VIOLIN: Vaccine Investigation and Online Information Network

Plasmodium spp.

Table of Contents

Protective Antigens

I. Vaccine Related Protective Antigens

1. ABRA

Gene Name : ABRA
VO ID : VO_0010926
Other Database IDs : swissprot:: P22620; GI:113005
Taxonomy ID : 5835
Gene Strand (Orientation) : ?
Protein Name : Merozoite Surface Protein 9 (MSP-9), PFL1385c, Acid-Basic Repeat Antigen (ABRA), 101 kd malaria antigen, 2277.t00277, p101

DNA Sequence : Show Sequence

>PFL1385c |MSP-9|Acid-Basic Repeat Antigen, ABRA, 101 kd malaria antigen, 2277.t00277, p101|Merozoite Surface Protein 9, MSP-9|Plasmodium falciparum|chr 12|STANFORD||Manual
ATGATGAACA TGAAAATTGT TTTATTCAGT TTATTGCTCT TTGTCATAAG ATGGAATATT
ATTAGTTGTA ATAAAAACGA CAAGAACCAA GGTGTTGATA TGAATGTTTT GAATAATTAT
GAAAATTTAT TTAAATTTGT TAAATGTGAA TATTGTAATG AACATACTTA TGTTAAAGGT
AAGAAAGCTC CTTCAGATCC TCAATGTGCT GATATAAAAG AAGAATGCAA AGAATTACTT
AAGGAAAAAC AATACACAGA TTCAGTTACA TATTTAATGG ATGGTTTTAA ATCAGCAAAT
AATTCAGCAA ATAATGGTAA AAAAAATAAC GCTGAAGAAA TGAAAAATTT AGTAAATTTC
TTACAATCTC ATAAGAAATT AATTAAAGCA TTAAAAAAGA ATATTGAAAG TATACAAAAT
AAGAAACACT TAATTTATAA AAACAAATCA TATAATCCAT TATTACTTTC TTGTGTTAAA
AAAATGAATA TGTTAAAAGA AAATGTTGAC TATATTCAAA AAAATCAAAA CTTATTTAAA
GAATTAATGA ATCAAAAAGC TACCTACTCT TTTGTTAATA CCAAAAAAAA AATTATTTCT
TTAAAATCAC AAGGTCATAA AAAAGAAACC TCACAAAATC AAAATGAAAA TAACGACAAT
CAAAAATATC AAGAAGTTAA TGATGAAGAT GATGTAAATG ATGAAGAAGA TACAAACGAT
GACGAAGATA CTAACGATGA AGAAGATACA AACGATGACG AAGATACAAA TGATGACGAA
GATACTAACG ATGAAGAAGA TACTAACGAC GAAGAAGATC ATGAAAATAA TAATGCTACA
GCATACGAAT TAGGTATCGT CCCAGTTAAC GATGTGTTAA ATGTTAATAT GAAAAATATG
ATAACAGGAA ATAATTTTAT GGATGTTGTT AAAAATACAT TAGCTCAATC AGGTGGATTA
GGAAGTAATG ATTTAATAAA TTTCTTAAAT CAAGGTAAAG AAATAGGAGA AAATTTATTA
AACATAACAA AGATGAACTT GGGAGATAAG AATAATCTTG AAAGTTTTCC TTTAGATGAA
TTAAATATGT TAAAAGATAA TTTAATAAAC TATGAATTCA TATTAGATAA TTTGAAAACA
AGTGTTTTAA ATAAATTAAA AGATTTATTA TTAAGATTAT TATACAAAGC ATATGTATCA
TATAAGAAAA GAAAAGCTCA AGAAAAAGGA TTACCAGAAC CTACTGTTAC TAATGAAGAA
TATGTTGAAG AATTAAAGAA AGGTATTCTA GATATGGGTA TCAAATTATT ATTTAGTAAA
GTTAAAAGCC TATTAAAAAA ATTAAAAAAT AAAATATTCC CTAAGAAAAA AGAAGATAAT
CAAGCAGTAG ATACCAAAAG TATGGAAGAA CCCAAAGTTA AAGCACAACC AGCTCTTAGA
GGTGTTGAAC CAACGGAAGA TTCTAATATT ATGAACAGTA TTAATAATGT TATGGATGAA
ATTGATTTCT TTGAAAAAGA ATTAATCGAA AATAATAATA CACCTAATGT TGTACCACCA
ACTCAATCAA AAAAAAAAAA CAAAAATGAA ACTGTATCTG GTATGGATGA AAATTTTGAT
AATCATCCTG AAAATTATTT TAAAGAAGAA TATTATTATG ATGAAAATGA TGATATGGAA
GTAAAAGTTA AAAAAATAGG TGTCACATTA AAAAAATTTG AACCACTTAA AAATGGAAAT
GTTAGTGAAA CCATTAAATT GATTCATTTA GGAAATAAAG ATAAAAAACA CATTGAAGCT
ATAAACAACG ATATTCAAAT TATTAAACAA GAATTACAAG CTATTTATAA TGAACTTATG
AATTATACAA ATGGAAACAA AAATATTCAA CAAATATTTC AACAAAATAT TCTAGAAAAT
GATGTTCTTA ATCAAGAAAC GGAGGAAGAA ATGGAAAAAC AAGTTGAAGC AATCACCAAG
CAAATAGAAG CTGAAGTGGA TGCCCTCGCA CCAAAAAATA AGGAAGAAGA AGAAAAAGAA
AAGGAAAAAG AAGAAAAAGA AAAAGAAGAA AAAGAAAAAG AAAAAGAAGA AAAAGAAAAA
GAAGAAAAAG AAAAAGAAGA AAAAGAAAAA GAAGAAAAAG AAGAAGAAAA AAAAGAAAAA
GAAGAAGAAC AAGAAGAAGA AGAAGAAGAA GAAATAGTAC CAGAAAATTT GACAACTGAA
GAATCAAAAT AA

Protein Sequence : Show Sequence

>gi|113005|sp|P22620|ABRA_PLAFC 101 kDa malaria antigen (p101) (Acidic basic repeat antigen)
MMNMKIVLFSLLLFVIRWNIISCNKNDKNQGVDMNVLNNYENLFKFVKCEYCNEHTYVKGKKAPSDPQCA
DIKEECKELLKEKQYTDSVTYLMDGFKSANNSANNGKKNNAEEMKNLVNFLQSHKKLIKALKKNIESIQN
KKHLIYKNKSYNPLLLSCVKKMNMLKENVDYIQKNQNLFKELMNQKATYSFVNTKKKIISLKSQGHKKET
SQNQNENNDNQKYQEVNDEDDVNDEEDTNDDEDTNDEEDTNDDEDTNDDEDTNDEEDTNDEEDHENNNAT
AYELGIVPVNDVLNVNMKNMITGNNFMDVVKNTLAQSGGLGSNDLINFLNQGKEIGENLLNITKMNLGDK
NNLESFPLDELNMLKDNLINYEFILDNLKTSVLNKLKDLLLRLLYKAYVSYKKRKAQEKGLPEPTVTNEE
YVEELKKGILDMGIKLLFSKVKSLLKKLKNKIFPKKKEDNQAVDTKSMEEPKVKAQPALRGVEPTEDSNI
MNSINNVMDEIDFFEKELIENNNTPNVVPPTQSKKKNKNETVSGMDENFDNHPENYFKEEYYYDENDDME
VKVKKIGVTLKKFEPLKNGNVSETIKLIHLGNKDKKHIEAINNDIQIIKQELQAIYNELMNYTNGNKNIQ
QIFQQNILENDVLNQETEEEMEKQVEAITKQIEAEVDALAPKNKEEEEKEKEKEKEKEEKEKEEKEKEEK
EKEKEEKEKEKEEKEEEKKEKEEEQEEEEEEIVPENLTTEESK

Molecule Role : Protective antigen
Molecule Role Annotation : Protective antigen (Kushwaha et al., 2001)
Related Vaccine(s): Recombinant ABRA protein vaccine

2. AMA-1 from P. berghei

Gene Name : AMA-1 from P. berghei
Sequence Strain (Speices/Organism) : Plasmodium berghei
VO ID : VO_0011224
NCBI Protein GI : 1438889
Other Database IDs : CDD:174781
Taxonomy ID : 5821
Gene Strand (Orientation) : ?
Protein Name : apical membrane antigen-1
Protein Length : 556
Protein Note : Apical membrane antigen 1; cl03588

Protein Sequence : Show Sequence

>gi|1438889|gb|AAC47192.1| apical membrane antigen-1 [Plasmodium berghei]
MKEIYYILILCSIYLINLSNCSEGPNNVISENGHINYDMIQKENTERSTKLINPWEKYTEKYDIERMHGS
GIRVDLGEDARVENRDYRIPSGKCPVIGKGITIQNSEVSFLTPVATGDQSVRSGGLALPKTDVHLSPITI
DNLKTMYKEHTEIVKLNNMSLCAKHTSFYVPGNNANSAYRHPAVYDKSNSTCYMLYVAAQENMGPRYCSN
NANNDNQPFCFTPEKIEKYKNLSYLTKNLRDDWETSCPNKSIKNAKFGIWVDGYCKDYQKHTVHDSDSLL
KCNQIIFNESASDQPKQYEKHLEDTTKFRQGVAERNGKLIGEALLPIGSYKSDQIKSHGRGYNWGNYDSQ
NKKCYIFETKPTCLINDRNFIATTALSSTEEFEEQFPCDIYKNKINEEIKVLNKNISNGNNSIEFPRIFI
STDKNSLNCPCEPTQLTESSCNFYVCNCVEKRQYIAENNDVEIKEELEVHMKAHQTREVIVIIIFICVGI
ILVILLVGYFFKSNKKGENYDRMGQADIYGKANSRKDGMLDPEVSFWGEDKRASHTTPVLMEKPYY

Molecule Role : Protective antigen
Molecule Role Annotation : Mice immunized with recombinant PbAMA-1 were partially protected from the challenge of P. berghei (Li et al., 2007).

3. AMA-1 from P. chabaudi

Gene Name : AMA-1 from P. chabaudi
Sequence Strain (Speices/Organism) : Plasmodium chabaudi
VO ID : VO_0011237
NCBI Protein GI : 1469500
Other Database IDs : CDD:174781
Taxonomy ID : 5825
Gene Strand (Orientation) : ?
Protein Name : apical membrane antigen 1
Protein Length : 340
Protein Note : DK is a cloned line derived from 556KA

Protein Sequence : Show Sequence

>gi|1469500|gb|AAB36511.1| apical membrane antigen 1 [Plasmodium chabaudi]
DLIPKENTERSHKLINPWEKFMEKYDIEKVHGSGIRVDLGEDARVENQDYRIPSGKCPVMGKGITIQNSK
VSFLTRVATGNQKVREGGLAFPQTDVNISPITIDNLKLMYKDHKEILALNDMSLCAKHASFYVPGTNVNT
AYRHPAVYDKSNKTCYILYVAAQENMGPRYCSNEEDNENQPFCFTPEKKDEYKNLSYLTKNLREDWETSC
PNKSIQNAKFGVWVDGYCSEYQKKEVHDNKTLLECNQIVFNESASDQPKQYEKHLEDTAKIRRGIVDRNG
KLIGEALLPIGSYRADQVKSKGKGYNWANYDKKTKKCYIFNKKPTCLINDKDFVATTALS

Molecule Role : Protective antigen
Molecule Role Annotation : Mice immunized with a refolded, recombinant, Plasmodium chabaudi AMA1 fragment (AMA1B) can withstand subsequent challenge with P. chabaudi adami (Xu et al., 2000).

4. AMA1 from P. falciparum 3D7

Gene Name : AMA1 from P. falciparum 3D7
Sequence Strain (Speices/Organism) : Plasmodium falciparum 3D7
VO ID : VO_0010923
NCBI Gene ID : 810891
NCBI Protein GI : 124804478
Locus Tag : PF11_0344
Genbank Accession : AE014186
Protein Accession : XP_001348015
Other Database IDs : UniProt: P22621
Taxonomy ID : 36329
Chromosome No : 11
Gene Starting Position : 1293853
Gene Ending Position : 1295721
Gene Strand (Orientation) : +
Protein Name : Apical membrane antigen 1 (AMA1); PF11_0344; AMA-1, Pf83, RMA1, RMA 1, rhoptry membrane antigen
Protein pI : 5.23
Protein Weight : 69161.85
Protein Length : 622
Protein Note : This is apical membrane antigen 1 (AMA1), or designated at PF11_0344 (PF11_0344 in GeneDB).

DNA Sequence : Show Sequence

>ref|NC_004315.2|:1293853-1295721 Plasmodium falciparum 3D7 chromosome 11, complete sequence
AATGAGAAAATTATACTGCGTATTATTATTGAGCGCCTTTGAGTTTACATATATGATAAACTTTGGAAGA
GGACAGAATTATTGGGAACATCCATATCAAAATAGTGATGTGTATCGTCCAATCAACGAACATAGGGAAC
ATCCAAAAGAATACGAATATCCATTACACCAGGAACATACATACCAACAAGAAGATTCAGGAGAAGACGA
AAATACATTACAACACGCATATCCAATAGACCACGAAGGTGCCGAACCCGCACCACAAGAACAAAATTTA
TTTTCAAGCATTGAAATAGTAGAAAGAAGTAATTATATGGGTAATCCATGGACGGAATATATGGCAAAAT
ATGATATTGAAGAAGTTCATGGTTCAGGTATAAGAGTAGATTTAGGAGAAGATGCTGAAGTAGCTGGAAC
TCAATATAGACTTCCATCAGGGAAATGTCCAGTATTTGGTAAAGGTATAATTATTGAGAATTCAAATACT
ACTTTTTTAACACCGGTAGCTACGGGAAATCAATATTTAAAAGATGGAGGTTTTGCTTTTCCTCCAACAG
AACCTCTTATGTCACCAATGACATTAGATGAAATGAGACATTTTTATAAAGATAATAAATATGTAAAAAA
TTTAGATGAATTGACTTTATGTTCAAGACATGCAGGAAATATGATTCCAGATAATGATAAAAATTCAAAT
TATAAATATCCAGCTGTTTATGATGACAAAGATAAAAAGTGTCATATATTATATATTGCAGCTCAAGAAA
ATAATGGTCCTAGATATTGTAATAAAGACGAAAGTAAAAGAAACAGCATGTTTTGTTTTAGACCAGCAAA
AGATATATCATTTCAAAACTATACATATTTAAGTAAGAATGTAGTTGATAACTGGGAAAAAGTTTGCCCT
AGAAAGAATTTACAGAATGCAAAATTCGGATTATGGGTCGATGGAAATTGTGAAGATATACCACATGTAA
ATGAATTTCCAGCAATTGATCTTTTTGAATGTAATAAATTAGTTTTTGAATTGAGTGCTTCGGATCAACC
TAAACAATATGAACAACATTTAACAGATTATGAAAAAATTAAAGAAGGTTTCAAAAATAAGAACGCTAGT
ATGATCAAAAGTGCTTTTCTTCCCACTGGTGCTTTTAAAGCAGATAGATATAAAAGTCATGGTAAGGGTT
ATAATTGGGGAAATTATAACACAGAAACACAAAAATGTGAAATTTTTAATGTCAAACCAACATGTTTAAT
TAACAATTCATCATACATTGCTACTACTGCTTTGTCCCATCCCATCGAAGTTGAAAACAATTTTCCATGT
TCATTATATAAAGATGAAATAATGAAAGAAATCGAAAGAGAATCAAAACGAATTAAATTAAATGATAATG
ATGATGAAGGGAATAAAAAAATTATAGCTCCAAGAATTTTTATTTCAGATGATAAAGACAGTTTAAAATG
CCCATGTGACCCTGAAATGGTAAGTAATAGTACATGTCGTTTCTTTGTATGTAAATGTGTAGAAAGAAGG
GCAGAAGTAACATCAAATAATGAAGTTGTAGTTAAAGAAGAATATAAAGATGAATATGCAGATATTCCTG
AACATAAACCAACTTATGATAAAATGAAAATTATAATTGCATCATCAGCTGCTGTCGCTGTATTAGCAAC
TATTTTAATGGTTTATCTTTATAAAAGAAAAGGAAATGCTGAAAAATATGATAAAATGGATGAACCACAA
GATTATGGGAAATCAAATTCAAGAAATGATGAAATGTTAGATCCTGAGGCATCTTTTTGGGGGGAAGAAA
AAAGAGCATCACATACAACACCAGTTCTGATGGAAAAACCATACTATTA

Protein Sequence : Show Sequence

>gi|124804478|ref|XP_001348015.1| apical membrane antigen 1,  AMA1 [Plasmodium falciparum 3D7]
MRKLYCVLLLSAFEFTYMINFGRGQNYWEHPYQNSDVYRPINEHREHPKEYEYPLHQEHTYQQEDSGEDE
NTLQHAYPIDHEGAEPAPQEQNLFSSIEIVERSNYMGNPWTEYMAKYDIEEVHGSGIRVDLGEDAEVAGT
QYRLPSGKCPVFGKGIIIENSNTTFLTPVATGNQYLKDGGFAFPPTEPLMSPMTLDEMRHFYKDNKYVKN
LDELTLCSRHAGNMIPDNDKNSNYKYPAVYDDKDKKCHILYIAAQENNGPRYCNKDESKRNSMFCFRPAK
DISFQNYTYLSKNVVDNWEKVCPRKNLQNAKFGLWVDGNCEDIPHVNEFPAIDLFECNKLVFELSASDQP
KQYEQHLTDYEKIKEGFKNKNASMIKSAFLPTGAFKADRYKSHGKGYNWGNYNTETQKCEIFNVKPTCLI
NNSSYIATTALSHPIEVENNFPCSLYKDEIMKEIERESKRIKLNDNDDEGNKKIIAPRIFISDDKDSLKC
PCDPEMVSNSTCRFFVCKCVERRAEVTSNNEVVVKEEYKDEYADIPEHKPTYDKMKIIIASSAAVAVLAT
ILMVYLYKRKGNAEKYDKMDEPQDYGKSNSRNDEMLDPEASFWGEEKRASHTTPVLMEKPYY

Molecule Role : Protective antigen
Related Vaccine(s): FMP1/AS02A

5. CS from P. berghei str. ANKA

Gene Name : CS from P. berghei str. ANKA
Sequence Strain (Speices/Organism) : Plasmodium berghei str. ANKA
VO ID : VO_0011217
NCBI Gene ID : 3428738
NCBI Protein GI : 68076353
Locus Tag : PB001026.00.0
Genbank Accession : CAAI01007452
Protein Accession : XP_680096
Taxonomy ID : 5823
Gene Starting Position : 10083
Gene Ending Position : 10823
Gene Strand (Orientation) : -
Protein pI : 4.35
Protein Weight : 25535.43
Protein Length : 244

DNA Sequence : Show Sequence

>ref|NW_674890.1|:10083-10823 Plasmodium berghei strain ANKA contig PB_RP0839, whole genome shotgun sequence
TTTAATTAAAGAATACTAATACTAATAATATTACAAATCCTAATGAATTGCTTACAATATTAAATATACT
TGAACATTTATCCATTTTACAAATTTCAGTATCAATTCTTCTAAGGTCAAATCTTCTGCTTTCTTATTTG
AACCTTTTCGTTTTCTAACTCTTATACCAGAACCACATGTTACGTTACATTGAGACCATTCCTCTGTGAT
ACTATCCCTGATCTGTTTAACAAATTCTAGTATTTTTTCCGCGCTTGGGATATAAGAATCGTCATTATTA
TTATTTTTGTTATTGTTATTACCACCTGGCTGTGGTTGTGGCTGTGGTCGTGGCTGTGGTTGTGGCTGTG
GCTGTGGTTGTGGCTGTGGCTGTGGTTGTGGCTGCGGCCGTGGCTGTGGTTGTGGATTGTTATTTCCTTG
TGGTGGTGCTGGGTCATTTGGGTTTGGTGGTGGTGGGTCATTTGCGTTTGGTGGTGCTGGGTCATTTGGG
TTTGGTGGTGGTGGGTCATTTGCGTTTGGTGGTGTTGGGTCATTTGCGTTTGGTGGTGCTGGGTCATTTG
CGTTTGGTGGTGCTGGGTCATTTGCGTTTGGTGGTGCTGGGTCATTTGCGTTTGGTGGTGGTGGGTCATT
TGCGTTTGGTGGTGGTGGAGTCATTTGGGTTTGGTGGTGGTGGGTCATTTGGGTTTGGTGGTGGTGGGTC
ATTTGGGTTTGGTGGTGGTGGGTCATTTGGGTTTGGTGGTG

