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Plasmodium spp.

Table of Contents
  1. Protective Antigens
    1. ABRA
    2. AMA-1
    3. AMA-1 from P. berghei
    4. AMA1 from P. falciparum 3D7
    5. AMA1 from P. knowlesi
    6. cjaA
    7. CS from P. berghei str. ANKA
    8. CS from P. falciparum
    9. CS from P. yoelii str. 17XNL
    10. CSP from P. knowlesi
    11. eba-175
    12. FCR3S1.2-var1
    13. GLURP
    14. HEP17
    15. HSP60 from P. yoelii
    16. Hsp90
    17. Kbeta
    18. LSA-3
    19. MSP-1
    20. msp-8
    21. MSP1
    22. MSP1 from P. berghei
    23. MSP1 from P. knowlesi
    24. MSP1 from P. yoelii str. 17XNL
    25. msp3
    26. MSP4/5
    27. PF10_0155 enolase
    28. pfCelTOS
    29. RESA
    30. SERA-5
    31. SSP2
    32. SSP2 from P. knowlesi
    33. TRAP from P. falciparum
1. ABRA
  • Gene Name : ABRA
  • Sequence Strain (Species/Organism) : Plasmodium falciparum Camp
  • VO ID : VO_0010926
  • NCBI Protein GI : 160047
  • Other Database IDs : swissprot:: P22620; GI:113005
  • Taxonomy ID : 5833
  • Gene Strand (Orientation) : ?
  • Protein Name : p101/acidic basic repeat antigen
  • Protein pI : 4.52
  • Protein Weight : 83059.95
  • Protein Length : 824
  • DNA Sequence : Show Sequence
    >PFL1385c |MSP-9|Acid-Basic Repeat Antigen, ABRA, 101 kd malaria antigen, 2277.t00277, p101|Merozoite Surface Protein 9, MSP-9|Plasmodium falciparum|chr 12|STANFORD||Manual
    ATGATGAACA TGAAAATTGT TTTATTCAGT TTATTGCTCT TTGTCATAAG ATGGAATATT
    ATTAGTTGTA ATAAAAACGA CAAGAACCAA GGTGTTGATA TGAATGTTTT GAATAATTAT
    GAAAATTTAT TTAAATTTGT TAAATGTGAA TATTGTAATG AACATACTTA TGTTAAAGGT
    AAGAAAGCTC CTTCAGATCC TCAATGTGCT GATATAAAAG AAGAATGCAA AGAATTACTT
    AAGGAAAAAC AATACACAGA TTCAGTTACA TATTTAATGG ATGGTTTTAA ATCAGCAAAT
    AATTCAGCAA ATAATGGTAA AAAAAATAAC GCTGAAGAAA TGAAAAATTT AGTAAATTTC
    TTACAATCTC ATAAGAAATT AATTAAAGCA TTAAAAAAGA ATATTGAAAG TATACAAAAT
    AAGAAACACT TAATTTATAA AAACAAATCA TATAATCCAT TATTACTTTC TTGTGTTAAA
    AAAATGAATA TGTTAAAAGA AAATGTTGAC TATATTCAAA AAAATCAAAA CTTATTTAAA
    GAATTAATGA ATCAAAAAGC TACCTACTCT TTTGTTAATA CCAAAAAAAA AATTATTTCT
    TTAAAATCAC AAGGTCATAA AAAAGAAACC TCACAAAATC AAAATGAAAA TAACGACAAT
    CAAAAATATC AAGAAGTTAA TGATGAAGAT GATGTAAATG ATGAAGAAGA TACAAACGAT
    GACGAAGATA CTAACGATGA AGAAGATACA AACGATGACG AAGATACAAA TGATGACGAA
    GATACTAACG ATGAAGAAGA TACTAACGAC GAAGAAGATC ATGAAAATAA TAATGCTACA
    GCATACGAAT TAGGTATCGT CCCAGTTAAC GATGTGTTAA ATGTTAATAT GAAAAATATG
    ATAACAGGAA ATAATTTTAT GGATGTTGTT AAAAATACAT TAGCTCAATC AGGTGGATTA
    GGAAGTAATG ATTTAATAAA TTTCTTAAAT CAAGGTAAAG AAATAGGAGA AAATTTATTA
    AACATAACAA AGATGAACTT GGGAGATAAG AATAATCTTG AAAGTTTTCC TTTAGATGAA
    TTAAATATGT TAAAAGATAA TTTAATAAAC TATGAATTCA TATTAGATAA TTTGAAAACA
    AGTGTTTTAA ATAAATTAAA AGATTTATTA TTAAGATTAT TATACAAAGC ATATGTATCA
    TATAAGAAAA GAAAAGCTCA AGAAAAAGGA TTACCAGAAC CTACTGTTAC TAATGAAGAA
    TATGTTGAAG AATTAAAGAA AGGTATTCTA GATATGGGTA TCAAATTATT ATTTAGTAAA
    GTTAAAAGCC TATTAAAAAA ATTAAAAAAT AAAATATTCC CTAAGAAAAA AGAAGATAAT
    CAAGCAGTAG ATACCAAAAG TATGGAAGAA CCCAAAGTTA AAGCACAACC AGCTCTTAGA
    GGTGTTGAAC CAACGGAAGA TTCTAATATT ATGAACAGTA TTAATAATGT TATGGATGAA
    ATTGATTTCT TTGAAAAAGA ATTAATCGAA AATAATAATA CACCTAATGT TGTACCACCA
    ACTCAATCAA AAAAAAAAAA CAAAAATGAA ACTGTATCTG GTATGGATGA AAATTTTGAT
    AATCATCCTG AAAATTATTT TAAAGAAGAA TATTATTATG ATGAAAATGA TGATATGGAA
    GTAAAAGTTA AAAAAATAGG TGTCACATTA AAAAAATTTG AACCACTTAA AAATGGAAAT
    GTTAGTGAAA CCATTAAATT GATTCATTTA GGAAATAAAG ATAAAAAACA CATTGAAGCT
    ATAAACAACG ATATTCAAAT TATTAAACAA GAATTACAAG CTATTTATAA TGAACTTATG
    AATTATACAA ATGGAAACAA AAATATTCAA CAAATATTTC AACAAAATAT TCTAGAAAAT
    GATGTTCTTA ATCAAGAAAC GGAGGAAGAA ATGGAAAAAC AAGTTGAAGC AATCACCAAG
    CAAATAGAAG CTGAAGTGGA TGCCCTCGCA CCAAAAAATA AGGAAGAAGA AGAAAAAGAA
    AAGGAAAAAG AAGAAAAAGA AAAAGAAGAA AAAGAAAAAG AAAAAGAAGA AAAAGAAAAA
    GAAGAAAAAG AAAAAGAAGA AAAAGAAAAA GAAGAAAAAG AAGAAGAAAA AAAAGAAAAA
    GAAGAAGAAC AAGAAGAAGA AGAAGAAGAA GAAATAGTAC CAGAAAATTT GACAACTGAA
    GAATCAAAAT AA
  • Protein Sequence : Show Sequence
    >AAA29462.1 p101/acidic basic repeat antigen [Plasmodium falciparum]
    MMNMKIVLFSLLLFVIRWNIISCNKNDKNQGVDMNVLNNYENLFKFVKCEYCNEHTYVKGKKAPSDPQCA
    DIKEECKELLKEKQYTDSVTYLMDGFKSANNSANNGKKNNAEEMKNLVNFLQSHKKLIKALKKNIESIQN
    KKHLIYKNKSYNPLLLSCVKKMNMLKENVDYIQKNQNLFKELMNQKATYSFVNTKKKIISLKSQGHKKET
    SQNQNENNDNQKYQEVNDEDDVNDEEDTNDDEDTNDEEDTNDDEDTNDDEDTNDEEDTNDEEDHENNNAT
    AYELGIVPVNDVLNVNMKNMITGNNFMDVVKNTLAQSGGLGSNDLINFLNQGKEIGENLLNITKMNLGDK
    NNLESFPLDELNMLKDNLINYEFILDNLKTSVLNKLKDLLLRLLYKAYVSYKKRKAQEKGLPEPTVTNEE
    YVEELKKGILDMGIKLLFSKVKSLLKKLKNKIFPKKKEDNQAVDTKSMEEPKVKAQPALRGVEPTEDSNI
    MNSINNVMDEIDFFEKELIENNNTPNVVPPTQSKKKNKNETVSGMDENFDNHPENYFKEEYYYDENDDME
    VKVKKIGVTLKKFEPLKNGNVSETIKLIHLGNKDKKHIEAINNDIQIIKQELQAIYNELMNYTNGNKNIQ
    QIFQQNILENDVLNQETEEEMEKQVEAITKQIEAEVDALAPKNKEEEEKEKEKEKEKEEKEKEEKEKEEK
    EKEKEEKEKEKEEKEEEKKEKEEEQEEEEEEIVPENLTTEESK
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Protective antigen (Kushwaha et al., 2001)
  • Related Vaccine(s): Recombinant ABRA protein vaccine
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.420
  • Trans-membrane helices: 0
  • Detailed Vaxign Results Vaxign Results
2. AMA-1
  • Gene Name : AMA-1
  • Sequence Strain (Species/Organism) : Plasmodium chabaudi
  • VO ID : VO_0011237
  • NCBI Protein GI : 1469500
  • Other Database IDs : CDD:302876
  • Taxonomy ID : 5825
  • Gene Strand (Orientation) : ?
  • Protein Name : apical membrane antigen 1
  • Protein pI : 8.37
  • Protein Weight : 37252.97
  • Protein Length : 415
  • Protein Note : DK is a cloned line derived from 556KA
  • Protein Sequence : Show Sequence
    >AAB36511.1 apical membrane antigen 1, partial [Plasmodium chabaudi]
    DLIPKENTERSHKLINPWEKFMEKYDIEKVHGSGIRVDLGEDARVENQDYRIPSGKCPVMGKGITIQNSK
    VSFLTRVATGNQKVREGGLAFPQTDVNISPITIDNLKLMYKDHKEILALNDMSLCAKHASFYVPGTNVNT
    AYRHPAVYDKSNKTCYILYVAAQENMGPRYCSNEEDNENQPFCFTPEKKDEYKNLSYLTKNLREDWETSC
    PNKSIQNAKFGVWVDGYCSEYQKKEVHDNKTLLECNQIVFNESASDQPKQYEKHLEDTAKIRRGIVDRNG
    KLIGEALLPIGSYRADQVKSKGKGYNWANYDKKTKKCYIFNKKPTCLINDKDFVATTALS
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Mice immunized with a refolded, recombinant, Plasmodium chabaudi AMA1 fragment (AMA1B) can withstand subsequent challenge with P. chabaudi adami (Xu et al., 2000).
  • Related Vaccine(s): P. chabaudi AMA1 Protein Vaccine
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.409
  • Trans-membrane helices: 0
  • Detailed Vaxign Results Vaxign Results
3. AMA-1 from P. berghei
  • Gene Name : AMA-1 from P. berghei
  • Sequence Strain (Species/Organism) : Plasmodium berghei
  • VO ID : VO_0011224
  • NCBI Protein GI : 1438889
  • Other Database IDs : CDD:280571
  • Taxonomy ID : 5821
  • Gene Strand (Orientation) : ?
  • Protein Name : apical membrane antigen-1
  • Protein pI : 6.68
  • Protein Weight : 61320.86
  • Protein Length : 624
  • Protein Note : Apical membrane antigen 1; pfam02430
  • Protein Sequence : Show Sequence
    >AAC47192.1 apical membrane antigen-1 [Plasmodium berghei]
    MKEIYYILILCSIYLINLSNCSEGPNNVISENGHINYDMIQKENTERSTKLINPWEKYTEKYDIERMHGS
    GIRVDLGEDARVENRDYRIPSGKCPVIGKGITIQNSEVSFLTPVATGDQSVRSGGLALPKTDVHLSPITI
    DNLKTMYKEHTEIVKLNNMSLCAKHTSFYVPGNNANSAYRHPAVYDKSNSTCYMLYVAAQENMGPRYCSN
    NANNDNQPFCFTPEKIEKYKNLSYLTKNLRDDWETSCPNKSIKNAKFGIWVDGYCKDYQKHTVHDSDSLL
    KCNQIIFNESASDQPKQYEKHLEDTTKFRQGVAERNGKLIGEALLPIGSYKSDQIKSHGRGYNWGNYDSQ
    NKKCYIFETKPTCLINDRNFIATTALSSTEEFEEQFPCDIYKNKINEEIKVLNKNISNGNNSIEFPRIFI
    STDKNSLNCPCEPTQLTESSCNFYVCNCVEKRQYIAENNDVEIKEELEVHMKAHQTREVIVIIIFICVGI
    ILVILLVGYFFKSNKKGENYDRMGQADIYGKANSRKDGMLDPEVSFWGEDKRASHTTPVLMEKPYY
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Mice immunized with recombinant PbAMA-1 were partially protected from the challenge of P. berghei (Li et al., 2007).
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.405
  • Trans-membrane helices: 1
  • Detailed Vaxign Results Vaxign Results
4. AMA1 from P. falciparum 3D7
  • Gene Name : AMA1 from P. falciparum 3D7
  • Sequence Strain (Species/Organism) : Plasmodium falciparum 3D7
  • VO ID : VO_0010923
  • NCBI Gene ID : 810891
  • NCBI Protein GI : 124804478
  • Locus Tag : PF3D7_1133400
  • Genbank Accession : LN999945
  • Protein Accession : XP_001348015
  • 3D structure: PDB ID : 1Z40
  • Other Database IDs : UniProt: P22621
  • Taxonomy ID : 36329
  • Chromosome No : 11
  • Gene Starting Position : 1293855
  • Gene Ending Position : 1295723
  • Gene Strand (Orientation) : +
  • Protein Name : Apical membrane antigen 1 (AMA1); PF11_0344; AMA-1, Pf83, RMA1, RMA 1, rhoptry membrane antigen
  • Protein pI : 5.23
  • Protein Weight : 69161.85
  • Protein Length : 622
  • Protein Note : This is apical membrane antigen 1 (AMA1), or designated at PF11_0344 (PF11_0344 in GeneDB).
  • DNA Sequence : Show Sequence
    >NC_037282.1:1293855-1295723 Plasmodium falciparum 3D7 chromosome 11, complete sequence
    AATGAGAAAATTATACTGCGTATTATTATTGAGCGCCTTTGAGTTTACATATATGATAAACTTTGGAAGA
    GGACAGAATTATTGGGAACATCCATATCAAAATAGTGATGTGTATCGTCCAATCAACGAACATAGGGAAC
    ATCCAAAAGAATACGAATATCCATTACACCAGGAACATACATACCAACAAGAAGATTCAGGAGAAGACGA
    AAATACATTACAACACGCATATCCAATAGACCACGAAGGTGCCGAACCCGCACCACAAGAACAAAATTTA
    TTTTCAAGCATTGAAATAGTAGAAAGAAGTAATTATATGGGTAATCCATGGACGGAATATATGGCAAAAT
    ATGATATTGAAGAAGTTCATGGTTCAGGTATAAGAGTAGATTTAGGAGAAGATGCTGAAGTAGCTGGAAC
    TCAATATAGACTTCCATCAGGGAAATGTCCAGTATTTGGTAAAGGTATAATTATTGAGAATTCAAATACT
    ACTTTTTTAACACCGGTAGCTACGGGAAATCAATATTTAAAAGATGGAGGTTTTGCTTTTCCTCCAACAG
    AACCTCTTATGTCACCAATGACATTAGATGAAATGAGACATTTTTATAAAGATAATAAATATGTAAAAAA
    TTTAGATGAATTGACTTTATGTTCAAGACATGCAGGAAATATGATTCCAGATAATGATAAAAATTCAAAT
    TATAAATATCCAGCTGTTTATGATGACAAAGATAAAAAGTGTCATATATTATATATTGCAGCTCAAGAAA
    ATAATGGTCCTAGATATTGTAATAAAGACGAAAGTAAAAGAAACAGCATGTTTTGTTTTAGACCAGCAAA
    AGATATATCATTTCAAAACTATACATATTTAAGTAAGAATGTAGTTGATAACTGGGAAAAAGTTTGCCCT
    AGAAAGAATTTACAGAATGCAAAATTCGGATTATGGGTCGATGGAAATTGTGAAGATATACCACATGTAA
    ATGAATTTCCAGCAATTGATCTTTTTGAATGTAATAAATTAGTTTTTGAATTGAGTGCTTCGGATCAACC
    TAAACAATATGAACAACATTTAACAGATTATGAAAAAATTAAAGAAGGTTTCAAAAATAAGAACGCTAGT
    ATGATCAAAAGTGCTTTTCTTCCCACTGGTGCTTTTAAAGCAGATAGATATAAAAGTCATGGTAAGGGTT
    ATAATTGGGGAAATTATAACACAGAAACACAAAAATGTGAAATTTTTAATGTCAAACCAACATGTTTAAT
    TAACAATTCATCATACATTGCTACTACTGCTTTGTCCCATCCCATCGAAGTTGAAAACAATTTTCCATGT
    TCATTATATAAAGATGAAATAATGAAAGAAATCGAAAGAGAATCAAAACGAATTAAATTAAATGATAATG
    ATGATGAAGGGAATAAAAAAATTATAGCTCCAAGAATTTTTATTTCAGATGATAAAGACAGTTTAAAATG
    CCCATGTGACCCTGAAATGGTAAGTAATAGTACATGTCGTTTCTTTGTATGTAAATGTGTAGAAAGAAGG
    GCAGAAGTAACATCAAATAATGAAGTTGTAGTTAAAGAAGAATATAAAGATGAATATGCAGATATTCCTG
    AACATAAACCAACTTATGATAAAATGAAAATTATAATTGCATCATCAGCTGCTGTCGCTGTATTAGCAAC
    TATTTTAATGGTTTATCTTTATAAAAGAAAAGGAAATGCTGAAAAATATGATAAAATGGATGAACCACAA
    GATTATGGGAAATCAAATTCAAGAAATGATGAAATGTTAGATCCTGAGGCATCTTTTTGGGGGGAAGAAA
    AAAGAGCATCACATACAACACCAGTTCTGATGGAAAAACCATACTATTA
    
    
  • Protein Sequence : Show Sequence
    >XP_001348015.1 apical membrane antigen 1 [Plasmodium falciparum 3D7]
    MRKLYCVLLLSAFEFTYMINFGRGQNYWEHPYQNSDVYRPINEHREHPKEYEYPLHQEHTYQQEDSGEDE
    NTLQHAYPIDHEGAEPAPQEQNLFSSIEIVERSNYMGNPWTEYMAKYDIEEVHGSGIRVDLGEDAEVAGT
    QYRLPSGKCPVFGKGIIIENSNTTFLTPVATGNQYLKDGGFAFPPTEPLMSPMTLDEMRHFYKDNKYVKN
    LDELTLCSRHAGNMIPDNDKNSNYKYPAVYDDKDKKCHILYIAAQENNGPRYCNKDESKRNSMFCFRPAK
    DISFQNYTYLSKNVVDNWEKVCPRKNLQNAKFGLWVDGNCEDIPHVNEFPAIDLFECNKLVFELSASDQP
    KQYEQHLTDYEKIKEGFKNKNASMIKSAFLPTGAFKADRYKSHGKGYNWGNYNTETQKCEIFNVKPTCLI
    NNSSYIATTALSHPIEVENNFPCSLYKDEIMKEIERESKRIKLNDNDDEGNKKIIAPRIFISDDKDSLKC
    PCDPEMVSNSTCRFFVCKCVERRAEVTSNNEVVVKEEYKDEYADIPEHKPTYDKMKIIIASSAAVAVLAT
    ILMVYLYKRKGNAEKYDKMDEPQDYGKSNSRNDEMLDPEASFWGEEKRASHTTPVLMEKPYY
    
    
  • Molecule Role : Protective antigen
  • Related Vaccine(s): FMP1/AS02A
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.200
  • Trans-membrane helices: 1
  • Detailed Vaxign Results Vaxign Results
5. AMA1 from P. knowlesi
  • Gene Name : AMA1 from P. knowlesi
  • Sequence Strain (Species/Organism) : Plasmodium knowlesi strain H
  • NCBI Protein GI : 221056402
  • Other Database IDs : CDD:240241
    EnsemblGenomes-Gn:PKH_093110
    EnsemblGenomes-Tr:PKH_093110
    GOA:B3L5E1
    InterPro: IPR003298
    InterPro: IPR024056
    UniProtKB/TrEMBL: B3L5E1
  • Taxonomy ID : 5851
  • Gene Strand (Orientation) : ?
  • Protein Name : apical merozoite antigen 1
  • Protein pI : 6.98
  • Protein Weight : 62359.812
  • Protein Length : 647
  • Protein Note : apical membrane antigen 1; Provisional
  • Protein Sequence : Show Sequence
    >XP_002259339.1 apical merozoite antigen 1 [Plasmodium knowlesi strain H]
    MNKIYYILFLSAQCLVHMGKCERNQKTTRLTRSANNASLEKGPIIERSIRMSNPWKAFMEKYDLERAHNS
    GIRIDLGEDAEVGNSKYRIPAGKCPVFGKGIVIENSNVSFLTPVATGAQRLKEGGFAFPNADDHISPITI
    ANLKERYKENADLMKLNDIALCKTHAASFVIAEDQNTSYRHPAVYDEKNKTCYMLYLSAQENMGPRYCSP
    DSQNKDAMFCFKPDKNEKFDNLVYLSKNVSNDWENKCPRKNLGNAKFGLWVDGNCEEIPYVNEVEARSLR
    ECNRIVFEASASDQPRQYEEELTDYEKIQEGFRQNNRDMIKSAFLPVGAFNSDNFKSKGRGYNWANFDSV
    NNKCYIFNTKPTCLINDKNFFATTALSHPQEVDNEFPCSIYKDEIEREIKKQSRNMNLYSVDKERIVLPR
    IFISTDKESIKCPCEPEHISNSTCNFYVCNCVEKRAEIKENNEVIIKEEFKEDYENPDGKHKKKMLLIII
    GVTGAVCVVAVASLFYFRKKAQDDKYDKMDQAEAYGKTANTRKDEMLDPEASFWGEDKRASHTTPVLMEK
    PYY
    
