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COVID-19 Vaccines Knowledgebase
We are facing challenges to quickly deliver effective and safe vaccines aganist COVID-19 pandemic. To help the public and researchers stay updated on COVID-19 vaccine development, immunization registry, and post-licensure vaccine safety monitoring, we have developed this COVID-19 Vaccines Knowledgebase (Cov19Vax) website to quickly and comprehensively update the news and knowledge about COVID-19 vaccines.
Note that we target to keep updating this page in a weekly or even daily basis. Please provide us any new information that you think is better to be included on this website.
Contents:
- Vaccines in clinical trials
- Vaccines in Phase III clinical trial
- Vaccines in Phase II clinical trial
- Vaccines in Phase I clinical trial
- Vaccines in preclinical research
- DNA vaccines
- Inactivated vaccines
- Recombinant vector vaccines
- RNA vaccines
- Subunit vaccines
- Vaccine safety
- Safety issues found in clinical trials
- Safety issues found in lab animals
- References
- Websites
- Journal articles
- Announcements
I. Vaccines in clinical trials
- Vaccines in Phase III clinical trial
- Ad26COVS1 vaccine
- Other names: JNJ-78436735
- Clinical trial ID:
- Type: Recombinant vector vaccine
- Manufacturer: Janssen Pharmaceutical Companies
- Publications:
- Mercado et al. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques. Nature. 2020; ; . [PubMed: 32731257].
- VIOLIN
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- Ad5-nCoV vaccine
- Clinical trial ID:
- Type: Recombinant vector vaccine
- Manufacturer: CanSino Biologics
- Publications:
- Zhu et al. Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet. 2020; 396(10249); 479-488. [PubMed: 32702299].
- Zhu et al. Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial. Lancet. 2020; 395(10240); 1845-1854. [PubMed: 32450106].
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- BNT162b1 vaccine
- Clinical trial ID:
- Type: mRNA vaccine
- Manufacturer: BioNTech; Pfizer
- Publications:
- Sahin et al. COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T-cell responses. Nature. 2020; ; . [PubMed: 32998157].
- Mulligan et al. Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults. Nature. 2020; ; . [PubMed: 32785213].
- ChAdOx1 nCoV19 vaccine
- Other names: AZD1222
- Clinical trial ID:
- Type: Recombinant vector vaccine
- Manufacturer: AstraZeneca
- Publications:
- Folegatti et al. Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial. Lancet. 2020; 396(10249); 467-478. [PubMed: 32702298].
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- COVID-19 inactivated virus vaccine by Beijing Institute of Biological Products
- Other names: BBIBP-CorV vaccine
- Clinical trial ID:
- Type: Inactivated or “killed” vaccine
- Manufacturer: Beijing Institute of Biological Products; Sinopharm
- Publications:
- Wang et al. Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2. Cell. 2020;182(3); 713-721. [PubMed: 32778225].
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- COVID-19 inactivated virus vaccine by Wuhan Institute of Biological Products
- Clinical trial ID:
- Type: Inactivated or “killed” vaccine
- Manufacturer: Wuhan Institute of Biological Products; Sinopharm
- Publications:
- Xia et al. Effect of an Inactivated Vaccine Against SARS-CoV-2 on Safety and Immunogenicity Outcomes: Interim Analysis of 2 Randomized Clinical Trials. JAMA. 2020; 324(10); 1–10. [PubMed: 32789505].
- VIOLIN
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- Gam-COVID-Vac
- Other names: Sputnik V
- Clinical trial ID:
- Type: Recombinant vector vaccine
- Manufacturer: Gamaleya Research Institute
- Publications:
- Logunov et al. Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia. Lancet. 2020; 396(10255); 887-897. [PubMed: 32896291].
- VIOLIN
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- mRNA-1273 vaccine
- Clinical trial ID:
- Type: mRNA vaccine
- Manufacturer: Moderna
- Publications:
- Anderson et al. Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults. N Engl J Med. 2020; ; . [PubMed: 32991794].
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- NVX-CoV2373 vaccine
- Clinical trial ID:
- Type: Nanoparticle vaccine
- Manufacturer: Novavax
- Publications:
- Keech et al. Phase 1-2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine. N Engl J Med. 2020; ; . [PubMed: 32877576].
