: NCT04497298
• Age subgroups: 18-55 years
• Location: Belgium, France
• Type: Recombinant vector vaccine
• Manufacturer: Merck; Themis Bioscience; Institut Pasteur
19. UB-612
• Clinical trial ID:
• Phase I: NCT04545749
• Age subgroups: 20-55 years
• Location: Taiwan
• Type: Subunit vaccine
• Manufacturer: COVAXX; United Biomedical Inc. Asia
20. UQ-1-SARS-CoV-2-Sclamp
• Clinical trial ID:
• Phase I: ACTRN12620000674932
• Age subgroups: 18-55 years
• Location: Australia
• Phase I: NCT04495933
• Age subgroups: 18-55 years
• Location: Australia
• Type: Subunit vaccine
• Manufacturer: University of Queensland; CSL
21. V590
• Clinical trial ID:
• Phase I: NCT04569786
• Age subgroups: 18-54 years; 55 years and above
• Location: USA
• Type: Recombinant vector vaccine
• Manufacturer: Merck
22. VXA-CoV2-1
• Clinical trial ID:
• Phase I: NCT04563702
• Age subgroups: 18-54 years
• Location: USA
• Type: Recombinant vector vaccine
• Manufacturer: Vaxart

Provenance: All data in Cov19VaxKB originates from manual curation of reliable resources.

Note: The page was updated on November 28, 2020. We plan to update this page on a weekly or even a daily basis. Please provide us with any new information that you believe would be useful if included on the website.