VIOLIN: Vaccine Investigation and Online Information Network

Influenza virus

Table of Contents

Protective Antigens

I. Vaccine Related Protective Antigens

1. HA from Equine influenza virus H3N8

Gene Name : HA from Equine influenza virus H3N8
Sequence Strain (Speices/Organism) : Equine influenza virus H3N8
VO ID : VO_0011112
NCBI Protein GI : 404517
Other Database IDs : CDD:109560
Taxonomy ID : 31660
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin
Protein Length : 565
Protein Note : HA

Protein Sequence : Show Sequence

>gi|404517|gb|AAB27733.1| hemagglutinin [Equine influenza virus H3N8]
MKTTIILILLTHWVYSQNPTSGNNTATLCLGHHAVANGTLVKTITDDQIEVTNATELVQSISIGKICNNS
YRVLDGRNCTLIDAMLGDPHCDDFQYENWDLFIERSSAFSNCYPYDIPDHASLRSIVASSGTLEFTAEGF
TWTGVTQNGGSGACKRGSADSFFSRLNWLTKSGNSYPILNVTMPNNKNFDKLYIWGIHHPSSNKEQTKLY
IQESGRVTVSTERSQQTVIPNIGSRPWVRGQSGRISIYWTIVKPGDILMINSNGNLVAPRGYFKLRTGES
SVMRSDALIGTCVSECITPNGSIPNDKPFQNVNKVTYGKCPKYIRQNTLKLATGMRNVPEKQIRGIFGAI
AGFIENGWEGMVDGWYGFRYQNSEGTGQAADLKSTQAAIDQINGKLNRVIERTNEKFHQIEKEFSEVEGR
IQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDAEMNKLFEKTRRQLRENAEDMGGGCFKIYHKCDN
ACIGSIRNGTYDHYIYRDEALNNRFQIKGVELKSGYKDWILWISFAISCLLICVVLLGFIMWACQKGNIR
CNICI

Molecule Role : Protective antigen
Molecule Role Annotation : Skin and mucosal vaccination provided complete protection from clinical signs of infection with ponies subjected to a challenge infection of Equine influenza virus, while skin vaccination provided partial protection; DNA vaccination provided partial protection from viral shedding (Lunn et al., 1999).
Related Vaccine(s): Influenza virus DNA vaccine encoding HA of Equine influenza virus H3N8

2. HA from Influenza A virus (A/Aichi/2/1968(H3N2)), (X31)

Gene Name : HA from Influenza A virus (A/Aichi/2/1968(H3N2)), (X31)
Sequence Strain (Speices/Organism) : Influenza A virus (A/Aichi/2/1968(H3N2)), (X31)
VO ID : VO_0011115
NCBI Protein GI : 324132
Other Database IDs : CDD:109560
Taxonomy ID : 387139
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin precursor
Protein Length : 566
Protein Note : signal peptide

Protein Sequence : Show Sequence

>gi|324132|gb|AAA43178.1| hemagglutinin precursor [Influenza A virus (A/Aichi/2/1968(H3N2))]
MKTIIALSYIFCLALGQDLPGNDNSTATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNN
PHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEG
FTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGIHHPSTNQEQTSL
YVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGK
SSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTRGLFGA
IAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEG
RIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEEMGNGCFKIYHKCD
NACIESIRNGTYDHDVYRDEALNNRFQIKGVELKSGYKDWILWISFAISCFLLCVVLLGFIMWACQRGNI
RCNICI

Molecule Role : Protective antigen
Molecule Role Annotation : Two cyclic peptide analogues corresponding to residues 139-146 (site A) of influenza A virus haemagglutinin (strain X31) were synthesized. When OF1 mice were immunized with cyclic peptides, approximately 80% of the animals were protected against an intranasal challenge with influenza virus (Muller et al., 1990).

3. HA from Influenza A virus (A/chicken/Guangdong/02/2007(H9N2))

Gene Name : HA from Influenza A virus (A/chicken/Guangdong/02/2007(H9N2))
Sequence Strain (Speices/Organism) : Influenza A virus (A/chicken/Guangdong/02/2007(H9N2))
VO ID : VO_0011139
NCBI Protein GI : 206812650
Other Database IDs : CDD:109560
Taxonomy ID : 563925
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin
Protein Length : 560
Protein Note : Hemagglutinin; pfam00509

Protein Sequence : Show Sequence

>gi|206812650|gb|ACI22603.1| hemagglutinin [Influenza A virus (A/chicken/Guangdong/02/2007(H9N2))]
METVSIITMLLVVTVSNADKICIGYQSTNSTETVDTLTENNVPVTHAKELLHTEHNGMLCATTLGNPLIL
DTCTIEGLIYGNPSCDLLLGGREWSYIVERPSAVNGLCYPGNVENLEELRSLFSSASSYQRIQIFPDTIW
NVSYSGTSKACSDSFYRSMRWLTQKNNAYPIQDAQYTNNREKNILFMWGINHPPTDTVQTNLYTRTDTTT
SVATEEINRTFKPLIGPRPLVNGLQGRIDYYWSVLKPGQTLRIRSNGNLIAPWYGHILSGESHGRILKTD
LKRGSCTVQCQTEKGGLNTTLPFQNVSKYAFGNCSKYVGVKSLKLAVGLRSVPSRSSRGLFGAIAGFIEG
GWSGLVAGWYGFQHSNDQGVGMAADKDSTQKAIDKITSKVNNIVDKMNKQYEIIDHEFSEVETRLNMINN
KIDDQIQDIWAYNAELLVLLENQKTLDEHDANVNNLYNKVKRALGSNAVEDGKGCFELYHKCDDQCMETI
RNGTYNRRKYQEESKLERQRIEGVKLESEGTYKILTIYSTVASSLVVAMGFAAFLFWAMSNGSCRCNICI

Molecule Role : Protective antigen
Molecule Role Annotation : Using reverse genetics, we constructed a recombinant NDV expressing an H9 AIV hemagglutinin (HA) from an H9N2 field isolate, A/Chicken/ Shandong/2/2007. When tested, 90% of chickens were protected from clinical disease, mortality, and virus shedding against challenge with homologous H9N2 AIV (Ge et al., 2010).

4. HA from Influenza A virus (A/chicken/Henan/12/2004(H5N1))

Gene Name : HA from Influenza A virus (A/chicken/Henan/12/2004(H5N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/chicken/Henan/12/2004(H5N1))
VO ID : VO_0011133
NCBI Protein GI : 61698018
Other Database IDs : CDD:109560
Taxonomy ID : 319102
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin
Protein Length : 568
Protein Note : Hemagglutinin; pfam00509

Protein Sequence : Show Sequence

>gi|61698018|gb|AAX53506.1| hemagglutinin [Influenza A virus (A/chicken/Henan/12/2004(H5N1))]
MEKIVLLLAIVSLVKSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKTHNGKLCDLDGVKPLILRD
CSVAGWLLGNPMCDEFINVPEWSYIVEKASPANGLCYPGDFNDYEELKHLLSRINHFEKIQIIPKSSWSN
HEASSGVSSACPYQGKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTRLYQNP
TTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSAI
MKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNSPQRERRRKKRGLFG
AIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLE
RRIENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKC
DNECMESVRNGTYDYPQYSEEARLKREEISGVKLESIGTYQILSIYSTVASSLALAIMVAGLSLWMCSNG
SLQCRICI

Molecule Role : Protective antigen
Molecule Role Annotation : Plasmids carrying the HA, NA, NP, M1, and M2 genes, respectively, of the avian influenza virus (AIV) A/Chicken/Henan/12/2004(H5N1) strain were administered to mice, and the mice were challenged with the homologous virus later. The mice immunized with HA plasmid once and the NA plasmid twice survived 100% (Chen et al., 2009).
Related Vaccine(s): Influenza virus DNA vaccine encoding HA from Influenza A virus (A/chicken/Henan/12/2004(H5N1))

5. HA from Influenza A virus (A/chicken/Indonesia/7/2003(H5N1))

Gene Name : HA from Influenza A virus (A/chicken/Indonesia/7/2003(H5N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/chicken/Indonesia/7/2003(H5N1))
VO ID : VO_0011142
NCBI Protein GI : 129282887
Other Database IDs : CDD:109560
Taxonomy ID : 430432
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin
Protein Length : 568
Protein Note : Hemagglutinin; pfam00509

Protein Sequence : Show Sequence

>gi|129282887|gb|ABO30346.1| hemagglutinin [Influenza A virus (A/chicken/Indonesia/7/2003(H5N1))]
MEKIVLLLAIVSLVKSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKTHNGKLCDLDGVKPLILRD
CSVAGWLLGNPMCDEFINVPEWSYIVEKANPANDLCYPGNLNDYEELKHLLSRINHFEKIQIIPKSSWSD
HEASSGVSSACPYQGKSSFFRNVVWLIKKNSAYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTRLYQNP
TTYISVGTSTLNQRLVPKIAIRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSAI
MKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNSPQRERRRKKRGLFG
AIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLE
RRIENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKC
DNECMESIRNGTYNYPQYSEEARLKREEISGVKLESIGTYQILSIYSTVASSLALAIMMAGLSLWMCSNG
SLQCRICI

Molecule Role : Protective antigen
Molecule Role Annotation : All specific-pathogen-free chickens immunized with (vFP2211) expressing a modified synthetic HA gene from H5N1 A/chicken/Indonesia/7/2003 were clinically protected from HPAI challenge (Bublot et al., 2010).