Protein Sequence : Show Sequence

>gi|68076353|ref|XP_680096.1| circumsporozoite (CS) protein [Plasmodium berghei strain ANKA]
PPPNPNDPPPPNPNDPPPPNPNDPPPPNPNTPPPPNANDPPPPNANDPAPPNANDPAPPNANDPAPPNAN
DPTPPNANDPPPPNPNDPAPPNANDPPPPNPNDPAPPQGNNNPQPQPRPQPQPQPQPQPQPQPQPQPRPQ
PQPQPGGNNNNKNNNNDDSYIPSAEKILEFVKQIRDSITEEWSQCNVTCGSGIRVRKRKGSNKKAEDLRR
IDTEICKMDKCSSIFNIVSNSLGFVILLVLVFFN

Molecule Role : Protective antigen
Molecule Role Annotation : Researchers produced a prototypic malaria vaccine based on a highly versatile self-assembling polypeptide nanoparticle (SAPN) platform that can repetitively display antigenic epitopes. Researchers used this platform to display a tandem repeat of the B cell immunodominant repeat epitope (DPPPPNPN)(2)D of the malaria parasite Plasmodium berghei circumsporozoite (CS) protein. Administered in saline, without the need for a heterologous adjuvant, the SAPN construct P4c-Mal conferred a long-lived, protective immune response to mice with a broad range of genetically distinct immune backgrounds including the H-2(b), H-2(d), and H-2(k) alleles. Mice were protected against an initial challenge of parasites up to 6 mo after the last immunization or for up to 15 mo against a second challenge after an initial challenge of parasites had successfully been cleared. (Kaba et al., 2009).
Related Vaccine(s): Plasmodium berghei CS Protein Subunit Vaccine

6. CS from P. falciparum

Gene Name : CS from P. falciparum
Sequence Strain (Speices/Organism) : Plasmodium falciparum
VO ID : VO_0011218
NCBI Protein GI : 552191
Other Database IDs : CDD:154951
Taxonomy ID : 5833
Gene Strand (Orientation) : ?
Protein Name : circumsporozoite protein
Protein Length : 424
Protein Note : Thrombospondin type 1 domain; cl02514

Protein Sequence : Show Sequence

>gi|552191|gb|AAA63422.1| circumsporozoite protein [Plasmodium falciparum]
MMRKLAILSVSSFLFVEALFQEYQCYGSSSNTRVLNELNYDNAGTNLYNELEMNYYGKQENWYSLKKNSR
SLGENDDGNNNNGDNGREGKDEDKRDGNNEDNEKLRKPKHKKLKQPGDGNPDPNANPNVDPNANPNVDPN
ANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNAN
PNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPN
ANPNANPNANPNANPNANPNKNNQGNGQGHNMPNDPNRNVDENANANNAVKNNNNEEPSDKHIEQYLKKI
QNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYENDIEKKICKMEKCSSVFNVVNSSIGLIMVLSF
LFLN

Molecule Role : Protective antigen
Molecule Role Annotation : We employed a P. berghei parasite line that expresses a heterologous CSP (CS) from P. falciparum in order to assess the role of the CSP in the protection conferred by vaccination with radiation-attenuated P. berghei parasites. Our data demonstrated that sterile immunity could be obtained despite the absence of immune responses specific to the CSP expressed by the parasite used for challenge (Grüner et al., 2007).

7. CS from P. yoelii str. 17XNL

Gene Name : CS from P. yoelii str. 17XNL
Sequence Strain (Speices/Organism) : Plasmodium yoelii yoelii str. 17XNL
VO ID : VO_0011219
NCBI Gene ID : 3830374
NCBI Protein GI : 83317409
Locus Tag : PY03168
Genbank Accession : AABL01000897
Protein Accession : XP_731149
Taxonomy ID : 352914
Gene Starting Position : 0
Gene Ending Position : 413
Gene Strand (Orientation) : +
Protein pI : 4.57
Protein Weight : 14411.64
Protein Length : 137

DNA Sequence : Show Sequence

>ref|NW_865424.3|:1-413 Plasmodium yoelii yoelii str. 17XNL MALPY00900, whole genome shotgun sequence
CCACCCCAACAACCACCCCAACAACCACCACAACAGCCACCACAACAGCCACCACAACAGCCACCACAAC
AGCCACCACAACAACCACGCCCACAGCCAGATGGTAATAACAACAATAACAATAATAATGGTAATAATAA
TGAAGATTCTTATGTCCCAAGCGCGGAACAAATACTAGAATTTGTTAAACAGATAAGTAGTCAACTCACA
GAGGAATGGTCTCAATGTAGTGTAACCTGTGGTTCTGGTGTAAGAGTTAGAAAACGAAAAAATGTAAACA
AGCAACCAGAAAATTTGACCTTAGAGGATATTGATACTGAAATTTGTAAAATGGATAAATGTTCAAGTAT
ATTTAATATTGTAAGCAATTCATTAGGATTTGTAATATTATTAGTATTAGTATTCTTTAATTA

Protein Sequence : Show Sequence

>gi|83317409|ref|XP_731149.1| circumsporozoite protein [Plasmodium yoelii yoelii str. 17XNL]
PPQQPPQQPPQQPPQQPPQQPPQQPPQQPRPQPDGNNNNNNNNGNNNEDSYVPSAEQILEFVKQISSQLT
EEWSQCSVTCGSGVRVRKRKNVNKQPENLTLEDIDTEICKMDKCSSIFNIVSNSLGFVILLVLVFFN

Molecule Role : Protective antigen
Molecule Role Annotation : Study showed that immunization with irradiated sporozoites (IrrSpz) of a P. berghei line whose endogenous CS was replaced by that of P. yoelii conferred sterile protection against challenge with wild type P. berghei sporozoites (Mauduit et al., 2009).

8. eba-175

Gene Name : eba-175
Sequence Strain (Speices/Organism) : Plasmodium falciparum 3D7
NCBI Gene ID : 2654998
NCBI Protein GI : 296004911
Locus Tag : MAL7P1.176
Genbank Accession : AL844506
Protein Accession : XP_001349207
Taxonomy ID : 36329
Chromosome No : 7
Gene Starting Position : 1413430
Gene Ending Position : 1418304
Gene Strand (Orientation) : ?
Protein pI : 5.47
Protein Weight : 168527.84
Protein Length : 1502
Protein Note : Also known as eba 175; eba175

DNA Sequence : Show Sequence

>ref|NC_004328.2|:1413430-1418304 Plasmodium falciparum 3D7 chromosome 7
AATGAAATGTAATATTAGTATATATTTTTTTGCTTCCTTCTTTGTGTTATATTTTGCAAAAGCTAGGAAT
GAATATGATATAAAAGAGAATGAAAAATTTTTAGACGTGTATAAAGAAAAATTTAATGAATTAGATAAAA
AGAAATATGGAAATGTTCAAAAAACTGATAAGAAAATATTTACTTTTATAGAAAATAAATTAGATATTTT
AAATAATTCAAAATTTAATAAAAGATGGAAGAGTTATGGAACTCCAGATAATATAGATAAAAATATGTCT
TTAATAAATAAACATAATAATGAAGAAATGTTTAACAACAATTATCAATCATTTTTATCGACAAGTTCAT
TAATAAAGCAAAATAAATATGTTCCTATTAACGCTGTACGTGTGTCTAGGATATTAAGTTTCCTGGATTC
TAGAATTAATAATGGAAGAAATACTTCATCTAATAACGAAGTTTTAAGTAATTGTAGGGAAAAAAGGAAA
GGAATGAAATGGGATTGTAAAAAGAAAAATGATAGAAGCAACTATGTATGTATTCCTGATCGTAGAATCC
AATTATGCATTGTTAATCTTAGCATTATTAAAACATATACAAAAGAGACCATGAAGGATCATTTCATTGA
AGCCTCTAAAAAAGAATCTCAACTTTTGCTTAAAAAAAATGATAACAAATATAATTCTAAATTTTGTAAT
GATTTGAAGAATAGTTTTTTAGATTATGGACATCTTGCTATGGGAAATGATATGGATTTTGGAGGTTATT
CAACTAAGGCAGAAAACAAAATTCAAGAAGTTTTTAAAGGGGCTCATGGGGAAATAAGTGAACATAAAAT
TAAAAATTTTAGAAAAAAATGGTGGAATGAATTTAGAGAGAAACTTTGGGAAGCTATGTTATCTGAGCAT
AAAAATAATATAAATAATTGTAAAAATATTCCCCAAGAAGAATTACAAATTACTCAATGGATAAAAGAAT
GGCATGGAGAATTTTTGCTTGAAAGAGATAATAGATCAAAATTGCCAAAAAGTAAATGTAAAAATAATAC
ATTATATGAAGCATGTGAGAAGGAATGTATTGATCCATGTATGAAATATAGAGATTGGATTATTAGAAGT
AAATTTGAATGGCATACGTTATCGAAAGAATATGAAACTCAAAAAGTTCCAAAGGAAAATGCGGAAAATT
ATTTAATCAAAATTTCAGAAAACAAGAATGATGCTAAAGTAAGTTTATTATTGAATAATTGTGATGCTGA
ATATTCAAAATATTGTGATTGTAAACATACTACTACTCTCGTTAAAAGCGTTTTAAATGGTAACGACAAT
ACAATTAAGGAAAAGCGTGAACATATTGATTTAGATGATTTTTCTAAATTTGGATGTGATAAAAATTCCG
TTGATACAAACACAAAGGTGTGGGAATGTAAAAAACCTTATAAATTATCCACTAAAGATGTATGTGTACC
TCCGAGGAGGCAAGAATTATGTCTTGGAAACATTGATAGAATATACGATAAAAACCTATTAATGATAAAA
GAGCATATTCTTGCTATTGCAATATATGAATCAAGAATATTGAAACGAAAATATAAGAATAAAGATGATA
AAGAAGTTTGTAAAATCATAAATAAAACTTTCGCTGATATAAGAGATATTATAGGAGGTACTGATTATTG
GAATGATTTGAGCAATAGAAAATTAGTAGGAAAAATTAACACAAATTCAAATTATGTTCACAGGAATAAA
CAAAATGATAAGCTTTTTCGTGATGAGTGGTGGAAAGTTATTAAAAAAGATGTATGGAATGTGATATCAT
GGGTATTCAAGGATAAAACTGTTTGTAAAGAAGATGATATTGAAAATATACCACAATTCTTCAGATGGTT
TAGTGAATGGGGTGATGATTATTGCCAGGATAAAACAAAAATGATAGAGACTCTGAAGGTTGAATGCAAA
GAAAAACCTTGTGAAGATGACAATTGTAAACGTAAATGTAATTCATATAAAGAATGGATATCAAAAAAAA
AAGAAGAGTATAATAAACAAGCCAAACAATACCAAGAATATCAAAAAGGAAATAATTACAAAATGTATTC
TGAATTTAAATCTATAAAACCAGAAGTTTATTTAAAGAAATACTCGGAAAAATGTTCTAACCTAAATTTC
GAAGATGAATTTAAGGAAGAATTACATTCAGATTATAAAAATAAATGTACGATGTGTCCAGAAGTAAAGG
ATGTACCAATTTCTATAATAAGAAATAATGAACAAACTTCGCAAGAAGCAGTTCCTGAGGAAAGCACTGA
AATAGCACACAGAACGGAAACTCGTACGGATGAACGAAAAAATCAGGAACCAGCAAATAAGGATTTAAAG
AATCCACAACAAAGTGTAGGAGAGAACGGAACTAAAGATTTATTACAAGAAGATTTAGGAGGATCACGAA
GTGAAGACGAAGTGACACAAGAATTTGGAGTAAATCATGGAATACCTAAGGGTGAGGATCAAACGTTAGG
AAAATCTGACGCCATTCCAAACATAGGCGAACCCGAAACGGGAATTTCCACTACAGAAGAAAGTAGACAT
GAAGAAGGCCACAATAAACAAGCATTGTCTACTTCAGTCGATGAGCCTGAATTATCTGATACACTTCAAT
TGCATGAAGATACTAAAGAAAATGATAAACTACCCCTAGAATCATCTACAATCACATCTCCTACGGAAAG
TGGAAGTTCTGATACAGAGGAAACTCCATCTATCTCTGAAGGACCAAAAGGAAATGAACAAAAAAAACGT
GATGACGATAGTTTGAGTAAAATAAGTGTATCACCAGAAAATTCAAGACCTGAAACTGATGCTAAAGATA
CTTCTAACTTGTTAAAATTAAAAGGAGATGTTGATATTAGTATGCCTAAAGCAGTTATTGGGAGCAGTCC
TAATGATAATATAAATGTTACTGAACAAGGGGATAATATTTCCGGGGTGAATTCTAAACCTTTATCTGAT
GATGTACGTCCAGATAAAAATCATGAAGAGGTGAAAGAACATACTAGTAATTCTGATAATGTTCAACAGT
CTGGAGGAATTGTTAATATGAATGTTGAGAAAGAACTAAAAGATACTTTAGAAAATCCTTCTAGTAGCTT
GGATGAAGGAAAAGCACATGAAGAATTATCAGAACCAAATCTAAGCAGTGACCAAGATATGTCTAATACA
CCTGGACCTTTGGATAACACCAGTGAAGAAACTACAGAAAGAATTAGTAATAATGAATATAAAGTTAACG
AGAGGGAAGGTGAGAGAACGCTTACTAAGGAATATGAAGATATTGTTTTGAAAAGTCATATGAATAGAGA
ATCAGACGATGGTGAATTATATGACGAAAATTCAGACTTATCTACTGTAAATGATGAATCAGAAGACGCT
GAAGCAAAAATGAAAGGAAATGATACATCTGAAATGTCGCATAATAGTAGTCAACATATTGAGAGTGATC
AACAGAAAAACGATATGAAAACTGTTGGTGATTTGGGAACCACACATGTACAAAACGAAATTAGTGTTCC
TGTTACAGGAGAAATTGATGAAAAATTAAGGGAAAGTAAAGAATCAAAAATTCATAAGGCTGAAGAGGAA
AGATTAAGTCATACAGATATACATAAAATTAATCCTGAAGATAGAAATAGTAATACATTACATTTAAAAG
ATATAAGAAATGAGGAAAACGAAAGACACTTAACTAATCAAAACATTAATATTAGTCAAGAAAGGGATTT
GCAAAAACATGGATTCCATACCATGAATAATCTACATGGAGATGGAGTTTCCGAAAGAAGTCAAATTAAT
CATAGTCATCATGGAAACAGACAAGATCGGGGGGGAAATTCTGGGAATGTTTTAAATATGAGATCTAATA
ATAATAATTTTAATAATATTCCAAGTAGATATAATTTATATGATAAAAAATTAGATTTAGATCTTTATGA
AAACAGAAATGATAGTACAACAAAAGAATTAATAAAGAAATTAGCAGAAATAAATAAATGTGAGAACGAA
ATTTCTGTAAAATATTGTGACCATATGATTCATGAAGAAATCCCATTAAAAACATGCACTAAAGAAAAAA
CAAGAAATCTGTGTTGTGCAGTATCAGATTACTGTATGAGCTATTTTACATATGATTCAGAGGAATATTA
TAATTGTACGAAAAGGGAATTTGATGATCCATCTTATACATGTTTCAGAAAGGAGGCTTTTTCAAGTATG
ATATTCAAATTTTTAATAACAAATAAAATATATTATTATTTTTATACTTACAAAACTGCAAAAGTAACAA
TAAAAAAAATTAATTTCTCATTAATTTTTTTTTTCTTTTTTTCTTTTTAGGTATGCCATATTATGCAGGA
GCAGGTGTGTTATTTATTATATTGGTTATTTTAGGTGCTTCACAAGCCAAATATCAAAGGTTAGAAAAAA
TAAATAAAAATAAAATTGAGAAGAATGTAAATTAAATATATATATATATATATATATATATATATTGTAT
TATATATTTTTTTTTTATAGTTCTGAAGGAGTTATGAATGAGAATAATGAGAATAATTTTTTATTTGAAG
TTACTGATAATTTAGATAAATTATCCAATATGTGTAATACAAATATAAAAAAAAATAATAAATAAATAAA
TAATTACAAGGAAATAAAAATGATATATATTATTACATTATGTTTGTTTACTTTTATATTATCCTATAAT
ATTTATTTTTATTTTATGTTTTTTTTTTTTCAGTCAATCAACAAGTACAGGAAACTAATATCAACGATTT
TTCTGAATACCATGAGGATATAAATGATATTAATTTTAAGAAATG

Protein Sequence : Show Sequence

>gi|296004911|ref|XP_001349207.2| erythrocyte binding antigen 175 [Plasmodium falciparum 3D7]
MKCNISIYFFASFFVLYFAKARNEYDIKENEKFLDVYKEKFNELDKKKYGNVQKTDKKIFTFIENKLDIL
NNSKFNKRWKSYGTPDNIDKNMSLINKHNNEEMFNNNYQSFLSTSSLIKQNKYVPINAVRVSRILSFLDS
RINNGRNTSSNNEVLSNCREKRKGMKWDCKKKNDRSNYVCIPDRRIQLCIVNLSIIKTYTKETMKDHFIE
ASKKESQLLLKKNDNKYNSKFCNDLKNSFLDYGHLAMGNDMDFGGYSTKAENKIQEVFKGAHGEISEHKI
KNFRKKWWNEFREKLWEAMLSEHKNNINNCKNIPQEELQITQWIKEWHGEFLLERDNRSKLPKSKCKNNT
LYEACEKECIDPCMKYRDWIIRSKFEWHTLSKEYETQKVPKENAENYLIKISENKNDAKVSLLLNNCDAE
YSKYCDCKHTTTLVKSVLNGNDNTIKEKREHIDLDDFSKFGCDKNSVDTNTKVWECKKPYKLSTKDVCVP
PRRQELCLGNIDRIYDKNLLMIKEHILAIAIYESRILKRKYKNKDDKEVCKIINKTFADIRDIIGGTDYW
NDLSNRKLVGKINTNSNYVHRNKQNDKLFRDEWWKVIKKDVWNVISWVFKDKTVCKEDDIENIPQFFRWF
SEWGDDYCQDKTKMIETLKVECKEKPCEDDNCKRKCNSYKEWISKKKEEYNKQAKQYQEYQKGNNYKMYS
EFKSIKPEVYLKKYSEKCSNLNFEDEFKEELHSDYKNKCTMCPEVKDVPISIIRNNEQTSQEAVPEESTE
IAHRTETRTDERKNQEPANKDLKNPQQSVGENGTKDLLQEDLGGSRSEDEVTQEFGVNHGIPKGEDQTLG
KSDAIPNIGEPETGISTTEESRHEEGHNKQALSTSVDEPELSDTLQLHEDTKENDKLPLESSTITSPTES
GSSDTEETPSISEGPKGNEQKKRDDDSLSKISVSPENSRPETDAKDTSNLLKLKGDVDISMPKAVIGSSP
NDNINVTEQGDNISGVNSKPLSDDVRPDKNHEEVKEHTSNSDNVQQSGGIVNMNVEKELKDTLENPSSSL
DEGKAHEELSEPNLSSDQDMSNTPGPLDNTSEETTERISNNEYKVNEREGERTLTKEYEDIVLKSHMNRE
SDDGELYDENSDLSTVNDESEDAEAKMKGNDTSEMSHNSSQHIESDQQKNDMKTVGDLGTTHVQNEISVP
VTGEIDEKLRESKESKIHKAEEERLSHTDIHKINPEDRNSNTLHLKDIRNEENERHLTNQNINISQERDL
QKHGFHTMNNLHGDGVSERSQINHSHHGNRQDRGGNSGNVLNMRSNNNNFNNIPSRYNLYDKKLDLDLYE
NRNDSTTKELIKKLAEINKCENEISVKYCDHMIHEEIPLKTCTKEKTRNLCCAVSDYCMSYFTYDSEEYY
NCTKREFDDPSYTCFRKEAFSSMPYYAGAGVLFIILVILGASQAKYQSSEGVMNENNENNFLFEVTDNLD
KLSNMFNQQVQETNINDFSEYHEDINDINFKK

Molecule Role : Protective antigen
Molecule Role Annotation : 1 of 3 Monkeys vaccinated with EBA-175 was protected from challenge of parasitized erythrocytes (Sim et al., 2001).