    
  • Molecule Role : Protective antigen
  • Related Vaccine(s): P. knowlesi DNA vaccine encoding PkCSP, PkSSP2, PkAMA1, and PkMSP1p42
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.361
  • Trans-membrane helices: 1
  • Detailed Vaxign Results Vaxign Results
6. cjaA
  • Gene Name : cjaA
  • Sequence Strain (Species/Organism) : P. vivax SouthernMex-62 isolate
  • VO ID : VO_0010957
  • 3D structure: PDB ID : 1Z27
  • Other Database IDs : CDD:270412
    GOA:P94643
    InterPro: IPR001638
    UniProtKB/TrEMBL: P94643
  • Taxonomy ID : 197
  • Gene Strand (Orientation) : ?
  • Protein pI : 4.9
  • Protein Weight : 29158.88
  • Protein Length : 324
  • Protein Note : Substrate binding domain of ABC cysteine transporter; the type 2 periplasmic binding protein fold; cd13694
  • DNA Sequence : Show Sequence
    >gi|154184258:1-660 Plasmodium vivax isolate SouthernMex-62 ookinete surface protein (Pvs25) gene, complete cds
    ATGAACTCCTACTACAGCCTCTTCGTTTTTTTCCTCGTCCAAATTGCGCTAAAGTATAGCAAGGCAGCCG
    TCACGGTAGACACCATATGCAAAAATGGACAGCTGGTTCAAATGAGTAACCACTTTAAGTGTATGTGTAA
    CGAAGGGCTGGTGCACCTTTCCGAAAATACATGTGAAGAAAAAAATGAATGCAAGAAAGAAACCCTAGGC
    AAAGCATGCGGGGAATTTGGCCAGTGTATAGAAAACCCAGACCCAGCAAAGGTAAACATGTACAAATGTG
    GTTGCATTGAGGGCTACACTTTGAAGGAAGACACTTGTGTGCTTGATGTATGTCAATACAAAAATTGTGG
    AGAAAGTGGCGAATGCATTGTTGAGTACCTCTCGGAAACCCAAAGTGCAGGTTGCTCATGTGCTATTGGC
    AAAGTCCCCAATCCAGAAGATGAGAAAAAATGTACCAAAACGGGAGAAACTGCTTGTCAATTGAAATGTA
    ACACAGATAATGAAGTCTGCAAAAATGTTGAAGGAGTTTACAAGTGCCAGTGTATGGAAGGCTTTACGTT
    CGACAAAGAGAAAAATGTATGCCTTTCCTATTCTGTATTTAACATCCTAAACTACTCCCTCTTCTTTATC
    ATCCTGCTTGTCCTTTCGTACGTCATATAA
  • Protein Sequence : Show Sequence
    >CAA71822.1 cjaA [Campylobacter jejuni]
    MKKMLLSIFTTFVAVFLAACGGNSDSGASNSLERIKQDGVVRIGVFGDKPPFGYVDEKGVNQGYDIVLAK
    RIAKELLGDENKVQFVLVEAANRVEFLKSNKVDIILANFTQTPERAEQVDFCLPYMKVALGVAVPQDSNI
    SSIEDLKDKTLLLNKGTTADAYFTKEYPDIKTLKYDQNTETFAALIDQRGDALSHDNTLLFAWVKEHPEF
    KMAIKELGNKDVIAPAVKKGDKELKEFIDNLITKLGEEQFFHKAYDETLKSHFGDDVKADDVVIEGGKI
    
    
  • Molecule Role : Protective antigen
  • Related Vaccine(s): P. vivax PVS25 with Montanide ISA-720
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.352
  • Trans-membrane helices: 0
  • Detailed Vaxign Results Vaxign Results
7. CS from P. berghei str. ANKA
  • Gene Name : CS from P. berghei str. ANKA
  • Sequence Strain (Species/Organism) : Plasmodium berghei ANKA
  • VO ID : VO_0011217
  • NCBI Gene ID : 3428738
  • NCBI Protein GI : 1269284025
  • Locus Tag : PBANKA_040320
  • Genbank Accession : LK023119
  • Protein Accession : XP_022712148
  • Taxonomy ID : 5823
  • Chromosome No : 4
  • Gene Starting Position : 126554
  • Gene Ending Position : 127576
  • Gene Strand (Orientation) : -
  • Protein pI : 5.2
  • Protein Weight : 35858.22
  • Protein Length : 340
  • DNA Sequence : Show Sequence
    >NC_036162.1:126554-127576 Plasmodium berghei ANKA genome assembly PBANKA01, chromosome : 4
    TTTAATTAAAGAATACTAATACTAATAATATTACAAATCCTAATGAATTGCTTACAATATTAAATATACT
    TGAACATTTATCCATTTTACAAATTTCAGTATCAATATCTTCTAAGGTCAAATCTTCTGCTTTCTTATTT
    GAACCTTTTCGTTTTCTAACTCTTATACCAGAACCACATGTTACGTTACATTGAGACCATTCCTCTGTGA
    TACTATCCCTGATCTGTTTAACAAATTCTAGTATTTTTTCCGCGCTTGGGATATAAGAATCGTCATTATT
    ATTATTTTTGTTATTGTTATTACCACCTGGCTGTGGTTGTGGCTGTGGTCGTGGCTGTGGTTGTGGCTGT
    GGCTGTGGTTGTGGCTGTGGCTGTGGTTGTGGCTGCGGCCGTGGCTGTGGTTGTGGATTGTTATTTCCTT
    GTGGTGGTGCTGGGTCATTTGGGTTTGGTGGTGGTGGGTCATTTGCGTTTGGTGGTGCTGGGTCATTTGG
    GTTTGGTGGTGGTGGGTCATTTGCGTTTGGTGGTGCTGGGTCATTTGCGTTTGGTGGTGCTGGGTCATTT
    GCGTTTGGTGGTGCTGGGTCATTTGCGTTTGGTGGTGCTGGGTCATTTGCGTTTGGTGGTGGTGGGTCAT
    TTGCGTTTGGTGGTGGTGGGTCATTTGGGTTTGGTGGTGGTGGGTCATTTGGGTTTGGTGGTGGTGGGTC
    ATTTGGGTTTGGTGGTGGTGGGTCATTTGGGTTTGGTGGTGGTGGTGGTTGTTTCAATTTATTATTACGC
    TCTATTTTTTCGTTTTTTTTCTCATTTTTTTTTCCTTCGGGAGCATCGGCAAGTAATCTGTTGACTGTAT
    TTCGATTGTATATTTTTCCATTCTTAGAGTTAAGCACGTGATACAATTTATTATCATTTCCTTCATTGTA
    ACATAGCTCGTTTAAGTTCCTTTGGGCTTGGATGCTTTTATTTTGTCCATATCCTGGAAGTAGAGAATTA
    ACTAATAAAAGTGACGCTACAACTAAAATGGTACACTTCTTCA
    
    
  • Protein Sequence : Show Sequence
    >XP_022712148.1 circumsporozoite (CS) protein [Plasmodium berghei ANKA]
    MKKCTILVVASLLLVNSLLPGYGQNKSIQAQRNLNELCYNEGNDNKLYHVLNSKNGKIYNRNTVNRLLAD
    APEGKKNEKKNEKIERNNKLKQPPPPPNPNDPPPPNPNDPPPPNPNDPPPPNPNDPPPPNANDPPPPNAN
    DPAPPNANDPAPPNANDPAPPNANDPAPPNANDPPPPNPNDPAPPNANDPPPPNPNDPAPPQGNNNPQPQ
    PRPQPQPQPQPQPQPQPQPQPRPQPQPQPGGNNNNKNNNNDDSYIPSAEKILEFVKQIRDSITEEWSQCN
    VTCGSGIRVRKRKGSNKKAEDLTLEDIDTEICKMDKCSSIFNIVSNSLGFVILLVLVFFN
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Researchers produced a prototypic malaria vaccine based on a highly versatile self-assembling polypeptide nanoparticle (SAPN) platform that can repetitively display antigenic epitopes. Researchers used this platform to display a tandem repeat of the B cell immunodominant repeat epitope (DPPPPNPN)(2)D of the malaria parasite Plasmodium berghei circumsporozoite (CS) protein. Administered in saline, without the need for a heterologous adjuvant, the SAPN construct P4c-Mal conferred a long-lived, protective immune response to mice with a broad range of genetically distinct immune backgrounds including the H-2(b), H-2(d), and H-2(k) alleles. Mice were protected against an initial challenge of parasites up to 6 mo after the last immunization or for up to 15 mo against a second challenge after an initial challenge of parasites had successfully been cleared. (Kaba et al., 2009).
  • Related Vaccine(s): P. berghei DNA vaccine CSP-3p28 , P. berghei DNA vaccine encoding PbCSP , Plasmodium berghei CS Protein Subunit Vaccine
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.483
  • Trans-membrane helices: 1
  • Detailed Vaxign Results Vaxign Results
8. CS from P. falciparum
  • Gene Name : CS from P. falciparum
  • Sequence Strain (Species/Organism) : Plasmodium falciparum
  • VO ID : VO_0011218
  • NCBI Protein GI : 552191
  • Other Database IDs : CDD:278517
  • Taxonomy ID : 5833
  • Gene Strand (Orientation) : ?
  • Protein Name : circumsporozoite protein
  • Protein pI : 4.85
  • Protein Weight : 44428.05
  • Protein Length : 502
  • Protein Note : Thrombospondin type 1 domain; pfam00090
  • Protein Sequence : Show Sequence
    >AAA63422.1 circumsporozoite protein, partial [Plasmodium falciparum]
    MMRKLAILSVSSFLFVEALFQEYQCYGSSSNTRVLNELNYDNAGTNLYNELEMNYYGKQENWYSLKKNSR
    SLGENDDGNNNNGDNGREGKDEDKRDGNNEDNEKLRKPKHKKLKQPGDGNPDPNANPNVDPNANPNVDPN
    ANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNAN
    PNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPN
    ANPNANPNANPNANPNANPNKNNQGNGQGHNMPNDPNRNVDENANANNAVKNNNNEEPSDKHIEQYLKKI
    QNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYENDIEKKICKMEKCSSVFNVVNSSIGLIMVLSF
    LFLN
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : We employed a P. berghei parasite line that expresses a heterologous CSP (CS) from P. falciparum in order to assess the role of the CSP in the protection conferred by vaccination with radiation-attenuated P. berghei parasites. Our data demonstrated that sterile immunity could be obtained despite the absence of immune responses specific to the CSP expressed by the parasite used for challenge (Grüner et al., 2007).
  • Related Vaccine(s): P. falciparum CS expressed in irradiated P. berghei as Vaccine
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.694
  • Trans-membrane helices: 0
  • Detailed Vaxign Results Vaxign Results
9. CS from P. yoelii str. 17XNL
  • Gene Name : CS from P. yoelii str. 17XNL
  • Sequence Strain (Species/Organism) : Plasmodium yoelii yoelii 17XNL
  • VO ID : VO_0011219
  • NCBI Gene ID : 3830374
  • NCBI Protein GI : 83317409
  • Locus Tag : PY03168
  • Genbank Accession : AABL01000897
  • Protein Accession : XP_731149
  • Taxonomy ID : 352914
  • Gene Starting Position : 0
  • Gene Ending Position : 413
  • Gene Strand (Orientation) : +
  • Protein pI : 4.57
  • Protein Weight : 14411.64
  • Protein Length : 137
  • DNA Sequence : Show Sequence
    >NW_865424.3:1-413 Plasmodium yoelii yoelii str. 17XNL MALPY00900, whole genome shotgun sequence
    CCACCCCAACAACCACCCCAACAACCACCACAACAGCCACCACAACAGCCACCACAACAGCCACCACAAC
    AGCCACCACAACAACCACGCCCACAGCCAGATGGTAATAACAACAATAACAATAATAATGGTAATAATAA
    TGAAGATTCTTATGTCCCAAGCGCGGAACAAATACTAGAATTTGTTAAACAGATAAGTAGTCAACTCACA
    GAGGAATGGTCTCAATGTAGTGTAACCTGTGGTTCTGGTGTAAGAGTTAGAAAACGAAAAAATGTAAACA
    AGCAACCAGAAAATTTGACCTTAGAGGATATTGATACTGAAATTTGTAAAATGGATAAATGTTCAAGTAT
    ATTTAATATTGTAAGCAATTCATTAGGATTTGTAATATTATTAGTATTAGTATTCTTTAATTA
    
    
  • Protein Sequence : Show Sequence
    >XP_731149.1 circumsporozoite protein, partial [Plasmodium yoelii yoelii 17XNL]
    PPQQPPQQPPQQPPQQPPQQPPQQPPQQPRPQPDGNNNNNNNNGNNNEDSYVPSAEQILEFVKQISSQLT
    EEWSQCSVTCGSGVRVRKRKNVNKQPENLTLEDIDTEICKMDKCSSIFNIVSNSLGFVILLVLVFFN
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Study showed that immunization with irradiated sporozoites (IrrSpz) of a P. berghei line whose endogenous CS was replaced by that of P. yoelii conferred sterile protection against challenge with wild type P. berghei sporozoites (Mauduit et al., 2009).
  • Related Vaccine(s): P. yoelii DNA vaccine pDIP/PyCSP. 1
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.433
  • Trans-membrane helices: 1
  • Detailed Vaxign Results Vaxign Results
10. CSP from P. knowlesi
  • Gene Name : CSP from P. knowlesi
  • Sequence Strain (Species/Organism) : Plasmodium knowlesi strain H
  • NCBI Protein GI : 221060580
  • Other Database IDs : CDD:319368
    EnsemblGenomes-Gn:PKH_134120
    EnsemblGenomes-Tr:PKH_134120
    GOA:B3LAV3
    InterPro: IPR001841
    InterPro: IPR013083
    UniProtKB/TrEMBL: B3LAV3
  • Taxonomy ID : 5851
  • Gene Strand (Orientation) : ?
  • Protein Name : circumsporozoite protein, putative
  • Protein pI : 5.61
  • Protein Weight : 73901.662
  • Protein Length : 795
  • Protein Note : RING finger, H2 subclass, found in the PA-TM-RING ubiquitin ligase family; cd16454
  • Protein Sequence : Show Sequence
    >XP_002260935.1 circumsporozoite protein, putative [Plasmodium knowlesi strain H]
    MSISEHTGNEVSIAERKKKEEGSGGVINDKNVSPTDDGESMPHPMEKMKGAANDEKSVEVENCAPVGENE
    LRSSVLCVGCSGEASHIEEGSAKFVGEENPRTEVDSDKKAQPEGILNEVKNVKNEIDVEKKHKTQISNND
    TYVENAPNDNTCGEGCSNPHMNHDNKACDNGDDNDKIPNTGGTSNGGVIPNISGVLNVEDDCPLDEGNFS
    ADDRPEENADSTSSFMLEEDINLSRRAYRNFHICSIFIHGTLLLMVTLLMGILCHDFIKLSPISQKEKTM
    TYFCGLLLSMLALHLCLNLYMSLVLLRQSEVSKMLKSVEAKIHVIVLVYFSMCAYIYFFEDKYYPISSTF
    SFAIILAIIYYFMPIFLYIILRLLFIVVILVLVFVKRKSPTPKKILKKLKIMKYVEYRKYCEEEACFGSA
    YFTNWKELNGEGVSAPREATTTTAMEGGHIIATSGGDNKGEEVSSGDSTSNRNAEGKTISTATSCIRDIS
    ANGSGHPKGGDPPSSSPNDRPTRSGNSSTRSNLERHLFYDRAGVAIGRGGGSDNRGGTRPNDRGRDDPAN
    GNHQNGSDNANKHPPASYDNNCDAPNTSGEENGERNGGPNKDGKSAAVFEYFQKVLKKKNNSVQNDNVKV
    VHENNMEEHSFHINIECSDYVCSICCVEYLNEDDICILPCNYLHYYHKECIFKWLKRNNDCPLCRKPIGK
    I
    
    
  • Molecule Role : Protective antigen
  • Related Vaccine(s): P. knowlesi DNA vaccine encoding PkCSP, PkSSP2, PkAMA1, and PkMSP1p42
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.242
  • Trans-membrane helices: 4
  • Detailed Vaxign Results Vaxign Results
11. eba-175
  • Gene Name : eba-175
  • Sequence Strain (Species/Organism) : Plasmodium falciparum 3D7
  • VO ID : VO_0012382
  • NCBI Gene ID : 2654998
  • NCBI Protein GI : 296004911
  • Locus Tag : PF3D7_0731500
  • Genbank Accession : AL844506
  • Protein Accession : XP_001349207
  • Taxonomy ID : 36329
  • Chromosome No : 7
  • Gene Starting Position : 1358054
  • Gene Ending Position : 1362928
  • Gene Strand (Orientation) : +
  • Protein pI : 5.47
  • Protein Weight : 168527.84
  • Protein Length : 1502
  • Protein Note : Also known as eba 175; eba175
  • DNA Sequence : Show Sequence
    >NC_004328.3:1358054-1362928 Plasmodium falciparum 3D7 chromosome 7
    AATGAAATGTAATATTAGTATATATTTTTTTGCTTCCTTCTTTGTGTTATATTTTGCAAAAGCTAGGAAT
    GAATATGATATAAAAGAGAATGAAAAATTTTTAGACGTGTATAAAGAAAAATTTAATGAATTAGATAAAA
    AGAAATATGGAAATGTTCAAAAAACTGATAAGAAAATATTTACTTTTATAGAAAATAAATTAGATATTTT
    AAATAATTCAAAATTTAATAAAAGATGGAAGAGTTATGGAACTCCAGATAATATAGATAAAAATATGTCT
    TTAATAAATAAACATAATAATGAAGAAATGTTTAACAACAATTATCAATCATTTTTATCGACAAGTTCAT
    TAATAAAGCAAAATAAATATGTTCCTATTAACGCTGTACGTGTGTCTAGGATATTAAGTTTCCTGGATTC
    TAGAATTAATAATGGAAGAAATACTTCATCTAATAACGAAGTTTTAAGTAATTGTAGGGAAAAAAGGAAA
    GGAATGAAATGGGATTGTAAAAAGAAAAATGATAGAAGCAACTATGTATGTATTCCTGATCGTAGAATCC
    AATTATGCATTGTTAATCTTAGCATTATTAAAACATATACAAAAGAGACCATGAAGGATCATTTCATTGA
    AGCCTCTAAAAAAGAATCTCAACTTTTGCTTAAAAAAAATGATAACAAATATAATTCTAAATTTTGTAAT
    GATTTGAAGAATAGTTTTTTAGATTATGGACATCTTGCTATGGGAAATGATATGGATTTTGGAGGTTATT
    CAACTAAGGCAGAAAACAAAATTCAAGAAGTTTTTAAAGGGGCTCATGGGGAAATAAGTGAACATAAAAT
    TAAAAATTTTAGAAAAAAATGGTGGAATGAATTTAGAGAGAAACTTTGGGAAGCTATGTTATCTGAGCAT
    AAAAATAATATAAATAATTGTAAAAATATTCCCCAAGAAGAATTACAAATTACTCAATGGATAAAAGAAT
    GGCATGGAGAATTTTTGCTTGAAAGAGATAATAGATCAAAATTGCCAAAAAGTAAATGTAAAAATAATAC
    ATTATATGAAGCATGTGAGAAGGAATGTATTGATCCATGTATGAAATATAGAGATTGGATTATTAGAAGT
    AAATTTGAATGGCATACGTTATCGAAAGAATATGAAACTCAAAAAGTTCCAAAGGAAAATGCGGAAAATT
    ATTTAATCAAAATTTCAGAAAACAAGAATGATGCTAAAGTAAGTTTATTATTGAATAATTGTGATGCTGA
    ATATTCAAAATATTGTGATTGTAAACATACTACTACTCTCGTTAAAAGCGTTTTAAATGGTAACGACAAT
    ACAATTAAGGAAAAGCGTGAACATATTGATTTAGATGATTTTTCTAAATTTGGATGTGATAAAAATTCCG
    TTGATACAAACACAAAGGTGTGGGAATGTAAAAAACCTTATAAATTATCCACTAAAGATGTATGTGTACC
    TCCGAGGAGGCAAGAATTATGTCTTGGAAACATTGATAGAATATACGATAAAAACCTATTAATGATAAAA
    GAGCATATTCTTGCTATTGCAATATATGAATCAAGAATATTGAAACGAAAATATAAGAATAAAGATGATA
    AAGAAGTTTGTAAAATCATAAATAAAACTTTCGCTGATATAAGAGATATTATAGGAGGTACTGATTATTG
    GAATGATTTGAGCAATAGAAAATTAGTAGGAAAAATTAACACAAATTCAAATTATGTTCACAGGAATAAA
    CAAAATGATAAGCTTTTTCGTGATGAGTGGTGGAAAGTTATTAAAAAAGATGTATGGAATGTGATATCAT
    GGGTATTCAAGGATAAAACTGTTTGTAAAGAAGATGATATTGAAAATATACCACAATTCTTCAGATGGTT
    TAGTGAATGGGGTGATGATTATTGCCAGGATAAAACAAAAATGATAGAGACTCTGAAGGTTGAATGCAAA
    GAAAAACCTTGTGAAGATGACAATTGTAAACGTAAATGTAATTCATATAAAGAATGGATATCAAAAAAAA
    AAGAAGAGTATAATAAACAAGCCAAACAATACCAAGAATATCAAAAAGGAAATAATTACAAAATGTATTC
    TGAATTTAAATCTATAAAACCAGAAGTTTATTTAAAGAAATACTCGGAAAAATGTTCTAACCTAAATTTC
    GAAGATGAATTTAAGGAAGAATTACATTCAGATTATAAAAATAAATGTACGATGTGTCCAGAAGTAAAGG
    ATGTACCAATTTCTATAATAAGAAATAATGAACAAACTTCGCAAGAAGCAGTTCCTGAGGAAAGCACTGA
    AATAGCACACAGAACGGAAACTCGTACGGATGAACGAAAAAATCAGGAACCAGCAAATAAGGATTTAAAG
    AATCCACAACAAAGTGTAGGAGAGAACGGAACTAAAGATTTATTACAAGAAGATTTAGGAGGATCACGAA
    GTGAAGACGAAGTGACACAAGAATTTGGAGTAAATCATGGAATACCTAAGGGTGAGGATCAAACGTTAGG
    AAAATCTGACGCCATTCCAAACATAGGCGAACCCGAAACGGGAATTTCCACTACAGAAGAAAGTAGACAT
    GAAGAAGGCCACAATAAACAAGCATTGTCTACTTCAGTCGATGAGCCTGAATTATCTGATACACTTCAAT
    TGCATGAAGATACTAAAGAAAATGATAAACTACCCCTAGAATCATCTACAATCACATCTCCTACGGAAAG
    TGGAAGTTCTGATACAGAGGAAACTCCATCTATCTCTGAAGGACCAAAAGGAAATGAACAAAAAAAACGT
    GATGACGATAGTTTGAGTAAAATAAGTGTATCACCAGAAAATTCAAGACCTGAAACTGATGCTAAAGATA
    CTTCTAACTTGTTAAAATTAAAAGGAGATGTTGATATTAGTATGCCTAAAGCAGTTATTGGGAGCAGTCC
    TAATGATAATATAAATGTTACTGAACAAGGGGATAATATTTCCGGGGTGAATTCTAAACCTTTATCTGAT
    GATGTACGTCCAGATAAAAATCATGAAGAGGTGAAAGAACATACTAGTAATTCTGATAATGTTCAACAGT
    CTGGAGGAATTGTTAATATGAATGTTGAGAAAGAACTAAAAGATACTTTAGAAAATCCTTCTAGTAGCTT
    GGATGAAGGAAAAGCACATGAAGAATTATCAGAACCAAATCTAAGCAGTGACCAAGATATGTCTAATACA
    CCTGGACCTTTGGATAACACCAGTGAAGAAACTACAGAAAGAATTAGTAATAATGAATATAAAGTTAACG
    AGAGGGAAGGTGAGAGAACGCTTACTAAGGAATATGAAGATATTGTTTTGAAAAGTCATATGAATAGAGA
    ATCAGACGATGGTGAATTATATGACGAAAATTCAGACTTATCTACTGTAAATGATGAATCAGAAGACGCT
    GAAGCAAAAATGAAAGGAAATGATACATCTGAAATGTCGCATAATAGTAGTCAACATATTGAGAGTGATC
    AACAGAAAAACGATATGAAAACTGTTGGTGATTTGGGAACCACACATGTACAAAACGAAATTAGTGTTCC
    TGTTACAGGAGAAATTGATGAAAAATTAAGGGAAAGTAAAGAATCAAAAATTCATAAGGCTGAAGAGGAA
    AGATTAAGTCATACAGATATACATAAAATTAATCCTGAAGATAGAAATAGTAATACATTACATTTAAAAG
    ATATAAGAAATGAGGAAAACGAAAGACACTTAACTAATCAAAACATTAATATTAGTCAAGAAAGGGATTT
    GCAAAAACATGGATTCCATACCATGAATAATCTACATGGAGATGGAGTTTCCGAAAGAAGTCAAATTAAT
    CATAGTCATCATGGAAACAGACAAGATCGGGGGGGAAATTCTGGGAATGTTTTAAATATGAGATCTAATA
    ATAATAATTTTAATAATATTCCAAGTAGATATAATTTATATGATAAAAAATTAGATTTAGATCTTTATGA
    AAACAGAAATGATAGTACAACAAAAGAATTAATAAAGAAATTAGCAGAAATAAATAAATGTGAGAACGAA
    ATTTCTGTAAAATATTGTGACCATATGATTCATGAAGAAATCCCATTAAAAACATGCACTAAAGAAAAAA
    CAAGAAATCTGTGTTGTGCAGTATCAGATTACTGTATGAGCTATTTTACATATGATTCAGAGGAATATTA
    TAATTGTACGAAAAGGGAATTTGATGATCCATCTTATACATGTTTCAGAAAGGAGGCTTTTTCAAGTATG
    ATATTCAAATTTTTAATAACAAATAAAATATATTATTATTTTTATACTTACAAAACTGCAAAAGTAACAA
    TAAAAAAAATTAATTTCTCATTAATTTTTTTTTTCTTTTTTTCTTTTTAGGTATGCCATATTATGCAGGA
    GCAGGTGTGTTATTTATTATATTGGTTATTTTAGGTGCTTCACAAGCCAAATATCAAAGGTTAGAAAAAA
    TAAATAAAAATAAAATTGAGAAGAATGTAAATTAAATATATATATATATATATATATATATATATTGTAT
    TATATATTTTTTTTTTATAGTTCTGAAGGAGTTATGAATGAGAATAATGAGAATAATTTTTTATTTGAAG
    TTACTGATAATTTAGATAAATTATCCAATATGTGTAATACAAATATAAAAAAAAATAATAAATAAATAAA
    TAATTACAAGGAAATAAAAATGATATATATTATTACATTATGTTTGTTTACTTTTATATTATCCTATAAT
    ATTTATTTTTATTTTATGTTTTTTTTTTTTCAGTCAATCAACAAGTACAGGAAACTAATATCAACGATTT
    TTCTGAATACCATGAGGATATAAATGATATTAATTTTAAGAAATG
    