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- PiCoVacc vaccine
- Other names: CoronaVac
- Clinical trial ID:
- Type: Inactivated or “killed” vaccine
- Manufacturer: Sinovac
- Publications:
- Gao et al. Rapid development of an inactivated vaccine candidate for SARS-CoV-2. Science (New York, N.Y.). 2020; 369(6499); 77-81. [PubMed: 32376603].
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Vaccines in Phase II clinical trial
- AG0301-COVID19
- ARCT-021 vaccine
- Other names: LUNAR-COV19
- Clinical trial ID:
- Type: RNA vaccine
- Manufacturer: Arcturus Therapeutics; Duke-NUS Medical School
- VIOLIN
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- BBV152
- Other names: Covaxin
- Clinical trial ID:
- Type: Inactivated or “killed” vaccine
- Manufacturer: Bharat Biotech; National Institute of Virology
- COVID-19 inactivated virus by Chinese Academy of Medical Sciences
- Other names: Covaxin
- Clinical trial ID:
- Type: Inactivated or “killed” vaccine
- Manufacturer: Institute of Medical Biology, Chinese Academy of Medical Sciences
- VIOLIN
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- COVID-19 protein subunit vaccine by Sanofi and GSK
- Clinical trial ID:
- Type: Subunit vaccine
- Manufacturer: Sanofi Pasteur; GSK
- CVnCoV
- Clinical trial ID:
- Type: RNA vaccine
- Manufacturer: Curevac
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- EpiVacCorona vaccine
- Clinical trial ID:
- Type: Peptide vaccine
- Manufacturer: Federal Budgetary Research Institution State Research Center of Virology and Biotechnology
- GX19
- Clinical trial ID:
- Type: DNA vaccine
- Manufacturer: Genexine
- VIOLIN
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- INO-4800 vaccine
- Clinical trial ID:
- Type: DNA vaccine
- Manufacturer: Inovio Pharmaceuticals
- KBP-COVID-19
- Clinical trial ID:
- Type: Subunit vaccine
- Manufacturer: Kentucky BioProcessing
- QazCovid-in
- Clinical trial ID:
- Type: Inactivated or "killed" vaccine
- Manufacturer: Research Institute for Biological Safety Problems; National Scientific Center for Phthisiopulmonology of the Republic of Kazakhstan
- RBD-CuMVTT vaccine
- Clinical trial ID:
- Type: Virus Like Particle
- Manufacturer: Anhui Zhifei Longcom Biopharmaceutical; Institute of Microbiology, Chinese Academy of Sciences
- Publications:
- Dai et al. A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS. Cell. 2020; 182(3); 722-733. [PubMed: 32645327].
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- RBD-HBsAg VLP vaccine
- Clinical trial ID:
- Type: Virus Like Particle
- Manufacturer: Serum Institute of India
- ZyCoV-D vaccine
- Clinical trial ID:
- Type: DNA vaccine
- Manufacturer: Zydus Cadila
- VIOLIN
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Vaccines in Phase I clinical trial
- ARCoV
- Clinical trial ID:
- Type: mRNA vaccine
- Manufacturer: Academy of Military Sciences, Walvax Biotech.
- Publications:
- Zhang et al. A Thermostable mRNA Vaccine against COVID-19. Cell. 2020; 182(5); 1271-1283. [PubMed: 32795413].
- VIOLIN
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- ChulaCov19
- Clinical trial ID:
- Type: mRNA vaccine
- Manufacturer: Chulalongkorn University
- COVAC1 vaccine
- Clinical trial ID:
- Type: RNA vaccine
- Manufacturer: Imperial College London; Morningside Ventures
- Publications:
- McKay et al. Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice. Nat Commun. 2020; 11(1); 3523. [PubMed: 32647131].