9. EMP1

Gene Name : EMP1
Sequence Strain (Speices/Organism) : Plasmodium falciparum
VO ID : VO_0011229
NCBI Protein GI : 2961468
Other Database IDs : CDD:147552
CDD:111855
CDD:140204
Taxonomy ID : 5833
Gene Strand (Orientation) : ?
Protein Name : erythrocyte membrane protein 1
Protein Length : 2228
Protein Note : Duffy binding domain; pfam05424

Protein Sequence : Show Sequence

>gi|2961468|gb|AAC05730.1| erythrocyte membrane protein 1 [Plasmodium falciparum]
MATSGGSGGTQDEDAKHVLDEFGQKVHDEVHGEAKNYVSELKGSLSLASILGETAFTVKSMQTESKYTEL
IEANSKRNPCKKDGKGNDVDRFSVKEQAGYDNKKMKCSNGMTCAPFRRLHLCNKNFPNMNSNDSSKAKHD
LLAEVCMAAKYEGESIKTHYPKYDSKYPGSDFPMCTMLARSFADIGDIIRGRDLYLGNKKKKQNGKETER
EKLEQKLKEIFKKIHDNLKDKEAQKRYNGDEDPNFYKLREDWWTANRETVWGAMTCSKELDNSSYFRATC
NDTGQGPSQTHNKCRCDKDKGANAGKPKAGDGDVTIVPTYFDYVPQYLRWFEEWAEDFCRKKKKKLENLE
KQCRGKDKSDEYRYCSRNGYDCEQTISRKGKVRMGKGCTDCFFACHSYENWIDNQRKQFDKQKKYTKEIS
DGGGRKKRAVGGTTKYEGYEKSFYEKLKNDGYGTVDAFLGLLNNEKACKDITDGGKINFKEVNSGGGVVG
GGSGGTSGASGTNDENKGTFYRSEYCQPCPDCGVQHKGGNQWERKTKVKKMRWSKLYKPINGKMVLLLKS
LKVVKDMMILKKNWKEFCLTQNSSDGSVGSVVTTGASGGNSEKKELYDEWKCYKHNEVQKVNVQGEVEED
DDELKGAGGLCILPNPKKNKEVSEAKSQNNHADIQKTFHDFFYYWVAHMLKDSIHWRTKRLKSCISDGKT
MKCRNGCNKKCDCFEKWVKQKETEWKPIKDHFKTQEGIPEGYYFTTLELILKLQFLKEDTEENTENSLDA
EEAEELKHLQKILKLENENNLAVVNAGTEQKTLMDKLLNHELNDATKCKDCPLPEEDKSRGRSADPSPDI
FIPRPEEKEDDENEDDDEDEVRDDEETAKETTEGSATDTTTSLDVCPIVGKVLTKDNESLQDACSLKYGG
NNSRLGWRCVTPSGEPTTSSDKNGAICVPPRRRRLYIKKIVDWATKTESPQASGSEASSTSGSTTPPDSK
EALLKAFVESAAIETFFLWHRYKEEKKAVAQEGAGHGLPRVEEGSPEYDPEDKLKEGKIPDGFLRQMFYT
LGDYRDILFSGSNDTTSVSKDTPSSSNDNLKNIVLLASGSTEQEREKMNKYKEIKNFRKCSTERSAPNLV
SHPQTWWENNGKYIWHGMVCALTSKDKIAKGVEKKPQKIENPENLWDEANKKPKPPQYQYTNVKLDENSG
TSPRTTQTQASSDNTPTTLTHFVKRPTYFRWFEEWGESFCRERKKRLKQIKVDCKVENGDVGRCSGDGEA
CDSISTHDYSTVPSFNCPGCGKHCSSYRKWIERKKIEFHKQSNAYGQQKTDATRNNGNTFDKEFCKTLET
WPDAAKFLERLKNGPCKTNKEYGGDDIDFEKDSKTFQHTEYCGPCPKFKTNCQNGNCGVSGLNGNCDGKD
SIDAKEIAKMRSSTTDVVMRVSDNDTNTFEGDDLKDACQHANIFKGIRKDVWKCGYVCGVDICEQTNINE
RTDGKEYIQIRALFKRWVENFLEDYNKINDKISHCIKKGEGSKCINGCEKNSKCLEKWIEKKIAEWENIK
KRFNDQYENKDQPDYNVKSILEELIPKIAVVNDQDNVIKLCVFENSKGCTLISNTQNNKENDAIDCMLKK
LGVKAKNCPGKPSGEKQSDCKEPPPLPDEEDQNPEENTLEPPKFCPPTTQPPEEKGGETCGNKEEKKDEK
KEESEEPAKEESGPAAEEPAPTAESEETETNFPEPPGTGPAAPPSTPAPPTPDTPPPLRPQADEPFDSTI
LQTTIPFGVALALGSIAFLFLKKKTKASVGNLFQILQIPKSDYDIPTLKSSNRYIPYVSDRYKGKTYIYM
EGDSDEDKYAFMSDTTDVTSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSGNNTTASGKNTPSDTRND
IQNDGIPSSKITDNEWNQLKKEFISNMLQNQPNDVPNDYTSGNSSTNTNITTTSRHNVDNNTNTTMSRDN
MEENLLLPSIHDRNLYSGEEYSYNVNMVNSMNDIPINRDNNVYSGIDLINDSLSGGKPIDIYDEVLKRKE
NELFGTENTKRTSTQNVAKITNSDPIHNQLELFHKWLDRHRDMCEKWKNKEDILNKLKEEWNKENINNSG
KTYNSDNKPSHNHVLNTDVSIQIDMDNPKTKNEITNMDTNQDKSTMDTILDDLEKYNDPYYYDFYEDDII
YHDVDVEKSSMDDIYVDHNNVTSNNMDVPTKMHIEMNIVNNKKEIFEEEYPISDIWNI

Molecule Role : Protective antigen
Molecule Role Annotation : Immunized animals were challenged in vivo with various parasite strains or clones of malaria. Immunization with the PfEMP1-DBL1 alpha domain abolished the PfEMP1-dependent sequestration of the homologous strain in immunized rats and substantially inhibited parasite adhesion in immunized monkeys. Protection against sequestration of heterologous parasite strains was also confirmed by direct or indirect challenge in the rat model (Moll et al., 2007).

10. GLURP

Gene Name : GLURP
Sequence Strain (Speices/Organism) : Plasmodium falciparum 3D7
VO ID : VO_0011343
NCBI Gene ID : 810501
NCBI Protein GI : 124802897
Locus Tag : PF10_0344
Genbank Accession : AE014185
Protein Accession : XP_001347628
Taxonomy ID : 36329
Chromosome No : 10
Gene Starting Position : 1399191
Gene Ending Position : 1402892
Gene Strand (Orientation) : +
Protein Name : glutamate-rich protein
Protein pI : 3.98
Protein Weight : 130731.93
Protein Length : 1233

DNA Sequence : Show Sequence

>ref|NC_004314.2|:1399191-1402892 Plasmodium falciparum 3D7 chromosome 10, complete sequence
AATGAGAAACCTTTTCCATATTACCATTTGTTTAGTTACACTTAATTTATTTATATTGGAAATAAATGCA
AAAACCAATACAAGTGAGAATAGAAATAAACGAATCGGGGGTCCTAAATTAAGGGGTAATGTTACAAGTA
ATATAAAGTTCCCATCAGATAACAAAGGTAAAATTATAAGAGGTTCGAATGATAAACTTAATAAAAACTC
TGAAGATGTTTTAGAACAAAGCGAAAAATCGCTTGTTTCAGAAAATGTTCCTAGTGGATTAGATATAGAT
GATATCCCTAAAGAATCTATTTTTATTCAAGAAGATCAAGAAGGTCAAACTCATTCTGAATTAAATCCTG
AAACATCAGAACATAGTAAAGATTTAAATAATAATGATTCAAAAAATGAATCTAGTGATATTATTTCAGT
AAATAATAAATCAAATAAAGTACAAAATCATTTTGAATCATTATCAGATTTAGAATTACTTGAAAATTCC
TCACAAGATAATTTAGACAAAGATACAATTTCAACAGAACCTTTTCCTAATCAAAAACATAAAGACTTAC
AACAAGATTTAAATGATGAACCTTTAGAACCCTTTCCTACACAAATACATAAAGATTATAAAGAAAAAAA
TTTAATAAATGAAGAAGATTCAGAACCATTTCCCAGACAAAAGCATAAAAAGGTAGACAATCATAATGAA
GAAAAAAACGTATTTCATGAAAATGGTTCTGCAAATGGTAATCAAGGAAGTTTGAAACTTAAATCATTCG
ATGAACATTTAAAAGATGAAAAAATAGAAAATGAACCACTTGTTCATGAAAATTTATCCATACCAAATGA
TCCAATAGAACAAATATTAAATCAACCTGAACAAGAAACAAATATCCAGGAACAATTGTATAATGAAAAA
CAAAATGTTGAAGAAAAACAAAATTCTCAAATACCTTCGTTAGATTTAAAAGAACCAACAAATGAAGATA
TTTTACCAAATCATAATCCATTAGAAAATATAAAACAAAGTGAATCAGAAATAAATCATGTACAAGATCA
TGCGCTACCAAAAGAGAATATAATAGACAAACTTGATAATCAAAAAGAACACATCGATCAATCACAACAT
AATATAAATGTATTACAAGAAAATAACATAAACAATCACCAATTAGAACCTCAAGAGAAACCTAATATTG
AATCGTTTGAACCTAAAAATATAGATTCAGAAATTATTCTTCCTGAAAATGTTGAAACAGAAGAAATAAT
AGATGATGTGCCTTCCCCTAAACATTCTAACCATGAAACATTTGAAGAAGAAACAAGTGAATCTGAACAT
GAAGAAGCCGTATCTGAAAAAAATGCCCACGAAACTGTCGAACATGAAGAAACTGTGTCTCAAGAAAGCA
ATCCTGAAAAAGCTGATAATGATGGAAATGTATCTCAAAACAGCAACAACGAATTAAATGAAAATGAATT
CGTTGAATCGGAAAAAAGCGAGCATGAACCAGCTGAAAATGAAGAAAGTAGTCTTGAAGAAGGTCATCAT
GAAGAAATTGTACCTGAACAAAATAATGAAGAATCAGGTGAAAGTAAATTAGTTGATAATGATGAAGGTG
GTTTTGAAGAAGCTCATCATGAAAATTTTTCATCTGAAGTAAGTAACTCTGAATTAAATGAAAATGAATT
TGTTGAATCTGACAAAAGTGTAACTGAACCTGCTGAACATGAAGAAGTTGTATCTGAAGAAAGCAACCCT
GAACCAGCTGAAAATGAAGAAAGTAGTATAGAAGAAGCTCATCAGGAAGAAATTGTACCTGAACAAAATG
ATGAAGAATCAGGTGAAAGTGGATTAGTTGATAATGAAGAAGGTGATTTTGAAGAACCTAATCATGAAGA
ATTTGAACCTGATCAAAATGACTCTGAATTAAGTGAAAATGAATTAGTTGAATCAGAAAAAAGTGTATCT
GAACCAGCTGAACATGTAGAAATTGTATCAGAAAAAAGTGTATCTGAACCAGCTGAACACGTAGAAATTG
TATCTGAAAAAAGTACATCCGAACCAGCTGAACATGTAGAAAGTGTATCTGAACAAAGTAATAACGAACC
ATCCGAAAAGAAAGATGGACCAGTTCCTTCAAAACCATTTGAAGAAATTGAAAAAGTGGATGTTCAACCT
AAAATTGTAGACCTTCAAATAATTGAACCTAATTTTGTTGACTCACAACCAAATCCACAAGAACCAGTTG
AACCATCATTTGTCAAAATTGAAAAAGTTCCTTCTGAAGAAAATAAACATGCAAGTGTTGATCCTGAAGT
AAAAGAAAAAGAAAATGTATCTGAAGTTGTTGAAGAAAAACAAAATTCACAAGAATCAGTTGAAGAAATT
CCAGTAAATGAGGATGAATTTGAAGATGTTCACACTGAACAATTAGATTTAGATCATAAAACAGTTGATC
CAGAAATAGTAGAAGTTGAAGAAATTCCTTCAGAACTACATGAAAATGAAGTGGCTCATCCAGAAATTGT
TGAAATTGAGGAAGTTTTTCCTGAACCAAATCAAAATAACGAATTTCAAGAAATTAATGAAGATGATAAA
AGTGCACATATTCAGCATGAAATAGTAGAAGTAGAAGAAATACTTCCAGAAGATGATAAAAATGAAAAAG
TTGAACATGAAATAGTAGAAGTTGAAGAAATTCTACCAGAAGATAAAAATGAAAAAGTTCAACATGAAAT
AGTAGAGGTTGAAGAAATTCTACCAGAAGATAAAAATGAAAAAGTTGAACATGAAATAGTAGAAGTTGAA
GAAATTCTACCAGAAGATAAAAATGAAAAAGGTCAACATGAAATAGTAGAGGTTGAAGAAATTCTACCAG
AAGATAAAAATGAAAAAGTTCAACATGAAATAGTAGAAGTTGAAGAAATTCTACCAGAAGATAAAAATGA
AAAAGGTCAACATGAAATAGTAGAGGTTGAAGAAATTCTACCAGAAGATAAAAATGAAAAAGTTGAACAT
GAAATAGTAGAAGTTGAAGAAATTCTACCAGAAGATAAAAATGAAAAAGGTCAACATGAAATAGTAGAGG
TTGAAGAAATTCTACCAGAAGATGATAAAAATGAAAAAGGTCAACATGAAATAGTAGAGGTTGAAGAAAT
TCTTCCAGAAATTGTTGAAATTGAAGAAGTACCATCACAAACAAATAACAATGAAAATATTGAAACTATA
AAACCAGAAGAAAAAAAGAATGAATTTAGTGTTGTTGAAGAAAAAGCAATTCCACAAGAACCCGTGGTAC
CTACATTAAATGAAAATGAAAACGTTACTCCCAAACCATCTGAAGGTGAATCCACTAAACCAGATATAGT
TCAAATTAAAATAGTACAAGAAAATAAACCAAATAAAAAGGAAACACCAGTAGTAGATGGTCCAAAACAT
GTAGAACAAAATATACAAGAAGATGATAATGATGAAGAGGATGATGATGATATAGATTTTGAAGGATTAT
CAAGAAAAGATGATGAAAAGGATTCATCAAATAAAAATAAAAAGAAATCATCTTTTATAACATATATATC
TACAAAGAAATTTAAAAAAGTATCTCAAACTATTGTAAGTGTTATGATTAATGCATATGATGGTGTTATT
CAAGTTGTAAGTACAATTAAAGGAATAGCAAAGGATATAGTAATATTTTTCCAAAACATTTA

Protein Sequence : Show Sequence

>gi|124802897|ref|XP_001347628.1| glutamate-rich protein [Plasmodium falciparum 3D7]
MRNLFHITICLVTLNLFILEINAKTNTSENRNKRIGGPKLRGNVTSNIKFPSDNKGKIIRGSNDKLNKNS
EDVLEQSEKSLVSENVPSGLDIDDIPKESIFIQEDQEGQTHSELNPETSEHSKDLNNNDSKNESSDIISV
NNKSNKVQNHFESLSDLELLENSSQDNLDKDTISTEPFPNQKHKDLQQDLNDEPLEPFPTQIHKDYKEKN
LINEEDSEPFPRQKHKKVDNHNEEKNVFHENGSANGNQGSLKLKSFDEHLKDEKIENEPLVHENLSIPND
PIEQILNQPEQETNIQEQLYNEKQNVEEKQNSQIPSLDLKEPTNEDILPNHNPLENIKQSESEINHVQDH
ALPKENIIDKLDNQKEHIDQSQHNINVLQENNINNHQLEPQEKPNIESFEPKNIDSEIILPENVETEEII
DDVPSPKHSNHETFEEETSESEHEEAVSEKNAHETVEHEETVSQESNPEKADNDGNVSQNSNNELNENEF
VESEKSEHEPAENEESSLEEGHHEEIVPEQNNEESGESKLVDNDEGGFEEAHHENFSSEVSNSELNENEF
VESDKSVTEPAEHEEVVSEESNPEPAENEESSIEEAHQEEIVPEQNDEESGESGLVDNEEGDFEEPNHEE
FEPDQNDSELSENELVESEKSVSEPAEHVEIVSEKSVSEPAEHVEIVSEKSTSEPAEHVESVSEQSNNEP
SEKKDGPVPSKPFEEIEKVDVQPKIVDLQIIEPNFVDSQPNPQEPVEPSFVKIEKVPSEENKHASVDPEV
KEKENVSEVVEEKQNSQESVEEIPVNEDEFEDVHTEQLDLDHKTVDPEIVEVEEIPSELHENEVAHPEIV
EIEEVFPEPNQNNEFQEINEDDKSAHIQHEIVEVEEILPEDDKNEKVEHEIVEVEEILPEDKNEKVQHEI
VEVEEILPEDKNEKVEHEIVEVEEILPEDKNEKGQHEIVEVEEILPEDKNEKVQHEIVEVEEILPEDKNE
KGQHEIVEVEEILPEDKNEKVEHEIVEVEEILPEDKNEKGQHEIVEVEEILPEDDKNEKGQHEIVEVEEI
LPEIVEIEEVPSQTNNNENIETIKPEEKKNEFSVVEEKAIPQEPVVPTLNENENVTPKPSEGESTKPDIV
QIKIVQENKPNKKETPVVDGPKHVEQNIQEDDNDEEDDDDIDFEGLSRKDDEKDSSNKNKKKSSFITYIS
TKKFKKVSQTIVSVMINAYDGVIQVVSTIKGIAKDIVIFFQNI

Molecule Role : Protective antigen
Molecule Role Annotation : Some of the S. sciureus monkeys immunized with MSP-3(212-380)-AS02 or GLURP(27-500)-alum were able to fully or partially control parasitaemia upon an experimental P. falciparum [Falciparum Uganda Palo Alto (FUP-SP) strain] blood-stage infection, and this protection was related to the prechallenge antibody titres induced. The data are indicative that MSP-3 and GLURP can induce protective immunity against an experimental P. falciparum infection using adjuvants that are acceptable for human use and this should trigger further studies with those new antigens (Carvalho et al., 2004).

11. HEP17

Gene Name : HEP17
Sequence Strain (Speices/Organism) : Plasmodium yoelii
VO ID : VO_0011228
NCBI Protein GI : 1399353
Other Database IDs : CDD:174853
Taxonomy ID : 5861
Gene Strand (Orientation) : ?
Protein Name : hepatocyte erythrocyte protein 17 kDa
Protein Length : 169
Protein Note : Circumsporozoite-related antigen (CRA); cl05880

Protein Sequence : Show Sequence

>gi|1399353|gb|AAC47199.1| hepatocyte erythrocyte protein 17 kDa [Plasmodium yoelii]
MKINIASIIFIIFSLCLVNDAYGKNKYGKNGKYGSQNVIKKHGEPVINVQDLISDMVRKEEEIVKLTKNK
KSLRKINVALATALSVVSAILLGGAGLVMYNTEKGRRPFQIGKSKKGGSAMARDSSFPMNEESPLGFSPE
EMEAVASKFRESMLKDGVPAPSNTPNVQN

Molecule Role : Protective antigen
Molecule Role Annotation : Immunization of mice with subunit vaccines based on the Plasmodium yoelii 17kDa hepatocyte erythrocyte protein (PyHEP17), orthologue of Plasmodium falciparum exported protein 1 (PfExp1), induces antigen-specific immune responses and protects against sporozoite challenge (Dobaño and Doolan, 2007).