6. HA from Influenza A virus (A/chicken/Italy/13474/99(H7N1))

Gene Name : HA from Influenza A virus (A/chicken/Italy/13474/99(H7N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/chicken/Italy/13474/99(H7N1))
VO ID : VO_0011116
NCBI Protein GI : 32261025
Other Database IDs : CDD:109560
GOA:Q7TDW9
HSSP: Q701T7
InterPro: IPR000149
InterPro: IPR001364
InterPro: IPR008980
UniProtKB/TrEMBL: Q7TDW9
Taxonomy ID : 199442
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin
Protein Length : 564
Protein Note : Hemagglutinin; pfam00509

Protein Sequence : Show Sequence

>gi|32261025|emb|CAD37074.1| hemagglutinin [Influenza A virus (A/chicken/Italy/13474/99(H7N1))]
MNTQILVFALVAIIPTNADKICLGHHAVSNGTKVNTLTERGVEVVNATETVERTNVPRICSKGKRTVDLG
QCGLLGTITGPPQCDQFLEFSADLIIERREGSDVCYPGKFVNEEALRQILRESGGIDKEAMGFTYSGIRT
NGTTSTCRRSGSSFYAEMKWLLSNTDNAAFPQMTKSYKNTRKDPALIIWGIHHSGSTTEQTKLYGSGNKL
ITVGSSNYQQSFVPSPGERPQVNGQSGRIDFHWLMLNPNDTVTFSFNGAFIAPDRASFLRGKSMGIQSGV
QVDANCEGDCYHSGGTIISNLPFQNINSRAVGKCPRYVKQESLLLATGMKNVPEIPKGSRVRRGLFGAIA
GFIENGWEGLIDGWYGFRHQNAQGEGTAADYKSTQSAIDQVTGKLNRLIEKTNQQFELIDNEFTEVEKQI
GNVINWTRDSMTEVWSYNAELLVAMENQHTIDLTDSEMNKLYERVKRLLRENAEEDGTGCFEIFHKCDDD
CMASIRNNTYDHSKYREEAMQNRIQIDPVKLSSGYKDVILWFSFGASCFILLAIAMGLVFICVRNGNMRC
TICI

Molecule Role : Protective antigen
Molecule Role Annotation : Mice and ferrets were immunised with two doses of the split virus vaccine (12-24 microg haemagglutinin derived from Influenza A virus (A/chicken/Italy/13474/99(H7N1))) with or without aluminium hydroxide adjuvant and challenged 3 weeks after second dose with the highly pathogenic A/chicken/Italy/13474/99 (H7N1) virus. The vaccine induced significant protection from disease after challenge with the wild-type virus. In the murine lethal challenge model, vaccination effectively prevented death and, furthermore, formulation with adjuvant reduced excessive weight loss and viral shedding (Cox et al., 2009).

7. HA from Influenza A virus (A/duck/Badung-Bali/05/2005(H5N1))

Gene Name : HA from Influenza A virus (A/duck/Badung-Bali/05/2005(H5N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/duck/Badung-Bali/05/2005(H5N1))
VO ID : VO_0011118
NCBI Protein GI : 190344179
Other Database IDs : CDD:109560
Taxonomy ID : 389226
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin
Protein Length : 529
Protein Note : subtype: H5N1

Protein Sequence : Show Sequence

>gi|190344179|gb|ABG20467.2| hemagglutinin [Influenza A virus (A/duck/Badung-Bali/05/2005(H5N1))]
DQICIGYHANNSTEQVDTIMEKNVTVTHAKDILEKTHNGKLCDLDGVKPLILRDCSVAGWLLGNPMCDEF
TNVPEWSYIVEKANPANDLCYPGNFNDYEELKHLLSRINHFEKIQIIPKSSWSDHEASLGVSSACPYQGQ
SSFFRNVVWLIKKNSAYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTRLYQNPTTYISVGTSTLNQRLV
PKIATRSKVNGQSGRMEFFWTIFKPNDAINFESNGNFIAPEYAYKIVKKGDSAIMKSELEYGNCNTECQT
PMGAINSSMPFHNIHPLTIRECPKYMKSSRLVLATGLRNSPQGERRRKKRGLFGAIAGFIEGGWQGMVDG
WYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLERRIENLNKKMEDGFLD
VWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLKDNAKELGNGCFEFYHKCDNECMESIRNGTYNYP
QYSEEARLKREEISGVKLESIGTYQILSIYSTVASSLAL

Molecule Role : Protective antigen
Molecule Role Annotation : Mice vaccinated with a recombinant VLP vaccine from both influenza A H5N1 clade 1 and clade 2 isolates (Influenza A virus (A/duck/Badung-Bali/05/2005(H5N1))) with pandemic potential were protected against challenge with lethal reassortant viruses expressing the H5N1 HA and NA, regardless if the H5N1 clade was homologous or heterologous to the vaccine (Bright et al., 2008).

8. HA from Influenza A virus (A/environment/Hong Kong/156/1997(H5N1))

Gene Name : HA from Influenza A virus (A/environment/Hong Kong/156/1997(H5N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/environment/Hong Kong/156/1997(H5N1))
VO ID : VO_0011121
NCBI Protein GI : 269826115
Other Database IDs : CDD:109560
Taxonomy ID : 680785
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin
Protein Length : 568
Protein Note : passaged in allantoic fluid

Protein Sequence : Show Sequence

>gi|269826115|gb|ACZ48512.1| hemagglutinin [Influenza A virus (A/environment/Hong Kong/156/1997(H5N1))]
MEKTVLLLATVSLVKSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILERTHNGKLCDLNGVKPLILRD
CSVAGWLLGNPMCDEFINVPEWSYIVEKASPANDLCYPGNFNDYEELKHLLSRINHFEKIQIIPKSSWSN
HDASSGVSSACPYLGRSSFFRNVVWLIKKNSAYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTKLYQNP
TTYISVGTSTLNQRLVPEIATRPKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSTI
MKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNTPQRERRRKKRGLFG
AIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIINKMNTQFEAVGREFNNLE
RRIENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKC
DNECMESVKNGTYDYPQYSEEARLNREEISGVKLESMGTYQILSIYSTVASSLALAIMVAGLSLWMCSNG
SLQCRICI

Molecule Role : Protective antigen
Molecule Role Annotation : Researchers report that a DNA vaccine encoding hemagglutinin from the index human influenza isolate A/HK/156/97 provides immunity against H5N1 infection of mice (Kodihalli et al., 1999).
Related Vaccine(s): Influenza virus DNA vaccine encoding HA from Influenza A virus (A/environment/Hong Kong/156/1997(H5N1))

9. HA from Influenza A virus (A/equine/Kentucky/1/1981(H3N8))

Gene Name : HA from Influenza A virus (A/equine/Kentucky/1/1981(H3N8))
Sequence Strain (Speices/Organism) : Influenza A virus (A/equine/Kentucky/1/1981(H3N8))
VO ID : VO_0011302
NCBI Nucleotide GI : 166079523
NCBI Protein GI : 166079524
Protein Accession : ABY81481.1
Other Database IDs : CDD:109560
Taxonomy ID : 475467
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin
Protein Length : 565
Protein Note : Hemagglutinin; pfam00509

DNA Sequence : Show Sequence

>gi|166079523|gb|CY028828.1| Influenza A virus (A/equine/Kentucky/1/1981(H3N8)) segment 4, complete sequence
TCTGTCAATCATGAAGACAACCATTATTTTGATACTACTGACCCATTGGGTCTACAGTCAAAACCCAACC
AGTGGCAACAACACAGCCACACTATGTCTGGGACACCATGCAGTAGCAAATGGAACATTGGTAAAAACAA
TAACTGATGACCAAATTGAGGTGACAAATGCTACTGAATTAGTTCAGAGCACTTCAATAGGGAAAATATG
CAACAACCCATATAGGGTTCTAGATGGAAGAAACTGCACATTAATAGATGCAATGCTAGGAGATCCCCAC
TGTGATGTTTTTCAGTATGAGAATTGGGACCTCTTCATAGAAAGAAGCAGCGCTTTCAGCAATTGCTACC
CATATGACATCCCTGACTATGCATCGCTCCGGTCTATTGTGGCATCTTCAGGAACATTAGAATTCACAGC
AGAGGGATTCACATGGACAGGTGTCACTCAAAACGGAAGAAGTGGAGCCTGCAGAAGGGGGTCAGCCGAT
AGTTTCTTTAGCCGACTGAATTGGCTAACAAAATCTGGAAATTCTTACCCCACATTGAATGTAACAATGC
CTAACAATAACAATTTCGATAAACTATACATCTGGGGGATCCATCACCCGAGCACAAACAATGAGCAGAC
AAAATTGTATATCCAAGAATCAGGGCGAGTAACAGTCTCAACAAAAAGAAGTCAACAAACAATAATCCCC
AACATCGGATCTAGACCGTGGGTCAGGGGTCAATCAGGCAGGATAAGCATATATTGGACCATTGTGAAAC
CTGGAGATATCCTAATGATAAACAGTAATGGCAACTTAGTTGCACCGCGGGGATATTTTAAAATGCGAAC
AGGGAAAAGCTCTGTAATGAGATCAGATGCACCCATAGACACTTGTGTGTCCGAGTGTATTACACCAAAT
GGAAGCATCCCCAACGACAAACCATTTCAAAATGTGAACAAAGTTACATATGGAAAATGCCCCAAGTATA
TCAAGCAGAATACTTTGAAGCTGGCCACTGGGATGAGGAATGTACCAGAAAAGCAAATCAGAGGAATCTT
TGGAGCAATAGCGGGATTCATAGAAAACGGCTGGGAAGGAATGGTTGATGGGTGGTATGGATTCCGATAT
CAGAATTCGGAAGGAACAGGACAAGCTGCAGATCTAAAGAGCACTCAAGCAGCCATCGACCAGATCAATG
GAAAATTGAACAGAGTGATTGAAAGGACCAATGAGAAATTCCATCAAATAGAGAAGGAATTCTCAGAAGT
AGAAGGGAGAATCCAGGACTTGGAGAAGTATGTAGAAGACACCAAAATAGACCTATGGTCCTACAATGCA
GAGTTACTGGTGGCTCTAGAAAATCAACATACGATTGACTTAACAGATGCAGAAATGAATAAATTATTCG
AGAAGACTAGGCGCCAGTTAAGAGAAAACGCGGAAGACATGGGGGGTGGATGTTTCAAGATTTATCACAA
ATGTGATAATGCATGCATTGGATCAATAAGAAATGGGACATATGACCATTACATATACAGAGATGAAGCA
TTAAACAACCGATTTCAAATTAAAGGTGTTGAATTGAAATCAGGCTACAAAGATTGGATACTGTGGATTT
CATTCGCCATATCATGCTTCTTAATTTGCGTTGTTCTATTGGGTTTCATCATGTGGGCTTGCCAAAAAGG
CAACATCAGATGCAACATTTGCATTTGAGTAAACTGATAGTTAAA

Protein Sequence : Show Sequence

>gi|166079524|gb|ABY81481.1| hemagglutinin [Influenza A virus (A/equine/Kentucky/1/1981(H3N8))]
MKTTIILILLTHWVYSQNPTSGNNTATLCLGHHAVANGTLVKTITDDQIEVTNATELVQSTSIGKICNNP
YRVLDGRNCTLIDAMLGDPHCDVFQYENWDLFIERSSAFSNCYPYDIPDYASLRSIVASSGTLEFTAEGF
TWTGVTQNGRSGACRRGSADSFFSRLNWLTKSGNSYPTLNVTMPNNNNFDKLYIWGIHHPSTNNEQTKLY
IQESGRVTVSTKRSQQTIIPNIGSRPWVRGQSGRISIYWTIVKPGDILMINSNGNLVAPRGYFKMRTGKS
SVMRSDAPIDTCVSECITPNGSIPNDKPFQNVNKVTYGKCPKYIKQNTLKLATGMRNVPEKQIRGIFGAI
AGFIENGWEGMVDGWYGFRYQNSEGTGQAADLKSTQAAIDQINGKLNRVIERTNEKFHQIEKEFSEVEGR
IQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDAEMNKLFEKTRRQLRENAEDMGGGCFKIYHKCDN
ACIGSIRNGTYDHYIYRDEALNNRFQIKGVELKSGYKDWILWISFAISCFLICVVLLGFIMWACQKGNIR
CNICI

