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pCMV-TPA/ZS7 DNA vaccine plasmid |
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DNA Vaccine Plasmid ID |
110 |
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DNA Vaccine Plasmid Name |
pCMV-TPA/ZS7 DNA vaccine plasmid |
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Plasmid VO ID |
VO_0005024
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Promoter Names |
CMV |
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Plasmid Description |
Also contains a synthetic chimeric intron, the ospC gene from B. burgdorferi strain ZS7, and the SV40 late poly(A) signal sequence (Scheiblhofer et al., 2003). Generated from pCMV-ZS7 by attaching the human tissue plasminogen activator (TPA) leader sequence to the 5' end of ospC ZS7 (Weiss et al., 1999). |
| Related Vaccine(s) |
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| References |
Scheiblhofer et al., 2003: Scheiblhofer S, Weiss R, Dürnberger H, Mostböck S, Breitenbach M, Livey I, Thalhamer J. A DNA vaccine encoding the outer surface protein C from Borrelia burgdorferi is able to induce protective immune responses. Microbes and infection / Institut Pasteur. 2003; 5(11); 939-946. [PubMed: 12941385].
Weiss et al., 1999: Weiss R, Dürnberger J, Mostböck S, Scheiblhofer S, Hartl A, Breitenbach M, Strasser P, Dorner F, Livey I, Crowe B, Thalhamer J. Improvement of the immune response against plasmid DNA encoding OspC of Borrelia by an ER-targeting leader sequence. Vaccine. 1999; 18(9-10); 815-824. [PubMed: 10580194].
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