12. Hsp90

Gene Name : Hsp90
Sequence Strain (Speices/Organism) : Plasmodium falciparum
VO ID : VO_0011241
NCBI Protein GI : 1093612
Other Database IDs : CDD:173995
CDD:109249
Taxonomy ID : 5833
Gene Strand (Orientation) : ?
Protein Length : 747
Protein Note : Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; cl00075

Protein Sequence : Show Sequence

>gi|1093612|prf||2104278A heat shock protein 90
MSTETFAFNADIRQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESITDTQKLSAEPEFFIRIIPDK
TNNTLTIEDSGIGMTKNDLINNLGTIARSGTKAFMEAIQASGDISMIGQFGVGFYSAYLVADHVVVISKN
NDDEQYVWESAAGGSFTVTKDETNEKLGRGTKIILHLKEDQLEYLEEKRIKDLVKKHSEFISFPIKLYCE
RQNEKEITASEEEEEGEGEGEREGEEEEEEKKKKTGEDKNADESKEENEDEEKKEDNEEDDNKTDHPKVE
DVTEELENAEKKKKEKRKKKIHTVEHEWEELNKQKPLWMRKPEEVTNEEYASFYKSLTNDWEDHLAVKHF
SVEGQLEFKALLFIPKRAPFDMFENRKKRNNIKLYVRRVFIMDDCEEIIPEWLNFVKGVVDSEDLPLNIS
RESLQQNKILKVIKKNLIKKCLDMFSELAENKENYKKFYEQFSKNLKLGIHEDNANRTKITELLRFQTSK
SGDEMIGLKEYVDRMKENQKDIYYITGESINAVSNSPFLEALTKKGFEVIYMVDPIDEYAVQQLKDFDGK
KLKCCTKEGLDIDDSEEAKKDFETLKAEYEGLCKVIKDVLHEKVEKVVVGQRITDSPCVLVTSEFGWSAN
MERIMKAQALRDNSMTSYMLSKKIMEINARHPIISALKQKADADKSDKTVKDLIWLLFDTSLLTSGFALE
EPTTFSKRIHRMIKLGLSIDEEENNDIDLPPLEETVDATDSKMEEVD

Molecule Role : Protective antigen
Molecule Role Annotation : A monkey vaccination trial using a Plasmodium falciparum protein fraction containing antigens of 90-110 kDa is reported. Three monkeys out of five resisted a heavy challenge dose of highly virulent parasites. Hsp90 was found in the immunoprecipitates obtained with SERP antisera. Interestingly, the response to hsp90 correlated with protection, high antibody titres being found only in the protected monkeys (Bonnefoy et al., 1994).
Related Vaccine(s): P. falciparum Hsp90 Protein Subunit Vaccine

13. Kbeta

Gene Name : Kbeta
Sequence Strain (Speices/Organism) : Plasmodium falciparum 3D7
VO ID : VO_0011233
NCBI Gene ID : 813054
NCBI Protein GI : 124506397
Locus Tag : PFE1195w
Genbank Accession : AL844504
Protein Accession : XP_001351796
Taxonomy ID : 36329
Chromosome No : 5
Gene Starting Position : 998747
Gene Ending Position : 1002118
Gene Strand (Orientation) : ?
Protein pI : 4.54
Protein Weight : 120404.67
Protein Length : 1123

DNA Sequence : Show Sequence

>ref|NC_004326.1|:998747-1002118 Plasmodium falciparum 3D7 chromosome 5
AATGGATAAAATTGTAGAAGTTATTGAAGGATTAAGCAGCTCTGAGAGTCATATAAGAAATGAATGTGAA
AATACGTTAAATTATTATAAAAAGAATGATTTAAATAATACAGTATTATCTATATTGAAATTATTAAAAA
CCCATAAAGATAGTCAAGTTCGATTACAATGTGCTATATTAATTAGGAATATATTTCGTGTGTATATAAA
GTCCACACATGTGGATGTGGAAGAAAAAGAAAAAAATGAGAATTCGATTGGAAATGCAGAAGAAGAGAAT
TATTGGGTATTATTACCTGATAATTTAAAGAATATTGTAAAATCTGAATTGATTAGTAATATAGGAACTG
AAACAGATAAGATGGTTCGAAGTAATATATGTAATAATATTATAGATTTATCATCAAAATTATTATTACA
TAATCAATGGCCTGAGTTATTATCAGTAACATTTGAATTTTGTAATTCTAATAACGTTGATGTATTAATA
AGTGGATATAAAATATTAGGTGGTATCTTAAGTTGTATTCCAGATGAATTAGATGGAAAACAAGAAATAA
TATCTTCCATATGTATGAAAGGTTTAAATTCATCAAATGTACAAGTACGTGGAGAATGTATTAATTTAAT
ATCATGTATTGTTGAAGATAATAGTTCATCCTTAGTTAAGAGTGTACATGGTTGTATCCCATTAATATTA
CAATCATTAAGTTTGATGGCAAAGAATAGTAGTTCAGATATTGCTGTTCTAGAAGAATGTGAGAAAGTAC
TTCAATCTATTGGTAAAATGATAGATTATAATGCTAAATTTTTTACTAAGCATATAACAAGTTTGTGTGA
TATATTATTTAGTATTTGTATGAAAGATGAAAATGAATTGAACTATGATTTTGATAATAGCTTGAAGTCC
CTAAGTATTGAAGCTTTAGTTACCATTCCAGAACGTCGACCAAAAATGGCTTTATCTGTACCTCATTTTG
TAGATAAGATTATACATTTGTCTATGTTATTTATGCTTGACATTAATAATGATTGTTTTAATGAATGGAT
GAATTCTATAAAAGAAGGTAAAGACGATAGTCAGGAGTTATATGACATAGGTGAAGAGTCCTTAGATCGT
GTTGGTAAAGCATTTAGTGAGTTAGAAGAAGCTGAATTTATTCATATTCTTTTTAATAAAGTATCAGAAT
TTTTAATGAAAAATACTTGGGAACATAAATATGTCGGTATTATGGCTATTGCACAAACTATAGAATATTT
ACCAGAAGATGAAATTGAAGAACAATTAGAACATGTTATAAAAATGTTGTTACAAATATTAGTTGATCAA
GATGTTAGAGTACGTTATGCAGCATGTCAAGCCATTGGACAAATATCTTTAGATCATCAACCATATGTAC
AGAAAGAATTTTTTTCAGAAATTTTATCAGCATTAATTAATACCATGAACGATGTACATTTAAGAGTTCA
ATCACATGCTACAGCAGCTTTTGTAAATTATGCAGAAGAATTAGATAAAATGGCTTTATTACCATATGCA
GATATTATTATAGATATTTTATTACAAAAATTGAATTCTTCAAATTATTTATTAGTAAGAGAACAAGCTG
TTACTGCTATAGCGGTTATTGCAGGTGTTATTGAAGAAGACTTTTTAAAATATTATTCTACTGTTGTACC
TATGATGAAAGATATTATTCAAAAGGCAGTTTCTGAAGAAGAAAGAACATGCAGAGGTAAAGCCATTGAA
TGTATTTCAATTATTGGTTTATCGGTTGGTAAAGATATTTTTATTGAAGATGCTAAAGAATGTATGAATG
CATTATTACAAATTAGCAGTACAAAAATGGATCCTGATGATACTGTAAAAGAATATATTCAAGAAGCTAT
TGGTCGTATATGTAGAGCATTAGGTAATGACTTTTATCCATATCTAAGTAGTATAGTACCGACCATATTA
TCTGTACTCTCCGTTTTACCAAAACCATTAACAGATGATGAAGAAGATCTAACCATAACTATGGTATCTA
ATGGACAATATGTAGGATTGAAAACATCCTTATTAGAAGATCAAGAAAAAGCTTTAGATTTATTAATTAT
TATTATTGAAGTATTAAAAGAAAATTATAAGGATTATATTCAAGCAACAGCTACAGCTGTGTTGCCAATG
TTAAATTATGAATTGTCAGATGAAATTAAACAAAAGGCATTAACAGCTGTTAGTGAATTAATTGAATCAG
CAAGAATATTATCTGAAAAAACGGATAATGATAAATCCATGTTACTAGCCATATTAACAGCAGCAGCAGA
AAAAGTATTAAAAAGTCTATTAGAAACAAAATTAGATGACAATTATGAATATATATTAGATGTTATGATA
ATCGAATCCCATGGATTATATATGTGCTTACAAAAAGCGGGATCGAATGTATTGCCAGAAAATACATTAA
AATTATTTTTTAATCAAATCTTTGCCCTATTACAATATTCAACAGATAGAAGGGTAGTATATAATCAAAA
AAAAAATAATGATGATGTAGATGAAGATGAATTATTAATAATTGATAGAGAAGAGGAATTAGAACAGAAT
TATCGAACAAATTTATTAGATATCTTAGGAGTATTAATTAAATATCACCCAACACAATTCTTAAATACAT
GTTGTGAATTATGTATTGGATTTATTAATAATTATATGAATTCTCCTAATTCAGAAGATGTAGCATTAGC
ATTATATGTATGTGATGATTTGTTAGAATTCTTACAAGAAAAGAGTGTAAACCTATGGGACTTTTTCATG
AACCCATTATTATTAAATATTAATCATGCAGATGATAAAGTAAAACAAGCGGCATGTTATGGTGTTATAC
AAGCAACCAAAATTGAAGCATTTGGAAAGTATGCAAATATTGCAGTAGAATATTTATTAAAATTAGTACA
TGAAAGTACATCAAATAAAAAACCAAAAGAATATATCTCAGCTATTGATAATGCTATAGCAGCATTAGGT
GATGTTGTTCTTATGCATACATCAAAATTTAATAATGCAGAAGATCTCATAAAAGTATGGTTAAATCATT
TACCAATAAAAGAAGATGATGCAGAAGGTAGAAGAGTACATAAAAATCTTATAGATTTAGTTTCACAAAA
CCATCCTCTCTTGTTCGGAAAAGATAATTCTAATACAGCAAAAATTATTGAAATATTCTTAACAATATAT
GAAACTGATTTTTCAGATACTGACTGTAACAAAAAAATCTCAACACTTATCAATTCATTGGATAAATCAT
ATTTAAATAATTTAGCTTCTTCAACTTTGTCACATAAGCAAGCCAAAAAATTGAACAACATTTTGAATCC
AAACAGAAAATA

Protein Sequence : Show Sequence

>gi|124506397|ref|XP_001351796.1| karyopherin beta [Plasmodium falciparum 3D7]
MDKIVEVIEGLSSSESHIRNECENTLNYYKKNDLNNTVLSILKLLKTHKDSQVRLQCAILIRNIFRVYIK
STHVDVEEKEKNENSIGNAEEENYWVLLPDNLKNIVKSELISNIGTETDKMVRSNICNNIIDLSSKLLLH
NQWPELLSVTFEFCNSNNVDVLISGYKILGGILSCIPDELDGKQEIISSICMKGLNSSNVQVRGECINLI
SCIVEDNSSSLVKSVHGCIPLILQSLSLMAKNSSSDIAVLEECEKVLQSIGKMIDYNAKFFTKHITSLCD
ILFSICMKDENELNYDFDNSLKSLSIEALVTIPERRPKMALSVPHFVDKIIHLSMLFMLDINNDCFNEWM
NSIKEGKDDSQELYDIGEESLDRVGKAFSELEEAEFIHILFNKVSEFLMKNTWEHKYVGIMAIAQTIEYL
PEDEIEEQLEHVIKMLLQILVDQDVRVRYAACQAIGQISLDHQPYVQKEFFSEILSALINTMNDVHLRVQ
SHATAAFVNYAEELDKMALLPYADIIIDILLQKLNSSNYLLVREQAVTAIAVIAGVIEEDFLKYYSTVVP
MMKDIIQKAVSEEERTCRGKAIECISIIGLSVGKDIFIEDAKECMNALLQISSTKMDPDDTVKEYIQEAI
GRICRALGNDFYPYLSSIVPTILSVLSVLPKPLTDDEEDLTITMVSNGQYVGLKTSLLEDQEKALDLLII
IIEVLKENYKDYIQATATAVLPMLNYELSDEIKQKALTAVSELIESARILSEKTDNDKSMLLAILTAAAE
KVLKSLLETKLDDNYEYILDVMIIESHGLYMCLQKAGSNVLPENTLKLFFNQIFALLQYSTDRRVVYNQK
KNNDDVDEDELLIIDREEELEQNYRTNLLDILGVLIKYHPTQFLNTCCELCIGFINNYMNSPNSEDVALA
LYVCDDLLEFLQEKSVNLWDFFMNPLLLNINHADDKVKQAACYGVIQATKIEAFGKYANIAVEYLLKLVH
ESTSNKKPKEYISAIDNAIAALGDVVLMHTSKFNNAEDLIKVWLNHLPIKEDDAEGRRVHKNLIDLVSQN
HPLLFGKDNSNTAKIIEIFLTIYETDFSDTDCNKKISTLINSLDKSYLNNLASSTLSHKQAKKLNNILNP
NRK

Molecule Role : Protective antigen
Molecule Role Annotation : Two large fragments of PfKbeta representing the N- and C-terminal halves were expressed in E. coli. The recombinant proteins were highly immunogenic in mice, and also found to be the target for immune response in natural infections of Plasmodium spp. Immunization with recombinant PfKbeta fragments was partially protective against a heterologous challenge infection in mice (Mohmmed et al., 2005).

14. LSA-3

Gene Name : LSA-3
Sequence Strain (Speices/Organism) : Plasmodium falciparum 3D7
NCBI Gene ID : 812783
NCBI Protein GI : 124801463
Locus Tag : PFB0915w
Genbank Accession : AE001362
Protein Accession : XP_001349701
Taxonomy ID : 36329
Chromosome No : 2
Gene Starting Position : 796749
Gene Ending Position : 801583
Gene Strand (Orientation) : +
Protein Name : Liver stage antigen 3
Protein pI : 3.86
Protein Weight : 156020.34
Protein Length : 1558

DNA Sequence : Show Sequence

>ref|NC_000910.2|:796749-801583 Plasmodium falciparum 3D7 chromosome 2, complete sequence
AATGACAAATAGTAATTACAAATCAAATAATAAAACATATAATGAAAATAATAATGAACAAATAACTACC
ATATTTAATAGAACAAATATGAATCCGATAAAAAAATGTCATATGAGAGAAAAAATAAATAAGTACTTTT
TTTTGATCAAAATTTTGACATGCACCATTTTAATATGGGCTGTACAATATGCTAATAACGTAAGATAAAA
AACTAAATAATAAATATAAATAAAAAAAAAAAAAAAAAAAAAAAAAATCAACTATATAGTATGTATAATA
TATATATATATATATATATATATATATTTATTTTTATTTATTTATTAATTTTTTTTTTTTTTATATTATC
TTTTTAGTCTGATATAAACAAGAGTTGGAAAAAAAATACGTATGTAGATAAGAAATTGAATAAACTATTT
AACAGAAGTTTAGGAGAATCTCAAGTAAATGGTGAATTAGCTAGTGAAGAAGTAAAGGAAAAAATTCTTG
ACTTATTAGAAGAAGGAAATACATTAACTGAAAGTGTAGATGATAATAAAAATTTAGAAGAAGCCGAAGA
TATAAAGGAAAATATCTTATTAAGTAATATAGAAGAACCAAAAGAAAATATTATTGACAATTTATTAAAT
AATATTGGACAAAATTCAGAAAAACAAGAAAGTGTATCAGAAAATGTACAAGTCAGTGATGAACTTTTTA
ATGAATTATTAAATAGTGTAGATGTTAATGGAGAAGTAAAAGAAAATATTTTGGAGGAAAGTCAAGTTAA
TGACGATATTTTTAATAGTTTAGTAAAAAGTGTTCAACAAGAACAACAACACAATGTTGAAGAAAAAGTT
GAAGAAAGTGTAGAAGAAAATGACGAAGAAAGTGTAGAAGAAAATGTAGAAGAAAATGTAGAAGAAAATG
ACGACGAAAGTGTAGCCTCAAGTGTTGAAGAAAGTATAGCTTCAAGTGTTGATGAAAGTATAGATTCAAG
TATTGAAGAAAATGTAGCTCCAACTGTTGAAGAAATCGTAGCTCCAACTGTTGAAGAAATTGTAGCTCCA
AGTGTTGTAGAAAGTGTGGCTCCAAGTGTTGAAGAAAGTGTAGAAGAAAATGTTGAAGAAAGTGTAGCTG
AAAATGTTGAAGAAAGTGTAGCTGAAAATGTTGAAGAAAGTGTAGCTGAAAATGTTGAAGAAAGTGTAGC
TGAAAATGTTGAAGAAAGTGTAGCTGAAAATGTTGAAGAAAGTGTAGCTGAAAATGTTGAAGAAATCGTA
GCTCCAACTGTTGAAGAAAGTGTAGCTCCAACTGTTGAAGAAATTGTAGCTCCAAGTGTTGAAGAAAGTG
TAGCTCCAAGTGTTGAAGAAATTGTAGTTCCAACTGTTGAAGAAAGTGTAGCTGAAAATGTTGAAGAAAT
CGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAACTGTTGAAGAA
AGTGTAGCTCCAACTGTTGAAGAAATTGTAGCTCCAAGTGTTGAAGAAAGTGTAGCTCCAAGTGTTGAAG
AAATTGTAGTTCCAACTGTTGAAGAAAGTGTAGCTGAAAATGTTGAAGAAAGTGTAGCTGAAAATGTTGA
AGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAGTGTT
GAAGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAGTG
TTGAAGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAC
AGTTGAAGAAATCGTAGCTCCAACAGTTGAAGAAATTGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCA
ACTGTTGAAGAAAGTGTTGCTGAAAACGTTGCAACAAATTTATCAGACAATCTTTTAAGTAATTTATTAG
GTGGTATCGAAACTGAGGAAATAAAGGACAGTATATTAAATGAGATAGAAGAAGTAAAAGAAAATGTAGT
CACCACAATACTAGAAAACGTAGAAGAAACTACAGCTGAAAGTGTAACTACTTTTAGTAACATATTAGAG
GAGATACAAGAAAATACTATTACTAATGATACTATAGAGGAAAAATTAGAAGAACTCCACGAAAATGTAT
TAAGTGCCGCTTTAGAAAATACCCAAAGTGAAGAGGAAAAGAAAGAAGTAATAGATGTAATTGAAGAAGT
AAAAGAAGAGGTCGCTACCACTTTAATAGAAACTGTGGAACAGGCAGAAGAAGAGAGCGCAAGTACAATT
ACGGAAATATTTGAAAATTTAGAAGAAAATGCAGTAGAAAGTAATGAAAATGTTGCAGAGAATTTAGAGA
AATTAAACGAAACTGTATTTAATACTGTATTAGATAAAGTAGAGGAAACAGTAGAAATTAGCGGAGAAAG
TTTAGAAAACAATGAAATGGATAAAGCATTTTTTAGTGAAATATTTGATAATGTAAAAGGAATACAAGAA
AATTTATTAACAGGTATGTTTCGAAGTATAGAAACCAGTATAGTAATCCAATCAGAAGAAAAGGTTGATT
TGAATGAAAATGTGGTTAGTTCGATTTTAGATAATATAGAAAATATGAAAGAAGGTTTATTAAATAAATT
AGAAAATATTTCAAGTACTGAAGGTGTTCAAGAAACTGTAACTGAACATGTAGAACAAAATGTATATGTG
GATGTTGATGTTCCTGCTATGAAAGATCAATTTTTAGGAATATTAAATGAGGCAGGAGGGTTGAAAGAAA
TGTTTTTTAATTTGGAAGATGTATTTAAAAGTGAAAGTGATGTAATTACTGTAGAAGAAATTAAGGATGA
ACCGGTTCAAAAAGAGGTAGAAAAAGAAACTGTTAGTATTATTGAAGAAATGGAAGAAAATATTGTAGAT
GTATTAGAGGAAGAAAAAGAAGATTTAACAGACAAGATGATAGATGCAGTAGAAGAATCCATAGAAATAT
CTTCAGATTCTAAAGAAGAAACTGAATCTATTAAAGATAAAGAAAAAGATGTTTCACTAGTTGTTGAAGA
AGTTCAAGACAATGATATGGATGAAAGTGTTGAGAAAGTTTTAGAATTGAAAAATATGGAAGAGGAGTTA
ATGAAGGATGCTGTTGAAATAAATGACATTACTAGCAAACTTATTGAAGAAACTCAAGAGTTAAATGAAG
TAGAAGCAGATTTAATAAAAGATATGGAAAAATTAAAAGAATTAGAGAAAGCATTATCAGAAGATTCTAA
AGAAATAATAGATGCAAAAGATGATACATTAGAAAAAGTTATTGAAGAGGAACATGATATAACGACGACG
TTGGATGAAGTTGTAGAATTAAAAGATGTCGAAGAAGACAAGATCGAAAAAGTATCTGATTTAAAAGATC
TTGAAGAAGATATATTAAAAGAAGTAAAAGAAATCAAAGAACTTGAAAGTGAAATTTTAGAAGATTATAA
AGAATTAAAAACTATTGAAACAGATATTTTAGAAGAGAAAAAAGAAATAGAAAAAGATCATTTTGAAAAA
TTCGAAGAAGAAGCTGAAGAAATAAAAGATCTTGAAGCAGATATATTAAAAGAAGTATCTTCATTAGAAG
TTGAAGAAGAAAAAAAATTAGAAGAAGTACACGAATTAAAAGAAGAGGTAGAACATATAATAAGTGGTGA
TGCGCATATAAAAGGTTTGGAAGAAGATGATTTAGAAGAAGTAGATGATTTAAAAGGAAGTATATTAGAC
ATGTTAAAGGGAGATATGGAATTAGGGGATATGGATAAGGAAAGTTTAGAAGATGTAACAGCAAAACTTG
GAGAAAGAGTTGAATCCTTAAAAGATGTTTTATCTAGTGCATTAGGCATGGATGAAGAACAAATGAAAAC
AAGAAAAAAAGCTCAAAGACCTAAATTGGAAGAAGTATTATTAAAAGAAGAGGTTAAAGAAGAACCAAAG
AAAAAAATAACAAAAAAGAAAGTAAGGTTTGATATTAAGGATAAGGAACCAAAAGATGAAATAGTAGAAG
TTGAAATGAAAGATGAAGATATAGATGAAGATATAGAAGAAGATGTAGAAGAAGATATAGAAGAAGATAA
AGTTGAAGATATAGATGAAGATATAGATGAAGATATAGATGAAGATATAGGTGAAGACAAAGATGAAGTT
ATAGATTTAATAGTCCAAAAAGAGAAACGCATTGAAAAGGTTAAAGAGAAAAAGAAAAAATTAGAAAAAA
AAGTTGAAGAAGGTGTTAGTGGTCTTAAAAAACACGTAGACGAAGTAATGAAATATGTTCAAAAAATTGA
TAAAGAAGTTGATAAAGAAGTATCTAAAGCTTTAGAATCAAAAAATGATGTTACTAATGTTTTAAAACAA
AATCAAGATTTTTTTAGTAAAGTTAAAAACTTCGTAAAAAAATATAAAGTATTTGCTGCACCATTCATAT
CTGCCGTTGCAGCATTTGCATCATATGTAGTTGGGTTCTTTACATTTTCTTTATTTTCATCATGTGTAAC
AATAGCTTCTTCAACTTACTTATTATCAAAAGTTGACAAAACTATAAATAAAAATAAGGAGAGACCGTTT
TATTCATTTGTATTTGATATCTTTAAGAATTTAAAACATTATTTACAACAAATGAAAGAAAAATTTAGTA
AAGAAAAAAATAATAATGTAATAGAAGTAACAAACAAAGCTGAGAAAAAAGGTAATGTACAGGTAACAAA
TAAAACCGAGAAAACAACTAAAGTTGATAAAAATAATAAAGTACCGAAAAAAAGTAGAACGCAAAAATCA
AAATA