Molecule Role : Protective antigen
Molecule Role Annotation : Skin and mucosal vaccination of ponies with HA from influenza virus A/equine/Ky/1/81 provided complete protection from clinical signs of infection after challenge, while skin vaccination provided partial protection; DNA vaccination provided partial protection from viral shedding (Lunn et al., 1999).
Related Vaccine(s): Influenza virus DNA vaccine encoding HA from Influenza A virus (A/equine/Kentucky/1/1981(H3N8))

10. HA from Influenza A virus (A/Fukuoka/C29/85(H3N2))

Gene Name : HA from Influenza A virus (A/Fukuoka/C29/85(H3N2))
Sequence Strain (Speices/Organism) : Influenza A virus (A/Fukuoka/C29/85(H3N2))
VO ID : VO_0011127
NCBI Protein GI : 221306
Other Database IDs : CDD:109560
Taxonomy ID : 62549
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin
Protein Length : 109
Protein Note : Hemagglutinin; pfam00509

Protein Sequence : Show Sequence

>gi|221306|dbj|BAA02776.1| hemagglutinin [Influenza A virus (A/Fukuoka/C29/85(H3N2))]
DKPFQNVNKITYGACPRYVKQNTLKLATGMRNVPEKQTRGIFGAIAGFIENGWEGMVDGWYGFRHQNSEG
TGQAADLKSTQAAIDQINGKLNRLIEKTNEKFHQIEKEF

Molecule Role : Protective antigen
Molecule Role Annotation : The inoculation of HA vaccine prepared from influenza viruses A/Yamagata/120/86 (H1N1) or A/Fukuoka/C29/85 (H3N2) together with CTB provided partial protection against PR-8 infection in Balb/c mice (Tamura et al., 1989).
Related Vaccine(s): Influenza virus HA protein vaccine (Influenza A virus (A/Fukuoka/C29/85(H3N2)))

11. HA from Influenza A virus (A/Goose/Guangdong/1/96(H5N1))

Gene Name : HA from Influenza A virus (A/Goose/Guangdong/1/96(H5N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/Goose/Guangdong/1/96(H5N1))
VO ID : VO_0011125
NCBI Gene ID : 3654620
NCBI Protein GI : 73852955
Locus Tag : FLUAVH5N1_s4gp1
Genbank Accession : AF144305
Protein Accession : YP_308669
Taxonomy ID : 93838
Segment No : segment 4
Gene Starting Position : 21
Gene Ending Position : 1727
Gene Strand (Orientation) : +
Protein Name : hemagglutinin
Protein pI : 6.67
Protein Weight : 61079.8
Protein Length : 568

DNA Sequence : Show Sequence

>gi|73852954:21-1727 Influenza A virus (A/Goose/Guangdong/1/96(H5N1)) segment 4, complete sequence
AATGGAGAAAATAGTGCTTCTTCTTGCAATAGTCAGTCTTGTCAAAAGTGATCAGATTTGCATTGGTTAC
CATGCAAACAACTCGACAGAGCAGGTTGACACAATAATGGAAAAGAACGTTACTGTTACACATGCCCAAG
ACATACTGGAAAAGACACACAATGGGAAGCTCTGCGATCTAAATGGAGTGAAGCCTCTCATTTTGAGAGA
TTGTAGTGTAGCTGGATGGCTCCTCGGAAACCCTATGTGTGACGAATTCATCAATGTGCCGGAATGGTCT
TACATAGTGGAGAAGGCCAGTCCAGCCAATGACCTCTGTTACCCAGGGGATTTCAACGACTATGAAGAAC
TGAAACACCTATTGAGCAGAACAAACCATTTTGAGAAAATTCAGATCATCCCCAAAAGTTCTTGGTCCAA
TCATGATGCCTCATCAGGGGTGAGCTCAGCATGTCCATACCATGGGAGGTCCTCCTTTTTCAGAAATGTG
GTATGGCTTATCAAAAAGAACAGTGCATACCCAACAATAAAGAGGAGCTACAATAATACCAACCAAGAAG
ATCTTTTAGTACTGTGGGGGATTCACCATCCTAATGATGCGGCAGAGCAGACAAAGCTCTATCAAAACCC
AACCACTTACATTTCCGTTGGAACATCAACACTGAACCAGAGATTGGTTCCAGAAATAGCTACTAGACCC
AAAGTAAACGGGCAAAGTGGAAGAATGGAGTTCTTCTGGACAATTTTAAAGCCGAATGATGCCATCAATT
TCGAGAGTAATGGAAATTTCATTGCTCCAGAATATGCATACAAAATTGTCAAGAAAGGGGACTCAGCAAT
TATGAAAAGTGAATTGGAATATGGTAACTGCAACACCAAGTGTCAAACTCCAATGGGGGCGATAAACTCT
AGTATGCCATTCCACAACATACACCCCCTCACCATCGGGGAATGCCCCAAATATGTGAAATCAAACAGAT
TAGTCCTTGCGACTGGACTCAGAAATACCCCTCAGAGAGAGAGAAGAAGAAAAAAGAGAGGACTATTTGG
AGCTATAGCAGGTTTTATAGAGGGAGGATGGCAGGGAATGGTAGATGGTTGGTATGGGTACCACCATAGC
AATGAGCAGGGGAGTGGATACGCTGCAGACAAAGAATCCACTCAAAAGGCAATAGATGGAGTCACCAATA
AGGTCAACTCGATCATTGACAAAATGAACACTCAGTTTGAGGCCGTTGGAAGGGAATTTAATAACTTGGA
AAGGAGGATAGAGAATTTAAACAAGCAGATGGAAGACGGATTCCTAGATGTCTGGACTTATAATGCTGAA
CTTCTGGTTCTCATGGAAAATGAGAGAACTCTAGACTTTCATGACTCAAATGTCAAGAACCTTTATGACA
AGGTCCGACTACAGCTTAGGGATAATGCAAAGGAGCTGGGTAATGGTTGTTTCGAGTTCTATCACAAATG
TGATAATGAATGTATGGAAAGTGTAAAAAACGGAACGTATGACTACCCGCAGTATTCAGAAGAAGCAAGA
CTAAACAGAGAGGAAATAAGTGGAGTAAAATTGGAATCAATGGGAACTTACCAAATACTGTCAATTTATT
CAACAGTGGCGAGTTCCCTAGCACTGGCAATCATGGTAGCTGGTCTATCTTTATGGATGTGCTCCAATGG
ATCGTTACAATGCAGAATTTGCATTTA

Protein Sequence : Show Sequence

>gi|73852955|ref|YP_308669.1| hemagglutinin [Influenza A virus (A/Goose/Guangdong/1/96(H5N1))]
MEKIVLLLAIVSLVKSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKTHNGKLCDLNGVKPLILRD
CSVAGWLLGNPMCDEFINVPEWSYIVEKASPANDLCYPGDFNDYEELKHLLSRTNHFEKIQIIPKSSWSN
HDASSGVSSACPYHGRSSFFRNVVWLIKKNSAYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTKLYQNP
TTYISVGTSTLNQRLVPEIATRPKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSAI
MKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNTPQRERRRKKRGLFG
AIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLE
RRIENLNKQMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKC
DNECMESVKNGTYDYPQYSEEARLNREEISGVKLESMGTYQILSIYSTVASSLALAIMVAGLSLWMCSNG
SLQCRICI

Molecule Role : Protective antigen
Molecule Role Annotation : Results indicated that two doses of 10 microg of pCAGGoptiHA derived from Influenza A virus (A/Goose/Guangdong/1/96(H5N1)) could induce complete protection in chickens against H5 lethal virus challenge (Jiang et al., 2007).
Related Vaccine(s): Influenza virus DNA vaccine pCAGGoptiHA

12. HA from Influenza A virus (A/Hatay/2004/(H5N1))

Gene Name : HA from Influenza A virus (A/Hatay/2004/(H5N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/Hatay/2004/(H5N1))
VO ID : VO_0011143
NCBI Protein GI : 56311402
Other Database IDs : CDD:109560
GOA:Q5QQ29
HSSP: P03442
InterPro: IPR000149
InterPro: IPR001364
InterPro: IPR008980
UniProtKB/TrEMBL: Q5QQ29
Taxonomy ID : 303316
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin
Protein Length : 568
Protein Note : Hemagglutinin; pfam00509

Protein Sequence : Show Sequence

>gi|56311402|emb|CAI29278.1| hemagglutinin [Influenza A virus (A/Hatay/2004/(H5N1))]
MEKIVLLLAIVSLVKSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKTHNGKLCALDGVKPLILRD
CSVAGWLLGNPMCDEFINVPEWSYIVEKANPVNDLCYPGDFNDYEELKHLLSRINHFEKIQIIPKSSWSS
HEASLGVSSACPYQGKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQIKLYQNP
TTYISVGTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKLVKKGDSTI
MKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNSPQRERRRKKRGLFG
AIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLE
RRIENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKC
DNECMESVRSGTYDYPQYSEEARLKREEISGVKLESIGIYQILSIYSTVASSLALAIMVAGLSLWMCSNG
SLQCRICI

Molecule Role : Protective antigen
Molecule Role Annotation : A neutralizing monoclonal antibody (mAb) 9F4 against the hemagglutinin (HA) of the influenza A/chicken/hatay/2004 H5N1 virus was generated. MAb 9F4 was found to be protective, both prophylactically and therapeutically, against lethal viral challenge of mice (Oh et al., 2010).

13. HA from Influenza A virus (A/Hawaii/01/1991(H3N2))

Gene Name : HA from Influenza A virus (A/Hawaii/01/1991(H3N2))
Sequence Strain (Speices/Organism) : Influenza A virus (A/Hawaii/01/1991(H3N2))
VO ID : VO_0011132
NCBI Protein GI : 110313990
Other Database IDs : CDD:109560
Taxonomy ID : 387158
Gene Strand (Orientation) : ?
Protein Name : haemagglutinin
Protein Length : 329
Protein Note : egg isolate

Protein Sequence : Show Sequence

>gi|110313990|gb|ABG66978.1| haemagglutinin [Influenza A virus (A/Hawaii/01/1991(H3N2))]
QKLPGNDNSTATLCLGHHAVPNGTLVKTITNDQIEVTNATELVQSSSTGRICDSPHRILDGKNCTLIDAL
LGDPHCDGFQNKEWDLFVERSKAYSNCYPYDVPDYASLRSLVASSGTLEFINEDFNWTGVAQSGESYACK
RGSVKSFFSRLNWLHKSEYKYPALNVTMPNNGKFDKLYIWGVHHPSTDREQTSLYVRASGRVTVSTKRSQ
QTVIPNIGSRPWVRGLSSRISIYWTIVKPGDILLINSTGNLIAPRGYFKIRTGKSSIMRSDAPIGTCSSE
CITPNGSIPNDKPFQNVNRITYGACPRYVKQNTLKLATGMRNVPEKQTR

Molecule Role : Protective antigen
Molecule Role Annotation : A DNA vaccine encoding HA (from Influenza A virus (A/Hawaii/01/1991(H3N2))), NP and M1 (from a 1989 strain) protected ferrets better against challenge with the antigenic drift variant A/Georgia/03/93 than did the inactivated vaccine from the 1992-93 influenza season. Researchers report that the same DNA vaccine protected ferrets against a second, further divergent, drift variant (A/Johannesburg/33/94) (Donnelly et al., 1997).