    
  • Protein Sequence : Show Sequence
    >XP_001349207.2 erythrocyte binding antigen-175 [Plasmodium falciparum 3D7]
    MKCNISIYFFASFFVLYFAKARNEYDIKENEKFLDVYKEKFNELDKKKYGNVQKTDKKIFTFIENKLDIL
    NNSKFNKRWKSYGTPDNIDKNMSLINKHNNEEMFNNNYQSFLSTSSLIKQNKYVPINAVRVSRILSFLDS
    RINNGRNTSSNNEVLSNCREKRKGMKWDCKKKNDRSNYVCIPDRRIQLCIVNLSIIKTYTKETMKDHFIE
    ASKKESQLLLKKNDNKYNSKFCNDLKNSFLDYGHLAMGNDMDFGGYSTKAENKIQEVFKGAHGEISEHKI
    KNFRKKWWNEFREKLWEAMLSEHKNNINNCKNIPQEELQITQWIKEWHGEFLLERDNRSKLPKSKCKNNT
    LYEACEKECIDPCMKYRDWIIRSKFEWHTLSKEYETQKVPKENAENYLIKISENKNDAKVSLLLNNCDAE
    YSKYCDCKHTTTLVKSVLNGNDNTIKEKREHIDLDDFSKFGCDKNSVDTNTKVWECKKPYKLSTKDVCVP
    PRRQELCLGNIDRIYDKNLLMIKEHILAIAIYESRILKRKYKNKDDKEVCKIINKTFADIRDIIGGTDYW
    NDLSNRKLVGKINTNSNYVHRNKQNDKLFRDEWWKVIKKDVWNVISWVFKDKTVCKEDDIENIPQFFRWF
    SEWGDDYCQDKTKMIETLKVECKEKPCEDDNCKRKCNSYKEWISKKKEEYNKQAKQYQEYQKGNNYKMYS
    EFKSIKPEVYLKKYSEKCSNLNFEDEFKEELHSDYKNKCTMCPEVKDVPISIIRNNEQTSQEAVPEESTE
    IAHRTETRTDERKNQEPANKDLKNPQQSVGENGTKDLLQEDLGGSRSEDEVTQEFGVNHGIPKGEDQTLG
    KSDAIPNIGEPETGISTTEESRHEEGHNKQALSTSVDEPELSDTLQLHEDTKENDKLPLESSTITSPTES
    GSSDTEETPSISEGPKGNEQKKRDDDSLSKISVSPENSRPETDAKDTSNLLKLKGDVDISMPKAVIGSSP
    NDNINVTEQGDNISGVNSKPLSDDVRPDKNHEEVKEHTSNSDNVQQSGGIVNMNVEKELKDTLENPSSSL
    DEGKAHEELSEPNLSSDQDMSNTPGPLDNTSEETTERISNNEYKVNEREGERTLTKEYEDIVLKSHMNRE
    SDDGELYDENSDLSTVNDESEDAEAKMKGNDTSEMSHNSSQHIESDQQKNDMKTVGDLGTTHVQNEISVP
    VTGEIDEKLRESKESKIHKAEEERLSHTDIHKINPEDRNSNTLHLKDIRNEENERHLTNQNINISQERDL
    QKHGFHTMNNLHGDGVSERSQINHSHHGNRQDRGGNSGNVLNMRSNNNNFNNIPSRYNLYDKKLDLDLYE
    NRNDSTTKELIKKLAEINKCENEISVKYCDHMIHEEIPLKTCTKEKTRNLCCAVSDYCMSYFTYDSEEYY
    NCTKREFDDPSYTCFRKEAFSSMPYYAGAGVLFIILVILGASQAKYQSSEGVMNENNENNFLFEVTDNLD
    KLSNMFNQQVQETNINDFSEYHEDINDINFKK
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : 1 of 3 Monkeys vaccinated with EBA-175 was protected from challenge of parasitized erythrocytes (Sim et al., 2001).
  • Related Vaccine(s): P. falciparum DNA Vaccine encoding EBA-175
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.494
  • Trans-membrane helices: 1
  • Detailed Vaxign Results Vaxign Results
12. FCR3S1.2-var1
  • Gene Name : FCR3S1.2-var1
  • Sequence Strain (Species/Organism) : Plasmodium falciparum
  • VO ID : VO_0011229
  • NCBI Protein GI : 2961468
  • Other Database IDs : CDD:292087
    CDD:283158
    CDD:281064
    CDD:114603
    CDD:292085
  • Taxonomy ID : 5833
  • Gene Strand (Orientation) : ?
  • Protein Name : erythrocyte membrane protein 1
  • Protein pI : 5.45
  • Protein Weight : 244016.11
  • Protein Length : 2328
  • Protein Note : N-terminal segments of PfEMP1; pfam15447
  • Protein Sequence : Show Sequence
    >AAC05730.1 erythrocyte membrane protein 1 [Plasmodium falciparum]
    MATSGGSGGTQDEDAKHVLDEFGQKVHDEVHGEAKNYVSELKGSLSLASILGETAFTVKSMQTESKYTEL
    IEANSKRNPCKKDGKGNDVDRFSVKEQAGYDNKKMKCSNGMTCAPFRRLHLCNKNFPNMNSNDSSKAKHD
    LLAEVCMAAKYEGESIKTHYPKYDSKYPGSDFPMCTMLARSFADIGDIIRGRDLYLGNKKKKQNGKETER
    EKLEQKLKEIFKKIHDNLKDKEAQKRYNGDEDPNFYKLREDWWTANRETVWGAMTCSKELDNSSYFRATC
    NDTGQGPSQTHNKCRCDKDKGANAGKPKAGDGDVTIVPTYFDYVPQYLRWFEEWAEDFCRKKKKKLENLE
    KQCRGKDKSDEYRYCSRNGYDCEQTISRKGKVRMGKGCTDCFFACHSYENWIDNQRKQFDKQKKYTKEIS
    DGGGRKKRAVGGTTKYEGYEKSFYEKLKNDGYGTVDAFLGLLNNEKACKDITDGGKINFKEVNSGGGVVG
    GGSGGTSGASGTNDENKGTFYRSEYCQPCPDCGVQHKGGNQWERKTKVKKMRWSKLYKPINGKMVLLLKS
    LKVVKDMMILKKNWKEFCLTQNSSDGSVGSVVTTGASGGNSEKKELYDEWKCYKHNEVQKVNVQGEVEED
    DDELKGAGGLCILPNPKKNKEVSEAKSQNNHADIQKTFHDFFYYWVAHMLKDSIHWRTKRLKSCISDGKT
    MKCRNGCNKKCDCFEKWVKQKETEWKPIKDHFKTQEGIPEGYYFTTLELILKLQFLKEDTEENTENSLDA
    EEAEELKHLQKILKLENENNLAVVNAGTEQKTLMDKLLNHELNDATKCKDCPLPEEDKSRGRSADPSPDI
    FIPRPEEKEDDENEDDDEDEVRDDEETAKETTEGSATDTTTSLDVCPIVGKVLTKDNESLQDACSLKYGG
    NNSRLGWRCVTPSGEPTTSSDKNGAICVPPRRRRLYIKKIVDWATKTESPQASGSEASSTSGSTTPPDSK
    EALLKAFVESAAIETFFLWHRYKEEKKAVAQEGAGHGLPRVEEGSPEYDPEDKLKEGKIPDGFLRQMFYT
    LGDYRDILFSGSNDTTSVSKDTPSSSNDNLKNIVLLASGSTEQEREKMNKYKEIKNFRKCSTERSAPNLV
    SHPQTWWENNGKYIWHGMVCALTSKDKIAKGVEKKPQKIENPENLWDEANKKPKPPQYQYTNVKLDENSG
    TSPRTTQTQASSDNTPTTLTHFVKRPTYFRWFEEWGESFCRERKKRLKQIKVDCKVENGDVGRCSGDGEA
    CDSISTHDYSTVPSFNCPGCGKHCSSYRKWIERKKIEFHKQSNAYGQQKTDATRNNGNTFDKEFCKTLET
    WPDAAKFLERLKNGPCKTNKEYGGDDIDFEKDSKTFQHTEYCGPCPKFKTNCQNGNCGVSGLNGNCDGKD
    SIDAKEIAKMRSSTTDVVMRVSDNDTNTFEGDDLKDACQHANIFKGIRKDVWKCGYVCGVDICEQTNINE
    RTDGKEYIQIRALFKRWVENFLEDYNKINDKISHCIKKGEGSKCINGCEKNSKCLEKWIEKKIAEWENIK
    KRFNDQYENKDQPDYNVKSILEELIPKIAVVNDQDNVIKLCVFENSKGCTLISNTQNNKENDAIDCMLKK
    LGVKAKNCPGKPSGEKQSDCKEPPPLPDEEDQNPEENTLEPPKFCPPTTQPPEEKGGETCGNKEEKKDEK
    KEESEEPAKEESGPAAEEPAPTAESEETETNFPEPPGTGPAAPPSTPAPPTPDTPPPLRPQADEPFDSTI
    LQTTIPFGVALALGSIAFLFLKKKTKASVGNLFQILQIPKSDYDIPTLKSSNRYIPYVSDRYKGKTYIYM
    EGDSDEDKYAFMSDTTDVTSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSGNNTTASGKNTPSDTRND
    IQNDGIPSSKITDNEWNQLKKEFISNMLQNQPNDVPNDYTSGNSSTNTNITTTSRHNVDNNTNTTMSRDN
    MEENLLLPSIHDRNLYSGEEYSYNVNMVNSMNDIPINRDNNVYSGIDLINDSLSGGKPIDIYDEVLKRKE
    NELFGTENTKRTSTQNVAKITNSDPIHNQLELFHKWLDRHRDMCEKWKNKEDILNKLKEEWNKENINNSG
    KTYNSDNKPSHNHVLNTDVSIQIDMDNPKTKNEITNMDTNQDKSTMDTILDDLEKYNDPYYYDFYEDDII
    YHDVDVEKSSMDDIYVDHNNVTSNNMDVPTKMHIEMNIVNNKKEIFEEEYPISDIWNI
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Immunized animals were challenged in vivo with various parasite strains or clones of malaria. Immunization with the PfEMP1-DBL1 alpha domain abolished the PfEMP1-dependent sequestration of the homologous strain in immunized rats and substantially inhibited parasite adhesion in immunized monkeys. Protection against sequestration of heterologous parasite strains was also confirmed by direct or indirect challenge in the rat model (Moll et al., 2007).
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.604
  • Trans-membrane helices: 0
  • Detailed Vaxign Results Vaxign Results
13. GLURP
  • Gene Name : GLURP
  • Sequence Strain (Species/Organism) : Plasmodium falciparum 3D7
  • VO ID : VO_0011343
  • NCBI Gene ID : 810501
  • NCBI Protein GI : 124802897
  • Locus Tag : PF3D7_1035300
  • Genbank Accession : LN999944
  • Protein Accession : XP_001347628
  • Taxonomy ID : 36329
  • Chromosome No : 10
  • Gene Starting Position : 1399194
  • Gene Ending Position : 1402895
  • Gene Strand (Orientation) : +
  • Protein Name : glutamate-rich protein
  • Protein pI : 3.98
  • Protein Weight : 130731.93
  • Protein Length : 1233
  • DNA Sequence : Show Sequence
    >NC_037281.1:1399194-1402895 Plasmodium falciparum 3D7 chromosome 10, complete sequence
    AATGAGAAACCTTTTCCATATTACCATTTGTTTAGTTACACTTAATTTATTTATATTGGAAATAAATGCA
    AAAACCAATACAAGTGAGAATAGAAATAAACGAATCGGGGGTCCTAAATTAAGGGGTAATGTTACAAGTA
    ATATAAAGTTCCCATCAGATAACAAAGGTAAAATTATAAGAGGTTCGAATGATAAACTTAATAAAAACTC
    TGAAGATGTTTTAGAACAAAGCGAAAAATCGCTTGTTTCAGAAAATGTTCCTAGTGGATTAGATATAGAT
    GATATCCCTAAAGAATCTATTTTTATTCAAGAAGATCAAGAAGGTCAAACTCATTCTGAATTAAATCCTG
    AAACATCAGAACATAGTAAAGATTTAAATAATAATGATTCAAAAAATGAATCTAGTGATATTATTTCAGT
    AAATAATAAATCAAATAAAGTACAAAATCATTTTGAATCATTATCAGATTTAGAATTACTTGAAAATTCC
    TCACAAGATAATTTAGACAAAGATACAATTTCAACAGAACCTTTTCCTAATCAAAAACATAAAGACTTAC
    AACAAGATTTAAATGATGAACCTTTAGAACCCTTTCCTACACAAATACATAAAGATTATAAAGAAAAAAA
    TTTAATAAATGAAGAAGATTCAGAACCATTTCCCAGACAAAAGCATAAAAAGGTAGACAATCATAATGAA
    GAAAAAAACGTATTTCATGAAAATGGTTCTGCAAATGGTAATCAAGGAAGTTTGAAACTTAAATCATTCG
    ATGAACATTTAAAAGATGAAAAAATAGAAAATGAACCACTTGTTCATGAAAATTTATCCATACCAAATGA
    TCCAATAGAACAAATATTAAATCAACCTGAACAAGAAACAAATATCCAGGAACAATTGTATAATGAAAAA
    CAAAATGTTGAAGAAAAACAAAATTCTCAAATACCTTCGTTAGATTTAAAAGAACCAACAAATGAAGATA
    TTTTACCAAATCATAATCCATTAGAAAATATAAAACAAAGTGAATCAGAAATAAATCATGTACAAGATCA
    TGCGCTACCAAAAGAGAATATAATAGACAAACTTGATAATCAAAAAGAACACATCGATCAATCACAACAT
    AATATAAATGTATTACAAGAAAATAACATAAACAATCACCAATTAGAACCTCAAGAGAAACCTAATATTG
    AATCGTTTGAACCTAAAAATATAGATTCAGAAATTATTCTTCCTGAAAATGTTGAAACAGAAGAAATAAT
    AGATGATGTGCCTTCCCCTAAACATTCTAACCATGAAACATTTGAAGAAGAAACAAGTGAATCTGAACAT
    GAAGAAGCCGTATCTGAAAAAAATGCCCACGAAACTGTCGAACATGAAGAAACTGTGTCTCAAGAAAGCA
    ATCCTGAAAAAGCTGATAATGATGGAAATGTATCTCAAAACAGCAACAACGAATTAAATGAAAATGAATT
    CGTTGAATCGGAAAAAAGCGAGCATGAACCAGCTGAAAATGAAGAAAGTAGTCTTGAAGAAGGTCATCAT
    GAAGAAATTGTACCTGAACAAAATAATGAAGAATCAGGTGAAAGTAAATTAGTTGATAATGATGAAGGTG
    GTTTTGAAGAAGCTCATCATGAAAATTTTTCATCTGAAGTAAGTAACTCTGAATTAAATGAAAATGAATT
    TGTTGAATCTGACAAAAGTGTAACTGAACCTGCTGAACATGAAGAAGTTGTATCTGAAGAAAGCAACCCT
    GAACCAGCTGAAAATGAAGAAAGTAGTATAGAAGAAGCTCATCAGGAAGAAATTGTACCTGAACAAAATG
    ATGAAGAATCAGGTGAAAGTGGATTAGTTGATAATGAAGAAGGTGATTTTGAAGAACCTAATCATGAAGA
    ATTTGAACCTGATCAAAATGACTCTGAATTAAGTGAAAATGAATTAGTTGAATCAGAAAAAAGTGTATCT
    GAACCAGCTGAACATGTAGAAATTGTATCAGAAAAAAGTGTATCTGAACCAGCTGAACACGTAGAAATTG
    TATCTGAAAAAAGTACATCCGAACCAGCTGAACATGTAGAAAGTGTATCTGAACAAAGTAATAACGAACC
    ATCCGAAAAGAAAGATGGACCAGTTCCTTCAAAACCATTTGAAGAAATTGAAAAAGTGGATGTTCAACCT
    AAAATTGTAGACCTTCAAATAATTGAACCTAATTTTGTTGACTCACAACCAAATCCACAAGAACCAGTTG
    AACCATCATTTGTCAAAATTGAAAAAGTTCCTTCTGAAGAAAATAAACATGCAAGTGTTGATCCTGAAGT
    AAAAGAAAAAGAAAATGTATCTGAAGTTGTTGAAGAAAAACAAAATTCACAAGAATCAGTTGAAGAAATT
    CCAGTAAATGAGGATGAATTTGAAGATGTTCACACTGAACAATTAGATTTAGATCATAAAACAGTTGATC
    CAGAAATAGTAGAAGTTGAAGAAATTCCTTCAGAACTACATGAAAATGAAGTGGCTCATCCAGAAATTGT
    TGAAATTGAGGAAGTTTTTCCTGAACCAAATCAAAATAACGAATTTCAAGAAATTAATGAAGATGATAAA
    AGTGCACATATTCAGCATGAAATAGTAGAAGTAGAAGAAATACTTCCAGAAGATGATAAAAATGAAAAAG
    TTGAACATGAAATAGTAGAAGTTGAAGAAATTCTACCAGAAGATAAAAATGAAAAAGTTCAACATGAAAT
    AGTAGAGGTTGAAGAAATTCTACCAGAAGATAAAAATGAAAAAGTTGAACATGAAATAGTAGAAGTTGAA
    GAAATTCTACCAGAAGATAAAAATGAAAAAGGTCAACATGAAATAGTAGAGGTTGAAGAAATTCTACCAG
    AAGATAAAAATGAAAAAGTTCAACATGAAATAGTAGAAGTTGAAGAAATTCTACCAGAAGATAAAAATGA
    AAAAGGTCAACATGAAATAGTAGAGGTTGAAGAAATTCTACCAGAAGATAAAAATGAAAAAGTTGAACAT
    GAAATAGTAGAAGTTGAAGAAATTCTACCAGAAGATAAAAATGAAAAAGGTCAACATGAAATAGTAGAGG
    TTGAAGAAATTCTACCAGAAGATGATAAAAATGAAAAAGGTCAACATGAAATAGTAGAGGTTGAAGAAAT
    TCTTCCAGAAATTGTTGAAATTGAAGAAGTACCATCACAAACAAATAACAATGAAAATATTGAAACTATA
    AAACCAGAAGAAAAAAAGAATGAATTTAGTGTTGTTGAAGAAAAAGCAATTCCACAAGAACCCGTGGTAC
    CTACATTAAATGAAAATGAAAACGTTACTCCCAAACCATCTGAAGGTGAATCCACTAAACCAGATATAGT
    TCAAATTAAAATAGTACAAGAAAATAAACCAAATAAAAAGGAAACACCAGTAGTAGATGGTCCAAAACAT
    GTAGAACAAAATATACAAGAAGATGATAATGATGAAGAGGATGATGATGATATAGATTTTGAAGGATTAT
    CAAGAAAAGATGATGAAAAGGATTCATCAAATAAAAATAAAAAGAAATCATCTTTTATAACATATATATC
    TACAAAGAAATTTAAAAAAGTATCTCAAACTATTGTAAGTGTTATGATTAATGCATATGATGGTGTTATT
    CAAGTTGTAAGTACAATTAAAGGAATAGCAAAGGATATAGTAATATTTTTCCAAAACATTTA
    
