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Phase I COVID-19 Vaccines

This site presents COVID-19 vaccines that are currently in Phase I clinical trials as of February 17, 2021.

Existing vaccines in Phase I clinical trial include:

  1. AdCOVID
    • Clinical trial ID:
      • Phase I: NCT04679909
        • Age subgroups: 18-55 years
        • Location: USA
    • Type: Recombinant vector vaccine
    • Manufacturer: Altimmune, Inc.
    • VIOLIN: 5835
    • VO: VO_0005153
  2. AdimrSC-2f
    • Clinical trial ID:
      • Phase I: NCT04522089
        • Age subgroups: 20-60 years
        • Location: Taiwan
    • Type: Subunit vaccine
    • Manufacturer: Adimmune Corporation
    • VO: VO_0005173
  3. ARCoV
    • Clinical trial ID:
    • Type: mRNA vaccine
    • Manufacturer: Academy of Military Sciences, Walvax Biotech.
    • Publications:
      • Zhang et al. A Thermostable mRNA Vaccine against COVID-19. Cell. 2020; 182(5); 1271-1283. [PubMed: 32795413].
    • VIOLIN: 5783
    • VO: VO_0005161
  4. bacTRL-Spike
    • Clinical trial ID:
      • Phase I: NCT04334980
        • Age subgroups: 18-59 years
        • Location: Australia
    • Type: DNA vaccine
    • Manufacturer: Symvivo
    • VIOLIN: 5817
    • VO: VO_0005174
  5. ChulaCov19
    • Clinical trial ID:
      • Phase I: NCT04566276
        • Age subgroups:
          • Phase I: 18-55 years, 65-75 years
          • Phase II: 18-55 years, 65-75 years
        • Location: Australia
    • Type: mRNA vaccine
    • Manufacturer: Chulalongkorn University
    • VIOLIN: 5818
    • VO: VO_0005175
  6. COH04S1
    • Clinical trial ID:
      • Phase I: NCT04639466
        • Age subgroups: 18-55 years
        • Location: USA
    • Type: Recombinant vector vaccine
    • Manufacturer: City of Hope Medical Center
    • Publications
    • Chiuppesi et al. Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform. Nat Commun. 2020; 11(1); 6121. [PubMed: 33257686].
    • VIOLIN: 5819
    • VO: VO_0005176
  7. CORVax12
    • Clinical trial ID:
      • Phase I: NCT04627675
        • Age subgroups: 18-50 years, 60 years and above
        • Location: USA
    • Type: DNA vaccine
    • Manufacturer: Providence Health & Services, OncoSec Medical Inc.
    • VIOLIN: 5820
    • VO: VO_0005183
  8. COVID-19 aAPC vaccine
    • Clinical trial ID:
      • Phase I: NCT04299724
        • Age subgroups: 6 months to 80 years
        • Location: China
    • Type: Recombinant vector vaccine
    • Manufacturer: Shenzhen Geno-Immune Medical Institute
    • VIOLIN: 5821
    • VO: VO_0005184
  9. COVID-19 inactivated virus vaccine by Shifa Pharmed
    • Clinical trial ID:
    • Type: Inactivated or "killed" vaccine
    • Manufacturer: Shifa Pharmed Industrial Co
    • VIOLIN: 5815
  10. COVID-19 RNA vaccine by Shulan Hospital
    • Clinical trial ID:
    • Type: DNA vaccine
    • Manufacturer: Shulan Hospital, Center for Disease Control and Prevention of Guangxi Zhuang Autonomous Region
    • VIOLIN: 5822
    • VO: VO_0005185
  11. Covigenix VAX-001
    • Clinical trial ID:
      • Phase I: NCT04591184
        • Age subgroups: 18-54 years, 65-84 years
        • Location: Canada
    • Type: DNA vaccine
    • Manufacturer: Entos Pharmaceuticals
    • VIOLIN: 5823
    • VO: VO_0005186
  12. COVI-VAC
    • Clinical trial ID:
      • Phase I: NCT04619628
        • Age subgroups: 18-30 years
        • Location: UK
    • Type: Live, attenuated vaccine
    • Manufacturer: Codagenix, Inc.
    • VIOLIN: 5824
    • VO: VO_0005187
  13. ERUCOV-VAC
    • Clinical trial ID:
      • Phase I: NCT04691947
        • Age subgroups: 18-55 years
        • Location: Turkey
    • Type: Inactivated or "killed" vaccine
    • Manufacturer: Erciyes University
    • VIOLIN: 5836
    • VO: VO_0005188
  14. GRAd-CoV2
    • Clinical trial ID:
      • Phase I: NCT04528641
        • Age subgroups: 18-55 years, 65-85 years
        • Location: Italy
    • Type: Recombinant vector vaccine
    • Manufacturer: ReiThera, Leukocare, Univercells
    • VIOLIN: 5787
    • VO: VO_0005169
  15. hAd5-COVID-19
    • Clinical trial ID:
      • Phase I: NCT04732468
        • Age subgroups: 18-55 years
        • Location: USA
      • Phase I: NCT04591717
        • Age subgroups: 18-55 years
        • Location: USA
      • Phase I: NCT04710303
        • Age subgroups: 18-50 years
        • Location: USA
    • Type: Recombinant vector vaccine
    • Manufacturer: ImmunityBio, Inc.; NantKwest Inc.
    • VIOLIN: 5825
    • VO: VO_0005189
  16. IMP CoVac-1
    • Clinical trial ID:
      • Phase I: NCT04546841
        • Age subgroups: 18-55 years, 56-74 years, 75 years and above
        • Location: Germany
    • Type: Subunit vaccine
    • Manufacturer: University Hospital Tuebingen
    • VIOLIN: 5826
    • VO: VO_0005190
  17. LNP-nCoVsaRNA
    • Other names: COVAC1
    • Clinical trial ID:
    • Type: mRNA vaccine
    • Manufacturer: Imperial College London, Morningside Ventures
    • Publications:
      • McKay et al. Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice. Nat Commun. 2020; 11(1); 3523. [PubMed: 32647131].
    • VIOLIN: 5771
    • VO: VO_0005156
  18. MVA-SARS-2-S
    • Clinical trial ID:
      • Phase I: NCT04569383
        • Age subgroups: 18-55 years
        • Location: Germany
    • Type: Recombinant vector vaccine
    • Manufacturer: Universitätsklinikum Hamburg-Eppendorf, Ludwig-Maximilians - University of Munich
    • VIOLIN: 5827
    • VO: VO_0005191
  19. Razi Cov Pars
    • Clinical trial ID:
    • Type: Subunit vaccine
    • Manufacturer: Razi Vaccine and Serum Research Institute
    • VIOLIN: 5779
  20. Recombinant spike protein with Advax™ adjuvant
    • Clinical trial ID:
      • Phase I: NCT04453852
        • Age subgroups: 18-65 years
        • Location: Australia
    • Type: Subunit vaccine
    • Manufacturer: Vaxine, Medytox
    • VIOLIN: 5829
    • VO: VO_0005193
  21. VXA-CoV2-1
    • Clinical trial ID:
      • Phase I: NCT04563702
        • Age subgroups: 18-54 years
        • Location: USA
    • Type: Recombinant vector vaccine
    • Manufacturer: Vaxart
    • VIOLIN: 5832
    • VO: VO_0005196

Provenance: All data in Cov19VaxKB originates from manual curation of reliable resources.

Note: The page was updated on February 17, 2021. We plan to update this page on a weekly or even a daily basis. Please provide us with any new information that you believe would be useful if included on the website.