14. HA from Influenza A virus (A/Hong Kong/1/68(H3N2))

Gene Name : HA from Influenza A virus (A/Hong Kong/1/68(H3N2))
Sequence Strain (Speices/Organism) : Influenza A virus (A/Hong Kong/1/68(H3N2))
VO ID : VO_0011120
NCBI Protein GI : 16960108
Taxonomy ID : 10090
Gene Strand (Orientation) : ?
Protein Length : 377
Molecule Role : Protective antigen
Molecule Role Annotation : Vaccination with HA-VRP derived from Influenza A virus (A/Hong Kong/1/68(H3N2)) did not strongly stimulate either neutralizing or IgG1 antibodies but did induce IgG2a antibodies. Expression of IgG2a antibodies in this context correlated with clearance of virus and increased protection against lethal influenza challenge (Huber et al., 2006).
Related Vaccine(s): Influenza virus DNA vaccine encoding HA from Influenza A virus (A/Hong Kong/1/68(H3N2))

15. HA from Influenza A virus (A/Indonesia/CDC594/2006(H5N1))

Gene Name : HA from Influenza A virus (A/Indonesia/CDC594/2006(H5N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/Indonesia/CDC594/2006(H5N1))
VO ID : VO_0011131
NCBI Protein GI : 113495780
Other Database IDs : CDD:109560
Taxonomy ID : 400810
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin
Protein Length : 568
Protein Note : Hemagglutinin; pfam00509

Protein Sequence : Show Sequence

>gi|113495780|gb|ABI36144.1| hemagglutinin [Influenza A virus (A/Indonesia/CDC594/2006(H5N1))]
MEKIVLLLATVSLVKSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKTHNGKLCDLDGVKPLILRD
CSVAGWLLGNPMCDEFINVPEWSYIVEKANPANGLCYPGNFNDYEELKHLLSRINHFEKLQIIPKSSWSD
HEASLGVSSACPYLGRSSFFRNVVWLIKKNNTYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTRLYQNP
TTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSAI
MKSELEYGDCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNSPQRERRRKKRGLFG
AIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLE
RRIENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKC
DNECMESIRNGTYNYPQYSEEARLKREEISGVKLESIGIYQILSIYSTVASSLALAIMMAGLSLWMCSNG
SLQCRVCI

Molecule Role : Protective antigen
Molecule Role Annotation : Viral challenge studies showed that live BacHA derived from Influenza A virus (A/Indonesia/CDC594/2006(H5N1)) was able to provide 100% protection against 5 50% mouse lethal doses (MLD(50)) of homologous (clade 2.1) and heterologous (clade 1) H5N1 (Prabakaran et al., 2010).
Related Vaccine(s): BacHA derived from Influenza A virus (A/Indonesia/CDC669/2006(H5N1))

16. HA from Influenza A virus (A/Indonesia/CDC669/2006(H5N1))

Gene Name : HA from Influenza A virus (A/Indonesia/CDC669/2006(H5N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/Indonesia/CDC669/2006(H5N1))
VO ID : VO_0011130
NCBI Protein GI : 113497156
Other Database IDs : CDD:109560
Taxonomy ID : 400828
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin
Protein Length : 568
Protein Note : Hemagglutinin; pfam00509

Protein Sequence : Show Sequence

>gi|113497156|gb|ABI36428.1| hemagglutinin [Influenza A virus (A/Indonesia/CDC669/2006(H5N1))]
MEKIVLLLAIVSLVKSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKTHNGKLCDLDGVKPLILRD
CSVAGWLLGNPMCDEFINVPEWSYIVEKANPTNDLCYPGSFNDYEELKHLLSRINHFEKIQIIPKSSWSD
HEASSGVSSACPYLGSPSFFRNVVWLIKKNSTYPTIKKSYNNTNQEDLLVLWGIHHPNDAAEQTRLYQNP
TTYISIGTSTLNQRLVPKIATRSKVNGQSGRMEFFWAILKPNDAINFESNGNFIAPEYAYKIVKKGDSAI
MKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNSPQRESRRKKRGLFG
AIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLE
RRIENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKC
DNECMESIRNGTYNYPQYSEEARLKREEISGVKLESIGTYQILSIYSTVASSLALAIMIAGLSLWMCSNG
SLQCRICI

Molecule Role : Protective antigen
Molecule Role Annotation : Viral challenge studies showed that live BacHA derived from Influenza A virus (A/Indonesia/CDC669/2006(H5N1)) was able to provide 100% protection against 5 50% mouse lethal doses (MLD(50)) of homologous (clade 2.1) and heterologous (clade 1) H5N1 (Prabakaran et al., 2010).
Related Vaccine(s): BacHA derived from Influenza A virus (A/Indonesia/CDC669/2006(H5N1))

17. HA from Influenza A virus (A/Puerto Rico/8/1934(H1N1))

Gene Name : HA from Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/Puerto Rico/8/1934(H1N1))
VO ID : VO_0011114
NCBI Protein GI : 126599271
Other Database IDs : CDD:109560
Taxonomy ID : 211044
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin
Protein Length : 565
Protein Note : passage level ExMDCK6

Protein Sequence : Show Sequence

>gi|126599271|gb|ABO21709.1| hemagglutinin [Influenza A virus (A/Puerto Rico/8/1934(H1N1))]
MKANLLVLLCALAAADADTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCRLKGIAPLQLG
KCNIAGWLLGNPECDPLLPVRSWSYIVETPNSENGICYPGDFIDYEELREQLSSVSSFERFEIFPKESSW
PNHNTNGVTAACSHEGKSSFYRNLLWLTEKEGSYPKLKNSYVNKKGKEVLVLWGIHHPPNSKEQQNLYQN
ENAYVSVVTSNYNRRFTPEIAERPKVRDQAGRMNYYWTLLKPGDTIIFEANGNLIAPMYAFALSRGFGSG
IITSNASMHECNTKCQTPLGAINSSLPYQNIHPVTIGECPKYVRSAKLRMVTGLRNNPSIQSRGLFGAIA
GFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQNAINGITNKVNTVIEKMNIQFTAVGKEFNKLEKRM
ENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVKNLYEKVKSQLKNNAKEIGNGCFEFYHKCDNE
CMESVRNGTYDYPKYSEESKLNREKVDGVKLESMGIYQILAIYSTVASSLVLLVSLGAISFWMCSNGSLQ
CRICI

Molecule Role : Protective antigen
Molecule Role Annotation : A recombinant baculovirus expressing the hemagglutinin gene of the influenza virus, A/PR/8/34 (H1N1), under the control of the chicken beta-actin promoter, was constructed. Protection from a lethal challenge of the influenza virus was achieved by intranasal immunization of the recombinant baculovirus (Abe et al., 2003).
Related Vaccine(s): Recombinant baculovirus encoding HA from Influenza A virus (A/Puerto Rico/8/1934(H1N1))

18. HA from Influenza A virus (A/Solomon Islands/3/2006(H1N1))

Gene Name : HA from Influenza A virus (A/Solomon Islands/3/2006(H1N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/Solomon Islands/3/2006(H1N1))
VO ID : VO_0011124
NCBI Protein GI : 156123416
Other Database IDs : CDD:109560
Taxonomy ID : 464623
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin
Protein Length : 565
Protein Note : passage level E2/E1 antigenic type LR to New Caledonia/99; adamantane sensitive

Protein Sequence : Show Sequence

>gi|156123416|gb|ABU50586.1| hemagglutinin [Influenza A virus (A/Solomon Islands/3/2006(H1N1))]
MKVKLLVLLCTFTATYADTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCLLKGIAPLQLG
NCSVAGWILGNPECELLISRESWSYIVEKPNPENGTCYPGHFADYEELREQLSSVSSFERFEIFPKESSW
PNHTTTGVSASCSHNGESSFYKNLLWLTGKNGLYPNLSKSYANNKEKEVLVLWGVHHPPNIGDQRALYHT
ENAYVSVVSSHYSRKFTPEIAKRPKVRDREGRINYYWTLLEPGDTIIFEANGNLIAPRYAFALSRGFGSG
IINSNAPMDECDAKCQTPQGAINSSLPFQNVHPVTIGECPKYVRSAKLRMVTGLRNIPSIQSRGLFGAIA
GFIEGGWTGMVDGWYGYHHQNEQGSGYAADQKSTQNAINGITNKVNSVIEKMNTQFTAVGKEFNKLERRM
ENLNKKVDDGFIDIWTYNAELLVLLENERTLDFHDSNVKNLYEKVKSQLKNNAKEIGNGCFEFYHKCNDE
CMESVKNGTYDYPKYSEESKLNREKIDGVKLESMGVYQILAIYSTVASSRVLLVSLGAISFWMCSNGSLQ
CRICI

Molecule Role : Protective antigen
Molecule Role Annotation : In mouse models of influenza infection, the vaccines derived from Influenza A virus (A/Solomon Islands/3/2006(H1N1)) hemagglutinin elicit robust antibody responses that mitigate disease and protect mice from lethal challenge (Song et al., 2008).