Protein Sequence : Show Sequence

>gi|124801463|ref|XP_001349701.1| liver stage antigen 3 [Plasmodium falciparum 3D7]
MTNSNYKSNNKTYNENNNEQITTIFNRTNMNPIKKCHMREKINKYFFLIKILTCTILIWAVQYANNSDIN
KSWKKNTYVDKKLNKLFNRSLGESQVNGELASEEVKEKILDLLEEGNTLTESVDDNKNLEEAEDIKENIL
LSNIEEPKENIIDNLLNNIGQNSEKQESVSENVQVSDELFNELLNSVDVNGEVKENILEESQVNDDIFNS
LVKSVQQEQQHNVEEKVEESVEENDEESVEENVEENVEENDDESVASSVEESIASSVDESIDSSIEENVA
PTVEEIVAPTVEEIVAPSVVESVAPSVEESVEENVEESVAENVEESVAENVEESVAENVEESVAENVEES
VAENVEESVAENVEEIVAPTVEESVAPTVEEIVAPSVEESVAPSVEEIVVPTVEESVAENVEEIVAPSVE
EIVAPSVEEIVAPTVEESVAPTVEEIVAPSVEESVAPSVEEIVVPTVEESVAENVEESVAENVEEIVAPS
VEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPTVEEIVA
PTVEEIVAPSVEEIVAPTVEESVAENVATNLSDNLLSNLLGGIETEEIKDSILNEIEEVKENVVTTILEN
VEETTAESVTTFSNILEEIQENTITNDTIEEKLEELHENVLSAALENTQSEEEKKEVIDVIEEVKEEVAT
TLIETVEQAEEESASTITEIFENLEENAVESNENVAENLEKLNETVFNTVLDKVEETVEISGESLENNEM
DKAFFSEIFDNVKGIQENLLTGMFRSIETSIVIQSEEKVDLNENVVSSILDNIENMKEGLLNKLENISST
EGVQETVTEHVEQNVYVDVDVPAMKDQFLGILNEAGGLKEMFFNLEDVFKSESDVITVEEIKDEPVQKEV
EKETVSIIEEMEENIVDVLEEEKEDLTDKMIDAVEESIEISSDSKEETESIKDKEKDVSLVVEEVQDNDM
DESVEKVLELKNMEEELMKDAVEINDITSKLIEETQELNEVEADLIKDMEKLKELEKALSEDSKEIIDAK
DDTLEKVIEEEHDITTTLDEVVELKDVEEDKIEKVSDLKDLEEDILKEVKEIKELESEILEDYKELKTIE
TDILEEKKEIEKDHFEKFEEEAEEIKDLEADILKEVSSLEVEEEKKLEEVHELKEEVEHIISGDAHIKGL
EEDDLEEVDDLKGSILDMLKGDMELGDMDKESLEDVTAKLGERVESLKDVLSSALGMDEEQMKTRKKAQR
PKLEEVLLKEEVKEEPKKKITKKKVRFDIKDKEPKDEIVEVEMKDEDIDEDIEEDVEEDIEEDKVEDIDE
DIDEDIDEDIGEDKDEVIDLIVQKEKRIEKVKEKKKKLEKKVEEGVSGLKKHVDEVMKYVQKIDKEVDKE
VSKALESKNDVTNVLKQNQDFFSKVKNFVKKYKVFAAPFISAVAAFASYVVGFFTFSLFSSCVTIASSTY
LLSKVDKTINKNKERPFYSFVFDIFKNLKHYLQQMKEKFSKEKNNNVIEVTNKAEKKGNVQVTNKTEKTT
KVDKNNKVPKKSRTQKSK

Molecule Role : Protective antigen
Molecule Role Annotation : In chimpanzees (Pan troglodytes), the primates most closely related to humans and that share a similar susceptibility to P. falciparum liver-stage infection, immunization with LSA-3 induced protection against successive heterologous challenges with large numbers of P. falciparum sporozoites (Daubersies et al., 2000).

15. MSP1 from P. berghei

Gene Name : MSP1 from P. berghei
Sequence Strain (Speices/Organism) : Plasmodium berghei
VO ID : VO_0011225
NCBI Protein GI : 1762646
Taxonomy ID : 5821
Gene Strand (Orientation) : ?
Protein Name : merozoite surface protein 1
Protein Length : 111

Protein Sequence : Show Sequence

>gi|1762646|gb|AAC47502.1| merozoite surface protein 1 [Plasmodium berghei]
SGQSSTEPASTGTPSSGEVSTGTSTGGASAGVTNTGAATTGTSTGGASAGVTNTGAATTGTTGTGAATTG
TTGAEAVTTGNTGAEVTQVQIVPTLTPEEKKKKMDGLYAQI

Molecule Role : Protective antigen
Molecule Role Annotation : Mice vaccinated with recombinant rMSP1 (rPbMSP1), which was generated from Plasmodium berghei, in alum mounted significant protective immunity against challenge infection (P < 0.01). On day 121 after the booster, three out of ten mice immunized with rPbMSP1 in PBS survived parasite infection (P < 0.05) and eight out of ten mice vaccinated with r MSP1 in alum did (P < 0.01). Hence, immunization with MSP1 in alum obviously has conferred protective effects, which prevented death from P. berghei lethal infection in mice (P < 0.01) (Wan et al., 2007).

16. MSP1 from P. falciparum

Gene Name : MSP1 from P. falciparum
Sequence Strain (Speices/Organism) : Plasmodium falciparum
VO ID : VO_0010958
NCBI Protein GI : 94420988
Other Database IDs : PlasmoDB:PFI1475w
Taxonomy ID : 5833
Chromosome No : 9
Gene Starting Position : 1201802
Gene Ending Position : 1206964
Gene Strand (Orientation) : ?
Protein Name : merozoite surface protein 1
Protein Length : 116
Protein Note : clinical isolate

DNA Sequence : Show Sequence

>PFI1475w |MSP1|MSP-1, PMMSA, Pf190, merozoite surface antigen 1|merozoite surface protein 1, precursor|Plasmodium falciparum|chr 9|SANGER||Manual
ATGAAGATCA TATTCTTTTT ATGTTCATTT CTTTTTTTTA TTATAAATAC ACAATGTGTA
ACACATGAAA GTTATCAAGA ACTTGTCAAA AAACTAGAAG CTTTAGAAGA TGCAGTATTG
ACAGGTTATA GTTTATTTCA AAAGGAAAAA ATGGTATTAA ATGAAGAAGA AATTACTACA
AAAGGTGCAA GTGCTCAAAG TGGTGCAAGT GCTCAAAGTG GTGCAAGTGC TCAAAGTGGT
GCAAGTGCTC AAAGTGGTGC AAGTGCTCAA AGTGGTGCAA GTGCTCAAAG TGGTACAAGT
GGTCCAAGTG GTCCAAGTGG TACAAGTCCA TCATCTCGTT CAAACACTTT ACCTCGTTCA
AATACTTCAT CTGGTGCAAG CCCTCCAGCT GATGCAAGCG ATTCAGATGC TAAATCTTAC
GCTGATTTAA AACACAGAGT ACGAAATTAC TTGTTCACTA TTAAAGAACT CAAATATCCC
GAACTCTTTG ATTTAACCAA TCATATGTTA ACTTTGTGTG ATAATATTCA TGGTTTCAAA
TATTTAATTG ATGGATATGA AGAAATTAAT GAATTATTAT ATAAATTAAA CTTTTATTTT
GATTTATTAA GAGCAAAATT AAATGATGTA TGTGCTAATG ATTATTGTCA AATACCTTTC
AATCTTAAAA TTCGTGCAAA TGAATTAGAC GTACTTAAAA AACTTGTGTT CGGATATAGA
AAACCATTAG ACAATATTAA AGATAATGTA GGAAAAATGG AAGATTACAT TAAAAAAAAT
AAAACAACCA TAGCAAATAT AAATGAATTA ATTGAAGGAA GTAAGAAAAC AATTGATCAA
AATAAGAATG CAGATAATGA AGAAGGGAAA AAAAAATTAT ACCAAGCTCA ATATGATCTT
TCTATTTACA ATAAACAATT AGAAGAAGCA CATAATTTAA TAAGCGTTTT AGAAAAACGT
ATTGACACTT TAAAAAAAAA TGAAAACATA AAGAAATTAC TTGATAAGAT AAATGAAATT
AAAAATCCCC CACCGGCCAA TTCTGGAAAT ACACCAAATA CTCTCCTTGA TAAGAACAAA
AAAATCGAGG AACACGAAGA AAAAATAAAA GAAATTGCCA AAACTATTAA ATTTAACATT
GATAGTTTAT TTACTGATCC ACTTGAATTA GAATATTATT TAAGAGAAAA AAATAAAAAA
GTTGATGTAA CACCTAAATC ACAAGATCCT ACGAAATCTG TTCAAATACC AAAAGTTCCT
TATCCAAATG GTATTGTATA TCCTTTACCA CTCACTGATA TTCATAATTC ATTAGCTGCA
GATAATGATA AAAATTCATA TGGTGATTTA ATGAATCCTC ATACTAAAGA AAAAATTAAT
GAAAAAATTA TTACAGATAA TAAGGAAAGA AAAATATTCA TTAATAACAT TAAAAAAAAA
ATTGATTTAG AAGAAAAAAA CATTAATCAC ACAAAAGAAC AAAATAAAAA ATTACTTGAA
GATTATGAAA AGTCAAAAAA GGATTATGAA GAATTACTTG AAAAATTTTA TGAAATGAAA
TTTAATAATA ATTTTAACAA AGATGTCGTA GATAAAATAT TCAGTGCAAG ATATACATAT
AATGTTGAAA AACAAAGATA TAATAATAAA TTTTCATCCT CTAATAATTC TGTATATAAT
GTTCAAAAAT TAAAAAAGGC TCTTTCATAT CTTGAAGATT ATTCTTTAAG AAAAGGAATT
TCTGAAAAAG ATTTTAATCA TTATTATACT TTGAAAACTG GCCTCGAAGC TGATATAAAA
AAATTAACAG AAGAAATAAA GAGTAGTGAA AACAAAATTC TAGAAAAAAA TTTTAAAGGA
CTAACACATT CAGCAAATGG TTCCTTAGAA GTATCTGATA TTGTAAAATT ACAAGTACAA
AAAGTTTTAT TAATTAAAAA AATAGAAGAC TTAAGAAAGA TAGAATTATT TTTAAAAAAT
GCACAACTAA AAGATAGTAT TCATGTACCA AATATTTATA AACCACAAAA TAAACCAGAA
CCATATTATT TAATTGTATT AAAAAAAGAA GTAGATAAAT TAAAAGAATT TATACCAAAA
GTAAAAGACA TGTTAAAGAA AGAACAAGCT GTCTTATCAA GTATTACACA ACCTTTAGTT
GCAGCAAGCG AAACAACTGA AGATGGGGGT CACTCCACAC ACACATTATC CCAATCAGGA
GAAACAGAAG TAACAGAAGA AACAGAAGAA ACAGAAGAAA CAGTAGGACA CACAACAACG
GTAACAATAA CATTACCACC AACACAACCA TCACCACCAA AAGAAGTAAA AGTTGTTGAA
AATTCAATAG AACATAAGAG TAATGACAAT TCACAAGCCT TGACAAAAAC AGTTTATCTA
AAGAAATTAG ATGAATTTTT AACTAAATCA TATATATGTC ATAAATATAT TTTAGTATCA
AACTCTAGTA TGGACCAAAA ATTATTAGAG GTATATAATC TTACTCCAGA AGAAGAAAAT
GAATTAAAAT CATGTGATCC ATTAGATTTA TTATTTAATA TTCAAAATAA CATACCTGCT
ATGTATTCAT TATATGATAG TATGAACAAT GATTTACAAC ATCTCTTTTT TGAATTATAT
CAAAAGGAAA TGATTTATTA TTTACATAAA CTAAAAGAGG AAAATCACAT CAAAAAATTA
TTAGAGGAGC AAAAACAAAT AACTGGAACA TCATCTACAT CCAGTCCTGG AAATACAACC
GTAAATACTG CTCAATCCGC AACTCACAGT AATTCCCAAA ACCAACAATC AAATGCATCC
TCTACCAATA CCCAAAATGG TGTAGCTGTA TCATCTGGTC CTGCTGTAGT TGAAGAAAGT
CATGATCCCT TAACAGTATT GTCTATTAGT AACGATTTGA AAGGTATTGT TAGTCTCTTA
AATCTTGGAA ATAAAACTAA AGTACCTAAT CCATTAACCA TTTCTACAAC AGAGATGGAA
AAATTTTATG AGAATATTTT AAAAAATAAT GATACCTATT TTAATGATGA TATCAAACAA
TTCGTAAAAT CTAATTCAAA AGTAATTACA GGTTTGACCG AAACACAAAA AAATGCATTA
AATGATGAAA TTAAAAAATT AAAAGATACT TTACAGTTAT CATTTGATTT ATATAATAAA
TATAAATTAA AATTAGATAG ATTATTTAAT AAGAAAAAAG AACTTGGCCA AGACAAAATG
CAAATTAAAA AACTTACTTT ATTAAAAGAA CAATTAGAAT CAAAATTGAA TTCACTTAAT
AACCCACATA ATGTATTACA AAACTTTTCT GTTTTCTTTA ACAAAAAAAA AGAAGCTGAA
ATAGCAGAAA CTGAAAACAC ATTAGAAAAC ACAAAAATAT TATTGAAACA TTATAAAGGA
CTTGTTAAAT ATTATAATGG TGAATCATCT CCATTAAAAA CTTTAAGTGA AGTATCAATT
CAAACAGAAG ATAATTATGC CAATTTAGAA AAATTTAGAG TATTAAGTAA AATAGATGGA
AAACTCAATG ATAATTTACA TTTAGGAAAG AAAAAATTAT CTTTCTTATC AAGTGGATTA
CATCATTTAA TTACTGAATT AAAAGAAGTA ATAAAAAATA AAAATTATAC AGGTAATTCT
CCAAGTGAAA ATAATAAGAA AGTTAACGAA GCTTTAAAAT CTTACGAAAA TTTTCTCCCA
GAAGCAAAAG TTACAACAGT TGTAACTCCA CCTCAACCAG ATGTAACTCC ATCTCCATTA
TCTGTAAGGG TAAGTGGTAG TTCAGGATCC ACAAAAGAAG AAACACAAAT ACCAACTTCA
GGCTCTTTAT TAACAGAATT ACAACAAGTA GTACAATTAC AAAATTATGA CGAAGAAGAT
GATTCCTTAG TTGTATTACC CATTTTTGGA GAATCCGAAG ATAATGACGA ATATTTAGAT
CAAGTAGTAA CTGGAGAAGC AATATCTGTC ACAATGGATA ATATCCTCTC AGGATTTGAA
AATGAATATG ATGTTATATA TTTAAAACCT TTAGCTGGAG TATATAGAAG CTTAAAAAAA
CAAATTGAAA AAAACATTTT TACATTTAAT TTAAATTTGA ACGATATCTT AAATTCACGT
CTTAAGAAAC GAAAATATTT CTTAGATGTA TTAGAATCTG ATTTAATGCA ATTTAAACAT
ATATCCTCAA ATGAATACAT TATTGAAGAT TCATTTAAAT TATTGAATTC AGAACAAAAA
AACACACTTT TAAAAAGTTA CAAATATATA AAAGAATCAG TAGAAAATGA TATTAAATTT
GCACAGGAAG GTATAAGTTA TTATGAAAAG GTTTTAGCGA AATATAAGGA TGATTTAGAA
TCAATTAAAA AAGTTATCAA AGAAGAAAAG GAGAAGTTCC CATCATCACC ACCAACAACA
CCTCCGTCAC CAGCAAAAAC AGACGAACAA AAGAAGGAAA GTAAGTTCCT TCCATTTTTA
ACAAACATTG AGACCTTATA CAATAACTTA GTTAATAAAA TTGACGATTA CTTAATTAAC
TTAAAGGCAA AGATTAACGA TTGTAATGTT GAAAAAGATG AAGCACATGT TAAAATAACT
AAACTTAGTG ATTTAAAAGC AATTGATGAC AAAATAGATC TTTTTAAAAA CCCTTACGAC
TTCGAAGCAA TTAAAAAATT GATAAATGAT GATACGAAAA AAGATATGCT TGGCAAATTA
CTTAGTACAG GATTAGTTCA AAATTTTCCT AATACAATAA TATCAAAATT AATTGAAGGA
AAATTCCAAG ATATGTTAAA CATTTCACAA CACCAATGCG TAAAAAAACA ATGTCCAGAA
AATTCTGGAT GTTTCAGACA TTTAGATGAA AGAGAAGAAT GTAAATGTTT ATTAAATTAC
AAACAAGAAG GTGATAAATG TGTTGAAAAT CCAAATCCTA CTTGTAACGA AAATAATGGT
GGATGTGATG CAGATGCCAC ATGTACCGAA GAAGATTCAG GTAGCAGCAG AAAGAAAATC
ACATGTGAAT GTACTAAACC TGATTCTTAT CCACTTTTCG ATGGTATTTT CTGCAGTTCC
TCTAACTTCT TAGGAATATC ATTCTTATTA ATACTCATGT TAATATTATA CAGTTTCATT
TAA

Protein Sequence : Show Sequence

>gi|94420988|gb|ABF18819.1| merozoite surface protein 1 [Plasmodium falciparum]
MLNISQHQCVKKQCPENSGCFRHLDEREECKCLLNYKQEGDKCVENPNPTCNENNGGCDADATCTEEDSG
SSRKKITCECTKPDSYPLFDGIFCSSSNFLGISFLLILMLILYSFI

Molecule Role : Protective antigen
Molecule Role Annotation : Aotus monkeys were challenged with the virulent Vietnam Oak Knoll (FVO) strain of P. falciparum. Vaccination of A. nancymai with yMSP1(19) induced protective immune responses. Both of the A. nancymai vaccinated with yMSP1(19) self-resolved an otherwise lethal infection (Kumar et al., 1995).
Related Vaccine(s): P. falciparum MSP1 from transgenic mice with Freund's adjuvant , P. falciparum vaccine Combination B

17. MSP1 from P. vivax

Gene Name : MSP1 from P. vivax
Sequence Strain (Speices/Organism) : Plasmodium vivax
VO ID : VO_0011230
NCBI Protein GI : 26985160
Other Database IDs : CDD:116083
Taxonomy ID : 5855
Gene Strand (Orientation) : ?
Protein Name : merozoite surface protein 1
Protein Length : 1758
Protein Note : Merozoite surface protein 1 (MSP1) C-terminus; pfam07462