    
  • Protein Sequence : Show Sequence
    >XP_001347628.1 glutamate-rich protein [Plasmodium falciparum 3D7]
    MRNLFHITICLVTLNLFILEINAKTNTSENRNKRIGGPKLRGNVTSNIKFPSDNKGKIIRGSNDKLNKNS
    EDVLEQSEKSLVSENVPSGLDIDDIPKESIFIQEDQEGQTHSELNPETSEHSKDLNNNDSKNESSDIISV
    NNKSNKVQNHFESLSDLELLENSSQDNLDKDTISTEPFPNQKHKDLQQDLNDEPLEPFPTQIHKDYKEKN
    LINEEDSEPFPRQKHKKVDNHNEEKNVFHENGSANGNQGSLKLKSFDEHLKDEKIENEPLVHENLSIPND
    PIEQILNQPEQETNIQEQLYNEKQNVEEKQNSQIPSLDLKEPTNEDILPNHNPLENIKQSESEINHVQDH
    ALPKENIIDKLDNQKEHIDQSQHNINVLQENNINNHQLEPQEKPNIESFEPKNIDSEIILPENVETEEII
    DDVPSPKHSNHETFEEETSESEHEEAVSEKNAHETVEHEETVSQESNPEKADNDGNVSQNSNNELNENEF
    VESEKSEHEPAENEESSLEEGHHEEIVPEQNNEESGESKLVDNDEGGFEEAHHENFSSEVSNSELNENEF
    VESDKSVTEPAEHEEVVSEESNPEPAENEESSIEEAHQEEIVPEQNDEESGESGLVDNEEGDFEEPNHEE
    FEPDQNDSELSENELVESEKSVSEPAEHVEIVSEKSVSEPAEHVEIVSEKSTSEPAEHVESVSEQSNNEP
    SEKKDGPVPSKPFEEIEKVDVQPKIVDLQIIEPNFVDSQPNPQEPVEPSFVKIEKVPSEENKHASVDPEV
    KEKENVSEVVEEKQNSQESVEEIPVNEDEFEDVHTEQLDLDHKTVDPEIVEVEEIPSELHENEVAHPEIV
    EIEEVFPEPNQNNEFQEINEDDKSAHIQHEIVEVEEILPEDDKNEKVEHEIVEVEEILPEDKNEKVQHEI
    VEVEEILPEDKNEKVEHEIVEVEEILPEDKNEKGQHEIVEVEEILPEDKNEKVQHEIVEVEEILPEDKNE
    KGQHEIVEVEEILPEDKNEKVEHEIVEVEEILPEDKNEKGQHEIVEVEEILPEDDKNEKGQHEIVEVEEI
    LPEIVEIEEVPSQTNNNENIETIKPEEKKNEFSVVEEKAIPQEPVVPTLNENENVTPKPSEGESTKPDIV
    QIKIVQENKPNKKETPVVDGPKHVEQNIQEDDNDEEDDDDIDFEGLSRKDDEKDSSNKNKKKSSFITYIS
    TKKFKKVSQTIVSVMINAYDGVIQVVSTIKGIAKDIVIFFQNI
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Some of the S. sciureus monkeys immunized with MSP-3(212-380)-AS02 or GLURP(27-500)-alum were able to fully or partially control parasitaemia upon an experimental P. falciparum [Falciparum Uganda Palo Alto (FUP-SP) strain] blood-stage infection, and this protection was related to the prechallenge antibody titres induced. The data are indicative that MSP-3 and GLURP can induce protective immunity against an experimental P. falciparum infection using adjuvants that are acceptable for human use and this should trigger further studies with those new antigens (Carvalho et al., 2004).
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.164
  • Trans-membrane helices: 0
  • Detailed Vaxign Results Vaxign Results
14. HEP17
  • Gene Name : HEP17
  • Sequence Strain (Species/Organism) : Plasmodium yoelii
  • VO ID : VO_0011228
  • NCBI Protein GI : 1399353
  • Other Database IDs : CDD:284100
  • Taxonomy ID : 5861
  • Gene Strand (Orientation) : ?
  • Protein Name : hepatocyte erythrocyte protein 17 kDa
  • Protein pI : 10.09
  • Protein Weight : 17587.89
  • Protein Length : 243
  • Protein Note : Circumsporozoite-related antigen (CRA); pfam06589
  • Protein Sequence : Show Sequence
    >AAC47199.1 hepatocyte erythrocyte protein 17 kDa [Plasmodium yoelii]
    MKINIASIIFIIFSLCLVNDAYGKNKYGKNGKYGSQNVIKKHGEPVINVQDLISDMVRKEEEIVKLTKNK
    KSLRKINVALATALSVVSAILLGGAGLVMYNTEKGRRPFQIGKSKKGGSAMARDSSFPMNEESPLGFSPE
    EMEAVASKFRESMLKDGVPAPSNTPNVQN
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Immunization of mice with subunit vaccines based on the Plasmodium yoelii 17kDa hepatocyte erythrocyte protein (PyHEP17), orthologue of Plasmodium falciparum exported protein 1 (PfExp1), induces antigen-specific immune responses and protects against sporozoite challenge (Dobaño and Doolan, 2007).
  • Related Vaccine(s): P. yoelii DNA vaccine encoding PyHEP17 Protein
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.256
  • Trans-membrane helices: 2
  • Detailed Vaxign Results Vaxign Results
15. HSP60 from P. yoelii
  • Gene Name : HSP60 from P. yoelii
  • Sequence Strain (Species/Organism) : Plasmodium yoelii strain 17X(NL)
  • NCBI Protein GI : 3885993
  • Other Database IDs : CDD:185455
    CDD:239460
  • Taxonomy ID : 5861
  • Gene Strand (Orientation) : ?
  • Protein Name : heat shock protein 60
  • Protein pI : 6.86
  • Protein Weight : 58029.5
  • Protein Length : 643
  • Protein Note : Heat shock protein 60; Provisional
  • Protein Sequence : Show Sequence
    >AAC78150.1 heat shock protein 60 [Plasmodium yoelii]
    MLSRLCGKTIQNGNADKCVSMLNKIQKRNVAKDIRFGSDARTAMLIGCNKLADAVSVTLGPKGRNVIIEQ
    SFGSPKITKDGVTVAKSIEFNKKLANLGAQMVKQVAANTNDKAGDGTTTATILARSIFQQGCKAVDSGMN
    PMDLLRGINKGVEKVLEYLNSIKKDVTTTEEIFNVASISANGDKNIGQLIADTMKKVGKEGTITVTEGKT
    LQHELEIVEGIKFDRGYISPYFINNSKDQKVELDKPYILIHEKKISSVKSLLPVLEHVLQNQSSLLVIAE
    DVDSDALATLIVNKLRLGLKICAVKAPGFGEHRKALIHDIAVMTGSKVITEEAGLKLDDPDVISYLGKAK
    SINVSKDNTLIMEGEGKKEEISERCESIRNAIKNNTSDYEKEKLQERLAQITGGVALIKVGGISEVEVNE
    IKDRIQDALCATKAAVEEGIVPGGGSALLFASKELDSVQTDNYDQRVGVNIIKDACKAPIKQIAENAGHE
    GSVVAGNILKEKNSNMGFNAQEGKYVNMIESGIIDPTKVVKTAISDAASIASLLTTTEVAIVDSKDGKSE
    EMPSHMNSVNPMGDMGGMY
    
    
  • Molecule Role : Protective antigen
  • Related Vaccine(s): P. yoelii DNA vaccine pPyHsp60-VR1012
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.319
  • Trans-membrane helices: 0
  • Detailed Vaxign Results Vaxign Results
16. Hsp90
  • Gene Name : Hsp90
  • Sequence Strain (Species/Organism) : Plasmodium falciparum
  • VO ID : VO_0011241
  • NCBI Protein GI : 1093612
  • Other Database IDs : CDD:240341
    CDD:214643
    CDD:238030
    CDD:278607
  • Taxonomy ID : 5833
  • Gene Strand (Orientation) : ?
  • Protein pI : 4.63
  • Protein Weight : 82921.42
  • Protein Length : 796
  • Protein Note : heat shock protein 83 kDa (Hsp83); Provisional
  • Protein Sequence : Show Sequence
    >prf||2104278A heat shock protein 90
    MSTETFAFNADIRQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESITDTQKLSAEPEFFIRIIPDK
    TNNTLTIEDSGIGMTKNDLINNLGTIARSGTKAFMEAIQASGDISMIGQFGVGFYSAYLVADHVVVISKN
    NDDEQYVWESAAGGSFTVTKDETNEKLGRGTKIILHLKEDQLEYLEEKRIKDLVKKHSEFISFPIKLYCE
    RQNEKEITASEEEEEGEGEGEREGEEEEEEKKKKTGEDKNADESKEENEDEEKKEDNEEDDNKTDHPKVE
    DVTEELENAEKKKKEKRKKKIHTVEHEWEELNKQKPLWMRKPEEVTNEEYASFYKSLTNDWEDHLAVKHF
    SVEGQLEFKALLFIPKRAPFDMFENRKKRNNIKLYVRRVFIMDDCEEIIPEWLNFVKGVVDSEDLPLNIS
    RESLQQNKILKVIKKNLIKKCLDMFSELAENKENYKKFYEQFSKNLKLGIHEDNANRTKITELLRFQTSK
    SGDEMIGLKEYVDRMKENQKDIYYITGESINAVSNSPFLEALTKKGFEVIYMVDPIDEYAVQQLKDFDGK
    KLKCCTKEGLDIDDSEEAKKDFETLKAEYEGLCKVIKDVLHEKVEKVVVGQRITDSPCVLVTSEFGWSAN
    MERIMKAQALRDNSMTSYMLSKKIMEINARHPIISALKQKADADKSDKTVKDLIWLLFDTSLLTSGFALE
    EPTTFSKRIHRMIKLGLSIDEEENNDIDLPPLEETVDATDSKMEEVD
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : A monkey vaccination trial using a Plasmodium falciparum protein fraction containing antigens of 90-110 kDa is reported. Three monkeys out of five resisted a heavy challenge dose of highly virulent parasites. Hsp90 was found in the immunoprecipitates obtained with SERP antisera. Interestingly, the response to hsp90 correlated with protection, high antibody titres being found only in the protected monkeys (Bonnefoy et al., 1994).
  • Related Vaccine(s): P. falciparum Hsp90 Protein Subunit Vaccine
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.154
  • Trans-membrane helices: 0
  • Detailed Vaxign Results Vaxign Results
17. Kbeta
  • Gene Name : Kbeta
  • Sequence Strain (Species/Organism) : Plasmodium falciparum 3D7
  • VO ID : VO_0011233
  • NCBI Gene ID : 813054
  • NCBI Protein GI : 124506397
  • Locus Tag : PF3D7_0524000
  • Genbank Accession : AL844504
  • Protein Accession : XP_001351796
  • Taxonomy ID : 36329
  • Chromosome No : 5
  • Gene Starting Position : 998752
  • Gene Ending Position : 1002123
  • Gene Strand (Orientation) : +
  • Protein pI : 4.54
  • Protein Weight : 120404.67
  • Protein Length : 1123
  • DNA Sequence : Show Sequence
    >NC_004326.2:998752-1002123 Plasmodium falciparum 3D7 chromosome 5
    AATGGATAAAATTGTAGAAGTTATTGAAGGATTAAGCAGCTCTGAGAGTCATATAAGAAATGAATGTGAA
    AATACGTTAAATTATTATAAAAAGAATGATTTAAATAATACAGTATTATCTATATTGAAATTATTAAAAA
    CCCATAAAGATAGTCAAGTTCGATTACAATGTGCTATATTAATTAGGAATATATTTCGTGTGTATATAAA
    GTCCACACATGTGGATGTGGAAGAAAAAGAAAAAAATGAGAATTCGATTGGAAATGCAGAAGAAGAGAAT
    TATTGGGTATTATTACCTGATAATTTAAAGAATATTGTAAAATCTGAATTGATTAGTAATATAGGAACTG
    AAACAGATAAGATGGTTCGAAGTAATATATGTAATAATATTATAGATTTATCATCAAAATTATTATTACA
    TAATCAATGGCCTGAGTTATTATCAGTAACATTTGAATTTTGTAATTCTAATAACGTTGATGTATTAATA
    AGTGGATATAAAATATTAGGTGGTATCTTAAGTTGTATTCCAGATGAATTAGATGGAAAACAAGAAATAA
    TATCTTCCATATGTATGAAAGGTTTAAATTCATCAAATGTACAAGTACGTGGAGAATGTATTAATTTAAT
    ATCATGTATTGTTGAAGATAATAGTTCATCCTTAGTTAAGAGTGTACATGGTTGTATCCCATTAATATTA
    CAATCATTAAGTTTGATGGCAAAGAATAGTAGTTCAGATATTGCTGTTCTAGAAGAATGTGAGAAAGTAC
    TTCAATCTATTGGTAAAATGATAGATTATAATGCTAAATTTTTTACTAAGCATATAACAAGTTTGTGTGA
    TATATTATTTAGTATTTGTATGAAAGATGAAAATGAATTGAACTATGATTTTGATAATAGCTTGAAGTCC
    CTAAGTATTGAAGCTTTAGTTACCATTCCAGAACGTCGACCAAAAATGGCTTTATCTGTACCTCATTTTG
    TAGATAAGATTATACATTTGTCTATGTTATTTATGCTTGACATTAATAATGATTGTTTTAATGAATGGAT
    GAATTCTATAAAAGAAGGTAAAGACGATAGTCAGGAGTTATATGACATAGGTGAAGAGTCCTTAGATCGT
    GTTGGTAAAGCATTTAGTGAGTTAGAAGAAGCTGAATTTATTCATATTCTTTTTAATAAAGTATCAGAAT
    TTTTAATGAAAAATACTTGGGAACATAAATATGTCGGTATTATGGCTATTGCACAAACTATAGAATATTT
    ACCAGAAGATGAAATTGAAGAACAATTAGAACATGTTATAAAAATGTTGTTACAAATATTAGTTGATCAA
    GATGTTAGAGTACGTTATGCAGCATGTCAAGCCATTGGACAAATATCTTTAGATCATCAACCATATGTAC
    AGAAAGAATTTTTTTCAGAAATTTTATCAGCATTAATTAATACCATGAACGATGTACATTTAAGAGTTCA
    ATCACATGCTACAGCAGCTTTTGTAAATTATGCAGAAGAATTAGATAAAATGGCTTTATTACCATATGCA
    GATATTATTATAGATATTTTATTACAAAAATTGAATTCTTCAAATTATTTATTAGTAAGAGAACAAGCTG
    TTACTGCTATAGCGGTTATTGCAGGTGTTATTGAAGAAGACTTTTTAAAATATTATTCTACTGTTGTACC
    TATGATGAAAGATATTATTCAAAAGGCAGTTTCTGAAGAAGAAAGAACATGCAGAGGTAAAGCCATTGAA
    TGTATTTCAATTATTGGTTTATCGGTTGGTAAAGATATTTTTATTGAAGATGCTAAAGAATGTATGAATG
    CATTATTACAAATTAGCAGTACAAAAATGGATCCTGATGATACTGTAAAAGAATATATTCAAGAAGCTAT
    TGGTCGTATATGTAGAGCATTAGGTAATGACTTTTATCCATATCTAAGTAGTATAGTACCGACCATATTA
    TCTGTACTCTCCGTTTTACCAAAACCATTAACAGATGATGAAGAAGATCTAACCATAACTATGGTATCTA
    ATGGACAATATGTAGGATTGAAAACATCCTTATTAGAAGATCAAGAAAAAGCTTTAGATTTATTAATTAT
    TATTATTGAAGTATTAAAAGAAAATTATAAGGATTATATTCAAGCAACAGCTACAGCTGTGTTGCCAATG
    TTAAATTATGAATTGTCAGATGAAATTAAACAAAAGGCATTAACAGCTGTTAGTGAATTAATTGAATCAG
    CAAGAATATTATCTGAAAAAACGGATAATGATAAATCCATGTTACTAGCCATATTAACAGCAGCAGCAGA
    AAAAGTATTAAAAAGTCTATTAGAAACAAAATTAGATGACAATTATGAATATATATTAGATGTTATGATA
    ATCGAATCCCATGGATTATATATGTGCTTACAAAAAGCGGGATCGAATGTATTGCCAGAAAATACATTAA
    AATTATTTTTTAATCAAATCTTTGCCCTATTACAATATTCAACAGATAGAAGGGTAGTATATAATCAAAA
    AAAAAATAATGATGATGTAGATGAAGATGAATTATTAATAATTGATAGAGAAGAGGAATTAGAACAGAAT
    TATCGAACAAATTTATTAGATATCTTAGGAGTATTAATTAAATATCACCCAACACAATTCTTAAATACAT
    GTTGTGAATTATGTATTGGATTTATTAATAATTATATGAATTCTCCTAATTCAGAAGATGTAGCATTAGC
    ATTATATGTATGTGATGATTTGTTAGAATTCTTACAAGAAAAGAGTGTAAACCTATGGGACTTTTTCATG
    AACCCATTATTATTAAATATTAATCATGCAGATGATAAAGTAAAACAAGCGGCATGTTATGGTGTTATAC
    AAGCAACCAAAATTGAAGCATTTGGAAAGTATGCAAATATTGCAGTAGAATATTTATTAAAATTAGTACA
    TGAAAGTACATCAAATAAAAAACCAAAAGAATATATCTCAGCTATTGATAATGCTATAGCAGCATTAGGT
    GATGTTGTTCTTATGCATACATCAAAATTTAATAATGCAGAAGATCTCATAAAAGTATGGTTAAATCATT
    TACCAATAAAAGAAGATGATGCAGAAGGTAGAAGAGTACATAAAAATCTTATAGATTTAGTTTCACAAAA
    CCATCCTCTCTTGTTCGGAAAAGATAATTCTAATACAGCAAAAATTATTGAAATATTCTTAACAATATAT
    GAAACTGATTTTTCAGATACTGACTGTAACAAAAAAATCTCAACACTTATCAATTCATTGGATAAATCAT
    ATTTAAATAATTTAGCTTCTTCAACTTTGTCACATAAGCAAGCCAAAAAATTGAACAACATTTTGAATCC
    AAACAGAAAATA
    