19. HA from Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1))

Gene Name : HA from Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1))
VO ID : VO_0011140
NCBI Nucleotide GI : 46578137
NCBI Protein GI : 46578138
Protein Accession : AAS65615.2
Taxonomy ID : 266827
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin
Protein Note : HA

DNA Sequence : Show Sequence

>gi|46578137|gb|AY555150.2| Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) hemagglutinin gene, partial cds
TCATCTGTCAAATGGAGAAAATAGTGCTTCTTTTTGCAATAGTCAGTCTTGTTAAAAGTGATCAGATTTG
CATTGGTTACCATGCAAACAACTCGACAGAGCAGGTTGACACAATAATGGAAAAGAACGTTACTGTTACA
CATGCCCAAGACATACTGGAAAAGACACACAACGGGAAGCTCTGCGATCTAGATGGAGTGAAGCCTCTAA
TTTTGAGAGATTGTAGTGTAGCTGGATGGCTCCTCGGAAACCCAATGTGTGACGAATTCATCAATGTGCC
GGAATGGTCCTACATAGTGGAGAAGGCCAATCCAGTCAATGACCTCTGTTACCCAGGGGATTTCAATGAC
TATGAAGAATTGAAACACCTATTGAGCAGAATAAACCATTTTGAGAAAATTCAGATCATCCCCAAAAGTT
CTTGGTCCAGTCATGAAGCCTCATTAGGGGTGAGCTCAGCATGTCCATACCAGAGAAAGTCCTCCTTTTT
CAGAAATGTGGTATGGCTTATCAAAAAGAACAGTACATACCCAACAATAAAGAGGAGCTACAATAATACC
AACCAAGAAGATCTTTTGGTACTGTGGGGGATTCACCATCCTAATGATGCGGCAGAGCAGACAAAGCTCT
ATCAAAACCCAACCACCTATATTTCCGTTGGGACATCAACACTAAACCAGAGATTGGTACCAAGAATAGC
TACTAGATCCAAAGTAAACGGGCAAAGTGGAAGGATGGAGTTCTTCTGGACAATTTTAAAACCGAATGAT
GCAATCAACTTCGAGAGTAATGGAAATTTCATTGCTCCAGAATATGCATACAAAATTGTCAAGAAAGGGG
ACTCAACAATTATGAAAAGTGAATTGGAATATGGTAACTGCAACACCAAGTGTCAAACTCCAATGGGGGC
GATAAACTCTAGTATGCCATTCCACAATATACACCCTCTCACCATCGGGGAATGCCCCAAATATGTGAAA
TCAAACAGATTAGTCCTTGCGACTGGGCTCAGAAATAGCCCTCAAAGAGAGAGAAGAAGAAAAAAGAGAG
GATTATTTGGAGCTATAGCAGGTTTTATAGAGGGAGGATGGCAGGGAATGGTAGATGGTTGGTATGGGTA
CCACCATAGCAATGAGCAGGGGAGTGGGTACGCTGCAGACAAAGAATCCACTCAAAAGGCAATAGATGGA
GTCACCAATAAGGTCAACTCGATCATTGACAAAATGAACACTCAGTTTGAGGCCGTTGGAAGGGAATTTA
ACAACTTAGAAAGGAGAATAGAGAATTTAAACAAGAAGATGGAAGACGGGTTCCTAGATGTCTGGACTTA
TAATGCTGAACTTCTGGTTCTCATGGAAAATGAGAGAACTCTAGACTTTCATGACTCAAATGTCAAGAAC
CTTTACGACAAGGTCCGACTACAGCTTAGGGATAATGCAAAGGAACTGGGTAACGGTTGTTTCGAGTTCT
ATCATAAATGTGATAATGAATGTATGGAAAGTGTAAGAAACGGAACGTATGACTACCCGCAGTATTCAGA
AGAAGCAAGACTAAAAAGAGAGGAAATAAGTGGAGTAAAATTGGAATCAATAGGAATTTACCAAATACTG
TCAATTTATTCTACAGTGGCGAGTTCCCTAGCACTGGCAATCATGGTAGCTGGTCTATCCTTATGGATGT
GCTCCAATGGGTCGTTACAATGCAGAATTTGCATTTAAATTTGTGAGTTCAGATTG

Molecule Role : Protective antigen
Molecule Role Annotation : Immunization with DNA/rAd5 vaccines encoding HA derived from Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) conferred protection in ferrets against a stringent virus challenge (Rao et al., 2010).
Related Vaccine(s): Influenza virus DNA vaccine encoding HA from Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1))

20. HA from Influenza A virus (A/turkey/Ireland/1378/1983(H5N8))

Gene Name : HA from Influenza A virus (A/turkey/Ireland/1378/1983(H5N8))
Sequence Strain (Speices/Organism) : Influenza A virus (A/turkey/Ireland/1378/1983(H5N8))
VO ID : VO_0011141
NCBI Protein GI : 115279333
Other Database IDs : CDD:109560
Taxonomy ID : 380285
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin
Protein Length : 566
Protein Note : Hemagglutinin; pfam00509

Protein Sequence : Show Sequence

>gi|115279333|gb|ABI85117.1| hemagglutinin [Influenza A virus (A/turkey/Ireland/1378/1983(H5N8))]
MEKIVLLFAIVSLVRSDQICIGYHANNSTKQVDTIMEKNVTVTHAQDILEKTHNGKLCSLNGVKPLILRD
CSVAGWLLGNPMCDEFLNVPEWSYIVEKDNPVNGLCYPGDFNDYEELKHLLSCTKHFEKIRIIPRDSWPN
HEASLGVSSACPYNGRSSFFRNVVWLIKKNNAYPTIKRSYSNTNKEDLLILWGIHHPNDAAEQTKLYQNP
TTYVSVGTSTLNQRSIPKIATRPELNGQSGRMEFFWTILKPSDTINFESNGNFIAPEYAYKIVKKGDSAI
MKSGLEYGNCNTKCQTPIGAINSSMPLHNIHPLTIGECPKYVKSDRLVLATGLRNTPQRKRKKRGLFGAI
AGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQRAIDGITNKVNSIIDKMNTQFEAVGKEFNNLERR
IENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDANVKSLYDKVRLQLKDNARELGNGCFEFYHKCDN
ECMESIRNGTYNYPQYSEEARLNREEISGVKLESMGIYQILSIYSTVASSLALAIMIAGLSFWMCSNGSL
QCRICI

Molecule Role : Protective antigen
Molecule Role Annotation : All specific-pathogen-free chickens immunized with (vFP89) expressing the native hemagglutinin (HA) gene from H5N8 A/turkey/ Ireland/1378/83 were clinically protected from HPAI challenge (Bublot et al., 2010).

21. HA from Influenza A virus (A/Viet Nam/1203/2004(H5N1))

Gene Name : HA from Influenza A virus (A/Viet Nam/1203/2004(H5N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/Viet Nam/1203/2004(H5N1))
VO ID : VO_0011138
NCBI Protein GI : 159144921
Other Database IDs : CDD:109560
Taxonomy ID : 284218
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin
Protein Length : 564
Protein Note : Hemagglutinin; pfam00509

Protein Sequence : Show Sequence

>gi|159144921|gb|ABW90135.1| hemagglutinin [Influenza A virus (A/Viet Nam/1203/2004(H5N1))]
MEKIVLLFAIVSLVKSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKKHNGKLCDLDGVKPLILRD
CSVAGWLLGNPMCDEFINVPEWSYIVEKANPVNDLCYPGDFNDYEELKHLLSRINHFEKIQIIPKSSWSS
HEASLGVSSACPYQGKSSFFRNVVWLINKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTKLYQNP
TTYISVGTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSTI
MKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNSPQRETRGLFGAIAG
FIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLERRIE
NLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKCDNEC
MESVRNGTYDYPQYSEEARLKREEISGVKLESIGIYQILSIYSTVASSLALAIMVAGLSLWMCSNGSLQC
RICI

Molecule Role : Protective antigen
Molecule Role Annotation : Researchers evaluated the immunogenicity and efficacy of a panel of flagellin-based hemagglutinin (HA) globular head fusion vaccines in inbred mice. The HA globular head of these vaccines was derived from the A/Vietnam/1203/04 (VN04; H5N1) HA molecule. Results show that replacement of domain D3 of flagellin with the VN04 HA globular head creates a highly effective vaccine that elicits protective HAI titers which protect mice against disease and death in a lethal challenge model with H5 VN virus (Song et al., 2009).
Related Vaccine(s): Influenza virus HA protein vaccine (Influenza A virus (A/Viet Nam/1203/2004(H5N1)))

22. HA from Influenza A virus (A/whooper swan/Mongolia/3/05(H5N1))

Gene Name : HA from Influenza A virus (A/whooper swan/Mongolia/3/05(H5N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/whooper swan/Mongolia/3/05(H5N1))
VO ID : VO_0011144
NCBI Protein GI : 81687119
Other Database IDs : CDD:109560
Taxonomy ID : 344596
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin
Protein Length : 568
Protein Note : Hemagglutinin; pfam00509

Protein Sequence : Show Sequence

>gi|81687119|dbj|BAE48316.1| hemagglutinin [Influenza A virus (A/whooper swan/Mongolia/3/05(H5N1))]
MEKIVLLLAIVSLVKSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKTHNGKLCDLDGVKPLILRD
CSVAGWLLGNPMCDEFLNVPEWSYIVEKINPANDLCYPGNFNDYEELKHLLSRINHFEKIQIIPKSSWSD
HEASSGVSSACPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTRLYQNP
TTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPENAYKIVKKGDSTI
MKSELEYGNCNTKCQTPIGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNSPQGERRRRKRGLFG
AIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLE
RRIENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHRC
DNECMESVRNGTYDYPQYSEEARLKREEISGVKLESIGTYQILSIYSTVASSLALAIMVAGLSLWMCSNG
SLQCRICI

Molecule Role : Protective antigen
Molecule Role Annotation : Chickens immunized with attenuated Salmonella strains expressing the hemagglutinin (HA1) gene from a highly pathogenic avian influenza (HPAI) H5N1 (A/whooper swan/Mongolia/3/2005) demonstrated a statistically significant increase in survival compared to control groups (Liljebjelke et al., 2010).