Protein Sequence : Show Sequence

>gi|26985160|gb|AAN86248.1|AF435639_1 merozoite surface protein 1 [Plasmodium vivax]
MKALLFLFSFIFFVTKCQCETESYKQLVAKLDKLEALVVDGYELFHKKKLGESDIQVETNASANNNNNNQ
VSVLTSKIRNFVGKFLELQIPGHTDLLHLIRELAFEPNGIKYLVESYEEFNQLMHVINFHYDLLRAKLHD
MCAHDYCKIPEHLKISDKELDMLKKVVLGYRKPLDNIKDDIGKLETFITKNKITIKNISDLIIAENKKRS
GHPTTTTNGAGTQPANGSIAAASSETTQISGSSNSGSTGHGSSNSGSTGHGSSNSGSSGTGSSNSGSSGT
GSTGNGQSPPATADASSTNANYEAKKIIYQAVYNTIFYTNQLQEAQKLIAVLEKRVKVLKEHKDIKVLLE
KIATEKGKFPNNNLNVENPTDEQKTAKSNIADLEKKIEAIAKTVNFDLDGLFTDAEELEYYLREKAKMAG
TLIIPESTKSAGTPGKTVPTLKETYPHGISYALAENSIYELIEKIGSDETFGDLQNPDDGKQPKKGILIN
ETKRKELLEKIMNKIKIEEDKLPDLKKEYEEKYTVYEQKVKEFQPEFNYFYEARLDNTLVGEKFGEFKKK
REEYMKEKKKLESCSYEQNTNLINKLKKQLTYLEDYVLRKDIADDEIKHFSFMEWKLKSEIYDLAQEIRK
NENKLTIENKFDFSGVVELQVQKVLIIKKIEALKNVQNLLKNAKVKDDLYVPKVYKTGEKPEPYYLMVLK
REIDKLKDFIPKIESMIATEKNKPTVAAADIVAKGQSLRGASETGTTGNTVNAQTAVVQQPQHQVVNAVT
VQPGTTGHQAQGGEAETQTNSVQAAQVQQTPAGAGGQVASTQTTSQAPAPTQASPEPAPAAPPSTPAAAV
APAPAMSKLEYLEKLLDFLKSAYACHKHIFVTNSTMDKKLLKEYELNADEKTKINQNKCDELDLLFNVQN
NLPAMYSIYDSMSNELQNLYIELYQKEMVYNIYKNKDTDKKIKAFLETSNNKAAAPAQSAAKPSGQAGTT
PVTTTAPVTTTTVTPSPQTSVVTSTPPTPQAEENQRVGGNSEEKPEADTAQVEKFYEKHLSQIDKYNDYF
KKFLESKKEEIIKMDDTKWNALGKEIEELKKKLQVSLDHYGKYKLKLERFLKKKNKISNSKDQIKKLTSL
KNKLERRQNLLNNPTSVLKNYTAFFNKKRETEKKEVENTLKNTEILLKYYKARAKYYIGEPFPLKTLSEE
SMQKEDNYLNLEKFRVLSRLEGRLGKNIELEKENISYLSSGLLHVLTELKEIINDKKYSGKDHAKNIAEV
KKALQAYQELIPKVTSQESTSVAVTVPGAVVPGVPTAAAAGSGASGAVPPATGGVVPGVVESAEAQTQTQ
AQDYAEDYDKVIALPLFGNNDDDGEEDQVTTGEAESEAPEILVPAGISDYDVVYLKPLAGMYKTIKKQLE
NHVNAFNTNITDMLDSRLKKRNYFLEVLNSDLNPFKYSSSGEYIIKDPYKLLDLEKKKKLIGSYKYIGAS
IDKDLATANDGVAYYNKMGELYKTHLDGVKTEIKKVEDDIKTHDEKLQKLGSEVSQNSEKTQLNAKKAEL
EKYLPFLNSLQKEYESLVSKVNTYTDNLKKVINNCQLEKKEAEITVKKLQDYNKMDEKLEEYKKSEKKNE
VKSSGLLEKLMKSKLIKENESKEILSQLLNVQTQLLTMSSEHTCIDTNVPDNAACYRYLDGTEEWRCLLT
FKEEGGKCVPASNVTCKDNNGGCAPEAECKMTDSNKIVCKCTKEGSEPLFEGVFCSSSSFLSLSFLLLML
LFLLCMEL

Molecule Role : Protective antigen
Molecule Role Annotation : Immunization of BALB/c mice and Aotus monkeys with PvMSP-1 induced IgG antibodies (titer > 10(6)) that cross-reacted with P. vivax parasites. Immunized monkeys displayed partial protection against a challenge with P. vivax blood stages (Valderrama-Aguirre et al., 2005).

18. MSP1 from P. yoelii str. 17XNL

Gene Name : MSP1 from P. yoelii str. 17XNL
Sequence Strain (Speices/Organism) : Plasmodium yoelii yoelii str. 17XNL
VO ID : VO_0011212
NCBI Gene ID : 3791597
NCBI Protein GI : 82596427
Locus Tag : PY05748
Genbank Accession : AABL01001865
Protein Accession : XP_726257
Taxonomy ID : 352914
Gene Starting Position : 990
Gene Ending Position : 6308
Gene Strand (Orientation) : -
Protein pI : 5.05
Protein Weight : 188296.05
Protein Length : 1772

DNA Sequence : Show Sequence

>ref|NW_863564.3|:990-6308 Plasmodium yoelii yoelii str. 17XNL MALPY01871, whole genome shotgun sequence
TTTAAAATATATTAAATACAATTAATGTGATAATTAATAAAATTGATAATCCCATAAAGCTGGAAGAACT
ACAGAATACACCTTCATAATATGCATTAGGGGTTGGTTCTTTACATGTACATATAATTTTTTTGGAATTT
TCCGTACTTTCCGCATTTTGACAACTAGCAGTTGGATCACATCCACCATTGTTGATATCACAAGTAGGAT
TATTATTTTCTACACATGTATTACCTTCACCTTTTTTGTAACCTAATAAACATCTCCATTCTTCAGTACC
ATTATCATCTCTAAAACATCCAGCATTTTTAGGAATATCTCTTGTATCAACACATACATGTTTAGGGTCT
ACACCTAATAAATCCATACCATCCATGTTAAGCATTTTTGCTAATATTTTCTTTGATTCACCTTCTCCTA
CTAAACCAGATTTATTTAAGTTGTTTAAAGCTATTGAGGCTATGTGTTTATTATTTTCTGCATGTTCTAC
AAATTCGTCAAGTTTTTCGTCAATTTGTATGTATTTTTCTAAATTTTTTGTTAATATTTCAAATTCAGCT
TTTTCATTTTTATAATTATCAAGTCTATTTTGTAATTCTTCTGAATATTCTTCTGCTTGACCTATTACGG
TTTCATATAATCCTTTAAGATCTTCAAGGATTGGAATATATTTCTTTTTTTCTTCTTTATTGGTATCGTT
AGTTTCAGCTTCTATGGTAGCAATTTGTTCCTTTACTGCAGCTAATTGAGTGTTGTATAATTCAACCATT
TTGTTAAAGAATTTAATTCCGTCAGTAGTTGTTTCTATATCTTCATTTATACCTTTAGTAGCATATTTTA
AGTTTACTATTTGTTTGTCTTTTTTATCATTATCTAATAATTGATATGGATTTCTAATAACATATTTGTT
GGTACTTAAATCTTTGAATAAATCTAATTCATGGCTTAATACTTCAAGGAAATCATTTCTTTTTTGTGAT
TTATTATTTAATCCATTTGTCATGTCTTCTTTAATTGTTGAAAATTCTCTTAACATGTGTTTCTTTAATG
ATTTATATGTACTACCCAACCTTTTTGTGTATACATACAAACTTTCATTTGTAAATTCGGAAAGAATATC
TTTTTCTGGTGCATCTTCGGATTGACCACTTGCAATTTGATATATATCATCGTCTTCATTATCATCAACA
CTGCTTCCAGCTACCCGTGTATCGGTTCCTGATCCTGGTACTGCACCTGGTACTGCTCCTGGTACTGCAC
CTGGTACAGCTCCTGGTACTGCTCCTGGTACTGCTCCTTCTGGTGTTGCTGGTGCGTCAGCTGCTAGTGT
CGTTGTAACTGCGACTGCTGGAGTTGAAACTGTTACTCCCTTTGGAAGCAATTCTTTATATTGTTCGAAT
GCATTGGTAACTTCAGGGGCATTATCAGGGTTTTTTTTTCCGGTATAGTCTTTATCTTTTATAAGTTCTT
TAAATTCTTCAAATACGTGGTGTAAACCTCCTGATACATATGAAATTCTTTCCTTTCCTAAATTAATATT
TTTTTTTAATCTTAATTCTAATCGACTGTATGCTCTGAATTTTTCGATTTTCAAATAATTGGATTCTCTG
TCAAGTGATGCTTTAGATAATGTTTTTAAAGGAACAGCTTCAGAAGTAAAATATTTAGTACGAGCTTTGT
AGTATTTTAATAACATATCAGTATTTTTTAATGCATTATCTACATATTGTTTTTCAGCTTCTCTTCTCTT
GTTAAAGAAATTTACATAACCATTTAATATATAAAATACGCCATTAAGAGTTTGTTTTCTTTTTAATAAT
CGTGCTTTCAATATACTAAGATCTCTAATTTGTCGATTGGTTAGTTGAATTTGTTCATGTTTGTTATATA
ATCTTTCTAATTTTAATTTATATGTAGAATAACGATCATAATAATGTTCTGATAATTCCTTTAAGTGAGC
GATTTCAAGATATAATTGATTAACTTTTTCAGGTGTCAATGCTTTTATTAATTCTTTTTTAGATTTTATA
AAATTTATGAATTCAGTATTATTTCCATCAATTTGTTGTAAGTAAGATTTGTATAAATTGTCTAATTCAA
AATCATCGGCAGGCATATCCTCTTCACTTTCTGCTCGTGATCTAATACCTGAGTCAGGGTTTCCTGATTG
AGAATTTGCTGCTGGTGGTTGTGCAGGTGCTGGTGTAGATGTTGATGGTACTGCTGCCGCTGCTGCTGGG
GGTGTTACATCTGAGGTTGTACTTGCGTTAGATGCTGCTGATCCTGATGCTGATGTTCCTGCTGGTGTGG
CTGCGTTAGATGCTGTTGCTCCTTCTGTTCCTGATGCTCCTGCTTCTCCTGATGGTGTACCTTCGCCAGG
TGCTGATGATGATGCTTCTGTTGAGGTTGTTACCTCTGGTGTCGTGGATGTTACTGGTGTTTCTGGTTGT
TGCGAGACATCTGATGGTGCTGGTGCATCTGATTGTACATCAGGTGTTGCTTGTTGTTGTTGTTGTTCTG
TTGCTGCTGGAGTTACTGGTGTTGGTGCTGCTACTGGTTCTGGTTCAATGACGCCAGCTTTTACCAATAA
AGATTTAATAGATGGGTTTTCATCTTTTAATTTATATATATGATACATCATTTCTTTTTCATATAATTCA
GTATAAATGTTTTGTAAACCATCAACTATACTTTCATAAAGTGAATACATAGTAGGCATATTATTTTGAA
TAGCTAATAATACATCTAATTCACTGCATCTTTTTAATGTTCTTATTTTATCTTCTTCAGATGTAAGAGC
ATATTTGCTTAAAGCATCTTTGTTTATGGTAGAGTTTTGTAGTAAAACGTATTTATGGCATGAATATGAG
AATACTAAAAATTTTTGTAATTTTTCAAGATAATATAATTTTGTCATAACTGGTTTTGCAGGTGTTGTGG
ATGATGCAGCTTGTGATGGTTGTGTTTCTTGTGTGGTAGGGGGTATTGTTGTTTCTTCTGATGCTTCTGT
TGATGGGGATGCTGCTTCTGCTGGTGCGGGTGCTTCTGGTAATGTGGCTGAGGAGGATTCTGCTGCTGCT
GGGGTTGAAGATGAGGATGAGGATGAGGATGTTGAAGATTGTGTTGATCTATCTGTTGATGATTCAGCAC
TAGGGCCAGATGGTACTTCTTCAGATTCTCCAGTAATTGCAGGTCCTTGTTCCATTCTTTCCTTCTCTTT
AGCAATCATACTTTCGATTTTTGGAATAAATTGGGCAAGTCTGTCAACTTCTTTTTTTACAGCTATTAAA
TAGTATGGTTCTGGTTTTCCTTCATTACCGTATGTTTTTGGAACATATAGTTTGTCTTTTAATTGAGCTT
TGTTTAAAGATACTTCAGTTTTATTTAATTGCTCAATTTGTTTTGTTAATAAAGATTTTTGTATTTGCAA
TTCTACAAGTGTTGAAAGTGGTACATCTTTTGATGCAACTAATACATTTTGTTTTGCTTGAACAGCTTCT
GCTAATCTATTAATATTATATTGTAATTCTTTTTTTTTATTTGAAAAATATTCAATTTCATTACTAATTA
TATCTTTTCTTAATGAATAATCTTGTAAATAATTAAGTTGTTTATTTAATTTATTAATTAATTCTTTAGT
ATTTCCATATTCACAAGTGTTTAATTCGGTTTTCTTGGTCATATATTCATCTCTTTTTGTTTTGAATTTT
TCAAAAATTTCAGAAGTCAATTTATTTCTAAATTTTGATTCATAAAATTCTTTAGCTGCTTCTTTGAATG
GAGTTTTTTGTTGATTAAATTCTGTAAGTTTATTATCATAATTCGTTTTTAATGTTTCTAATTTTTTTTC
TTCTGCTTTTATTTTCTTTTTAATAGCTTTTATTAGATCTTTTCTGGCTTGTTCATTTGTGGCTAAATCT
CCTGTTAATGGTGTATTATCGGGATGTGTCAAATCACCATATGTTGTTTCAGCGGCATTATTGGCAATTT
TATTGTAAACATCATTTTCAGGTAATGGGTAACTAATACCATTTGGATAACGTATAGTTAATGGTATTAT
AGTTTCGGATGCTTTATTTTTTTTACAGGATGAAGTTGATAAATTGCAACTTTCTTTTTTTTTTTCTTTT
TTGAAATATTCTAATTCGATTGGATCTACAAATATTCCTTCTAAGTTGAATTTTATAGTTTTTGCAATTT
CTTTAATTTGAGCATAAAGTCCGGCTATTTTTTTCTGTTTTTCTTCTAATGTAAGAGTTGGAACGGGTTG
CACTTGAGCTGTTTGTGGATTAGTTGATGCTTCACCATTTTGTCCTACACTAGGTGTTACTGTAACAGAT
GCTACAGTGTTAGCTTGTTCTACACCTGTTCCTGCACTAGCTTGTCCTGATGAACTTGTTCCCGATGCAC
TTGATCCACCACTACCTGGTTCTGTACTAGATTGTCCTCCTGTAACTATTTGTGTTTCGGCAGTGACGAC
GGGGGCAGCATTGAGAACTTCAATTTGTTGCCATAATGGTTTGATGGCATCATTTTTCTTTAATGTAGAA
ACTCGTTTTTCTAAGACTTCGACAACCTTTTGTATTTCAGCTAATTGTTTTTTGTAAAATATAACATTGT
ACATAGCTTGGTATATTGGTTTTTTTTTATTATATTTATCGCTATCACAACTAGCGTCATTGCAATCTTC
GTTACCTTCAGGTTGTATTTTTTTTGTTTCTTCAGCAATAAGAGCGTTTAAAGCTGCAACAGTTTCTTTA
TTTCTTTCTATGTAAATTTCTAACTTTTCAATATCGTCTTGAATATTTTCTATTGGTTTTCTATAACCTA
AAATTACTTTTTTAAGCATTTCTGTTTCTTCTTCACTAATTTTAAGATGTTCAGGAATTTCACAATAATT
ATTTGCACACATATCATTTAATTTATCTCTAAGTACATCATAATAAAAATTTATTGCGTGCATTAATCCA
TTAAATTCTTCTTTACTTTCAATTAAATATTTTACTCCATATCTATTTGGGGTTAATGCTTTTATTAAAT
TGACTAATTCTGTTTGTTCTGTAAATCCTAATCCTTCAAATTTTGTAACAAAATCTTGTACTTGTTGTGC
AAAGTTATGATTTGTAAATGGATCAATAGTTTCAGTTGGTTGTGTTGCATTTATAATTACTTGACTTTTT
TGAAATAGTTCTAACCCATCCACTGACAATGATTCTAATTTTTCTAACTTTTGAATGAGATCATTATAAA
CTTCAATTGTTTCAGATTTGCATTTTATAGCAAAAAAAACGAAAGAAAATAAAAGTCCAATCACCTTCA

Protein Sequence : Show Sequence

>gi|82596427|ref|XP_726257.1| merozoite surface protein 1 precursor [Plasmodium yoelii yoelii str. 17XNL]
MKVIGLLFSFVFFAIKCKSETIEVYNDLIQKLEKLESLSVDGLELFQKSQVIINATQPTETIDPFTNHNF
AQQVQDFVTKFEGLGFTEQTELVNLIKALTPNRYGVKYLIESKEEFNGLMHAINFYYDVLRDKLNDMCAN
NYCEIPEHLKISEEETEMLKKVILGYRKPIENIQDDIEKLEIYIERNKETVAALNALIAEETKKIQPEGN
EDCNDASCDSDKYNKKKPIYQAMYNVIFYKKQLAEIQKVVEVLEKRVSTLKKNDAIKPLWQQIEVLNAAP
VVTAETQIVTGGQSSTEPGSGGSSASGTSSSGQASAGTGVEQANTVASVTVTPSVGQNGEASTNPQTAQV
QPVPTLTLEEKQKKIAGLYAQIKEIAKTIKFNLEGIFVDPIELEYFKKEKKKESCNLSTSSCKKNKASET
IIPLTIRYPNGISYPLPENDVYNKIANNAAETTYGDLTHPDNTPLTGDLATNEQARKDLIKAIKKKIKAE
EKKLETLKTNYDNKLTEFNQQKTPFKEAAKEFYESKFRNKLTSEIFEKFKTKRDEYMTKKTELNTCEYGN
TKELINKLNKQLNYLQDYSLRKDIISNEIEYFSNKKKELQYNINRLAEAVQAKQNVLVASKDVPLSTLVE
LQIQKSLLTKQIEQLNKTEVSLNKAQLKDKLYVPKTYGNEGKPEPYYLIAVKKEVDRLAQFIPKIESMIA
KEKERMEQGPAITGESEEVPSGPSAESSTDRSTQSSTSSSSSSSSTPAAAESSSATLPEAPAPAEAASPS
TEASEETTIPPTTQETQPSQAASSTTPAKPVMTKLYYLEKLQKFLVFSYSCHKYVLLQNSTINKDALSKY
ALTSEEDKIRTLKRCSELDVLLAIQNNMPTMYSLYESIVDGLQNIYTELYEKEMMYHIYKLKDENPSIKS
LLVKAGVIEPEPVAAPTPVTPAATEQQQQQATPDVQSDAPAPSDVSQQPETPVTSTTPEVTTSTEASSSA
PGEGTPSGEAGASGTEGATASNAATPAGTSASGSAASNASTTSDVTPPAAAAAVPSTSTPAPAQPPAANS
QSGNPDSGIRSRAESEEDMPADDFELDNLYKSYLQQIDGNNTEFINFIKSKKELIKALTPEKVNQLYLEI
AHLKELSEHYYDRYSTYKLKLERLYNKHEQIQLTNRQIRDLSILKARLLKRKQTLNGVFYILNGYVNFFN
KRREAEKQYVDNALKNTDMLLKYYKARTKYFTSEAVPLKTLSKASLDRESNYLKIEKFRAYSRLELRLKK
NINLGKERISYVSGGLHHVFEEFKELIKDKDYTGKKNPDNAPEVTNAFEQYKELLPKGVTVSTPAVAVTT
TLAADAPATPEGAVPGAVPGAVPGAVPGAVPGAVPGSGTDTRVAGSSVDDNEDDDIYQIASGQSEDAPEK
DILSEFTNESLYVYTKRLGSTYKSLKKHMLREFSTIKEDMTNGLNNKSQKRNDFLEVLSHELDLFKDLST
NKYVIRNPYQLLDNDKKDKQIVNLKYATKGINEDIETTTDGIKFFNKMVELYNTQLAAVKEQIATIEAET
NDTNKEEKKKYIPILEDLKGLYETVIGQAEEYSEELQNRLDNYKNEKAEFEILTKNLEKYIQIDEKLDEF
VEHAENNKHIASIALNNLNKSGLVGEGESKKILAKMLNMDGMDLLGVDPKHVCVDTRDIPKNAGCFRDDN
GTEEWRCLLGYKKGEGNTCVENNNPTCDINNGGCDPTASCQNAESTENSKKIICTCKEPTPNAYYEGVFC
SSSSFMGLSILLIITLIVFNIF

Molecule Role : Protective antigen
Molecule Role Annotation : Researchers found that the cysteine-rich, carboxyl-terminal region of the MSP-1 protein from the rodent malarial parasite Plasmodium yoelii yoelii can be expressed in a native configuration as a fusion protein in Escherichia coli. This recombinant polypeptide elicits antibodies in mice which recognize the native parasite MSP-1. Most significantly, both inbred and outbred mice immunized with the fusion protein in Ribi adjuvant are partially and in some cases completely protected against challenge infection with an otherwise lethal parasite strain (Daly and Long, 1993).