- VIOLIN
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- COVID-19 plant-derived VLP by Medicago
- Clinical trial ID:
- Type: Virus-like particle
- Manufacturer: Medicago
- DelNS1-2019-nCoV-RBD-OPT1
- Clinical trial ID:
- Type: Recombinant vector vaccine
- Manufacturer: Beijing Wantai Biological Pharmacy; Xiamen University
- GRAd-CoV2
- Clinical trial ID:
- Type: Recombinant vector vaccine
- Manufacturer: ReiThera
- VIOLIN
- VO
- MVA-SARS-2-S
- Clinical trial ID:
- Type: Recombinant vector vaccine
- Manufacturer: Universitätsklinikum Hamburg-Eppendorf; Ludwig-Maximilians - University of Munich
- MVC-COV1901
- Clinical trial ID:
- Type: Subunit vaccine
- Manufacturer: Medigen; Dynavax
- Recombinant spike protein with Advax™ adjuvant
- Clinical trial ID:
- Type: Subunit vaccine
- Manufacturer: Vaxine
- Soberana 01
- Clinical trial ID:
- Type: Subunit vaccine
- Manufacturer: Instituto Finlay de Vacunas, Cuba
- SCB-2019
- Clinical trial ID:
- Type: Subunit vaccine
- Manufacturer: Clover Biopharmaceuticals; GSK; Dynavax
- TMV-083
- Clinical trial ID:
- Type: Recombinant vector vaccine
- Manufacturer: Merck; Themis Bioscience; Institut Pasteur
- UB-612 vaccine
- Clinical trial ID:
- Type: Subunit vaccine
- Manufacturer: COVAXX
- UQ-1-SARS-CoV-2-Sclamp
- Clinical trial ID:
- Type: Subunit vaccine
- Manufacturer: University of Queensland; CSL
- V590 vaccine
- Clinical trial ID:
- Type: Recombinant vector vaccine
- Manufacturer: Merck
- VXA-CoV2-1
- Clinical trial ID:
- Type: Recombinant vector vaccine
- Manufacturer: Vaxart
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II. Vaccines in Preclinical Research
- DNA vaccines
- DIOS-CoVax2
- Manufacturer: DIOSynVax Ltd; University of Cambridge
Inactivated vaccines
Recombinant vector vaccines
- AdCOVID
- Manufacturer: Altimmune; University of Alabama in Birmingham
RNA vaccines
- BANCOVID
- Manufacturer: Globe Biotech Ltd.
- MRT5500
- Manufacturer: Sanofi; Translate Bio
Subunit vaccines
- DPX-COVID-19
- PittCoVacc
- Manufacturer: University of Pittsburgh
- Publications:
- Kim et al. Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development. EBioMedicine. 2020; 55; 102743. [PubMed: 32249203].
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III. Vaccine Safety
- Vaccine safety issues found in clinical trials:
- Vaccine safety issues found in research:
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IV. References
- Websites
- WHO Draft Landscape of COVID-19 Candidate Vaccines
- COVID-19 vaccine tracker by RAPS
- COVID-19 vaccine tracker by BioRender
- CDC: Ensuring the Safety of COVID-19 Vaccines in the United States
- Journal Articles
From He lab:
- Ong E, Wong M, Huffman A, He Y. COVID-19 coronavirus vaccine design using reverse vaccinology and machine learning. Frontiers in Immunology. 11:1581. doi: 10.3389/fimmu.2020.01581. (Published: 03 July 2020.) PMID: 32719684. PMCID: PMC7350702.
- He Y, Yu H, Ong E, Wang Y, Liu Y, Huffman A, Huang H, Beverley J, Hur J, Yang X, Chen L, Omenn GS, Athey B, Smith B. CIDO, a community-based ontology for coronavirus disease knowledge and data integration, sharing, and analysis. Scientific Data. (2020) 7:181. doi: 10.1038/s41597-020-0523-6. (Published: 12 June 2020) PMID: 32533075. PMCID: PMC7293349.
- Edison Ong, Xiaoqiang Huang, Robin Pearce, Yang Zhang, Yongqun He. Rational Design of SARS-CoV-2 Spike Glycoproteins To Increase Immunogenicity By T Cell
- Epitope Engineering. bioRxiv. Posted on August 14, 2020. URL: https://www.biorxiv.org/content/10.1101/2020.08.14.251496v1.
- Huffman A, Austin L, Wong MU, Ong E, He Y. Coronavirus vaccine collection, annotation, and ontology representation analysis. 6-page full length proceeding paper, accepted and orally represented by Mr. Anthony Huffman (Dr. He’s graduate student in Bioinformatics) in VDOS-2020, Zoom virtual meeting, September 19, 2020.
- Announcements
- FDA:
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