23. HA from Influenza A virus (A/WSN/1933(H1N1))

Gene Name : HA from Influenza A virus (A/WSN/1933(H1N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/WSN/1933(H1N1))
VO ID : VO_0011113
NCBI Protein GI : 324200
Other Database IDs : CDD:109560
Taxonomy ID : 382835
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin precursor
Protein Length : 565
Protein Note : signal peptide

Protein Sequence : Show Sequence

>gi|324200|gb|AAA43209.1| hemagglutinin precursor [Influenza A virus (A/WSN/1933(H1N1))]
MKAKLLVLLYAFVATDADTICIGYHANNSTDTVDTIFEKNVAVTHSVNLLEDRHNGKLCKLKGIAPLQLG
KCNITGWLLGNPECDSLLPARSWSYIVETPNSENGACYPGDFIDYEELREQLSSVSSLERFEIFPKESSW
PNHTFNGVTVSCSHRGKSSFYRNLLWLTKKGDSYPKLTNSYVNNKGKEVLVLWGVHHPSSSDEQQSLYSN
GNAYVSVASSNYNRRFTPEIAARPKVKDQHGRMNYYWTLLEPGDTIIFEATGNLIAPWYAFALSRGFESG
IITSNASMHECNTKCQTPQGSINSNLPFQNIHPVTIGECPKYVRSTKLRMVTGLRNIPSIQYRGLFGAIA
GFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQNAINGITNKVNSVIEKMNTQFTAVGKEFNNLEKRM
ENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDLNVKNLYEKVKSQLKNNAKEIGNGCFEFYHKCDNE
CMESVRNGTYDYPKYSEESKLNREKIDGVKLESMGVYQILAIYSTVASSLVLLVSLGAISFWMCSNGSLQ
CRICI

Molecule Role : Protective antigen
Molecule Role Annotation : A nonpathogenic vector of the cytoplasmic domain of the VSV G protein and expressing influenza virus HA (derived from Influenza A virus (A/WSN/1933(H1N1))) provides complete protection from lethal influenza virus challenge after intranasal administration. A second vector with VSV G deleted and expressing HA (DeltaG-HA) is also protective and nonpathogenic and has the advantage of not inducing neutralizing antibodies to the vector itself (Roberts et al., 1999).
Related Vaccine(s): Influenza virus DNA vaccine encoding HA from Influenza A virus (A/WSN/1933(H1N1))

24. HA from Influenza A virus (A/Yamagata/120/1986(H1N1))

Gene Name : HA from Influenza A virus (A/Yamagata/120/1986(H1N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/Yamagata/120/1986(H1N1))
VO ID : VO_0011126
NCBI Protein GI : 221344
Other Database IDs : CDD:109560
Taxonomy ID : 379740
Gene Strand (Orientation) : ?
Protein Name : hemagglutinin
Protein Length : 141
Protein Note : synonym: Influenza A virus (A/Yamagata/120/86 (H1N1))

Protein Sequence : Show Sequence

>gi|221344|dbj|BAA02766.1| hemagglutinin [Influenza A virus (A/Yamagata/120/1986(H1N1))]
PFQNVHPVTIGECPKYVRSTKLRMVTGLRNIPSIQSRGLFGAIAGFIEGGWTGMIDGWYGYHHQNEQGSG
YAADQKSTQNAINGITNKVNSVIEKMNTQFTAVGKEFNKLERRMENLNKKVDDGFLDIWTYNAELLVLLE
N

Molecule Role : Protective antigen
Molecule Role Annotation : The inoculation of HA vaccine prepared from influenza viruses A/Yamagata/120/86 (H1N1) or A/Fukuoka/C29/85 (H3N2) together with CTB provided partial protection against PR-8 infection in Balb/c mice (Tamura et al., 1989).
Related Vaccine(s): Influenza virus HA protein vaccine (Influenza A virus (A/Yamagata/120/1986(H1N1)))

25. HA from Influenza B virus (B/Ibaraki/2/85)

Gene Name : HA from Influenza B virus (B/Ibaraki/2/85)
Sequence Strain (Speices/Organism) : Influenza B virus (B/Ibaraki/2/85)
VO ID : VO_0011128
NCBI Protein GI : 122959
Other Database IDs : CDD:109560
Taxonomy ID : 107411
Gene Strand (Orientation) : ?
Protein Name : Hemagglutinin
Protein Length : 347
Protein Note : Hemagglutinin HA1 chain. /FTId=PRO_0000039110.

Protein Sequence : Show Sequence

>gi|122959|sp|P18878.1|HEMA_INBIB RecName: Full=Hemagglutinin; Contains: RecName: Full=Hemagglutinin HA1 chain
DRICTGITSSNSPHVVKTATQGEVNVTGVIPLTTTPTKSHFANLKGTKTRGKLCPKCLNCTDLDVALGRP
KCMGTIPSAKASILHEVKPVTSGCFPIMHDRTKIRQLPNLLRGYENIRLSTHNVINAETAPGGPYIVGTS
GSCPNVTNGNGFFATMAWAVPKNNNNKTATNPLTVEVPFICTEGEDQITVWGFHSDDETQMVKLYGDSKP
QKFTSSANGVTTHYVSQIGGFPNQAEDGGLPQSGRIVVDHMVQKSGKTGTITYQRGILLPQKVSCPSGRS
KVIKGSFPLIGEADCLHEKYGALNKSKPYYTGAHAKAIGNCPIWVKTPLKLANGTKYRPPAKLLKER

Molecule Role : Protective antigen
Molecule Role Annotation : Protection against a lethal influenza B virus infection was examined in BALB/c mice immunized with plasmid DNAs encoding hemagglutinin (HA), neuraminidase (NA and NB) and nucleoprotein (NP) from the B/Ibaraki/2/85 virus. Both HA and NA DNAs conferred complete protection against the lethal challenge in all the tested mouse strains (Chen et al., 2001).
Related Vaccine(s): Influenza virus DNA vaccine encoding HA from Influenza B virus (B/Ibaraki/2/85)

26. HA from Influenza B virus (Strain B/England/222/82)

Gene Name : HA from Influenza B virus (Strain B/England/222/82)
Sequence Strain (Speices/Organism) : Influenza B virus (Strain B/England/222/82)
VO ID : VO_0011117
NCBI Protein GI : 122955
Other Database IDs : CDD:109560
Taxonomy ID : 11527
Gene Strand (Orientation) : ?
Protein Name : Hemagglutinin
Protein Length : 583
Protein Note : A -> P (in Ref. 2; CAA35095).

Protein Sequence : Show Sequence

>gi|122955|sp|P10757.1|HEMA_INBEN RecName: Full=Hemagglutinin; Contains: RecName: Full=Hemagglutinin HA1 chain; Contains: RecName: Full=Hemagglutinin HA2 chain; Flags: Precursor
MKAIIVLLMVVTSNADRICTGITSSNSPHVVKTATQGEVNVTGVIPLTTTPTKSHFANLKGTKTRGKLCP
NCLNCTDLDVALARPKCMGTIPSAKASILHEVKPVTSGCFPIMHDRTKIRQLPNLLRGYENIKLSTRNVI
NAERAPGGPYIIGTSGSCPNVTNGNGFFATMAWAVPKDNKTATNPLTVEVPYICTKGEDQITVWGFHSDN
AIQMVKLYGDSKPQKFTSSANGVTTHYVSQIGGFPNQTEDGGLPQSGRIVVDYMVQKPGKTGTIVYQRGV
LLPQKVWCASGRSKVIKGSLPLIGEADCLHEKYGGLNKSKPYYTGEHAKAIGNCPIWVKTPLKLANGTKY
RPPAKLLKERGFFGAIAGFLEGGWEGMIAGWHGYTSHGAHGVAVAADLKSTQEAINKITKNLNSLSELEV
KNLQRLSGAMDELHNEILELDEKVDDLRADTISSQIELAVLLSNEGIINSEDEHLLALERKLKKMLGPSA
VDIGNGCFETKHKCNQTCLDRIAAGTFNAGEFSLPTFDSLNITAASLNDDGLDNHTILLYYSTAASSLAV
TLMIAIFIVYMVSRDNVSCSICL

Molecule Role : Protective antigen
Molecule Role Annotation : Immunization and challenge experiments in mice indicated that even though vaccination with the recombinant HA vaccinia viruses derived from Influenza B virus (Strain B/England/222/82) induced different levels of cross-reactive neutralizing antibodies, mice vaccinated with either recombinant vaccinia virus were protected from infection with either subpopulation of influenza virus (Rota et al., 1987).
Related Vaccine(s): Influenza virus DNA vaccine encoding HA from Influenza B virus (Strain B/England/222/82)

27. M1 from Influenza A virus (A/chicken/Henan/12/2004(H5N1))

Gene Name : M1 from Influenza A virus (A/chicken/Henan/12/2004(H5N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/chicken/Henan/12/2004(H5N1))
VO ID : VO_0011136
NCBI Protein GI : 61698034
Other Database IDs : CDD:109646
CDD:128998
Taxonomy ID : 319102
Gene Strand (Orientation) : ?
Protein Name : matrix protein 1
Protein Length : 252
Protein Note : Influenza Matrix protein (M1); pfam00598

Protein Sequence : Show Sequence

>gi|61698034|gb|AAX53515.1| matrix protein 1 [Influenza A virus (A/chicken/Henan/12/2004(H5N1))]
MSLLTEVETYVLSIIPSGPLKAEIAQKLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPS
ERGLQRRRFVQNALNGNGDPNNMDRAVKLYKKLKREITFHGAKEVALSYSTGALASCMGLIYNRMGTVTT
EVAFGLVCATCEQIADSQHRSHRQMATITNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVANQAR
QMVQAMRTIGTHPNSSAGLRDNLLENLQAYQKRMGVQMQRFK

Molecule Role : Protective antigen
Molecule Role Annotation : Plasmids carrying the HA, NA, NP, M1, and M2 genes, respectively, of the avian influenza virus (AIV) A/Chicken/Henan/12/2004(H5N1) strain were administered to mice, and the mice were challenged with the homologous virus later. The mice immunized with M1 plasmid survived 25% with five immunizations. The mixture of M1 and NP plasmids protected 95% of the mice against the homologous virus, and 80% of the mice against a challenge with heterologous H1N1 (PR8) virus (Chen et al., 2009).
Related Vaccine(s): Influenza virus DNA vaccine encoding M1 from Influenza A virus (A/chicken/Henan/12/2004(H5N1))

28. M2 from Influenza A virus (A/Puerto Rico/8/34(H1N1))

Gene Name : M2 from Influenza A virus (A/Puerto Rico/8/34(H1N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/Puerto Rico/8/34(H1N1))
VO ID : VO_0011119
NCBI Gene ID : 956528
NCBI Protein GI : 56583270
Locus Tag : FLUAVs7gp2
Genbank Accession : V01099
Protein Accession : NP_040979
Taxonomy ID : 211044
Gene Starting Position : 25
Gene Ending Position : 1006
Gene Strand (Orientation) : +
Protein Name : matrix protein 2
Protein pI : 5.72
Protein Weight : 10647.4
Protein Length : 97