    
  • Protein Sequence : Show Sequence
    >XP_001351796.1 karyopherin beta [Plasmodium falciparum 3D7]
    MDKIVEVIEGLSSSESHIRNECENTLNYYKKNDLNNTVLSILKLLKTHKDSQVRLQCAILIRNIFRVYIK
    STHVDVEEKEKNENSIGNAEEENYWVLLPDNLKNIVKSELISNIGTETDKMVRSNICNNIIDLSSKLLLH
    NQWPELLSVTFEFCNSNNVDVLISGYKILGGILSCIPDELDGKQEIISSICMKGLNSSNVQVRGECINLI
    SCIVEDNSSSLVKSVHGCIPLILQSLSLMAKNSSSDIAVLEECEKVLQSIGKMIDYNAKFFTKHITSLCD
    ILFSICMKDENELNYDFDNSLKSLSIEALVTIPERRPKMALSVPHFVDKIIHLSMLFMLDINNDCFNEWM
    NSIKEGKDDSQELYDIGEESLDRVGKAFSELEEAEFIHILFNKVSEFLMKNTWEHKYVGIMAIAQTIEYL
    PEDEIEEQLEHVIKMLLQILVDQDVRVRYAACQAIGQISLDHQPYVQKEFFSEILSALINTMNDVHLRVQ
    SHATAAFVNYAEELDKMALLPYADIIIDILLQKLNSSNYLLVREQAVTAIAVIAGVIEEDFLKYYSTVVP
    MMKDIIQKAVSEEERTCRGKAIECISIIGLSVGKDIFIEDAKECMNALLQISSTKMDPDDTVKEYIQEAI
    GRICRALGNDFYPYLSSIVPTILSVLSVLPKPLTDDEEDLTITMVSNGQYVGLKTSLLEDQEKALDLLII
    IIEVLKENYKDYIQATATAVLPMLNYELSDEIKQKALTAVSELIESARILSEKTDNDKSMLLAILTAAAE
    KVLKSLLETKLDDNYEYILDVMIIESHGLYMCLQKAGSNVLPENTLKLFFNQIFALLQYSTDRRVVYNQK
    KNNDDVDEDELLIIDREEELEQNYRTNLLDILGVLIKYHPTQFLNTCCELCIGFINNYMNSPNSEDVALA
    LYVCDDLLEFLQEKSVNLWDFFMNPLLLNINHADDKVKQAACYGVIQATKIEAFGKYANIAVEYLLKLVH
    ESTSNKKPKEYISAIDNAIAALGDVVLMHTSKFNNAEDLIKVWLNHLPIKEDDAEGRRVHKNLIDLVSQN
    HPLLFGKDNSNTAKIIEIFLTIYETDFSDTDCNKKISTLINSLDKSYLNNLASSTLSHKQAKKLNNILNP
    NRK
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Two large fragments of PfKbeta representing the N- and C-terminal halves were expressed in E. coli. The recombinant proteins were highly immunogenic in mice, and also found to be the target for immune response in natural infections of Plasmodium spp. Immunization with recombinant PfKbeta fragments was partially protective against a heterologous challenge infection in mice (Mohmmed et al., 2005).
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.081
  • Trans-membrane helices: 0
  • Detailed Vaxign Results Vaxign Results
18. LSA-3
  • Gene Name : LSA-3
  • Sequence Strain (Species/Organism) : Plasmodium falciparum 3D7
  • VO ID : VO_0012381
  • NCBI Gene ID : 812783
  • NCBI Protein GI : 124801463
  • Locus Tag : PF3D7_0220000
  • Genbank Accession : LN999943
  • Protein Accession : XP_001349701
  • Taxonomy ID : 36329
  • Chromosome No : 2
  • Gene Starting Position : 796751
  • Gene Ending Position : 801585
  • Gene Strand (Orientation) : +
  • Protein Name : Liver stage antigen 3
  • Protein pI : 3.86
  • Protein Weight : 156020.34
  • Protein Length : 1558
  • DNA Sequence : Show Sequence
    >NC_037280.1:796751-801585 Plasmodium falciparum 3D7 chromosome 2, complete sequence
    AATGACAAATAGTAATTACAAATCAAATAATAAAACATATAATGAAAATAATAATGAACAAATAACTACC
    ATATTTAATAGAACAAATATGAATCCGATAAAAAAATGTCATATGAGAGAAAAAATAAATAAGTACTTTT
    TTTTGATCAAAATTTTGACATGCACCATTTTAATATGGGCTGTACAATATGCTAATAACGTAAGATAAAA
    AACTAAATAATAAATATAAATAAAAAAAAAAAAAAAAAAAAAAAAAATCAACTATATAGTATGTATAATA
    TATATATATATATATATATATATATATTTATTTTTATTTATTTATTAATTTTTTTTTTTTTTATATTATC
    TTTTTAGTCTGATATAAACAAGAGTTGGAAAAAAAATACGTATGTAGATAAGAAATTGAATAAACTATTT
    AACAGAAGTTTAGGAGAATCTCAAGTAAATGGTGAATTAGCTAGTGAAGAAGTAAAGGAAAAAATTCTTG
    ACTTATTAGAAGAAGGAAATACATTAACTGAAAGTGTAGATGATAATAAAAATTTAGAAGAAGCCGAAGA
    TATAAAGGAAAATATCTTATTAAGTAATATAGAAGAACCAAAAGAAAATATTATTGACAATTTATTAAAT
    AATATTGGACAAAATTCAGAAAAACAAGAAAGTGTATCAGAAAATGTACAAGTCAGTGATGAACTTTTTA
    ATGAATTATTAAATAGTGTAGATGTTAATGGAGAAGTAAAAGAAAATATTTTGGAGGAAAGTCAAGTTAA
    TGACGATATTTTTAATAGTTTAGTAAAAAGTGTTCAACAAGAACAACAACACAATGTTGAAGAAAAAGTT
    GAAGAAAGTGTAGAAGAAAATGACGAAGAAAGTGTAGAAGAAAATGTAGAAGAAAATGTAGAAGAAAATG
    ACGACGAAAGTGTAGCCTCAAGTGTTGAAGAAAGTATAGCTTCAAGTGTTGATGAAAGTATAGATTCAAG
    TATTGAAGAAAATGTAGCTCCAACTGTTGAAGAAATCGTAGCTCCAACTGTTGAAGAAATTGTAGCTCCA
    AGTGTTGTAGAAAGTGTGGCTCCAAGTGTTGAAGAAAGTGTAGAAGAAAATGTTGAAGAAAGTGTAGCTG
    AAAATGTTGAAGAAAGTGTAGCTGAAAATGTTGAAGAAAGTGTAGCTGAAAATGTTGAAGAAAGTGTAGC
    TGAAAATGTTGAAGAAAGTGTAGCTGAAAATGTTGAAGAAAGTGTAGCTGAAAATGTTGAAGAAATCGTA
    GCTCCAACTGTTGAAGAAAGTGTAGCTCCAACTGTTGAAGAAATTGTAGCTCCAAGTGTTGAAGAAAGTG
    TAGCTCCAAGTGTTGAAGAAATTGTAGTTCCAACTGTTGAAGAAAGTGTAGCTGAAAATGTTGAAGAAAT
    CGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAACTGTTGAAGAA
    AGTGTAGCTCCAACTGTTGAAGAAATTGTAGCTCCAAGTGTTGAAGAAAGTGTAGCTCCAAGTGTTGAAG
    AAATTGTAGTTCCAACTGTTGAAGAAAGTGTAGCTGAAAATGTTGAAGAAAGTGTAGCTGAAAATGTTGA
    AGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAGTGTT
    GAAGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAGTG
    TTGAAGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAC
    AGTTGAAGAAATCGTAGCTCCAACAGTTGAAGAAATTGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCA
    ACTGTTGAAGAAAGTGTTGCTGAAAACGTTGCAACAAATTTATCAGACAATCTTTTAAGTAATTTATTAG
    GTGGTATCGAAACTGAGGAAATAAAGGACAGTATATTAAATGAGATAGAAGAAGTAAAAGAAAATGTAGT
    CACCACAATACTAGAAAACGTAGAAGAAACTACAGCTGAAAGTGTAACTACTTTTAGTAACATATTAGAG
    GAGATACAAGAAAATACTATTACTAATGATACTATAGAGGAAAAATTAGAAGAACTCCACGAAAATGTAT
    TAAGTGCCGCTTTAGAAAATACCCAAAGTGAAGAGGAAAAGAAAGAAGTAATAGATGTAATTGAAGAAGT
    AAAAGAAGAGGTCGCTACCACTTTAATAGAAACTGTGGAACAGGCAGAAGAAGAGAGCGCAAGTACAATT
    ACGGAAATATTTGAAAATTTAGAAGAAAATGCAGTAGAAAGTAATGAAAATGTTGCAGAGAATTTAGAGA
    AATTAAACGAAACTGTATTTAATACTGTATTAGATAAAGTAGAGGAAACAGTAGAAATTAGCGGAGAAAG
    TTTAGAAAACAATGAAATGGATAAAGCATTTTTTAGTGAAATATTTGATAATGTAAAAGGAATACAAGAA
    AATTTATTAACAGGTATGTTTCGAAGTATAGAAACCAGTATAGTAATCCAATCAGAAGAAAAGGTTGATT
    TGAATGAAAATGTGGTTAGTTCGATTTTAGATAATATAGAAAATATGAAAGAAGGTTTATTAAATAAATT
    AGAAAATATTTCAAGTACTGAAGGTGTTCAAGAAACTGTAACTGAACATGTAGAACAAAATGTATATGTG
    GATGTTGATGTTCCTGCTATGAAAGATCAATTTTTAGGAATATTAAATGAGGCAGGAGGGTTGAAAGAAA
    TGTTTTTTAATTTGGAAGATGTATTTAAAAGTGAAAGTGATGTAATTACTGTAGAAGAAATTAAGGATGA
    ACCGGTTCAAAAAGAGGTAGAAAAAGAAACTGTTAGTATTATTGAAGAAATGGAAGAAAATATTGTAGAT
    GTATTAGAGGAAGAAAAAGAAGATTTAACAGACAAGATGATAGATGCAGTAGAAGAATCCATAGAAATAT
    CTTCAGATTCTAAAGAAGAAACTGAATCTATTAAAGATAAAGAAAAAGATGTTTCACTAGTTGTTGAAGA
    AGTTCAAGACAATGATATGGATGAAAGTGTTGAGAAAGTTTTAGAATTGAAAAATATGGAAGAGGAGTTA
    ATGAAGGATGCTGTTGAAATAAATGACATTACTAGCAAACTTATTGAAGAAACTCAAGAGTTAAATGAAG
    TAGAAGCAGATTTAATAAAAGATATGGAAAAATTAAAAGAATTAGAGAAAGCATTATCAGAAGATTCTAA
    AGAAATAATAGATGCAAAAGATGATACATTAGAAAAAGTTATTGAAGAGGAACATGATATAACGACGACG
    TTGGATGAAGTTGTAGAATTAAAAGATGTCGAAGAAGACAAGATCGAAAAAGTATCTGATTTAAAAGATC
    TTGAAGAAGATATATTAAAAGAAGTAAAAGAAATCAAAGAACTTGAAAGTGAAATTTTAGAAGATTATAA
    AGAATTAAAAACTATTGAAACAGATATTTTAGAAGAGAAAAAAGAAATAGAAAAAGATCATTTTGAAAAA
    TTCGAAGAAGAAGCTGAAGAAATAAAAGATCTTGAAGCAGATATATTAAAAGAAGTATCTTCATTAGAAG
    TTGAAGAAGAAAAAAAATTAGAAGAAGTACACGAATTAAAAGAAGAGGTAGAACATATAATAAGTGGTGA
    TGCGCATATAAAAGGTTTGGAAGAAGATGATTTAGAAGAAGTAGATGATTTAAAAGGAAGTATATTAGAC
    ATGTTAAAGGGAGATATGGAATTAGGGGATATGGATAAGGAAAGTTTAGAAGATGTAACAGCAAAACTTG
    GAGAAAGAGTTGAATCCTTAAAAGATGTTTTATCTAGTGCATTAGGCATGGATGAAGAACAAATGAAAAC
    AAGAAAAAAAGCTCAAAGACCTAAATTGGAAGAAGTATTATTAAAAGAAGAGGTTAAAGAAGAACCAAAG
    AAAAAAATAACAAAAAAGAAAGTAAGGTTTGATATTAAGGATAAGGAACCAAAAGATGAAATAGTAGAAG
    TTGAAATGAAAGATGAAGATATAGATGAAGATATAGAAGAAGATGTAGAAGAAGATATAGAAGAAGATAA
    AGTTGAAGATATAGATGAAGATATAGATGAAGATATAGATGAAGATATAGGTGAAGACAAAGATGAAGTT
    ATAGATTTAATAGTCCAAAAAGAGAAACGCATTGAAAAGGTTAAAGAGAAAAAGAAAAAATTAGAAAAAA
    AAGTTGAAGAAGGTGTTAGTGGTCTTAAAAAACACGTAGACGAAGTAATGAAATATGTTCAAAAAATTGA
    TAAAGAAGTTGATAAAGAAGTATCTAAAGCTTTAGAATCAAAAAATGATGTTACTAATGTTTTAAAACAA
    AATCAAGATTTTTTTAGTAAAGTTAAAAACTTCGTAAAAAAATATAAAGTATTTGCTGCACCATTCATAT
    CTGCCGTTGCAGCATTTGCATCATATGTAGTTGGGTTCTTTACATTTTCTTTATTTTCATCATGTGTAAC
    AATAGCTTCTTCAACTTACTTATTATCAAAAGTTGACAAAACTATAAATAAAAATAAGGAGAGACCGTTT
    TATTCATTTGTATTTGATATCTTTAAGAATTTAAAACATTATTTACAACAAATGAAAGAAAAATTTAGTA
    AAGAAAAAAATAATAATGTAATAGAAGTAACAAACAAAGCTGAGAAAAAAGGTAATGTACAGGTAACAAA
    TAAAACCGAGAAAACAACTAAAGTTGATAAAAATAATAAAGTACCGAAAAAAAGTAGAACGCAAAAATCA
    AAATA
    
    
  • Protein Sequence : Show Sequence
    >XP_001349701.1 liver stage antigen 3 [Plasmodium falciparum 3D7]
    MTNSNYKSNNKTYNENNNEQITTIFNRTNMNPIKKCHMREKINKYFFLIKILTCTILIWAVQYANNSDIN
    KSWKKNTYVDKKLNKLFNRSLGESQVNGELASEEVKEKILDLLEEGNTLTESVDDNKNLEEAEDIKENIL
    LSNIEEPKENIIDNLLNNIGQNSEKQESVSENVQVSDELFNELLNSVDVNGEVKENILEESQVNDDIFNS
    LVKSVQQEQQHNVEEKVEESVEENDEESVEENVEENVEENDDESVASSVEESIASSVDESIDSSIEENVA
    PTVEEIVAPTVEEIVAPSVVESVAPSVEESVEENVEESVAENVEESVAENVEESVAENVEESVAENVEES
    VAENVEESVAENVEEIVAPTVEESVAPTVEEIVAPSVEESVAPSVEEIVVPTVEESVAENVEEIVAPSVE
    EIVAPSVEEIVAPTVEESVAPTVEEIVAPSVEESVAPSVEEIVVPTVEESVAENVEESVAENVEEIVAPS
    VEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPTVEEIVA
    PTVEEIVAPSVEEIVAPTVEESVAENVATNLSDNLLSNLLGGIETEEIKDSILNEIEEVKENVVTTILEN
    VEETTAESVTTFSNILEEIQENTITNDTIEEKLEELHENVLSAALENTQSEEEKKEVIDVIEEVKEEVAT
    TLIETVEQAEEESASTITEIFENLEENAVESNENVAENLEKLNETVFNTVLDKVEETVEISGESLENNEM
    DKAFFSEIFDNVKGIQENLLTGMFRSIETSIVIQSEEKVDLNENVVSSILDNIENMKEGLLNKLENISST
    EGVQETVTEHVEQNVYVDVDVPAMKDQFLGILNEAGGLKEMFFNLEDVFKSESDVITVEEIKDEPVQKEV
    EKETVSIIEEMEENIVDVLEEEKEDLTDKMIDAVEESIEISSDSKEETESIKDKEKDVSLVVEEVQDNDM
    DESVEKVLELKNMEEELMKDAVEINDITSKLIEETQELNEVEADLIKDMEKLKELEKALSEDSKEIIDAK
    DDTLEKVIEEEHDITTTLDEVVELKDVEEDKIEKVSDLKDLEEDILKEVKEIKELESEILEDYKELKTIE
    TDILEEKKEIEKDHFEKFEEEAEEIKDLEADILKEVSSLEVEEEKKLEEVHELKEEVEHIISGDAHIKGL
    EEDDLEEVDDLKGSILDMLKGDMELGDMDKESLEDVTAKLGERVESLKDVLSSALGMDEEQMKTRKKAQR
    PKLEEVLLKEEVKEEPKKKITKKKVRFDIKDKEPKDEIVEVEMKDEDIDEDIEEDVEEDIEEDKVEDIDE
    DIDEDIDEDIGEDKDEVIDLIVQKEKRIEKVKEKKKKLEKKVEEGVSGLKKHVDEVMKYVQKIDKEVDKE
    VSKALESKNDVTNVLKQNQDFFSKVKNFVKKYKVFAAPFISAVAAFASYVVGFFTFSLFSSCVTIASSTY
    LLSKVDKTINKNKERPFYSFVFDIFKNLKHYLQQMKEKFSKEKNNNVIEVTNKAEKKGNVQVTNKTEKTT
    KVDKNNKVPKKSRTQKSK
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : In chimpanzees (Pan troglodytes), the primates most closely related to humans and that share a similar susceptibility to P. falciparum liver-stage infection, immunization with LSA-3 induced protection against successive heterologous challenges with large numbers of P. falciparum sporozoites (Daubersies et al., 2000).
  • Related Vaccine(s): P. falciparum LSA-3 Protein Vaccine
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.161
  • Trans-membrane helices: 2
  • Detailed Vaxign Results Vaxign Results
19. MSP-1
  • Gene Name : MSP-1
  • Sequence Strain (Species/Organism) : Plasmodium falciparum
  • VO ID : VO_0010958
  • NCBI Protein GI : 94420988
  • Other Database IDs : CDD:289698
    CDD:304395
  • Taxonomy ID : 5833
  • Gene Strand (Orientation) : ?
  • Protein Name : merozoite surface protein 1
  • Protein pI : 4.55
  • Protein Weight : 13136.57
  • Protein Length : 192
  • Protein Note : clinical isolate
  • Protein Sequence : Show Sequence
    >ABF18819.1 merozoite surface protein 1, partial [Plasmodium falciparum]
    MLNISQHQCVKKQCPENSGCFRHLDEREECKCLLNYKQEGDKCVENPNPTCNENNGGCDADATCTEEDSG
    SSRKKITCECTKPDSYPLFDGIFCSSSNFLGISFLLILMLILYSFI
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Aotus monkeys were challenged with the virulent Vietnam Oak Knoll (FVO) strain of P. falciparum. Vaccination of A. nancymai with yMSP1(19) induced protective immune responses. Both of the A. nancymai vaccinated with yMSP1(19) self-resolved an otherwise lethal infection (Kumar et al., 1995).
  • Related Vaccine(s): P. falciparum MSP1 from transgenic mice with Freund's adjuvant , P. falciparum vaccine Combination B
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.565
  • Trans-membrane helices: 1
  • Detailed Vaxign Results Vaxign Results
20. msp-8
  • Gene Name : msp-8
  • Sequence Strain (Species/Organism) : Plasmodium yoelii
  • VO ID : VO_0011221
  • NCBI Protein GI : 58197887
  • Other Database IDs : CDD:315598
  • Taxonomy ID : 5861
  • Gene Strand (Orientation) : ?
  • Protein Name : merozoite surface protein 8
  • Protein pI : 4.67
  • Protein Weight : 45677.49
  • Protein Length : 476
  • Protein Note : EGF domain; pfam12947
  • Protein Sequence : Show Sequence
    >AAW65717.1 merozoite surface protein 8 [Plasmodium yoelii]
    MKKSSQIIIFLLLSLFCKFSIGNCNENGNGNINKANNNSIIRKERKRKSKSDFSKGEPENKEHEIINLYD
    DVQELLGPDEMNMLDKYSILGIDDCSNENENNKIISEYDLKAMKSVLLYKNRISRASINNLDDVKTVFKR
    CFNKDDPELSKSYEQIQNQVANEGTTIIDYLSNYISNIYIKINDEFVKNEEFQLSKYIPELEIINYVLYN
    GPKEIGNKIKNELIEINNLIISESLTSIYSSVVSGLNINCKIKDDLITILNLANGKYFKVNFSSQATMII
    PEQYSHESEHMKKISEYFIEKNRVCKNENCPINSNCYVIDSVETCRCIPGFSKNEESENLECLINESTSC
    ENNNGGCDVNANCILLEDKIMCECNNKFNGDGIYCSSAIYYGMNVFIFFLISIVCIYIM
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Immunization with Plasmodium yoelii merozoite surface protein (PyMSP)-8 protects mice from lethal malaria but does not prevent infection (Petritus and Burns, 2008).
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.263
  • Trans-membrane helices: 1
  • Detailed Vaxign Results Vaxign Results
21. MSP1
  • Gene Name : MSP1
  • Sequence Strain (Species/Organism) : Plasmodium vivax
  • VO ID : VO_0011230
  • NCBI Protein GI : 26985160
  • 3D structure: PDB ID : 2NPR
  • Other Database IDs : CDD:299863
    CDD:284802
    CDD:289698
    CDD:289699
  • Taxonomy ID : 5855
  • Gene Strand (Orientation) : ?
  • Protein Name : merozoite surface protein 1
  • Protein pI : 7.06
  • Protein Weight : 187587.32
  • Protein Length : 1844
  • Protein Note : The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; cl12013
  • Protein Sequence : Show Sequence
    >AAN86248.1 merozoite surface protein 1 [Plasmodium vivax]
    MKALLFLFSFIFFVTKCQCETESYKQLVAKLDKLEALVVDGYELFHKKKLGESDIQVETNASANNNNNNQ
    VSVLTSKIRNFVGKFLELQIPGHTDLLHLIRELAFEPNGIKYLVESYEEFNQLMHVINFHYDLLRAKLHD
    MCAHDYCKIPEHLKISDKELDMLKKVVLGYRKPLDNIKDDIGKLETFITKNKITIKNISDLIIAENKKRS
    GHPTTTTNGAGTQPANGSIAAASSETTQISGSSNSGSTGHGSSNSGSTGHGSSNSGSSGTGSSNSGSSGT
    GSTGNGQSPPATADASSTNANYEAKKIIYQAVYNTIFYTNQLQEAQKLIAVLEKRVKVLKEHKDIKVLLE
    KIATEKGKFPNNNLNVENPTDEQKTAKSNIADLEKKIEAIAKTVNFDLDGLFTDAEELEYYLREKAKMAG
    TLIIPESTKSAGTPGKTVPTLKETYPHGISYALAENSIYELIEKIGSDETFGDLQNPDDGKQPKKGILIN
    ETKRKELLEKIMNKIKIEEDKLPDLKKEYEEKYTVYEQKVKEFQPEFNYFYEARLDNTLVGEKFGEFKKK
    REEYMKEKKKLESCSYEQNTNLINKLKKQLTYLEDYVLRKDIADDEIKHFSFMEWKLKSEIYDLAQEIRK
    NENKLTIENKFDFSGVVELQVQKVLIIKKIEALKNVQNLLKNAKVKDDLYVPKVYKTGEKPEPYYLMVLK
    REIDKLKDFIPKIESMIATEKNKPTVAAADIVAKGQSLRGASETGTTGNTVNAQTAVVQQPQHQVVNAVT
    VQPGTTGHQAQGGEAETQTNSVQAAQVQQTPAGAGGQVASTQTTSQAPAPTQASPEPAPAAPPSTPAAAV
    APAPAMSKLEYLEKLLDFLKSAYACHKHIFVTNSTMDKKLLKEYELNADEKTKINQNKCDELDLLFNVQN
    NLPAMYSIYDSMSNELQNLYIELYQKEMVYNIYKNKDTDKKIKAFLETSNNKAAAPAQSAAKPSGQAGTT
    PVTTTAPVTTTTVTPSPQTSVVTSTPPTPQAEENQRVGGNSEEKPEADTAQVEKFYEKHLSQIDKYNDYF
    KKFLESKKEEIIKMDDTKWNALGKEIEELKKKLQVSLDHYGKYKLKLERFLKKKNKISNSKDQIKKLTSL
    KNKLERRQNLLNNPTSVLKNYTAFFNKKRETEKKEVENTLKNTEILLKYYKARAKYYIGEPFPLKTLSEE
    SMQKEDNYLNLEKFRVLSRLEGRLGKNIELEKENISYLSSGLLHVLTELKEIINDKKYSGKDHAKNIAEV
    KKALQAYQELIPKVTSQESTSVAVTVPGAVVPGVPTAAAAGSGASGAVPPATGGVVPGVVESAEAQTQTQ
    AQDYAEDYDKVIALPLFGNNDDDGEEDQVTTGEAESEAPEILVPAGISDYDVVYLKPLAGMYKTIKKQLE
    NHVNAFNTNITDMLDSRLKKRNYFLEVLNSDLNPFKYSSSGEYIIKDPYKLLDLEKKKKLIGSYKYIGAS
    IDKDLATANDGVAYYNKMGELYKTHLDGVKTEIKKVEDDIKTHDEKLQKLGSEVSQNSEKTQLNAKKAEL
    EKYLPFLNSLQKEYESLVSKVNTYTDNLKKVINNCQLEKKEAEITVKKLQDYNKMDEKLEEYKKSEKKNE
    VKSSGLLEKLMKSKLIKENESKEILSQLLNVQTQLLTMSSEHTCIDTNVPDNAACYRYLDGTEEWRCLLT
    FKEEGGKCVPASNVTCKDNNGGCAPEAECKMTDSNKIVCKCTKEGSEPLFEGVFCSSSSFLSLSFLLLML
    LFLLCMEL
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Immunization of BALB/c mice and Aotus monkeys with PvMSP-1 induced IgG antibodies (titer > 10(6)) that cross-reacted with P. vivax parasites. Immunized monkeys displayed partial protection against a challenge with P. vivax blood stages (Valderrama-Aguirre et al., 2005).
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.695
  • Trans-membrane helices: 1
  • Detailed Vaxign Results Vaxign Results
22. MSP1 from P. berghei
  • Gene Name : MSP1 from P. berghei
  • Sequence Strain (Species/Organism) : Plasmodium berghei
  • VO ID : VO_0011225
  • NCBI Protein GI : 1762646
  • Taxonomy ID : 5821
  • Gene Strand (Orientation) : ?
  • Protein Name : merozoite surface protein 1
  • Protein pI : 4.24
  • Protein Weight : 9906.72
  • Protein Length : 184
  • Protein Sequence : Show Sequence
    >AAC47502.1 merozoite surface protein 1, partial [Plasmodium berghei]
    SGQSSTEPASTGTPSSGEVSTGTSTGGASAGVTNTGAATTGTSTGGASAGVTNTGAATTGTTGTGAATTG
    TTGAEAVTTGNTGAEVTQVQIVPTLTPEEKKKKMDGLYAQI
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Mice vaccinated with recombinant rMSP1 (rPbMSP1), which was generated from Plasmodium berghei, in alum mounted significant protective immunity against challenge infection (P < 0.01). On day 121 after the booster, three out of ten mice immunized with rPbMSP1 in PBS survived parasite infection (P < 0.05) and eight out of ten mice vaccinated with r MSP1 in alum did (P < 0.01). Hence, immunization with MSP1 in alum obviously has conferred protective effects, which prevented death from P. berghei lethal infection in mice (P < 0.01) (Wan et al., 2007).
  • Related Vaccine(s): P. berghei MSP1 Protein Vaccine
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.713
  • Trans-membrane helices: 0
  • Detailed Vaxign Results Vaxign Results
23. MSP1 from P. knowlesi
  • Gene Name : MSP1 from P. knowlesi
  • Sequence Strain (Species/Organism) : Plasmodium knowlesi strain H
  • NCBI Protein GI : 221054886
  • Other Database IDs : CDD:284802
    CDD:289698
    CDD:289699
    EnsemblGenomes-Gn:PKH_072850
    EnsemblGenomes-Tr:PKH_072850
    GOA:B3L2X8
    InterPro: IPR010901
    InterPro: IPR024730
    InterPro: IPR024731
    UniProtKB/TrEMBL: B3L2X8
  • Taxonomy ID : 5851
  • Gene Strand (Orientation) : ?
  • Protein Name : merozoite surface protein 1, MSP-1
  • Protein pI : 5.06
  • Protein Weight : 192886.042
  • Protein Length : 1931
  • Protein Note : Merozoite surface protein 1 (MSP1) C-terminus; pfam07462
  • Protein Sequence : Show Sequence
    >XP_002258582.1 merozoite surface protein 1, MSP-1 [Plasmodium knowlesi strain H]
    MKALLFLFSLIFFVTKCQCETEDYKQLLVKLDKLEGLVVDGYELFHKNKISLDNIDAVQNIDGNNVNALA
    YKIRDIVGKYLELQIPGHGNLLHMIRELALDANGLKYLVENYEEFNQLMHVINFNYDLLRAKLNDMCAHE
    YCKIPEHLKISAKELDMLKKVVLGYRKPLDNIKDDIGKMEAFINKNKETINNINQLITAENAKIVGHPIN
    GVNVTGASSDAVANTGTPVAAAAGAAAAAVPGAIASPSPVESSTPENYDQKKVIFQAIYNFIFYTNQLEE
    AQKLMQVLEKRVKLLKEHKSIKALLEQIATEKNNLTTNNATTGGATTIPEEVQKKIADLEKQIVAIAKTV
    NFDMDGLFTNVEELEYYLREKAKMAGTLIGPESSQSTGTPGKAVPTLKETYPYGITYALPERTIYELIEK
    FGSEESFGDLQNPDNGRQPNKGIIINETKRKTLVDKIMSKIKLEEEKLPKLKKEYDEKMEQYKQKVQDFL
    PTLKYFYEGKLDNTLVGSKFDEFKNKREAYMKEKEELEKCTYEQSINLINKLKKQLTYLVDYTLKKDVTE
    DEINYFSDLEWKLKNEIYELAKEVRKNENKLIMENKFDFSGVLELQIHKVLMIKKIGALKNVQNLLKNAK
    LKDKLYIPKVYKTGQKPEPYYLIVLKKEIDKLKDFIPKIETMIATEKAKAPTEPVKVRAQSLRGASETAP
    SEPPTATESGSTTSASTAVQQPTQQAAQAAQAASPVTVTQPTETVTQTPAPATETAGEAAQETSPVSPTA
    PAVVSEAGTEGGEGTTEVVAQPEAASGETQTPTPGAVDASPAAPVPAGTPGTTDAAPEASVPAPAGSALP
    ATTAPAAAAPAAPAMSKLEYLEKLLEFLKSSYACHKHIFLTNSTMNPELLKQYALTTDEEKKIKESACDE
    LDLLFNVQNNLPSMYSIYDTMINDLQNLYIELYQKEMVYNIYKNKDTDTKIKAFLETLKSNAASVTPAVV
    PAAAPVVTPAPAEPVVTPAPAPGQAAPAAAPTTTNPSTTPSGTTTNAVSPTTAVTPGAQDTTQTTTQDTT
    VTEEGGVTVQASSEEEPETNIVNVEKIYEKHLSQMDKYNDYFIKFLESQKEKITSMTEEQANALGAEIEA
    LKKKVQVSLDHYGKYKLKLERFLEKKNKISNSKEHIKKLTSLKNKLERKLNFLNNPTSVLKNYIIFFNKK
    KEAEKKEVENTLKNTEILLKYYKARAKYYIGEPFPLKTLSEESLQKEDNYLNLEKFRVLSRMEGRLGNNI
    NLEKENISYLSSGLHHVFTELKEIIKNKKYTGNDHAKNTTAVKEALQAYEELLPKVATQTASLPPVAPPA
    VVPPVVPEAEAEAEAEAEAEPATSTQPATADTAAPTQTPAAPTQTPAEPATATATTGETAAAPAAPAPVE
    VQNAEVKAQEYGEDYDKVITLPLFGNDEDDVEDQEEKQIITGEAENAQPENIVPEGINEYEVVYIKPLAG
    MYKSIKKQLENHVAAFNTNITDMLDSRLKKRNYFLDVLDSELNPFKYSSSGEYIIKDPYKLLDLEQKKKL
    LGSYQYIGASVDKDLITAKDGMEYYNKMGELYKQHLEAVNAQIKEIEASVPGEQSQLNAQKEELKKYLPF
    LNSIQKEYESLVNMAHTYKENLKKFINNCQIEKKETEIIVKKLEDYTKIDENLEIYKKSKKESDVRSSGL
    LEKLKNSKLINEEESKKVLSQLLNVQTQMLNMSSAHKCIDTNVPENAACYRYLDGTEEWRCLLGFKEVGG
    KCVPASITCEENNGGCAPEAECTMDDKKEVECKCTKEGFEPLFEGVFCSSSSFLSLSFLLLILIFFLSME
    L
    