19. MSP3

Gene Name : MSP3
Sequence Strain (Speices/Organism) : Plasmodium falciparum
VO ID : VO_0011220
NCBI Protein GI : 113207288
Other Database IDs : CDD:148630
InterPro: IPR010784
UniProtKB/TrEMBL: Q0KGB6
Taxonomy ID : 5833
Gene Strand (Orientation) : ?
Protein Name : merozoite surface protein 3
Protein Length : 304
Protein Note : Merozoite surface protein (SPAM); pfam07133

Protein Sequence : Show Sequence

>gi|113207288|emb|CAJ44236.1| merozoite surface protein 3 [Plasmodium falciparum]
SKEIVKKYNLNLRNAILNNNSQIENEENVNTTITGNDFSGGEFLWPGYTEELKAKKASEDAEKAANDAEN
ASKEAEEAAKEAVNLKESDKSYTKAKEACTAASKAKKAVETALKAKDDAEKSSKADSISTKTKEYAEKAK
NAYEKAKNAYQKANQAVLKAKEASSYDYILGWEFGGGVPEHKKEENMLSHLYVSSKDKENISKENDDVLD
EKEEEAEETEEEELEEKNEEETESEISEDEEEEEEEEEKEEENDKKKEQEKEQSNENNDQKKDMEAQNLI
SKNQNNNEKNVKEAAESIMKTLAG

Molecule Role : Protective antigen
Molecule Role Annotation : Immunization with a recombinant yeast-expressed Plasmodium falciparum merozoite surface protein 3 (MSP3) protected Aotus nancymai monkeys against a virulent challenge infection (Tsai et al., 2009).
Related Vaccine(s): P. falciparum MSP3 Protein Subunit Vaccine

20. MSP4/5

Gene Name : MSP4/5
Sequence Strain (Speices/Organism) : Plasmodium yoelii
VO ID : VO_0011236
NCBI Protein GI : 49798469
Taxonomy ID : 73239
Gene Strand (Orientation) : ?
Protein Name : merozoite surface protein 4/5
Protein Length : 171

Protein Sequence : Show Sequence

>gi|49798469|gb|AAT68597.1| merozoite surface protein 4/5 [Plasmodium yoelii yoelii]
VHEISLINTKKYQRNIFCAKRILGDPPSANPSTSLNQNEDNHNSNPDANKGNTNKSDKLNGDNIPNSQSK
SENTNLSESPKTGTASNPPQPEPSVQPGNTNGDSQNSIHSDDEEEDDEDEDDDEEDCSVNNGGCGENLLC
EKMESGIIKCSCPSGYKLNGTSCIELLSAHS

Molecule Role : Protective antigen
Molecule Role Annotation : Oral immunization of mice with Escherichia coli-expressed Plasmodium yoelii merozoite surface protein 4/5 or the C-terminal 19-kDa fragment of merozoite surface protein 1 induced systemic antibody responses and protected mice against lethal malaria infection (Wang et al., 2004).
Related Vaccine(s): P. yoelii MSP1 and MSP4/5 Proteins Subunit Vaccine

21. MSP8

Gene Name : MSP8
Sequence Strain (Speices/Organism) : Plasmodium yoelii
VO ID : VO_0011221
NCBI Protein GI : 58197887
Taxonomy ID : 5861
Gene Strand (Orientation) : ?
Protein Name : merozoite surface protein 8
Protein Length : 409

Protein Sequence : Show Sequence

>gi|58197887|gb|AAW65717.1| merozoite surface protein 8 [Plasmodium yoelii]
MKKSSQIIIFLLLSLFCKFSIGNCNENGNGNINKANNNSIIRKERKRKSKSDFSKGEPENKEHEIINLYD
DVQELLGPDEMNMLDKYSILGIDDCSNENENNKIISEYDLKAMKSVLLYKNRISRASINNLDDVKTVFKR
CFNKDDPELSKSYEQIQNQVANEGTTIIDYLSNYISNIYIKINDEFVKNEEFQLSKYIPELEIINYVLYN
GPKEIGNKIKNELIEINNLIISESLTSIYSSVVSGLNINCKIKDDLITILNLANGKYFKVNFSSQATMII
PEQYSHESEHMKKISEYFIEKNRVCKNENCPINSNCYVIDSVETCRCIPGFSKNEESENLECLINESTSC
ENNNGGCDVNANCILLEDKIMCECNNKFNGDGIYCSSAIYYGMNVFIFFLISIVCIYIM

Molecule Role : Protective antigen
Molecule Role Annotation : Immunization with Plasmodium yoelii merozoite surface protein (PyMSP)-8 protects mice from lethal malaria but does not prevent infection (Petritus and Burns, 2008).

22. PF10_0155 enolase

Gene Name : PF10_0155 enolase
Sequence Strain (Speices/Organism) : Plasmodium falciparum 3D7
VO ID : VO_0011223
NCBI Gene ID : 810313
NCBI Protein GI : 124802328
Locus Tag : PF10_0155
Genbank Accession : AE014185
Protein Accession : XP_001347440
Taxonomy ID : 36329
Chromosome No : 10
Gene Starting Position : 636945
Gene Ending Position : 639469
Gene Strand (Orientation) : +
Protein pI : 6.54
Protein Weight : 45501.97
Protein Length : 446

DNA Sequence : Show Sequence

>ref|NC_004314.2|:636945-639469 Plasmodium falciparum 3D7 chromosome 10, complete sequence
AAATTAAAAAAAATTCTATTATACTTTCCAAAATTAAAATTATTATAAATTTTATAATTCTCTCTTTTGT
AATATTTTATTTTCTTAATATAATATTTTTTTAATATTCATTCTTATAAAAAAACTTTATATTCCTTTTA
TATTATTTTATTTTAAATAAAATATAAACATATTATACTTACTTTAAAAAAAATGGCTCATGTAATAACT
CGTATTAATGCCCGTGAAATTTTAGGTATAGATATTTTAATGTTATATATTTTTTCACTTTGTATATAAA
TACCTTATTATATGTTTTTAAATAAATGTATATTCAAAGAGCTATATTCATTTTTAACTTTTTTTATTTT
ATATTATAAGAATGAATATGATAGATAAATAAAGATATATATATTATATATATATATATATATATATATT
TATTTATTTATTTATTTATACATTAATGTATTAATATGTTTATTTTATGAATCCACGTGATATTTCTTTA
TGAATATGTATTCTATAGTTAACATATAATAATACATACGTATATAATAAGAATAACATAAGAATAAAAT
TTTTTTTTATTTTTTTTTTTGTAATACAATAATTTTTTTGTGTATCATTTTATTTTATTTTATTTTTAAT
ATCTGAACATATATAATTAAATGTGAAAATTATTTACAATATATATATATATATATATATATATATATAT
ATGTTACATTATTACTAATATCTGTATTTTATTTATTTTCTGTTGTTATATATTTTTTTTATATATAGAT
TCTAGAGGAAACCCAACTGTAGAAGTTGACTTAGAGACCAACTTAGGTATTTTCAGAGCTGCCGTACCAT
CTGGTGCCTCCACTGGTATTTATGAAGCCTTAGAATTAAGAGATAATGACAAGAGCAGGTACTTAGGAAA
GGGTGTTCAAAAAGCTATCAAGAACATTAATGAAATTATTGCTCCAAAATTGATTGGAATGAATTGTACT
GAACAAAAGAAAATTGACAATTTAATGGTTGAAGAATTAGATGGAAGTAAAAATGAATGGGGATGGTCAA
AAAGTAAATTAGGAGCTAATGCTATTTTAGCTATATCCATGGCTGTATGTAGAGCTGGTGCAGCTGCTAA
TAAAGTATCTTTATACAAATATTTGGCACAATTAGCTGGAAAGAAAAGTGACCAAATGGTATTACCAGTA
CCTTGTTTAAACGTTATCAATGGAGGATCCCATGCAGGAAACAAATTATCTTTCCAAGAATTTATGATAG
TGCCAGTTGGTGCTCCATCATTTAAAGAAGCCTTAAGATATGGTGCTGAAGTATATCATACCTTAAAATC
AGAAATTAAAAAGAAATATGGTATTGATGCAACCAATGTAGGTGATGAAGGTGGATTTGCTCCAAATATA
TTAAACGCTAATGAAGCTCTTGATTTATTAGTAACTGCCATTAAATCAGCTGGTTATGAAGGAAAGGTTA
AAATTGCTATGGATGTTGCAGCTTCTGAATTTTACAACAGTGAAAACAAAACATACGATTTAGATTTCAA
AACTCCAAATAATGACAAATCATTAGTTAAGACTGGAGCTCAATTAGTTGACTTATACATTGATTTAGTA
AAGAAATATCCAATTGTTTCTATTGAAGATCCATTTGATCAAGATGATTGGGAAAATTATGCTAAATTAA
CAGCAGCTATTGGAAAGGATGTTCAAATTGTTGGTGATGATTTATTAGTTACAAACCCAACCAGAATTAC
TAAAGCTCTTGAAAAAAATGCTTGCAATGCTTTACTTCTTAAAGTTAACCAAATCGGTTCTATTACTGAA
GCTATTGAAGCTTGCTTATTATCTCAAAAAAATAACTGGGGTGTTATGGTTTCTCACAGATCTGGTGAAA
CCGAAGATGTTTTTATTGCTGATTTAGTTGTTGCTTTAAGAACCGGACAAATCAAAACAGGAGCACCATG
CAGAAGTGAAAGAAACGCCAAATATAACCAATTATTAAGAATTGAAGAATCTTTAGGAAACAATGCTGTT
TTTGCTGGAGAAAAATTTAGATTACAATTAAATTAAAAAATATAATAAAGTAAAATTTATATATTTATAT
ATTTATATATTTCTTTATTTTATATATATATATATAATATATATAATTTATATGTTAAAAGAGAGAATTA
TAATATAAAATGCATATAAAAAAATATGTTCTTTTGTAATATATATATATATATATATTTATATATTTAT
GTGTGTATTTCTTTTATGCATGTATAAATTTTAATTAAGAGAAAGTAGGTATTAATTTTATATTTTGACC
TTTTTTTTATAAACTTATAACAAAACATATGATTAAACTGTACAAGAAAAATATAACATTTTGCACAATA
CTTATACATTTTACGTGCATATATATATATGTATATATTATATATTTACGTATGTCGAACGTTATTTTGA
ACAACCTTTTGTGATAAATCTTTCATTTGTTTTAATAACCTTCGGAATATTTAATACTATCATACAATTA
AAGAG

Protein Sequence : Show Sequence

>gi|124802328|ref|XP_001347440.1| enolase [Plasmodium falciparum 3D7]
MAHVITRINAREILDSRGNPTVEVDLETNLGIFRAAVPSGASTGIYEALELRDNDKSRYLGKGVQKAIKN
INEIIAPKLIGMNCTEQKKIDNLMVEELDGSKNEWGWSKSKLGANAILAISMAVCRAGAAANKVSLYKYL
AQLAGKKSDQMVLPVPCLNVINGGSHAGNKLSFQEFMIVPVGAPSFKEALRYGAEVYHTLKSEIKKKYGI
DATNVGDEGGFAPNILNANEALDLLVTAIKSAGYEGKVKIAMDVAASEFYNSENKTYDLDFKTPNNDKSL
VKTGAQLVDLYIDLVKKYPIVSIEDPFDQDDWENYAKLTAAIGKDVQIVGDDLLVTNPTRITKALEKNAC
NALLLKVNQIGSITEAIEACLLSQKNNWGVMVSHRSGETEDVFIADLVVALRTGQIKTGAPCRSERNAKY
NQLLRIEESLGNNAVFAGEKFRLQLN

Molecule Role : Protective antigen
Molecule Role Annotation : Mice immunized with r-Pfen (recombinant P. falciparum enolase protein) showed protection against a challenge with the 17XL lethal strain of the mouse malarial parasite Plasmodium yoelii (Pal-Bhowmick et al., 2007).
Related Vaccine(s): P. falciparum Pfen Protein Subunit Vaccine

23. Pvs25

Gene Name : Pvs25
Sequence Strain (Speices/Organism) : P. vivax SouthernMex-62 isolate
VO ID : VO_0010957
Other Database IDs : EU024472.1; GI:154184258
Taxonomy ID : 5855
Gene Strand (Orientation) : ?

DNA Sequence : Show Sequence

>gi|154184258:1-660 Plasmodium vivax isolate SouthernMex-62 ookinete surface protein (Pvs25) gene, complete cds
ATGAACTCCTACTACAGCCTCTTCGTTTTTTTCCTCGTCCAAATTGCGCTAAAGTATAGCAAGGCAGCCG
TCACGGTAGACACCATATGCAAAAATGGACAGCTGGTTCAAATGAGTAACCACTTTAAGTGTATGTGTAA
CGAAGGGCTGGTGCACCTTTCCGAAAATACATGTGAAGAAAAAAATGAATGCAAGAAAGAAACCCTAGGC
AAAGCATGCGGGGAATTTGGCCAGTGTATAGAAAACCCAGACCCAGCAAAGGTAAACATGTACAAATGTG
GTTGCATTGAGGGCTACACTTTGAAGGAAGACACTTGTGTGCTTGATGTATGTCAATACAAAAATTGTGG
AGAAAGTGGCGAATGCATTGTTGAGTACCTCTCGGAAACCCAAAGTGCAGGTTGCTCATGTGCTATTGGC
AAAGTCCCCAATCCAGAAGATGAGAAAAAATGTACCAAAACGGGAGAAACTGCTTGTCAATTGAAATGTA
ACACAGATAATGAAGTCTGCAAAAATGTTGAAGGAGTTTACAAGTGCCAGTGTATGGAAGGCTTTACGTT
CGACAAAGAGAAAAATGTATGCCTTTCCTATTCTGTATTTAACATCCTAAACTACTCCCTCTTCTTTATC
ATCCTGCTTGTCCTTTCGTACGTCATATAA

Protein Sequence : Show Sequence

>gi|154184259|gb|ABS70957.1| ookinete surface protein [Plasmodium vivax]
MNSYYSLFVFFLVQIALKYSKAAVTVDTICKNGQLVQMSNHFKCMCNEGLVHLSENTCEEKNECKKETLG
KACGEFGQCIENPDPAKVNMYKCGCIEGYTLKEDTCVLDVCQYKNCGESGECIVEYLSETQSAGCSCAIG
KVPNPEDEKKCTKTGETACQLKCNTDNEVCKNVEGVYKCQCMEGFTFDKEKNVCLSYSVFNILNYSLFFI
ILLVLSYVI

Molecule Role : Protective antigen
Related Vaccine(s): P. vivax PVS25 with Montanide ISA-720

24. RESA

Gene Name : RESA
VO ID : VO_0010959
Gene Strand (Orientation) : ?
Protein Name : RESA, ring-infected erythrocyte surface antigen, Pf155, MAL1P1.13
Protein Note : PlasmoDB:PFA0110w; EMBL: AL031745; UniProt: Q8I0U6_PLAF7

DNA Sequence : Show Sequence

>PFA0110w |RESA|Pf155|ring-infected erythrocyte surface antigen|Plasmodium falciparum|chr 1|SANGER|unspliced DNA
ATGAGACCTT TTCATGCATA TAGTTGGATT TTTTCTCAAC AATATATGGA TACAAAAAAT
GTTAAGGAAA AAAATCCCAC CATATATTCA TTTGATGATG AAGAAAAAAG AAATGAAAAT
AAGAGCTTTT TAAAGGTGTT GTGTTCTAAA CGTGGTGTTC TTCCAATTAT TGGAATACTA
TATATCATTT TAAATGTAAG TTTTTTTTTT TTTTTTTTTT TTTGAAATAA AATACATATT
TTTTATATTT AATTTTTTAT GTTAATGCTT ATTTTATTTT ATTCTATTCT TTTTTATATG
TCATGCATAT TTTATATATT ATAATACCGT TTTTAATAAT ATATAATATA TCTTTGTTAT
TATATATAAT TTTTTTTTTT TTTTTTTTTT TTTTTTCATA GGGTAATCTT GGATATAATG
GAAGTTCATC TTCTGGCGTA CAATTTACTG ATAGATGTTC AAGAAATTTA TACGGGGAAA
CATTGCCAGT AAACCCATAT GCTGATTCTG AAAACCCAAT AGTTGTAAGT CAGGTATTTG
GTTTACCCTT CGAAAAACCT ACGTTTACCT TAGAAAGTCC TCCTGATATT GATCATACAA
ATATTTTGGG TTTTAATGAG AAGTTCATGA CTGATGTAAA TAGATATCGA TATTCTAATA
ACTATGAAGC CATTCCTCAT ATAAGTGAGT TCAATCCACT TATTGTAGAT AAAGTTCTTT
TCGACTATAA CGAAAAGGTT GATAACTTAG GAAGAAGTGG AGGAGACATT ATAAAAAAAA
TGCAAACTTT ATGGGATGAA ATAATGGATA TTAATAAAAG AAAATATGAT TCTTTAAAAG
AAAAATTACA GAAAACTTAC AGTCAGTACA AGGTTCAATA TGATATGCCA AAAGAAGCAT
ATGAGAGCAA ATGGACACAA TGCATAAAAC TTATTGATCA AGGAGGAGAG AACCTTGAAG
AAAGATTGAA CTCACAATTT AAAAACTGGT ACAGGCAGAA ATATTTAAAT CTTGAAGAAT
ATAGAAGATT GACTGTGTTG AACCAAATCG CTTGGAAAGC TTTATCCAAC CAAATTCAAT
ATTCATGCAG AAAAATTATG AATAGTGACA TTTCTTCCTT TAAACATATA AATGAATTGA
AAAGTTTAGA ACACAGAGCC GCAAAAGCTG CAGAAGCAGA AATGAAGAAA AGAGCTCAAA
AACCGAAGAA GAAAAAAAGT AGAAGAGGAT GGTTATGTTG TGGGGGGGGA GATATCGAAA
CAGTTGAACC ACAACAAGAA GAACCAGTCC AAACCGTTCA AGAACAACAA GTAAATGAAT
ATGGTGATAT ATTACCATCA TTAAGGGCCA GTATTACTAA TTCAGCTATT AATTATTATG
ATACCGTAAA AGATGGTGTA TACTTAGACC ATGAAACATC AGATGCTCTT TATACAGATG
AAGATTTGTT ATTTGATTTG GAAAAACAAA AATATATGGA TATGTTAGAT ACATCTGAAG
AAGAATCTGT TAAAGAAAAT GAAGAAGAAC ACACTGTTGA TGATGAACAT GTAGAAGAAC
ACACTGCTGA TGACGAACAT GTAGAAGAAC CAACTGTTGC TGATGATGAA CATGTAGAAG
AACCAACTGT TGCTGATGAA CACGTAGAAG AACCAACTGT TGCTGAAGAA CATGTAGAAG
AACCAACTGT TGCTGAAGAA CACGTAGAAG AACCAGCTAG TGATGTTCAA CAAACTTCAG
AAGCAGCTCC AACAATTGAA ATCCCCGATA CATTATATTA CGATATATTA GGTGTTGGTG
TTAATGCTGA TATGAACGAA ATTACTGAAC GTTATTTTAA GTTAGCTGAA AATTACTATC
CATACCAAAG ATCAGGTTCT ACTGTTTTCC ACAACTTTAG GAAAGTCAAC GAAGCCTACC
AAGTTTTAGG AGATATTGAT AAAAAAAGAT GGTACAATAA ATACGGATAT GATGGAATAA
AACAAGTCAA CTTTATGAAT CCATCCATCT TTTATTTATT ATCTAGTTTA GAAAAATTTA
AAGATTTTAC CGGAACACCC CAAATAGTAA CTCTTTTGAG ATTCTTTTTT GAAAAGAGAT
TATCTATGAA TGATTTAGAG AATAAAAGTG AACATTTATT AAAATTTATG GAACAATATC
AAAAAGAAAG AGAAGCACAT GTATCTGAAT ATTTATTAAA TATATTACAA CCATGTATAG
CTGGTGATTC AAAATGGAAT GTACCAATTA TAACAAAACT TGAAGGTTTA AAAGGATCTC
GCTTTGATAT ACCAATATTA GAATCTTTAA GATGGATATT CAAACATGTC GCTAAAACAC
ATTTGAAAAA ATCCTCAAAA TCAGCTAAGA AACTTCAACA GAGAACCCAG GCTAATAAAC
AAGAATTAGC AAATATAAAT AATAACCTAA TGAGTACATT GAAAGAATAT GTAGGAAGTA
GTGAACAAAT GAATTCAATA ACATACAATT TCGAAAACAT CAATTCCAAT GTTGATAACG
GAAACCAATC AAAAAATATT TCAGATTTAA GTTATACAGA TCAGAAGGAA ATATTAGAAA
AAATTGTTAG TTATATAGTA GATATTTCCC TTTATGATAT AGAGAACACA GCTTTAAATG
CCGCTGAACA ATTGTTGTCA GATAATTCAG TAGATGAAAA AACTCTTAAA AAGAGAGCTC
AATCATTAAA AAAATTATCA TCCATTATGG AGAGATATGC AGGTGGTAAA AGAAACGATA
AAAAAGCAAA AAAATATGAT ACCCAAGATG TTGTAGGATA TATTATGCAT GGAATTAGCA
CAATTAATAA AGAAATGAAA AACCAAAATG AAAATGTACC CGAACATGTA CAACATAATG
CTGAAGCAAA TGTAGAACAT GATGCTGAAG AAAATGTAGA ACATGATGCT GAAGAAAATG
TTGAAGAAAA TGTAGAAGAA AATGTAGAAG AAAATGTAGA AGAAAATGTA GAAGAAAATG
TAGAAGAAAA TGTAGAAGAA AATGTAGAAG AAAATGTAGA AGAAAATGTT GAAGAAAATG
TAGAAGAAAA TGTTGAAGAA AATGTAGAAG AAAATGTAGA AGAAAATGTT GAAGAATATG
ATGAAGAAAA TGTTGAAGAA GTAGAAGAAA ATGTTGAAGA ATATGATGAA GAAAATGTTG
AAGAAGTAGA AGAAAATGTA GAAGAAAATG TAGAAGAAAA TGTAGAAGAA AATGTTGAAG
AATATGATGA AGAAAATGTT GAAGAAGTAG AAGAAAATGT AGAAGAAAAT GTAGAAGAAA
ATGTTGAAGA AAATGTAGAA GAAAATGTTG AAGAAGTAGA AGAAAATGTA GAAGAAAATG
TAGAAGAAAA TGTAGAAGAG AATGTTGAAG AGAATGTTGA AGAGAATGTT GAAGAATATG
ATGAAGAAAA TGTTGAAGAA CACAATGAAG AATATGATGA ATAA