DNA Sequence : Show Sequence

>gi|8486122:25-1006 Influenza A virus (A/Puerto Rico/8/34(H1N1)) segment 7, complete sequence
GATGAGTCTTCTAACCGAGGTCGAAACGTACGTTCTCTCTATCATCCCGTCAGGCCCCCTCAAAGCCGAG
ATCGCACAGAGACTTGAAGATGTCTTTGCAGGGAAGAACACCGATCTTGAGGTTCTCATGGAATGGCTAA
AGACAAGACCAATCCTGTCACCTCTGACTAAGGGGATTTTAGGATTTGTGTTCACGCTCACCGTGCCCAG
TGAGCGAGGACTGCAGCGTAGACGCTTTGTCCAAAATGCCCTTAATGGGAACGGGGATCCAAATAACATG
GACAAAGCAGTTAAACTGTATAGGAAGCTCAAGAGGGAGATAACATTCCATGGGGCCAAAGAAATCTCAC
TCAGTTATTCTGCTGGTGCACTTGCCAGTTGTATGGGCCTCATATACAACAGGATGGGGGCTGTGACCAC
TGAAGTGGCATTTGGCCTGGTATGTGCAACCTGTGAACAGATTGCTGACTCCCAGCATCGGTCTCATAGG
CAAATGGTGACAACAACCAACCCACTAATCAGACATGAGAACAGAATGGTTTTAGCCAGCACTACAGCTA
AGGCTATGGAGCAAATGGCTGGATCGAGTGAGCAAGCAGCAGAGGCCATGGAGGTTGCTAGTCAGGCTAG
GCAAATGGTGCAAGCGATGAGAACCATTGGGACTCATCCTAGCTCCAGTGCTGGTCTGAAAAATGATCTT
CTTGAAAATTTGCAGGCCTATCAGAAACGAATGGGGGTGCAGATGCAACGGTTCAAGTGATCCTCTCGCT
ATTGCCGCAAATATCATTGGGATCTTGCACTTGATATTGTGGATTCTTGATCGTCTTTTTTTCAAATGCA
TTTACCGTCGCTTTAAATACGGACTGAAAGGAGGGCCTTCTACGGAAGGAGTGCCAAAGTCTATGAGGGA
AGAATATCGAAAGGAACAGCAGAGTGCTGTGGATGCTGACGATGGTCATTTTGTCAGCATAGAGCTGGAG
TA

Protein Sequence : Show Sequence

>gi|56583270|ref|NP_040979.2| matrix protein 2 [Influenza A virus (A/Puerto Rico/8/34(H1N1))]
MSLLTEVETPIRNEWGCRCNGSSDPLAIAANIIGILHLILWILDRLFFKCIYRRFKYGLKGGPSTEGVPK
SMREEYRKEQQSAVDADDGHFVSIELE

Molecule Role : Protective antigen
Molecule Role Annotation : A targeted fusion protein based on the CTA1-DD adjuvant and containing tandem repeats of the matrix protein 2 (M2e) ectodomain epitope derived from Influenza A virus (A/Puerto Rico/8/34(H1N1)), CTA1-3M2e-DD, confers strong protective immunity against a potentially lethal challenge infection with influenza virus in mice. The formulation was highly effective for mucosal immunizations and promoted high M2e-specific serum IgG and mucosal IgA antibody titers and an hitherto unknown anti-M2e CD4 T cell immunity (Eliasson et al., 2008).
Additional Molecule Role : Virmugen
Additional Molecule Role Annotation : Mutant influenza virus that lacks the transmembrane and cytoplasmic tail domains of M2 (M2 knockout [M2KO]) from Influenza A virus (A/Puerto Rico/8/34(H1N1)) is attenuated in both cell culture and mice. Mice intranasally vaccinated with M2KO virus developed protective immune responses and survived a lethal challenge with the wild-type virus, suggesting that the M2KO virus has potential as a live attenuated vaccine (Watanabe et al., 2009).
Related Vaccine(s): Influenza virus CTA1-3M2e-DD protein vaccine

29. NA from Influenza A virus (A/Aichi/2/1968(H3N2))

Gene Name : NA from Influenza A virus (A/Aichi/2/1968(H3N2))
Sequence Strain (Speices/Organism) : Influenza A virus (A/Aichi/2/1968(H3N2))
VO ID : VO_0011123
NCBI Protein GI : 46401580
Other Database IDs : CDD:29333
Taxonomy ID : 387139
Gene Strand (Orientation) : ?
Protein Name : neuraminidase
Protein Length : 469
Protein Note : synonym: Influenza A virus (A/Aichi/2/68(H3N2))

Protein Sequence : Show Sequence

>gi|46401580|dbj|BAD16642.1| neuraminidase [Influenza A virus (A/Aichi/2/1968(H3N2))]
MNPNQKIITIGSVSLTIATVCFLMQIAILVTTVTLHFKQYECDSPASNQVMPCEPIIIERNITEIVYLNN
TTIDKEKCPKVVEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDHGKCYQFALGQGTTL
DNKHSNDTIHDRIPHRTLLMNELGVPFHLGTRQVCIAWSSSSCHDGKAWLHVCITGDDKNATASFIYDGR
LVDSIGSWSQNILRTQESECVCINGTCTVVMTDGSASGRADTRILFIEEGKIVHISPLSGSAQHVEECSC
YPRYPGVRCICRDNWKGSNRPVVDINMEDYSIDSSYVCSGLVGDTPRNDDRSSNSNCRNPNNERGNQGVK
GWAFDNGDDVWMGRTISKDLRSGYETFKVIGGWSTPNSKSQINRQVIVDSDNRSGYSGIFSVEGKSCINR
CFYVELIRGRKQETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI

Molecule Role : Protective antigen
Molecule Role Annotation : The protective effect of neuraminidase (NA) was studied in a mouse protection test using isolated neuraminidase of A2/Aichi/68(H3N2) virus and the complete recombinant virus A/eq(Heq-1)-HK(N2) as antigens. Immunized mice were protected against A2/Aichi(H3N2) challenge virus; however, the protection rate was low in comparison to animals immunized with comparable amounts of the complete A2/68(H3N2) virus9 (Reichert and Mauler, 1975).

30. NA from Influenza A virus (A/chicken/Henan/12/2004(H5N1))

Gene Name : NA from Influenza A virus (A/chicken/Henan/12/2004(H5N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/chicken/Henan/12/2004(H5N1))
VO ID : VO_0011135
NCBI Protein GI : 61698053
Other Database IDs : CDD:29333
Taxonomy ID : 319102
Gene Strand (Orientation) : ?
Protein Name : neuraminidase
Protein Length : 449
Protein Note : Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; cd00260

Protein Sequence : Show Sequence

>gi|61698053|gb|AAX53527.1| neuraminidase [Influenza A virus (A/chicken/Henan/12/2004(H5N1))]
MNPNQKIITIGSICMVIGIVSLMLQIGNMISIWVSHSIQTGNQHQAEPISNTNFLTEKAVASVTLAGNSS
LCPISGWAVHSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMS
CPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESE
CACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELEAPNYHYEECSCYPDAGEITCVCRDNWHGSN
RPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSPNGAYGVKGFSFKYGNGVWIGRTKSTNSRSG
FEMIWDPNGWTGTDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSG
SSISFCGVNSDTVGWSWPDGAELPFTIDK

Molecule Role : Protective antigen
Molecule Role Annotation : Plasmids carrying the HA, NA, NP, M1, and M2 genes, respectively, of the avian influenza virus (AIV) A/Chicken/Henan/12/2004(H5N1) strain were administered to mice, and the mice were challenged with the homologous virus later. The mice immunized with HA plasmid once and the NA plasmid twice survived 100% (Chen et al., 2009).
Related Vaccine(s): Influenza virus DNA vaccine encoding NA from Influenza A virus (A/chicken/Henan/12/2004(H5N1))

31. NA from Influenza B virus (B/Ibaraki/2/85)

Gene Name : NA from Influenza B virus (B/Ibaraki/2/85)
Sequence Strain (Speices/Organism) : Influenza B virus (B/Ibaraki/2/85)
VO ID : VO_0011129
NCBI Protein GI : 53829726
Other Database IDs : CDD:29333
Taxonomy ID : 107411
Gene Strand (Orientation) : ?
Protein Name : NA glycoprotein
Protein Length : 465
Protein Note : Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; cd00260

Protein Sequence : Show Sequence

>gi|53829726|gb|AAU94751.1| NA glycoprotein [Influenza B virus (B/Ibaraki/2/85)]
MLPSTIQTLTLFLTSGGVLLSLYVSASLSYLLYSDILLKFSPKITAPTMTLDCANASNVQAVNRSATKEM
TFLLPEPEWTYPRLSCQGSTFQKALLISPHRFGEARGNSAPLIIREPFIACGPKECKHFALTHYAAQPGG
YYNGTREDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGREWTYIGVDGPDSNALIKIKYGEAYT
DTYHSYANNILRTQESACNCIGGDCYLMITDGSASGISKCRFLKIREGRIIKEIFPTGRVEHTEECTCGF
ASNKTIECACRDNNYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGRGGIKGG
FVHQRMASKIGRWYSRTMSKTERMGMELYVKYDGDPWTDSDALAPSGVMVSMKEPGWYSFGFEIKDKKCD
VPCIGIEMVHDGGKKTWHSAATAIYCLMGSGQLLWDTVTGVDMAL

Molecule Role : Protective antigen
Molecule Role Annotation : Protection against a lethal influenza B virus infection was examined in BALB/c mice immunized with plasmid DNAs encoding hemagglutinin (HA), neuraminidase (NA and NB) and nucleoprotein (NP) from the B/Ibaraki/2/85 virus. Both HA and NA DNAs conferred complete protection against the lethal challenge in all the tested mouse strains (Chen et al., 2001).
Related Vaccine(s): Influenza virus DNA vaccine encoding NA from Influenza B virus (B/Ibaraki/2/85)

32. NP from Influenza A virus (A/chicken/Henan/12/2004(H5N1))

Gene Name : NP from Influenza A virus (A/chicken/Henan/12/2004(H5N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/chicken/Henan/12/2004(H5N1))
VO ID : VO_0011134
NCBI Protein GI : 61698066
Other Database IDs : CDD:144193
Taxonomy ID : 319102
Gene Strand (Orientation) : ?
Protein Name : nucleocapsid protein
Protein Length : 498
Protein Note : Influenza virus nucleoprotein; pfam00506

Protein Sequence : Show Sequence

>gi|61698066|gb|AAX53533.1| nucleocapsid protein [Influenza A virus (A/chicken/Henan/12/2004(H5N1))]
MASQGTKRSYEQMETGGERQNATEIRASVGRMVSGIGRFYIQMCTELKLSDYEGRLIQNSITIERMVLSA
FDERRNRYLEEHPSAGKDPKKTGGPIYRRRDGKWVRELILYDKEEIRRIWRQANNGEDATAGLTHLMIWH
SNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGE
NGRRTRIAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACV
YGLAVASGYDFEREGYSLVGIDPFRLLQNSQVFSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRGT
RVVPRGQLSTRGVQIASNENMEAMDSNTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPF
ERATIMAAFTGNTEGRTSDMRTEIIRMMESARPEDVSFQGRGVFELSDEKATNPIVPSFDMNNEGSYFFG
DNAEEYDN

Molecule Role : Protective antigen
Molecule Role Annotation : Plasmids carrying the HA, NA, NP, M1, and M2 genes, respectively, of the avian influenza virus (AIV) A/Chicken/Henan/12/2004(H5N1) strain were administered to mice, and the mice were challenged with the homologous virus later. The mice immunized with NP plasmid showed 60-80% survival rate with at least three immunizations. The mixture of M1 and NP plasmids protected 95% of the mice against the homologous virus, and 80% of the mice against a challenge with heterologous H1N1 (PR8) virus (Chen et al., 2009).
Related Vaccine(s): Infleunza virus DNA vaccine encoding NP from Influenza A virus (A/chicken/Henan/12/2004(H5N1))