    
  • Molecule Role : Protective antigen
  • Related Vaccine(s): P. knowlesi DNA vaccine encoding PkCSP, PkSSP2, PkAMA1, and PkMSP1p42
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.644
  • Trans-membrane helices: 1
  • Detailed Vaxign Results Vaxign Results
24. MSP1 from P. yoelii str. 17XNL
  • Gene Name : MSP1 from P. yoelii str. 17XNL
  • Sequence Strain (Species/Organism) : Plasmodium yoelii
  • VO ID : VO_0011212
  • NCBI Gene ID : 3791597
  • NCBI Protein GI : 82596427
  • Locus Tag : PY17X_0834400
  • Genbank Accession : LK934636
  • Protein Accession : XP_726257
  • Taxonomy ID : 5861
  • Chromosome No : 8
  • Gene Starting Position : 1276003
  • Gene Ending Position : 1281321
  • Gene Strand (Orientation) : +
  • Protein pI : 5.05
  • Protein Weight : 188296.05
  • Protein Length : 1772
  • DNA Sequence : Show Sequence
    >NC_036180.1:1276003-1281321 Plasmodium yoelii genome assembly PY17X01, chromosome : 8
    AATGAAGGTGATTGGACTTTTATTTTCTTTCGTTTTTTTTGCTATAAAATGCAAATCTGAAACAATTGAA
    GTTTATAATGATCTCATTCAAAAGTTAGAAAAATTAGAATCATTGTCAGTGGATGGGTTAGAACTATTTC
    AAAAAAGTCAAGTAATTATAAATGCAACACAACCAACTGAAACTATTGATCCATTTACAAATCATAACTT
    TGCACAACAAGTACAAGATTTTGTTACAAAATTTGAAGGATTAGGATTTACAGAACAAACAGAATTAGTC
    AATTTAATAAAAGCATTAACCCCAAATAGATATGGAGTAAAATATTTAATTGAAAGTAAAGAAGAATTTA
    ATGGATTAATGCACGCAATAAATTTTTATTATGATGTACTTAGAGATAAATTAAATGATATGTGTGCAAA
    TAATTATTGTGAAATTCCTGAACATCTTAAAATTAGTGAAGAAGAAACAGAAATGCTTAAAAAAGTAATT
    TTAGGTTATAGAAAACCAATAGAAAATATTCAAGACGATATTGAAAAGTTAGAAATTTACATAGAAAGAA
    ATAAAGAAACTGTTGCAGCTTTAAACGCTCTTATTGCTGAAGAAACAAAAAAAATACAACCTGAAGGTAA
    CGAAGATTGCAATGACGCTAGTTGTGATAGCGATAAATATAATAAAAAAAAACCAATATACCAAGCTATG
    TACAATGTTATATTTTACAAAAAACAATTAGCTGAAATACAAAAGGTTGTCGAAGTCTTAGAAAAACGAG
    TTTCTACATTAAAGAAAAATGATGCCATCAAACCATTATGGCAACAAATTGAAGTTCTCAATGCTGCCCC
    CGTCGTCACTGCCGAAACACAAATAGTTACAGGAGGACAATCTAGTACAGAACCAGGTAGTGGTGGATCA
    AGTGCATCGGGAACAAGTTCATCAGGACAAGCTAGTGCAGGAACAGGTGTAGAACAAGCTAACACTGTAG
    CATCTGTTACAGTAACACCTAGTGTAGGACAAAATGGTGAAGCATCAACTAATCCACAAACAGCTCAAGT
    GCAACCCGTTCCAACTCTTACATTAGAAGAAAAACAGAAAAAAATAGCCGGACTTTATGCTCAAATTAAA
    GAAATTGCAAAAACTATAAAATTCAACTTAGAAGGAATATTTGTAGATCCAATCGAATTAGAATATTTCA
    AAAAAGAAAAAAAAAAAGAAAGTTGCAATTTATCAACTTCATCCTGTAAAAAAAATAAAGCATCCGAAAC
    TATAATACCATTAACTATACGTTATCCAAATGGTATTAGTTACCCATTACCTGAAAATGATGTTTACAAT
    AAAATTGCCAATAATGCCGCTGAAACAACATATGGTGATTTGACACATCCCGATAATACACCATTAACAG
    GAGATTTAGCCACAAATGAACAAGCCAGAAAAGATCTAATAAAAGCTATTAAAAAGAAAATAAAAGCAGA
    AGAAAAAAAATTAGAAACATTAAAAACGAATTATGATAATAAACTTACAGAATTTAATCAACAAAAAACT
    CCATTCAAAGAAGCAGCTAAAGAATTTTATGAATCAAAATTTAGAAATAAATTGACTTCTGAAATTTTTG
    AAAAATTCAAAACAAAAAGAGATGAATATATGACCAAGAAAACCGAATTAAACACTTGTGAATATGGAAA
    TACTAAAGAATTAATTAATAAATTAAATAAACAACTTAATTATTTACAAGATTATTCATTAAGAAAAGAT
    ATAATTAGTAATGAAATTGAATATTTTTCAAATAAAAAAAAAGAATTACAATATAATATTAATAGATTAG
    CAGAAGCTGTTCAAGCAAAACAAAATGTATTAGTTGCATCAAAAGATGTACCACTTTCAACACTTGTAGA
    ATTGCAAATACAAAAATCTTTATTAACAAAACAAATTGAGCAATTAAATAAAACTGAAGTATCTTTAAAC
    AAAGCTCAATTAAAAGACAAACTATATGTTCCAAAAACATACGGTAATGAAGGAAAACCAGAACCATACT
    ATTTAATAGCTGTAAAAAAAGAAGTTGACAGACTTGCCCAATTTATTCCAAAAATCGAAAGTATGATTGC
    TAAAGAGAAGGAAAGAATGGAACAAGGACCTGCAATTACTGGAGAATCTGAAGAAGTACCATCTGGCCCT
    AGTGCTGAATCATCAACAGATAGATCAACACAATCTTCAACATCCTCATCCTCATCCTCATCTTCAACCC
    CAGCAGCAGCAGAATCCTCCTCAGCCACATTACCAGAAGCACCCGCACCAGCAGAAGCAGCATCCCCATC
    AACAGAAGCATCAGAAGAAACAACAATACCCCCTACCACACAAGAAACACAACCATCACAAGCTGCATCA
    TCCACAACACCTGCAAAACCAGTTATGACAAAATTATATTATCTTGAAAAATTACAAAAATTTTTAGTAT
    TCTCATATTCATGCCATAAATACGTTTTACTACAAAACTCTACCATAAACAAAGATGCTTTAAGCAAATA
    TGCTCTTACATCTGAAGAAGATAAAATAAGAACATTAAAAAGATGCAGTGAATTAGATGTATTATTAGCT
    ATTCAAAATAATATGCCTACTATGTATTCACTTTATGAAAGTATAGTTGATGGTTTACAAAACATTTATA
    CTGAATTATATGAAAAAGAAATGATGTATCATATATATAAATTAAAAGATGAAAACCCATCTATTAAATC
    TTTATTGGTAAAAGCTGGCGTCATTGAACCAGAACCAGTAGCAGCACCAACACCAGTAACTCCAGCAGCA
    ACAGAACAACAACAACAACAAGCAACACCTGATGTACAATCAGATGCACCAGCACCATCAGATGTCTCGC
    AACAACCAGAAACACCAGTAACATCCACGACACCAGAGGTAACAACCTCAACAGAAGCATCATCATCAGC
    ACCTGGCGAAGGTACACCATCAGGAGAAGCAGGAGCATCAGGAACAGAAGGAGCAACAGCATCTAACGCA
    GCCACACCAGCAGGAACATCAGCATCAGGATCAGCAGCATCTAACGCAAGTACAACCTCAGATGTAACAC
    CCCCAGCAGCAGCGGCAGCAGTACCATCAACATCTACACCAGCACCTGCACAACCACCAGCAGCAAATTC
    TCAATCAGGAAACCCTGACTCAGGTATTAGATCACGAGCAGAAAGTGAAGAGGATATGCCTGCCGATGAT
    TTTGAATTAGACAATTTATACAAATCTTACTTACAACAAATTGATGGAAATAATACTGAATTCATAAATT
    TTATAAAATCTAAAAAAGAATTAATAAAAGCATTGACACCTGAAAAAGTTAATCAATTATATCTTGAAAT
    CGCTCACTTAAAGGAATTATCAGAACATTATTATGATCGTTATTCTACATATAAATTAAAATTAGAAAGA
    TTATATAACAAACATGAACAAATTCAACTAACCAATCGACAAATTAGAGATCTTAGTATATTGAAAGCAC
    GATTATTAAAAAGAAAACAAACTCTTAATGGCGTATTTTATATATTAAATGGTTATGTAAATTTCTTTAA
    CAAGAGAAGAGAAGCTGAAAAACAATATGTAGATAATGCATTAAAAAATACTGATATGTTATTAAAATAC
    TACAAAGCTCGTACTAAATATTTTACTTCTGAAGCTGTTCCTTTAAAAACATTATCTAAAGCATCACTTG
    ACAGAGAATCCAATTATTTGAAAATCGAAAAATTCAGAGCATACAGTCGATTAGAATTAAGATTAAAAAA
    AAATATTAATTTAGGAAAGGAAAGAATTTCATATGTATCAGGAGGTTTACACCACGTATTTGAAGAATTT
    AAAGAACTTATAAAAGATAAAGACTATACCGGAAAAAAAAACCCTGATAATGCCCCTGAAGTTACCAATG
    CATTCGAACAATATAAAGAATTGCTTCCAAAGGGAGTAACAGTTTCAACTCCAGCAGTCGCAGTTACAAC
    GACACTAGCAGCTGACGCACCAGCAACACCAGAAGGAGCAGTACCAGGAGCAGTACCAGGAGCTGTACCA
    GGTGCAGTACCAGGAGCAGTACCAGGTGCAGTACCAGGATCAGGAACCGATACACGGGTAGCTGGAAGCA
    GTGTTGATGATAATGAAGACGATGATATATATCAAATTGCAAGTGGTCAATCCGAAGATGCACCAGAAAA
    AGATATTCTTTCCGAATTTACAAATGAAAGTTTGTATGTATACACAAAAAGGTTGGGTAGTACATATAAA
    TCATTAAAGAAACACATGTTAAGAGAATTTTCAACAATTAAAGAAGACATGACAAATGGATTAAATAATA
    AATCACAAAAAAGAAATGATTTCCTTGAAGTATTAAGCCATGAATTAGATTTATTCAAAGATTTAAGTAC
    CAACAAATATGTTATTAGAAATCCATATCAATTATTAGATAATGATAAAAAAGACAAACAAATAGTAAAC
    TTAAAATATGCTACTAAAGGTATAAATGAAGATATAGAAACAACTACTGACGGAATTAAATTCTTTAACA
    AAATGGTTGAATTATACAACACTCAATTAGCTGCAGTAAAGGAACAAATTGCTACCATAGAAGCTGAAAC
    TAACGATACCAATAAAGAAGAAAAAAAGAAATATATTCCAATCCTTGAAGATCTTAAAGGATTATATGAA
    ACCGTAATAGGTCAAGCAGAAGAATATTCAGAAGAATTACAAAATAGACTTGATAATTATAAAAATGAAA
    AAGCTGAATTTGAAATATTAACAAAAAATTTAGAAAAATACATACAAATTGACGAAAAACTTGACGAATT
    TGTAGAACATGCAGAAAATAATAAACACATAGCCTCAATAGCTTTAAACAACTTAAATAAATCTGGTTTA
    GTAGGAGAAGGTGAATCAAAGAAAATATTAGCAAAAATGCTTAACATGGATGGTATGGATTTATTAGGTG
    TAGACCCTAAACATGTATGTGTTGATACAAGAGATATTCCTAAAAATGCTGGATGTTTTAGAGATGATAA
    TGGTACTGAAGAATGGAGATGTTTATTAGGTTACAAAAAAGGTGAAGGTAATACATGTGTAGAAAATAAT
    AATCCTACTTGTGATATCAACAATGGTGGATGTGATCCAACTGCTAGTTGTCAAAATGCGGAAAGTACGG
    AAAATTCCAAAAAAATTATATGTACATGTAAAGAACCAACCCCTAATGCATATTATGAAGGTGTATTCTG
    TAGTTCTTCCAGCTTTATGGGATTATCAATTTTATTAATTATCACATTAATTGTATTTAATATATTTTA
    