>PFA0110w |RESA|Pf155|ring-infected erythrocyte surface antigen|Plasmodium falciparum|chr 1|SANGER|Spliced DNA
ATGAGACCTT TTCATGCATA TAGTTGGATT TTTTCTCAAC AATATATGGA TACAAAAAAT
GTTAAGGAAA AAAATCCCAC CATATATTCA TTTGATGATG AAGAAAAAAG AAATGAAAAT
AAGAGCTTTT TAAAGGTGTT GTGTTCTAAA CGTGGTGTTC TTCCAATTAT TGGAATACTA
TATATCATTT TAAATGGTAA TCTTGGATAT AATGGAAGTT CATCTTCTGG CGTACAATTT
ACTGATAGAT GTTCAAGAAA TTTATACGGG GAAACATTGC CAGTAAACCC ATATGCTGAT
TCTGAAAACC CAATAGTTGT AAGTCAGGTA TTTGGTTTAC CCTTCGAAAA ACCTACGTTT
ACCTTAGAAA GTCCTCCTGA TATTGATCAT ACAAATATTT TGGGTTTTAA TGAGAAGTTC
ATGACTGATG TAAATAGATA TCGATATTCT AATAACTATG AAGCCATTCC TCATATAAGT
GAGTTCAATC CACTTATTGT AGATAAAGTT CTTTTCGACT ATAACGAAAA GGTTGATAAC
TTAGGAAGAA GTGGAGGAGA CATTATAAAA AAAATGCAAA CTTTATGGGA TGAAATAATG
GATATTAATA AAAGAAAATA TGATTCTTTA AAAGAAAAAT TACAGAAAAC TTACAGTCAG
TACAAGGTTC AATATGATAT GCCAAAAGAA GCATATGAGA GCAAATGGAC ACAATGCATA
AAACTTATTG ATCAAGGAGG AGAGAACCTT GAAGAAAGAT TGAACTCACA ATTTAAAAAC
TGGTACAGGC AGAAATATTT AAATCTTGAA GAATATAGAA GATTGACTGT GTTGAACCAA
ATCGCTTGGA AAGCTTTATC CAACCAAATT CAATATTCAT GCAGAAAAAT TATGAATAGT
GACATTTCTT CCTTTAAACA TATAAATGAA TTGAAAAGTT TAGAACACAG AGCCGCAAAA
GCTGCAGAAG CAGAAATGAA GAAAAGAGCT CAAAAACCGA AGAAGAAAAA AAGTAGAAGA
GGATGGTTAT GTTGTGGGGG GGGAGATATC GAAACAGTTG AACCACAACA AGAAGAACCA
GTCCAAACCG TTCAAGAACA ACAAGTAAAT GAATATGGTG ATATATTACC ATCATTAAGG
GCCAGTATTA CTAATTCAGC TATTAATTAT TATGATACCG TAAAAGATGG TGTATACTTA
GACCATGAAA CATCAGATGC TCTTTATACA GATGAAGATT TGTTATTTGA TTTGGAAAAA
CAAAAATATA TGGATATGTT AGATACATCT GAAGAAGAAT CTGTTAAAGA AAATGAAGAA
GAACACACTG TTGATGATGA ACATGTAGAA GAACACACTG CTGATGACGA ACATGTAGAA
GAACCAACTG TTGCTGATGA TGAACATGTA GAAGAACCAA CTGTTGCTGA TGAACACGTA
GAAGAACCAA CTGTTGCTGA AGAACATGTA GAAGAACCAA CTGTTGCTGA AGAACACGTA
GAAGAACCAG CTAGTGATGT TCAACAAACT TCAGAAGCAG CTCCAACAAT TGAAATCCCC
GATACATTAT ATTACGATAT ATTAGGTGTT GGTGTTAATG CTGATATGAA CGAAATTACT
GAACGTTATT TTAAGTTAGC TGAAAATTAC TATCCATACC AAAGATCAGG TTCTACTGTT
TTCCACAACT TTAGGAAAGT CAACGAAGCC TACCAAGTTT TAGGAGATAT TGATAAAAAA
AGATGGTACA ATAAATACGG ATATGATGGA ATAAAACAAG TCAACTTTAT GAATCCATCC
ATCTTTTATT TATTATCTAG TTTAGAAAAA TTTAAAGATT TTACCGGAAC ACCCCAAATA
GTAACTCTTT TGAGATTCTT TTTTGAAAAG AGATTATCTA TGAATGATTT AGAGAATAAA
AGTGAACATT TATTAAAATT TATGGAACAA TATCAAAAAG AAAGAGAAGC ACATGTATCT
GAATATTTAT TAAATATATT ACAACCATGT ATAGCTGGTG ATTCAAAATG GAATGTACCA
ATTATAACAA AACTTGAAGG TTTAAAAGGA TCTCGCTTTG ATATACCAAT ATTAGAATCT
TTAAGATGGA TATTCAAACA TGTCGCTAAA ACACATTTGA AAAAATCCTC AAAATCAGCT
AAGAAACTTC AACAGAGAAC CCAGGCTAAT AAACAAGAAT TAGCAAATAT AAATAATAAC
CTAATGAGTA CATTGAAAGA ATATGTAGGA AGTAGTGAAC AAATGAATTC AATAACATAC
AATTTCGAAA ACATCAATTC CAATGTTGAT AACGGAAACC AATCAAAAAA TATTTCAGAT
TTAAGTTATA CAGATCAGAA GGAAATATTA GAAAAAATTG TTAGTTATAT AGTAGATATT
TCCCTTTATG ATATAGAGAA CACAGCTTTA AATGCCGCTG AACAATTGTT GTCAGATAAT
TCAGTAGATG AAAAAACTCT TAAAAAGAGA GCTCAATCAT TAAAAAAATT ATCATCCATT
ATGGAGAGAT ATGCAGGTGG TAAAAGAAAC GATAAAAAAG CAAAAAAATA TGATACCCAA
GATGTTGTAG GATATATTAT GCATGGAATT AGCACAATTA ATAAAGAAAT GAAAAACCAA
AATGAAAATG TACCCGAACA TGTACAACAT AATGCTGAAG CAAATGTAGA ACATGATGCT
GAAGAAAATG TAGAACATGA TGCTGAAGAA AATGTTGAAG AAAATGTAGA AGAAAATGTA
GAAGAAAATG TAGAAGAAAA TGTAGAAGAA AATGTAGAAG AAAATGTAGA AGAAAATGTA
GAAGAAAATG TAGAAGAAAA TGTTGAAGAA AATGTAGAAG AAAATGTTGA AGAAAATGTA
GAAGAAAATG TAGAAGAAAA TGTTGAAGAA TATGATGAAG AAAATGTTGA AGAAGTAGAA
GAAAATGTTG AAGAATATGA TGAAGAAAAT GTTGAAGAAG TAGAAGAAAA TGTAGAAGAA
AATGTAGAAG AAAATGTAGA AGAAAATGTT GAAGAATATG ATGAAGAAAA TGTTGAAGAA
GTAGAAGAAA ATGTAGAAGA AAATGTAGAA GAAAATGTTG AAGAAAATGT AGAAGAAAAT
GTTGAAGAAG TAGAAGAAAA TGTAGAAGAA AATGTAGAAG AAAATGTAGA AGAGAATGTT
GAAGAGAATG TTGAAGAGAA TGTTGAAGAA TATGATGAAG AAAATGTTGA AGAACACAAT
GAAGAATATG ATGAATAA

Protein Sequence : Show Sequence

>PFA0110w |RESA|Pf155|ring-infected erythrocyte surface antigen|Plasmodium falciparum|chr 1|SANGER||Manual
MRPFHAYSWI FSQQYMDTKN VKEKNPTIYS FDDEEKRNEN KSFLKVLCSK RGVLPIIGIL
YIILNGNLGY NGSSSSGVQF TDRCSRNLYG ETLPVNPYAD SENPIVVSQV FGLPFEKPTF
TLESPPDIDH TNILGFNEKF MTDVNRYRYS NNYEAIPHIS EFNPLIVDKV LFDYNEKVDN
LGRSGGDIIK KMQTLWDEIM DINKRKYDSL KEKLQKTYSQ YKVQYDMPKE AYESKWTQCI
KLIDQGGENL EERLNSQFKN WYRQKYLNLE EYRRLTVLNQ IAWKALSNQI QYSCRKIMNS
DISSFKHINE LKSLEHRAAK AAEAEMKKRA QKPKKKKSRR GWLCCGGGDI ETVEPQQEEP
VQTVQEQQVN EYGDILPSLR ASITNSAINY YDTVKDGVYL DHETSDALYT DEDLLFDLEK
QKYMDMLDTS EEESVKENEE EHTVDDEHVE EHTADDEHVE EPTVADDEHV EEPTVADEHV
EEPTVAEEHV EEPTVAEEHV EEPASDVQQT SEAAPTIEIP DTLYYDILGV GVNADMNEIT
ERYFKLAENY YPYQRSGSTV FHNFRKVNEA YQVLGDIDKK RWYNKYGYDG IKQVNFMNPS
IFYLLSSLEK FKDFTGTPQI VTLLRFFFEK RLSMNDLENK SEHLLKFMEQ YQKEREAHVS
EYLLNILQPC IAGDSKWNVP IITKLEGLKG SRFDIPILES LRWIFKHVAK THLKKSSKSA
KKLQQRTQAN KQELANINNN LMSTLKEYVG SSEQMNSITY NFENINSNVD NGNQSKNISD
LSYTDQKEIL EKIVSYIVDI SLYDIENTAL NAAEQLLSDN SVDEKTLKKR AQSLKKLSSI
MERYAGGKRN DKKAKKYDTQ DVVGYIMHGI STINKEMKNQ NENVPEHVQH NAEANVEHDA
EENVEHDAEE NVEENVEENV EENVEENVEE NVEENVEENV EENVEENVEE NVEENVEENV
EENVEENVEE YDEENVEEVE ENVEEYDEEN VEEVEENVEE NVEENVEENV EEYDEENVEE
VEENVEENVE ENVEENVEEN VEEVEENVEE NVEENVEENV EENVEENVEE YDEENVEEHN
EEYDE

Molecule Role : Protective antigen
Related Vaccine(s): P. falciparum vaccine Combination B

25. SERA-5

Gene Name : SERA-5
Sequence Strain (Speices/Organism) : Plasmodium falciparum
VO ID : VO_0011210
NCBI Protein GI : 238629807
Taxonomy ID : 5833
Gene Strand (Orientation) : ?
Protein Name : serine repeat antigen 5
Protein Length : 287

Protein Sequence : Show Sequence

>gi|238629807|gb|ACR49652.1| serine repeat antigen 5 [Plasmodium falciparum]
TGGGQAGNTGGGQAGNTGGGQAGNTVGDQAGSTGGSPQGSTGASQPGSSEPSNPVSSGHSVSTVSVSQTS
TSSEKQDTIQVKSALLKDYMGLKVTGPCNENFIMFLVPHIYIDVDTEDTNIELRTTLKKTNNAISFESNS
GSLEKKKYVKLPSNGTTGEQGSSTGTVRGDTEPISDSSSSSSSSSSSSSSSSSSSSSSSESLPANGPDSP
TVKPPRNLQNICETGKNFKLVVYIKENTLILKWKVYGETKDTTENNKVDVRKYLINEKETPFTNILIHAY
KEHNEQT

Molecule Role : Protective antigen
Molecule Role Annotation : Researchers constructed a new recombinant molecule of SERA5, namely SE36. Vaccination of Squirrel monkeys with SE36 protein and aluminium hydroxyl gel (SE36/AHG) conferred protection against high parasitemia and boosted serum anti-SE36 IgG after P. falciparum parasite challenge (Horii et al., 2010).
Related Vaccine(s): P. falciparum Subunit SE36 Protein Vaccine

26. TRAP from P. falciparum

Gene Name : TRAP from P. falciparum
Sequence Strain (Speices/Organism) : Plasmodium falciparum 3D7
VO ID : VO_0010920
NCBI Gene ID : 814170
NCBI Protein GI : 124513464
Locus Tag : PF13_0201
Genbank Accession : AL844509
Protein Accession : XP_001350088
Taxonomy ID : 36329
Chromosome No : 13
Gene Starting Position : 1465092
Gene Ending Position : 1466816
Gene Strand (Orientation) : -
Protein Name : Thrombospondin-related anonymous protein (TRAP), SSP-2, SSP2, Sporozoite specific protein 2, Sporozoite surface protein 2
Protein pI : 4.7
Protein Weight : 61465.35
Protein Length : 574

DNA Sequence : Show Sequence

>ref|NC_004331.2|:1465092-1466816 Plasmodium falciparum 3D7 chromosome 13
TTTAATTCCACTCGTTTTCTTCAGGTAATCTGAATTGTTCAGGTTCGTCCAAATCTTTATCTTCTTCACC
TAATGTTTCATCAAAAGGTGCAGGTTCTCCGGCATAGGGTGTTGCTGCTCCTGGTACTACGAATTTATAA
GCAAGTCCAGCACATGCGAGTAAAGCTAATCCTCCAGCTATTCCACCTGCAATTTTATATTTATTATCTG
ATCCTGCTTTTTTTTTATTATTATCTGGCTTTTCATGTTCTTCCCTTTCAGGATGTTTTGGAGTATTGTT
ATGTTTTCTATTGTATGATCTATTTTCATTATTTCTACCATGTGGACGTGTTTCTCTATCTTCACTATTA
GGTACGTGCCTATTTCCATTATTATCTTGACTTTGGGGGTCACTTTGTTTCCTTTCATTATCCAAAACTT
TTGGAGATAATGGTGAATATGGAATATATCTATCACTTTTATCATTTGGTAAATTATTTTGATTATCGTG
CTTATTTTCGGGTTTCTTTGGAATATCAAAGTTTTCTTCTCGATCGTCTTCTGGATTTTTTGGAACATCA
GAAGGTACTTCTTTTTCTGAATCTTCAGGTATATTTGGTTCTTGTTCAGGAATATCTGGATTTGGTGGAT
TTGGTGGATTTGGTGGATTTGGTGGATTTGGTGGATTTGGTGGATTTTCTGGATTTTCATCTAAATCAAA
TCCGTTTGGATTTTCACCCTTTCCTTCTTCTGGATTTGGTGAAGGTTCTTGTGGATTATTATCTATTATA
TTTTCGTTTGGTTTTTCGACAGCAAAATTATCTCCTCTTGGTCTAGGTTGATCATCTTCGGGTTCATCTG
GAACATCTAATGGTTCCCGTTTTGGAAGACATCTTTCTTCTTCACATTGTTCTTGTAATTCACTTGTACA
TCCTTCGTGTAAGATTTCTCTTTTTCTTGACCTGGTACCTTTACCACAAGTTACACTACATGGAGACCAT
TCGTCCCAAACACCACAACTTGCTGTTTTTTCTACTTCAACACAAACAGCCTTCATAAAGGGTCCGATAA
CATTTTTTACATTTTCCCATGCAGAATCAGCATACAAGTTACATTTACCATCTGATGGATGACAACCTAC
AAGAAATCTGTTGAAAGCTACATTAATACCTTGTCCAATACCAAAAACAGCTATTTTAACACCACGATCA
CTTAATTTTCTTGATTCTTTTAATGAATCTTGAATACTATCTGGAATTCCATCTGTTAATATAACAACTA
ATTGATTAGCATTCTCTCTATTGATTCGGTCATTTAAATGTTTTCTTACTTGTAACAGTGCATCAGTTAA
GTTTGTTTTACCATATGGAAGATTTGTACTTAAGAGTGACTTTATAATAATTAAAGCCTTCTCTTTGTTT
TTAGATGCATCACTATGTAATCTAATAATTTCTCTTGCATTGTTTGAAAAAACACTAGCATATAAGTGAA
TTGCATTATCATTAAGATTTAATTGTTGTATCAATTTCATAGCTAGAGGTACTGCATGGTTCACCCAATT
ATGACGACGTATACTTCCAGAACAATCCATTAGAAGGTAAAGATCTACCTCATCATTACATACTTCTTCA
CGATATTTTATTTCATCCACTATATTGTTTTGCACATCTCTACCATTAACTAGAAACAAATCAAAGAAAA
TCAAAAACACAATGACTAAATATTTAACATTCCCAAGATGATTCA

Protein Sequence : Show Sequence

>gi|124513464|ref|XP_001350088.1| Thrombospondin-related anonymous protein, TRAP [Plasmodium falciparum 3D7]
MNHLGNVKYLVIVFLIFFDLFLVNGRDVQNNIVDEIKYREEVCNDEVDLYLLMDCSGSIRRHNWVNHAVP
LAMKLIQQLNLNDNAIHLYASVFSNNAREIIRLHSDASKNKEKALIIIKSLLSTNLPYGKTNLTDALLQV
RKHLNDRINRENANQLVVILTDGIPDSIQDSLKESRKLSDRGVKIAVFGIGQGINVAFNRFLVGCHPSDG
KCNLYADSAWENVKNVIGPFMKAVCVEVEKTASCGVWDEWSPCSVTCGKGTRSRKREILHEGCTSELQEQ
CEEERCLPKREPLDVPDEPEDDQPRPRGDNFAVEKPNENIIDNNPQEPSPNPEEGKGENPNGFDLDENPE
NPPNPPNPPNPPNPPNPPNPDIPEQEPNIPEDSEKEVPSDVPKNPEDDREENFDIPKKPENKHDNQNNLP
NDKSDRYIPYSPLSPKVLDNERKQSDPQSQDNNGNRHVPNSEDRETRPHGRNNENRSYNRKHNNTPKHPE
REEHEKPDNNKKKAGSDNKYKIAGGIAGGLALLACAGLAYKFVVPGAATPYAGEPAPFDETLGEEDKDLD
EPEQFRLPEENEWN

Molecule Role : Protective antigen
Related Vaccine(s): DNA and MVA encoding ME-TRAP

II. References

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17. PF11_0344 in GeneDB: PF11_0344 in GeneDB [http://www.genedb.org/genedb/Dispatcher?formType=navBar&organism=malaria&desc=yes&wildcard=yes&name=PF11_0344&ohmr=.&ohmr2=.]

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