    
  • Protein Sequence : Show Sequence
    >XP_726257.1 merozoite surface protein 1 [Plasmodium yoelii]
    MKVIGLLFSFVFFAIKCKSETIEVYNDLIQKLEKLESLSVDGLELFQKSQVIINATQPTETIDPFTNHNF
    AQQVQDFVTKFEGLGFTEQTELVNLIKALTPNRYGVKYLIESKEEFNGLMHAINFYYDVLRDKLNDMCAN
    NYCEIPEHLKISEEETEMLKKVILGYRKPIENIQDDIEKLEIYIERNKETVAALNALIAEETKKIQPEGN
    EDCNDASCDSDKYNKKKPIYQAMYNVIFYKKQLAEIQKVVEVLEKRVSTLKKNDAIKPLWQQIEVLNAAP
    VVTAETQIVTGGQSSTEPGSGGSSASGTSSSGQASAGTGVEQANTVASVTVTPSVGQNGEASTNPQTAQV
    QPVPTLTLEEKQKKIAGLYAQIKEIAKTIKFNLEGIFVDPIELEYFKKEKKKESCNLSTSSCKKNKASET
    IIPLTIRYPNGISYPLPENDVYNKIANNAAETTYGDLTHPDNTPLTGDLATNEQARKDLIKAIKKKIKAE
    EKKLETLKTNYDNKLTEFNQQKTPFKEAAKEFYESKFRNKLTSEIFEKFKTKRDEYMTKKTELNTCEYGN
    TKELINKLNKQLNYLQDYSLRKDIISNEIEYFSNKKKELQYNINRLAEAVQAKQNVLVASKDVPLSTLVE
    LQIQKSLLTKQIEQLNKTEVSLNKAQLKDKLYVPKTYGNEGKPEPYYLIAVKKEVDRLAQFIPKIESMIA
    KEKERMEQGPAITGESEEVPSGPSAESSTDRSTQSSTSSSSSSSSTPAAAESSSATLPEAPAPAEAASPS
    TEASEETTIPPTTQETQPSQAASSTTPAKPVMTKLYYLEKLQKFLVFSYSCHKYVLLQNSTINKDALSKY
    ALTSEEDKIRTLKRCSELDVLLAIQNNMPTMYSLYESIVDGLQNIYTELYEKEMMYHIYKLKDENPSIKS
    LLVKAGVIEPEPVAAPTPVTPAATEQQQQQATPDVQSDAPAPSDVSQQPETPVTSTTPEVTTSTEASSSA
    PGEGTPSGEAGASGTEGATASNAATPAGTSASGSAASNASTTSDVTPPAAAAAVPSTSTPAPAQPPAANS
    QSGNPDSGIRSRAESEEDMPADDFELDNLYKSYLQQIDGNNTEFINFIKSKKELIKALTPEKVNQLYLEI
    AHLKELSEHYYDRYSTYKLKLERLYNKHEQIQLTNRQIRDLSILKARLLKRKQTLNGVFYILNGYVNFFN
    KRREAEKQYVDNALKNTDMLLKYYKARTKYFTSEAVPLKTLSKASLDRESNYLKIEKFRAYSRLELRLKK
    NINLGKERISYVSGGLHHVFEEFKELIKDKDYTGKKNPDNAPEVTNAFEQYKELLPKGVTVSTPAVAVTT
    TLAADAPATPEGAVPGAVPGAVPGAVPGAVPGAVPGSGTDTRVAGSSVDDNEDDDIYQIASGQSEDAPEK
    DILSEFTNESLYVYTKRLGSTYKSLKKHMLREFSTIKEDMTNGLNNKSQKRNDFLEVLSHELDLFKDLST
    NKYVIRNPYQLLDNDKKDKQIVNLKYATKGINEDIETTTDGIKFFNKMVELYNTQLAAVKEQIATIEAET
    NDTNKEEKKKYIPILEDLKGLYETVIGQAEEYSEELQNRLDNYKNEKAEFEILTKNLEKYIQIDEKLDEF
    VEHAENNKHIASIALNNLNKSGLVGEGESKKILAKMLNMDGMDLLGVDPKHVCVDTRDIPKNAGCFRDDN
    GTEEWRCLLGYKKGEGNTCVENNNPTCDINNGGCDPTASCQNAESTENSKKIICTCKEPTPNAYYEGVFC
    SSSSFMGLSILLIITLIVFNIF
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Researchers found that the cysteine-rich, carboxyl-terminal region of the MSP-1 protein from the rodent malarial parasite Plasmodium yoelii yoelii can be expressed in a native configuration as a fusion protein in Escherichia coli. This recombinant polypeptide elicits antibodies in mice which recognize the native parasite MSP-1. Most significantly, both inbred and outbred mice immunized with the fusion protein in Ribi adjuvant are partially and in some cases completely protected against challenge infection with an otherwise lethal parasite strain (Daly and Long, 1993).
  • Related Vaccine(s): P. yoelii DNA vaccine encoding MSP1 , rBCGMSP1-15
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.672
  • Trans-membrane helices: 1
  • Detailed Vaxign Results Vaxign Results
25. msp3
  • Gene Name : msp3
  • Sequence Strain (Species/Organism) : Plasmodium falciparum
  • VO ID : VO_0011220
  • NCBI Protein GI : 113207288
  • Other Database IDs : CDD:284533
    InterPro: IPR010784
    UniProtKB/TrEMBL: Q0KGB6
  • Taxonomy ID : 5833
  • Gene Strand (Orientation) : ?
  • Protein Name : merozoite surface protein 3
  • Protein pI : 4.26
  • Protein Weight : 33643.59
  • Protein Length : 383
  • Protein Note : Merozoite surface protein (SPAM); pfam07133
  • Protein Sequence : Show Sequence
    >CAJ44236.1 merozoite surface protein 3, partial [Plasmodium falciparum]
    SKEIVKKYNLNLRNAILNNNSQIENEENVNTTITGNDFSGGEFLWPGYTEELKAKKASEDAEKAANDAEN
    ASKEAEEAAKEAVNLKESDKSYTKAKEACTAASKAKKAVETALKAKDDAEKSSKADSISTKTKEYAEKAK
    NAYEKAKNAYQKANQAVLKAKEASSYDYILGWEFGGGVPEHKKEENMLSHLYVSSKDKENISKENDDVLD
    EKEEEAEETEEEELEEKNEEETESEISEDEEEEEEEEEKEEENDKKKEQEKEQSNENNDQKKDMEAQNLI
    SKNQNNNEKNVKEAAESIMKTLAG
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Immunization with a recombinant yeast-expressed Plasmodium falciparum merozoite surface protein 3 (MSP3) protected Aotus nancymai monkeys against a virulent challenge infection (Tsai et al., 2009).
  • Related Vaccine(s): P. falciparum MSP3 Protein Subunit Vaccine
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.547
  • Trans-membrane helices: 0
  • Detailed Vaxign Results Vaxign Results
26. MSP4/5
  • Gene Name : MSP4/5
  • Sequence Strain (Species/Organism) : Plasmodium yoelii
  • VO ID : VO_0011236
  • NCBI Protein GI : 49798469
  • Other Database IDs : CDD:289699
  • Taxonomy ID : 73239
  • Gene Strand (Orientation) : ?
  • Protein Name : merozoite surface protein 4/5
  • Protein pI : 4.1
  • Protein Weight : 18420.75
  • Protein Length : 253
  • Protein Note : EGF domain; pfam12947
  • Protein Sequence : Show Sequence
    >AAT68597.1 merozoite surface protein 4/5, partial [Plasmodium yoelii yoelii]
    VHEISLINTKKYQRNIFCAKRILGDPPSANPSTSLNQNEDNHNSNPDANKGNTNKSDKLNGDNIPNSQSK
    SENTNLSESPKTGTASNPPQPEPSVQPGNTNGDSQNSIHSDDEEEDDEDEDDDEEDCSVNNGGCGENLLC
    EKMESGIIKCSCPSGYKLNGTSCIELLSAHS
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Oral immunization of mice with Escherichia coli-expressed Plasmodium yoelii merozoite surface protein 4/5 or the C-terminal 19-kDa fragment of merozoite surface protein 1 induced systemic antibody responses and protected mice against lethal malaria infection (Wang et al., 2004).
  • Related Vaccine(s): P. yoelii MSP1 and MSP4/5 Proteins Subunit Vaccine
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.474
  • Trans-membrane helices: 0
  • Detailed Vaxign Results Vaxign Results
27. PF10_0155 enolase
  • Gene Name : PF10_0155 enolase
  • Sequence Strain (Species/Organism) : Plasmodium falciparum 3D7
  • VO ID : VO_0011223
  • NCBI Gene ID : 810313
  • NCBI Protein GI : 124802328
  • Locus Tag : PF3D7_1015900
  • Genbank Accession : LN999944
  • Protein Accession : XP_001347440
  • Taxonomy ID : 36329
  • Chromosome No : 10
  • Gene Starting Position : 637137
  • Gene Ending Position : 639010
  • Gene Strand (Orientation) : +
  • Protein pI : 6.54
  • Protein Weight : 45501.97
  • Protein Length : 446
  • DNA Sequence : Show Sequence
    >NC_037281.1:637137-639010 Plasmodium falciparum 3D7 chromosome 10, complete sequence
    AATGGCTCATGTAATAACTCGTATTAATGCCCGTGAAATTTTAGGTATAGATATTTTAATGTTATATATT
    TTTTCACTTTGTATATAAATACCTTATTATATGTTTTTAAATAAATGTATATTCAAAGAGCTATATTCAT
    TTTTAACTTTTTTTATTTTATATTATAAGAATGAATATGATAGATAAATAAAGATATATATATTATATAT
    ATATATATATATATATATTTATTTATTTATTTATTTATACATTAATGTATTAATATGTTTATTTTATGAA
    TCCACGTGATATTTCTTTATGAATATGTATTCTATAGTTAACATATAATAATACATACGTATATAATAAG
    AATAACATAAGAATAAAATTTTTTTTTATTTTTTTTTTTGTAATACAATAATTTTTTTGTGTATCATTTT
    ATTTTATTTTATTTTTAATATCTGAACATATATAATTAAATGTGAAAATTATTTACAATATATATATATA
    TATATATATATATATATATATGTTACATTATTACTAATATCTGTATTTTATTTATTTTCTGTTGTTATAT
    ATTTTTTTTATATATAGATTCTAGAGGAAACCCAACTGTAGAAGTTGACTTAGAGACCAACTTAGGTATT
    TTCAGAGCTGCCGTACCATCTGGTGCCTCCACTGGTATTTATGAAGCCTTAGAATTAAGAGATAATGACA
    AGAGCAGGTACTTAGGAAAGGGTGTTCAAAAAGCTATCAAGAACATTAATGAAATTATTGCTCCAAAATT
    GATTGGAATGAATTGTACTGAACAAAAGAAAATTGACAATTTAATGGTTGAAGAATTAGATGGAAGTAAA
    AATGAATGGGGATGGTCAAAAAGTAAATTAGGAGCTAATGCTATTTTAGCTATATCCATGGCTGTATGTA
    GAGCTGGTGCAGCTGCTAATAAAGTATCTTTATACAAATATTTGGCACAATTAGCTGGAAAGAAAAGTGA
    CCAAATGGTATTACCAGTACCTTGTTTAAACGTTATCAATGGAGGATCCCATGCAGGAAACAAATTATCT
    TTCCAAGAATTTATGATAGTGCCAGTTGGTGCTCCATCATTTAAAGAAGCCTTAAGATATGGTGCTGAAG
    TATATCATACCTTAAAATCAGAAATTAAAAAGAAATATGGTATTGATGCAACCAATGTAGGTGATGAAGG
    TGGATTTGCTCCAAATATATTAAACGCTAATGAAGCTCTTGATTTATTAGTAACTGCCATTAAATCAGCT
    GGTTATGAAGGAAAGGTTAAAATTGCTATGGATGTTGCAGCTTCTGAATTTTACAACAGTGAAAACAAAA
    CATACGATTTAGATTTCAAAACTCCAAATAATGACAAATCATTAGTTAAGACTGGAGCTCAATTAGTTGA
    CTTATACATTGATTTAGTAAAGAAATATCCAATTGTTTCTATTGAAGATCCATTTGATCAAGATGATTGG
    GAAAATTATGCTAAATTAACAGCAGCTATTGGAAAGGATGTTCAAATTGTTGGTGATGATTTATTAGTTA
    CAAACCCAACCAGAATTACTAAAGCTCTTGAAAAAAATGCTTGCAATGCTTTACTTCTTAAAGTTAACCA
    AATCGGTTCTATTACTGAAGCTATTGAAGCTTGCTTATTATCTCAAAAAAATAACTGGGGTGTTATGGTT
    TCTCACAGATCTGGTGAAACCGAAGATGTTTTTATTGCTGATTTAGTTGTTGCTTTAAGAACCGGACAAA
    TCAAAACAGGAGCACCATGCAGAAGTGAAAGAAACGCCAAATATAACCAATTATTAAGAATTGAAGAATC
    TTTAGGAAACAATGCTGTTTTTGCTGGAGAAAAATTTAGATTACAATTAAATTA
    
    
  • Protein Sequence : Show Sequence
    >XP_001347440.1 enolase [Plasmodium falciparum 3D7]
    MAHVITRINAREILDSRGNPTVEVDLETNLGIFRAAVPSGASTGIYEALELRDNDKSRYLGKGVQKAIKN
    INEIIAPKLIGMNCTEQKKIDNLMVEELDGSKNEWGWSKSKLGANAILAISMAVCRAGAAANKVSLYKYL
    AQLAGKKSDQMVLPVPCLNVINGGSHAGNKLSFQEFMIVPVGAPSFKEALRYGAEVYHTLKSEIKKKYGI
    DATNVGDEGGFAPNILNANEALDLLVTAIKSAGYEGKVKIAMDVAASEFYNSENKTYDLDFKTPNNDKSL
    VKTGAQLVDLYIDLVKKYPIVSIEDPFDQDDWENYAKLTAAIGKDVQIVGDDLLVTNPTRITKALEKNAC
    NALLLKVNQIGSITEAIEACLLSQKNNWGVMVSHRSGETEDVFIADLVVALRTGQIKTGAPCRSERNAKY
    NQLLRIEESLGNNAVFAGEKFRLQLN
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Mice immunized with r-Pfen (recombinant P. falciparum enolase protein) showed protection against a challenge with the 17XL lethal strain of the mouse malarial parasite Plasmodium yoelii (Pal-Bhowmick et al., 2007).
  • Related Vaccine(s): P. falciparum Pfen Protein Subunit Vaccine
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.191
  • Trans-membrane helices: 0
  • Detailed Vaxign Results Vaxign Results
28. pfCelTOS
  • Gene Name : pfCelTOS
  • NCBI Protein GI : 62954730
  • Other Database IDs : CDD:163532
  • Taxonomy ID : 5833
  • Gene Strand (Orientation) : ?
  • Protein Name : PF cell-traversal protein
  • Protein pI : 4.42
  • Protein Weight : 18979.58
  • Protein Length : 248
  • Protein Note : lysine-2,3-aminomutase; TIGR03820
  • Protein Sequence : Show Sequence
    >BAD97684.1 PF cell-traversal protein [Plasmodium falciparum]
    MNALRRLPVICSFLVFLVFSNVLCFRGNNGHNSSSSLYNGSQFIEQLNNSFTSAFLESQSMNKIGDDLAE
    TISNELVSVLQKNSPTFLESSFDIKSEVKKHAKSMLKELIKVGLPSFENLVAENVKPPKVDPATYGIIVP
    VLTSLFNKVETAVGAKVSDEIWNYNSPDVSESEESLSDDFFD
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Immunization with PfCelTOS resulted in potent humoral and cellular immune responses and most importantly induced sterile protection against a heterologous challenge with P. berghei sporozoites in a proportion of both inbred and outbred mice (Bergmann-Leitner et al., 2010).
  • Related Vaccine(s): P. falciparum pfCelTos protein vaccine
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.398
  • Trans-membrane helices: 0
  • Detailed Vaxign Results Vaxign Results
29. RESA
  • Gene Name : RESA
  • Sequence Strain (Species/Organism) : Plasmodium falciparum 3D7
  • VO ID : VO_0010959
  • NCBI Gene ID : 813159
  • NCBI Protein GI : 124505681
  • Locus Tag : PF3D7_0102200
  • Genbank Accession : AL844501
  • Protein Accession : XP_001350954
  • Taxonomy ID : 36329
  • Chromosome No : 1
  • Gene Starting Position : 98818
  • Gene Ending Position : 102281
  • Gene Strand (Orientation) : +
  • Protein Name : RESA, ring-infected erythrocyte surface antigen, Pf155, MAL1P1.13
  • Protein pI : 4.13
  • Protein Weight : 117293.03
  • Protein Length : 1085
  • Protein Note : Also known as Pf155
  • DNA Sequence : Show Sequence
    >NC_004325.2:98818-102281 Plasmodium falciparum 3D7, chromosome 1
    TATGAGACCTTTTCATGCATATAGTTGGATTTTTTCTCAACAATATATGGATACAAAAAATGTTAAGGAA
    AAAAATCCCACCATATATTCATTTGATGATGAAGAAAAAAGAAATGAAAATAAGAGCTTTTTAAAGGTGT
    TGTGTTCTAAACGTGGTGTTCTTCCAATTATTGGAATACTATATATCATTTTAAATGTAAGTTTTTTTTT
    TTTTTTTTTTTTTTGAAATAAAATACATATTTTTTATATTTAATTTTTTATGTTAATGCTTATTTTATTT
    TATTCTATTCTTTTTTATATGTCATGCATATTTTATATATTATAATACCGTTTTTAATAATATATAATAT
    ATCTTTGTTATTATATATAATTTTTTTTTTTTTTTTTTTTTTTTTTTCATAGGGTAATCTTGGATATAAT
    GGAAGTTCATCTTCTGGCGTACAATTTACTGATAGATGTTCAAGAAATTTATACGGGGAAACATTGCCAG
    TAAACCCATATGCTGATTCTGAAAACCCAATAGTTGTAAGTCAGGTATTTGGTTTACCCTTCGAAAAACC
    TACGTTTACCTTAGAAAGTCCTCCTGATATTGATCATACAAATATTTTGGGTTTTAATGAGAAGTTCATG
    ACTGATGTAAATAGATATCGATATTCTAATAACTATGAAGCCATTCCTCATATAAGTGAGTTCAATCCAC
    TTATTGTAGATAAAGTTCTTTTCGACTATAACGAAAAGGTTGATAACTTAGGAAGAAGTGGAGGAGACAT
    TATAAAAAAAATGCAAACTTTATGGGATGAAATAATGGATATTAATAAAAGAAAATATGATTCTTTAAAA
    GAAAAATTACAGAAAACTTACAGTCAGTACAAGGTTCAATATGATATGCCAAAAGAAGCATATGAGAGCA
    AATGGACACAATGCATAAAACTTATTGATCAAGGAGGAGAGAACCTTGAAGAAAGATTGAACTCACAATT
    TAAAAACTGGTACAGGCAGAAATATTTAAATCTTGAAGAATATAGAAGATTGACTGTGTTGAACCAAATC
    GCTTGGAAAGCTTTATCCAACCAAATTCAATATTCATGCAGAAAAATTATGAATAGTGACATTTCTTCCT
    TTAAACATATAAATGAATTGAAAAGTTTAGAACACAGAGCCGCAAAAGCTGCAGAAGCAGAAATGAAGAA
    AAGAGCTCAAAAACCGAAGAAGAAAAAAAGTAGAAGAGGATGGTTATGTTGTGGGGGGGGAGATATCGAA
    ACAGTTGAACCACAACAAGAAGAACCAGTCCAAACCGTTCAAGAACAACAAGTAAATGAATATGGTGATA
    TATTACCATCATTAAGGGCCAGTATTACTAATTCAGCTATTAATTATTATGATACCGTAAAAGATGGTGT
    ATACTTAGACCATGAAACATCAGATGCTCTTTATACAGATGAAGATTTGTTATTTGATTTGGAAAAACAA
    AAATATATGGATATGTTAGATACATCTGAAGAAGAATCTGTTAAAGAAAATGAAGAAGAACACACTGTTG
    ATGATGAACATGTAGAAGAACACACTGCTGATGACGAACATGTAGAAGAACCAACTGTTGCTGATGATGA
    ACATGTAGAAGAACCAACTGTTGCTGATGAACACGTAGAAGAACCAACTGTTGCTGAAGAACATGTAGAA
    GAACCAACTGTTGCTGAAGAACACGTAGAAGAACCAGCTAGTGATGTTCAACAAACTTCAGAAGCAGCTC
    CAACAATTGAAATCCCCGATACATTATATTACGATATATTAGGTGTTGGTGTTAATGCTGATATGAACGA
    AATTACTGAACGTTATTTTAAGTTAGCTGAAAATTACTATCCATACCAAAGATCAGGTTCTACTGTTTTC
    CACAACTTTAGGAAAGTCAACGAAGCCTACCAAGTTTTAGGAGATATTGATAAAAAAAGATGGTACAATA
    AATACGGATATGATGGAATAAAACAAGTCAACTTTATGAATCCATCCATCTTTTATTTATTATCTAGTTT
    AGAAAAATTTAAAGATTTTACCGGAACACCCCAAATAGTAACTCTTTTGAGATTCTTTTTTGAAAAGAGA
    TTATCTATGAATGATTTAGAGAATAAAAGTGAACATTTATTAAAATTTATGGAACAATATCAAAAAGAAA
    GAGAAGCACATGTATCTGAATATTTATTAAATATATTACAACCATGTATAGCTGGTGATTCAAAATGGAA
    TGTACCAATTATAACAAAACTTGAAGGTTTAAAAGGATCTCGCTTTGATATACCAATATTAGAATCTTTA
    AGATGGATATTCAAACATGTCGCTAAAACACATTTGAAAAAATCCTCAAAATCAGCTAAGAAACTTCAAC
    AGAGAACCCAGGCTAATAAACAAGAATTAGCAAATATAAATAATAACCTAATGAGTACATTGAAAGAATA
    TGTAGGAAGTAGTGAACAAATGAATTCAATAACATACAATTTCGAAAACATCAATTCCAATGTTGATAAC
    GGAAACCAATCAAAAAATATTTCAGATTTAAGTTATACAGATCAGAAGGAAATATTAGAAAAAATTGTTA
    GTTATATAGTAGATATTTCCCTTTATGATATAGAGAACACAGCTTTAAATGCCGCTGAACAATTGTTGTC
    AGATAATTCAGTAGATGAAAAAACTCTTAAAAAGAGAGCTCAATCATTAAAAAAATTATCATCCATTATG
    GAGAGATATGCAGGTGGTAAAAGAAACGATAAAAAAGCAAAAAAATATGATACCCAAGATGTTGTAGGAT
    ATATTATGCATGGAATTAGCACAATTAATAAAGAAATGAAAAACCAAAATGAAAATGTACCCGAACATGT
    ACAACATAATGCTGAAGCAAATGTAGAACATGATGCTGAAGAAAATGTAGAACATGATGCTGAAGAAAAT
    GTTGAAGAAAATGTAGAAGAAAATGTAGAAGAAAATGTAGAAGAAAATGTAGAAGAAAATGTAGAAGAAA
    ATGTAGAAGAAAATGTAGAAGAAAATGTAGAAGAAAATGTTGAAGAAAATGTAGAAGAAAATGTTGAAGA
    AAATGTAGAAGAAAATGTAGAAGAAAATGTTGAAGAATATGATGAAGAAAATGTTGAAGAAGTAGAAGAA
    AATGTTGAAGAATATGATGAAGAAAATGTTGAAGAAGTAGAAGAAAATGTAGAAGAAAATGTAGAAGAAA
    ATGTAGAAGAAAATGTTGAAGAATATGATGAAGAAAATGTTGAAGAAGTAGAAGAAAATGTAGAAGAAAA
    TGTAGAAGAAAATGTTGAAGAAAATGTAGAAGAAAATGTTGAAGAAGTAGAAGAAAATGTAGAAGAAAAT
    GTAGAAGAAAATGTAGAAGAGAATGTTGAAGAGAATGTTGAAGAGAATGTTGAAGAATATGATGAAGAAA
    ATGTTGAAGAACACAATGAAGAATATGATGAATA
    
    
  • Protein Sequence : Show Sequence
    >XP_001350954.1 ring-infected erythrocyte surface antigen [Plasmodium falciparum 3D7]
    MRPFHAYSWIFSQQYMDTKNVKEKNPTIYSFDDEEKRNENKSFLKVLCSKRGVLPIIGILYIILNGNLGY
    NGSSSSGVQFTDRCSRNLYGETLPVNPYADSENPIVVSQVFGLPFEKPTFTLESPPDIDHTNILGFNEKF
    MTDVNRYRYSNNYEAIPHISEFNPLIVDKVLFDYNEKVDNLGRSGGDIIKKMQTLWDEIMDINKRKYDSL
    KEKLQKTYSQYKVQYDMPKEAYESKWTQCIKLIDQGGENLEERLNSQFKNWYRQKYLNLEEYRRLTVLNQ
    IAWKALSNQIQYSCRKIMNSDISSFKHINELKSLEHRAAKAAEAEMKKRAQKPKKKKSRRGWLCCGGGDI
    ETVEPQQEEPVQTVQEQQVNEYGDILPSLRASITNSAINYYDTVKDGVYLDHETSDALYTDEDLLFDLEK
    QKYMDMLDTSEEESVKENEEEHTVDDEHVEEHTADDEHVEEPTVADDEHVEEPTVADEHVEEPTVAEEHV
    EEPTVAEEHVEEPASDVQQTSEAAPTIEIPDTLYYDILGVGVNADMNEITERYFKLAENYYPYQRSGSTV
    FHNFRKVNEAYQVLGDIDKKRWYNKYGYDGIKQVNFMNPSIFYLLSSLEKFKDFTGTPQIVTLLRFFFEK
    RLSMNDLENKSEHLLKFMEQYQKEREAHVSEYLLNILQPCIAGDSKWNVPIITKLEGLKGSRFDIPILES
    LRWIFKHVAKTHLKKSSKSAKKLQQRTQANKQELANINNNLMSTLKEYVGSSEQMNSITYNFENINSNVD
    NGNQSKNISDLSYTDQKEILEKIVSYIVDISLYDIENTALNAAEQLLSDNSVDEKTLKKRAQSLKKLSSI
    MERYAGGKRNDKKAKKYDTQDVVGYIMHGISTINKEMKNQNENVPEHVQHNAEANVEHDAEENVEHDAEE
    NVEENVEENVEENVEENVEENVEENVEENVEENVEENVEENVEENVEENVEENVEENVEEYDEENVEEVE
    ENVEEYDEENVEEVEENVEENVEENVEENVEEYDEENVEEVEENVEENVEENVEENVEENVEEVEENVEE
    NVEENVEENVEENVEENVEEYDEENVEEHNEEYDE
    
    
  • Molecule Role : Protective antigen
  • Related Vaccine(s): P. falciparum vaccine Combination B
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.212
  • Trans-membrane helices: 0
  • Detailed Vaxign Results Vaxign Results
30. SERA-5
  • Gene Name : SERA-5
  • Sequence Strain (Species/Organism) : Plasmodium falciparum
  • VO ID : VO_0011210
  • NCBI Protein GI : 238629807
  • 3D structure: PDB ID : 3CH2
  • Other Database IDs : CDD:185641
  • Taxonomy ID : 5833
  • Gene Strand (Orientation) : ?
  • Protein Name : serine repeat antigen 5
  • Protein pI : 6.14
  • Protein Weight : 28688.67
  • Protein Length : 362
  • Protein Note : Serine-repeat antigen protein; Provisional
  • Protein Sequence : Show Sequence
    >ACR49652.1 serine repeat antigen 5, partial [Plasmodium falciparum]
    TGGGQAGNTGGGQAGNTGGGQAGNTVGDQAGSTGGSPQGSTGASQPGSSEPSNPVSSGHSVSTVSVSQTS
    TSSEKQDTIQVKSALLKDYMGLKVTGPCNENFIMFLVPHIYIDVDTEDTNIELRTTLKKTNNAISFESNS
    GSLEKKKYVKLPSNGTTGEQGSSTGTVRGDTEPISDSSSSSSSSSSSSSSSSSSSSSSSESLPANGPDSP
    TVKPPRNLQNICETGKNFKLVVYIKENTLILKWKVYGETKDTTENNKVDVRKYLINEKETPFTNILIHAY
    KEHNEQT
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Researchers constructed a new recombinant molecule of SERA5, namely SE36. Vaccination of Squirrel monkeys with SE36 protein and aluminium hydroxyl gel (SE36/AHG) conferred protection against high parasitemia and boosted serum anti-SE36 IgG after P. falciparum parasite challenge (Horii et al., 2010).
  • Related Vaccine(s): P. falciparum Subunit SE36 Protein Vaccine
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.752
  • Trans-membrane helices: 0
  • Detailed Vaxign Results Vaxign Results
31. SSP2
  • Gene Name : SSP2
  • Sequence Strain (Species/Organism) : Plasmodium yoelii yoelii
  • NCBI Protein GI : 45645179
  • Other Database IDs : CDD:240420
    CDD:238748
    CDD:214559
  • Taxonomy ID : 73239
  • Gene Strand (Orientation) : ?
  • Protein Name : Sporozoite surface protein 2
  • Protein pI : 4.42
  • Protein Weight : 90008.58
  • Protein Length : 925
  • Protein Note : sporozoite surface protein 2 (SSP2); Provisional
  • Protein Sequence : Show Sequence
    >sp|Q01443.2|SSP2_PLAYO RecName: Full=Sporozoite surface protein 2; Flags: Precursor
    MKLLGNSKYIFVVLLLCISVFLNGQETLDEIKYSEEVCTEQIDIHILLDGSGSIGYSNWKAHVIPMLNTL
    VDNLNISNDEINVSLTLFSTNSRELIKLKGYGSTSKDSLRFILAHLQNNYSPNGNTNLTSALLVVDTLIN
    ERMYRPDAIQLAIILTDGIPNDLPRSTAVVHQLKRKHVNVAIIGVGAGVNNEYNRILVGCDRYAPCPYYS
    SGSWNEAQNMIKPFLTKVCQEVERIAHCGKWEEWSECSTTCDEGRKIRRRQILHPGCVSEMTTPCKVRDC
    PQIPIPPVIPNKIPEKPSNPEEPVNPNDPNDPNNPNNPNNPNNPNNPNNPNNPNNPNNPNNPNNPNNPNN
    PNNPNNPNNPNNPNNPNNPNNPNNPNNPNNPNDPSNPNNPNPKKRNPKRRNPNKPKPNKPNPNKPNPNEP
    SNPNKPNPNEPSNPNKPNPNEPSNPNKPNPNEPSNPNKPNPNEPLNPNEPSNPNEPSNPNAPSNPNEPSN
    PNEPSNPNEPSNPNEPSNPNEPSNPKKPSNPNEPSNPNEPLNPNEPSNPNEPSNPNEPSNPEEPSNPKEP
    SNPNEPSNPEEPNPEEPSNPKEPSNPEEPINPEELNPKEPSNPEESNPKEPINPEESNPKEPINPEDNEN
    PLIIQDEPIEPRNDSNVIPILPIIPQKGNNIPSNLPENPSDSEVEYPRPNDNGENSNNTMKSKKNIPNEP
    IPSPGDNPYKGHEERIPKPHRSNDDYVYDNNVNKNNKDEPEIPNNEYEEDKNKNQSKSNNGYKIAGGIIG
    GLAILGCAGVGYNFIAGSSAAGLAGAEPAPFEDVIPDDDKDIVENEQFKLPEDNDWN
    
    
  • Molecule Role : Protective antigen
  • Related Vaccine(s): P. yoelii DNA vaccine encoding PySSP2
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.269
  • Trans-membrane helices: 1
  • Detailed Vaxign Results Vaxign Results
32. SSP2 from P. knowlesi
  • Gene Name : SSP2 from P. knowlesi
  • Sequence Strain (Species/Organism) : Plasmodium knowlesi strain H
  • NCBI Protein GI : 221058683
  • Other Database IDs : CDD:240420
    EnsemblGenomes-Gn:PKH_121770
    EnsemblGenomes-Tr:PKH_121770
    InterPro: IPR000884
    InterPro: IPR002035
    UniProtKB/TrEMBL: B3L8N1
  • Taxonomy ID : 5851
  • Gene Strand (Orientation) : ?
  • Protein Name : sporozoite surface protein 2, putative
  • Protein pI : 4.27
  • Protein Weight : 60249.802
  • Protein Length : 675
  • Protein Note : sporozoite surface protein 2 (SSP2); Provisional
  • Protein Sequence : Show Sequence
    >XP_002259987.1 sporozoite surface protein 2, putative [Plasmodium knowlesi strain H]
    MKLLQNKSYLLVVFLLYVSIFARGDQKIVDEVKYNEEVCNEKVDLYLLVDGSGSIGYANWITRVIPMLTG
    LIENLNLSKDSINLYMSLFASHTTELIRLGSGPSMDKKQALNVVRDLRKGYEPYGNTSMSSALSEVEMHL
    KDRVNRPNAIQLVILMTDGIPNNKYRALELSRALKERNVKLAVIGIGQGINHQYNKLMAGCRPRERSCKF
    YSSADWSEAISLIKPFIAKVCTEVERIAKCGPWDDWTPCSVTCGKGTHSRSRPLLHAGCTTHMVKECEMD
    ECPVEPEPVPVPAPVPPTPEDENPRTTDEEDDHPNFHQGLDVPDVENDVPPENDGGDGNPFEENFFPPGD
    DTVPDESNVIPVPPTVPGGSNSEFSSDVENAAQYPENPENPENPENSENPENPENQNNPEDFPMEPDMSA
    DNKINEPTNPSDSGQGIPENVIPTPINNEKDIINKNKAVYPNGSNQSHDRYPKPHRNAGGYDNNPNANSD
    IPEGPFSSEEEQPEDKGKKSSNNGYKIAGGVIAGLALVGCVGFAYNFVSSGGAAGMAGEPAPFDEAMAED
    EKDAGEADQFKLPEDNDWN
    
    
  • Molecule Role : Protective antigen
  • Related Vaccine(s): P. knowlesi DNA vaccine encoding PkCSP, PkSSP2, PkAMA1, and PkMSP1p42
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.365
  • Trans-membrane helices: 1
  • Detailed Vaxign Results Vaxign Results
33. TRAP from P. falciparum
  • Gene Name : TRAP from P. falciparum
  • Sequence Strain (Species/Organism) : Plasmodium falciparum 3D7
  • VO ID : VO_0010920
  • NCBI Gene ID : 814170
  • NCBI Protein GI : 124513464
  • Locus Tag : PF3D7_1335900
  • Genbank Accession : AL844509
  • Protein Accession : XP_001350088
  • Taxonomy ID : 36329
  • Chromosome No : 13
  • Gene Starting Position : 1464894
  • Gene Ending Position : 1466618
  • Gene Strand (Orientation) : -
  • Protein Name : Thrombospondin-related anonymous protein (TRAP), SSP-2, SSP2, Sporozoite specific protein 2, Sporozoite surface protein 2
  • Protein pI : 4.7
  • Protein Weight : 61465.35
  • Protein Length : 574
  • DNA Sequence : Show Sequence
    >NC_004331.3:1464894-1466618 Plasmodium falciparum 3D7 chromosome 13
    TTTAATTCCACTCGTTTTCTTCAGGTAATCTGAATTGTTCAGGTTCGTCCAAATCTTTATCTTCTTCACC
    TAATGTTTCATCAAAAGGTGCAGGTTCTCCGGCATAGGGTGTTGCTGCTCCTGGTACTACGAATTTATAA
    GCAAGTCCAGCACATGCGAGTAAAGCTAATCCTCCAGCTATTCCACCTGCAATTTTATATTTATTATCTG
    ATCCTGCTTTTTTTTTATTATTATCTGGCTTTTCATGTTCTTCCCTTTCAGGATGTTTTGGAGTATTGTT
    ATGTTTTCTATTGTATGATCTATTTTCATTATTTCTACCATGTGGACGTGTTTCTCTATCTTCACTATTA
    GGTACGTGCCTATTTCCATTATTATCTTGACTTTGGGGGTCACTTTGTTTCCTTTCATTATCCAAAACTT
    TTGGAGATAATGGTGAATATGGAATATATCTATCACTTTTATCATTTGGTAAATTATTTTGATTATCGTG
    CTTATTTTCGGGTTTCTTTGGAATATCAAAGTTTTCTTCTCGATCGTCTTCTGGATTTTTTGGAACATCA
    GAAGGTACTTCTTTTTCTGAATCTTCAGGTATATTTGGTTCTTGTTCAGGAATATCTGGATTTGGTGGAT
    TTGGTGGATTTGGTGGATTTGGTGGATTTGGTGGATTTGGTGGATTTTCTGGATTTTCATCTAAATCAAA
    TCCGTTTGGATTTTCACCCTTTCCTTCTTCTGGATTTGGTGAAGGTTCTTGTGGATTATTATCTATTATA
    TTTTCGTTTGGTTTTTCGACAGCAAAATTATCTCCTCTTGGTCTAGGTTGATCATCTTCGGGTTCATCTG
    GAACATCTAATGGTTCCCGTTTTGGAAGACATCTTTCTTCTTCACATTGTTCTTGTAATTCACTTGTACA
    TCCTTCGTGTAAGATTTCTCTTTTTCTTGACCTGGTACCTTTACCACAAGTTACACTACATGGAGACCAT
    TCGTCCCAAACACCACAACTTGCTGTTTTTTCTACTTCAACACAAACAGCCTTCATAAAGGGTCCGATAA
    CATTTTTTACATTTTCCCATGCAGAATCAGCATACAAGTTACATTTACCATCTGATGGATGACAACCTAC
    AAGAAATCTGTTGAAAGCTACATTAATACCTTGTCCAATACCAAAAACAGCTATTTTAACACCACGATCA
    CTTAATTTTCTTGATTCTTTTAATGAATCTTGAATACTATCTGGAATTCCATCTGTTAATATAACAACTA
    ATTGATTAGCATTCTCTCTATTGATTCGGTCATTTAAATGTTTTCTTACTTGTAACAGTGCATCAGTTAA
    GTTTGTTTTACCATATGGAAGATTTGTACTTAAGAGTGACTTTATAATAATTAAAGCCTTCTCTTTGTTT
    TTAGATGCATCACTATGTAATCTAATAATTTCTCTTGCATTGTTTGAAAAAACACTAGCATATAAGTGAA
    TTGCATTATCATTAAGATTTAATTGTTGTATCAATTTCATAGCTAGAGGTACTGCATGGTTCACCCAATT
    ATGACGACGTATACTTCCAGAACAATCCATTAGAAGGTAAAGATCTACCTCATCATTACATACTTCTTCA
    CGATATTTTATTTCATCCACTATATTGTTTTGCACATCTCTACCATTAACTAGAAACAAATCAAAGAAAA
    TCAAAAACACAATGACTAAATATTTAACATTCCCAAGATGATTCA
    
    
  • Protein Sequence : Show Sequence
    >XP_001350088.1 thrombospondin-related anonymous protein [Plasmodium falciparum 3D7]
    MNHLGNVKYLVIVFLIFFDLFLVNGRDVQNNIVDEIKYREEVCNDEVDLYLLMDCSGSIRRHNWVNHAVP
    LAMKLIQQLNLNDNAIHLYASVFSNNAREIIRLHSDASKNKEKALIIIKSLLSTNLPYGKTNLTDALLQV
    RKHLNDRINRENANQLVVILTDGIPDSIQDSLKESRKLSDRGVKIAVFGIGQGINVAFNRFLVGCHPSDG
    KCNLYADSAWENVKNVIGPFMKAVCVEVEKTASCGVWDEWSPCSVTCGKGTRSRKREILHEGCTSELQEQ
    CEEERCLPKREPLDVPDEPEDDQPRPRGDNFAVEKPNENIIDNNPQEPSPNPEEGKGENPNGFDLDENPE
    NPPNPPNPPNPPNPPNPPNPDIPEQEPNIPEDSEKEVPSDVPKNPEDDREENFDIPKKPENKHDNQNNLP
    NDKSDRYIPYSPLSPKVLDNERKQSDPQSQDNNGNRHVPNSEDRETRPHGRNNENRSYNRKHNNTPKHPE
    REEHEKPDNNKKKAGSDNKYKIAGGIAGGLALLACAGLAYKFVVPGAATPYAGEPAPFDETLGEEDKDLD
    EPEQFRLPEENEWN
    
    
  • Molecule Role : Protective antigen
  • Related Vaccine(s): P. falciparum DNA and MVA encoding ME-TRAP
  • Localization(Probability):
    (Prob.=0)
  • Adhesin Probability: 0.244
  • Trans-membrane helices: 0
  • Detailed Vaxign Results Vaxign Results
II. References
1. Bergmann-Leitner et al., 2010: Bergmann-Leitner ES, Mease RM, De La Vega P, Savranskaya T, Polhemus M, Ockenhouse C, Angov E. Immunization with pre-erythrocytic antigen CelTOS from Plasmodium falciparum elicits cross-species protection against heterologous challenge with Plasmodium berghei. PloS one. 2010; 5(8); e12294. [PubMed: 20808868].
2. Bonnefoy et al., 1994: Bonnefoy S, Gysin J, Blisnick T, Guillotte M, Carcy B, Pereira da Silva L, Mercereau-Puijalon O. Immunogenicity and antigenicity of a Plasmodium falciparum protein fraction (90-110 kDa) able to protect squirrel monkeys against asexual blood stages. Vaccine. 1994; 12(1); 32-40. [PubMed: 8303938].
3. Carvalho et al., 2004: Carvalho LJ, Oliveira SG, Theisen M, Alves FA, Andrade MC, Zanini GM, Brígido MC, Oeuvray C, Póvoa MM, Muniz JA, Druilhe P, Daniel-Ribeiro CT. Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels. Scandinavian journal of immunology. 2004; 59(4); 363-372. [PubMed: 15049780].
4. Daly and Long, 1993: Daly TM, Long CA. A recombinant 15-kilodalton carboxyl-terminal fragment of Plasmodium yoelii yoelii 17XL merozoite surface protein 1 induces a protective immune response in mice. Infection and immunity. 1993; 61(6); 2462-2467. [PubMed: 8363656].
5. Daubersies et al., 2000: Daubersies P, Thomas AW, Millet P, Brahimi K, Langermans JA, Ollomo B, BenMohamed L, Slierendregt B, Eling W, Van Belkum A, Dubreuil G, Meis JF, Guérin-Marchand C, Cayphas S, Cohen J, Gras-Masse H, Druilhe P. Protection against Plasmodium falciparum malaria in chimpanzees by immunization with the conserved pre-erythrocytic liver-stage antigen 3. Nature medicine. 2000; 6(11); 1258-1263. [PubMed: 11062538].
6. Dobaño and Doolan, 2007: Dobaño C, Doolan DL. Identification of minimal CD8+ and CD4+ T cell epitopes in the Plasmodium yoelii hepatocyte erythrocyte protein 17kDa. Molecular immunology. 2007; 44(11); 3037-3048. [PubMed: 17303242].
7. Grüner et al., 2007: Grüner AC, Mauduit M, Tewari R, Romero JF, Depinay N, Kayibanda M, Lallemand E, Chavatte JM, Crisanti A, Sinnis P, Mazier D, Corradin G, Snounou G, Rénia L. Sterile protection against malaria is independent of immune responses to the circumsporozoite protein. PloS one. 2007; 2(12); e1371. [PubMed: 18159254].
8. Horii et al., 2010: Horii T, Shirai H, Jie L, Ishii KJ, Palacpac NQ, Tougan T, Hato M, Ohta N, Bobogare A, Arakaki N, Matsumoto Y, Namazue J, Ishikawa T, Ueda S, Takahashi M. Evidences of Protection Against Blood-stage Infection of Plasmodium falciparum by the Novel Protein Vaccine SE36. Parasitology international. 2010; ; . [PubMed: 20493274].
9. Kaba et al., 2009: Kaba SA, Brando C, Guo Q, Mittelholzer C, Raman S, Tropel D, Aebi U, Burkhard P, Lanar DE. A nonadjuvanted polypeptide nanoparticle vaccine confers long-lasting protection against rodent malaria. Journal of immunology (Baltimore, Md. : 1950). 2009; 183(11); 7268-7277. [PubMed: 19915055].
10. Kumar et al., 1995: Kumar S, Yadava A, Keister DB, Tian JH, Ohl M, Perdue-Greenfield KA, Miller LH, Kaslow DC. Immunogenicity and in vivo efficacy of recombinant Plasmodium falciparum merozoite surface protein-1 in Aotus monkeys. Molecular medicine (Cambridge, Mass.). 1995; 1(3); 325-332. [PubMed: 8529111].
11. Kushwaha et al., 2001: Kushwaha A, Rao PP, Suresh RP, Chauhan VS. Immunogenicity of recombinant fragments of Plasmodium falciparum acidic basic repeat antigen produced in Escherichia coli. Parasite immunology. 2001 Aug; 23(8); 435-44. [PubMed: 11489167].
12. Li et al., 2007: Li SL, Zhang DM, Cao Y, Pan WQ. [Expression and immunogenicity evaluation of ectodomain and subdomains of Plasmodium berghei apical membrane antigen 1]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases. 2007; 25(1); 1-5. [PubMed: 17639690].
13. Mauduit et al., 2009: Mauduit M, Grüner AC, Tewari R, Depinay N, Kayibanda M, Chavatte JM, Franetich JF, Crisanti A, Mazier D, Snounou G, Rénia L. A role for immune responses against non-CS components in the cross-species protection induced by immunization with irradiated malaria sporozoites. PloS one. 2009; 4(11); e7717. [PubMed: 19890387].
14. Mohmmed et al., 2005: Mohmmed A, Kishore S, Patra KP, Dasaradhi PV, Malhotra P, Chauhan VS. Identification of karyopherin beta as an immunogenic antigen of the malaria parasite using immune mice and human sera. Parasite immunology. 2005; 27(5); 197-203. [PubMed: 15987343].
15. Moll et al., 2007: Moll K, Pettersson F, Vogt AM, Jonsson C, Rasti N, Ahuja S, Spångberg M, Mercereau-Puijalon O, Arnot DE, Wahlgren M, Chen Q. Generation of cross-protective antibodies against Plasmodium falciparum sequestration by immunization with an erythrocyte membrane protein 1-duffy binding-like 1 alpha domain. Infection and immunity. 2007; 75(1); 211-219. [PubMed: 17074852].
16. Pal-Bhowmick et al., 2007: Pal-Bhowmick I, Mehta M, Coppens I, Sharma S, Jarori GK. Protective properties and surface localization of Plasmodium falciparum enolase. Infection and immunity. 2007; 75(11); 5500-5508. [PubMed: 17785475].
17. Petritus and Burns, 2008: Petritus PM, Burns JM Jr. Suppression of lethal Plasmodium yoelii malaria following protective immunization requires antibody-, IL-4-, and IFN-gamma-dependent responses induced by vaccination and/or challenge infection. Journal of immunology (Baltimore, Md. : 1950). 2008; 180(1); 444-453. [PubMed: 18097046].
18. PF11_0344 in GeneDB: PF11_0344 in GeneDB [http://www.genedb.org/genedb/Dispatcher?formType=navBar&organism=malaria&desc=yes&wildcard=yes&name=PF11_0344&ohmr=.&ohmr2=.]
19. Sim et al., 2001: Sim BK, Narum DL, Liang H, Fuhrmann SR, Obaldia N 3rd, Gramzinski R, Aguiar J, Haynes JD, Moch JK, Hoffman SL. Induction of biologically active antibodies in mice, rabbits, and monkeys by Plasmodium falciparum EBA-175 region II DNA vaccine. Molecular medicine (Cambridge, Mass.). 2001; 7(4); 247-254. [PubMed: 11471569].
20. Tsai et al., 2009: Tsai CW, Duggan PF, Jin AJ, Macdonald NJ, Kotova S, Lebowitz J, Hurt DE, Shimp RL Jr, Lambert L, Miller LH, Long CA, Saul A, Narum DL. Characterization of a protective Escherichia coli-expressed Plasmodium falciparum merozoite surface protein 3 indicates a non-linear, multi-domain structure. Molecular and biochemical parasitology. 2009; 164(1); 45-56. [PubMed: 19073223].
21. Valderrama-Aguirre et al., 2005: Valderrama-Aguirre A, Quintero G, Gómez A, Castellanos A, Pérez Y, Méndez F, Arévalo-Herrera M, Herrera S. Antigenicity, immunogenicity, and protective efficacy of Plasmodium vivax MSP1 PV200l: a potential malaria vaccine subunit. The American journal of tropical medicine and hygiene. 2005; 73(5 Suppl); 16-24. [PubMed: 16291762].
22. Wan et al., 2007: Wan Omar A, Roslaini AM, Ngah ZU, Azahari AA, Zahedi M, Baharudin O. A recombinant 19 kDa Plasmodium berghei merozoite surface protein 1 formulated with alum induces protective immune response in mice. Tropical biomedicine. 2007; 24(1); 119-126. [PubMed: 17568385].
23. Wang et al., 2004: Wang L, Goschnick MW, Coppel RL. Oral immunization with a combination of Plasmodium yoelii merozoite surface proteins 1 and 4/5 enhances protection against lethal malaria challenge. Infection and immunity. 2004; 72(10); 6172-6175. [PubMed: 15385527].
24. Xu et al., 2000: Xu H, Hodder AN, Yan H, Crewther PE, Anders RF, Good MF. CD4+ T cells acting independently of antibody contribute to protective immunity to Plasmodium chabaudi infection after apical membrane antigen 1 immunization. Journal of immunology (Baltimore, Md. : 1950). 2000; 165(1); 389-396. [PubMed: 10861076].