33. NP from Influenza A virus (A/chicken/Hubei/489/2004(H5N1))

Gene Name : NP from Influenza A virus (A/chicken/Hubei/489/2004(H5N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/chicken/Hubei/489/2004(H5N1))
VO ID : VO_0011137
NCBI Protein GI : 55233233
Other Database IDs : CDD:144193
Taxonomy ID : 298603
Gene Strand (Orientation) : ?
Protein Name : nucleoprotein
Protein Length : 498
Protein Note : Influenza virus nucleoprotein; pfam00506

Protein Sequence : Show Sequence

>gi|55233233|gb|AAV48549.1| nucleoprotein [Influenza A virus (A/chicken/Hubei/489/2004(H5N1))]
MASQGTKRSYEQMETGGERQNATEIRASVGRMVSGIGRFYIQMCTELKLSDYEGRLIQNSITIERMVLSA
FDERRNRYLEEHPSAGKDPKKTGGPIYRRRDGKWVRELILYDKEEIRRIWRQANNGEDATAGLTHLMIWH
SNLDDATSQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGE
NGRRTRIAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACV
YGLAVASGYDFEREGYSLVGIDPFRLLQNSQVFSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRGT
RVVPRGQLSTRGVQIASNENMEAMDSNTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPF
ERATIMAAFTGNTEGRTSDMRTEIIRMMESARPEDVSFQGRGVFELSDEKATNPIVPSFDMNNEGSYFFG
DNAEEYDN

Molecule Role : Protective antigen
Molecule Role Annotation : Vaccination with ptPAs/NP derived from Influenza A virus (A/chicken/Hubei/489/2004(H5N1)) efficiently cleared the homologous H5N1 influenza virus in the infected lungs and induced partial cross-protection against heterologous, highly pathogenic H5N1 strains in mice (Luo et al., 2008).
Related Vaccine(s): Influenza virus DNA vaccine encoding NP from Influenza A virus (A/chicken/Hubei/489/2004(H5N1))

34. NP from Influenza A virus (A/nt/60/1968(H3N2))

Gene Name : NP from Influenza A virus (A/nt/60/1968(H3N2))
Sequence Strain (Speices/Organism) : Influenza A virus (A/nt/60/1968(H3N2))
VO ID : VO_0011264
NCBI Protein GI : 324704
Other Database IDs : CDD:144193
Taxonomy ID : 384505
Protein Name : nucleoprotein
Protein Length : 498
Protein Note : Influenza virus nucleoprotein; pfam00506

Protein Sequence : Show Sequence

>gi|324704|gb|AAA43465.1| nucleoprotein [Influenza A virus (A/nt/60/1968(H3N2))]
MASQGTKRSYEQMETDGERQNATEIRASVGKMIDGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSA
FDERRNKYLEEHPSAGKDPKKTGGPIYKRVDGKWMRELVLYDKGEIRRIWRQANNGDDATAGLTHMMIWH
SNLNDTTYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGE
NGRKTRSAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACV
YGPAVASGYDFEKEGYSLVGIDPFKLLQNSQVYSLIRPNENPAHKSQLVWMACNSAAFEDLRVLSFIRGT
KVSPRGKLSTRGVQIASNENMDAMESSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPAFSVQRNLPF
DKPTIMAAFTGNTEGRTSDMRAEIIRMMEGAKPEEMSFQGRGVFELSDEKAANPIVPSFDMSNEGSYFFG
DNAEEYDN

Molecule Role : Protective antigen
Molecule Role Annotation : Mice immunized with Recombinant-derived nucleoprotein (rNP) from S. typhimurium expressing the cloned NP gene from A/NT/60/68 (Jones & Brownlee, 1985) were protected against a lethal challenge with Influenza A/Puerto Rico/8/34 (A/PR8) virus but showed considerable morbidity before recovery (Tite et al., 1990).
Related Vaccine(s): Influenza virus NP protein vaccine (Influenza A virus (A/nt/60/1968(H3N2)))

35. NP from Influenza A virus (A/Puerto Rico/8/34(H1N1))

Gene Name : NP from Influenza A virus (A/Puerto Rico/8/34(H1N1))
Sequence Strain (Speices/Organism) : Influenza A virus (A/Puerto Rico/8/34(H1N1))
VO ID : VO_0011122
NCBI Gene ID : 956531
NCBI Protein GI : 8486130
Locus Tag : FLUAVs5gp1
Genbank Accession : J02147
Protein Accession : NP_040982
Taxonomy ID : 211044
Gene Starting Position : 45
Gene Ending Position : 1541
Gene Strand (Orientation) : +
Protein Name : nucleocapsid protein
Protein pI : 9.56
Protein Weight : 53786.92
Protein Length : 498

DNA Sequence : Show Sequence

>gi|8486129:45-1541 Influenza A virus (A/Puerto Rico/8/34(H1N1)) segment 5, complete sequence
CATGGCGTCCCAAGGCACCAAACGGTCTTACGAACAGATGGAGACTGATGGAGAACGCCAGAATGCCACT
GAAATCAGAGCATCCGTCGGAAAAATGATTGGTGGAATTGGACGATTCTACATCCAAATGTGCACAGAAC
TTAAACTCAGTGATTATGAGGGACGGTTGATCCAAAACAGCTTAACAATAGAGAGAATGGTGCTCTCTGC
TTTTGACGAAAGGAGAAATAAATACCTGGAAGAACATCCCAGTGCGGGGAAGGATCCTAAGAAAACTGGA
GGACCTATATACAGAAGAGTAAACGGAAAGTGGATGAGAGAACTCATCCTTTATGACAAAGAAGAAATAA
GGCGAATCTGGCGCCAAGCTAATAATGGTGACGATGCAACGGCTGGTCTGACTCACATGATGATCTGGCA
TTCCAATTTGAATGATGCAACTTATCAGAGGACAAGGGCTCTTGTTCGCACCGGAATGGATCCCAGGATG
TGCTCTCTGATGCAAGGTTCAACTCTCCCTAGGAGGTCTGGAGCCGCAGGTGCTGCAGTCAAAGGAGTTG
GAACAATGGTGATGGAATTGGTCAGGATGATCAAACGTGGGATCAATGATCGGAACTTCTGGAGGGGTGA
GAATGGACGAAAAACAAGAATTGCTTATGAAAGAATGTGCAACATTCTCAAAGGGAAATTTCAAACTGCT
GCACAAAAAGCAATGATGGATCAAGTGAGAGAGAGCCGGGACCCAGGGAATGCTGAGTTCGAAGATCTCA
CTTTTCTAGCACGGTCTGCACTCATATTGAGAGGGTCGGTTGCTCACAAGTCCTGCCTGCCTGCCTGTGT
GTATGGACCTGCCGTAGCCAGTGGGTACGACTTTGAAAGAGAGGGATACTCTCTAGTCGGAATAGACCCT
TTCAGACTGCTTCAAAACAGCCAAGTGTACAGCCTAATCAGACCAAATGAGAATCCAGCACACAAGAGTC
AACTGGTGTGGATGGCATGCCATTCTGCCGCATTTGAAGATCTAAGAGTATTGAGCTTCATCAAAGGGAC
GAAGGTGGTCCCAAGAGGGAAGCTTTCCACTAGAGGAGTTCAAATTGCTTCCAATGAAAATATGGAGACT
ATGGAATCAAGTACACTTGAACTGAGAAGCAGGTACTGGGCCATAAGGACCAGAAGTGGAGGAAACACCA
ATCAACAGAGGGCATCTGCGGGCCAAATCAGCATACAACCTACGTTCTCAGTACAGAGAAATCTCCCTTT
TGACAGAACAACCGTTATGGCAGCATTCACTGGGAATACAGAGGGGAGAACATCTGACATGAGGACCGAA
ATCATAAGGATGATGGAAAGTGCAAGACCAGAAGATGTGTCTTTCCAGGGGCGGGGAGTCTTCGAGCTCT
CGGACGAAAAGGCAGCGAGCCCGATCGTGCCTTCCTTTGACATGAGTAATGAAGGATCTTATTTCTTCGG
AGACAATGCAGAGGAGTACGACAATTA

Protein Sequence : Show Sequence

>gi|8486130|ref|NP_040982.1| nucleocapsid protein [Influenza A virus (A/Puerto Rico/8/34(H1N1))]
MASQGTKRSYEQMETDGERQNATEIRASVGKMIGGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSA
FDERRNKYLEEHPSAGKDPKKTGGPIYRRVNGKWMRELILYDKEEIRRIWRQANNGDDATAGLTHMMIWH
SNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELVRMIKRGINDRNFWRGE
NGRKTRIAYERMCNILKGKFQTAAQKAMMDQVRESRDPGNAEFEDLTFLARSALILRGSVAHKSCLPACV
YGPAVASGYDFEREGYSLVGIDPFRLLQNSQVYSLIRPNENPAHKSQLVWMACHSAAFEDLRVLSFIKGT
KVVPRGKLSTRGVQIASNENMETMESSTLELRSRYWAIRTRSGGNTNQQRASAGQISIQPTFSVQRNLPF
DRTTVMAAFTGNTEGRTSDMRTEIIRMMESARPEDVSFQGRGVFELSDEKAASPIVPSFDMSNEGSYFFG
DNAEEYDN

Molecule Role : Protective antigen
Molecule Role Annotation : A simian adenovirus 24 (AdC7) vector expressing the influenza A/Puerto Rico/8/34 NP was tested for its efficacy in protecting BALB/c mice against two H5N1 strains. When tested in a mouse challenge model, there was a significantly improved survival rate following challenge with the Vietnam/1203/04 strain of H5N1 that has caused human outbreaks (Roy et al., 2007).
Related Vaccine(s): AdH5-FluA NP

36. NP from Influenza A virus H3N2

Gene Name : NP from Influenza A virus H3N2
Sequence Strain (Speices/Organism) : Influenza A virus H3N2
VO ID : VO_0011111
NCBI Protein GI : 3722159
Other Database IDs : CDD:144193
Taxonomy ID : 41857
Gene Strand (Orientation) : ?
Protein Name : nucleoprotein
Protein Length : 498
Protein Note : Influenza virus nucleoprotein; pfam00506

Protein Sequence : Show Sequence

>gi|3722159|gb|AAC63462.1| nucleoprotein [Influenza A virus H3N2]
MASQGTKRSYEQMETDGERQNATEIRASVGKMIDGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSA
FDERRNRYLEEHPSAGKDPKKTGGPIYKRVDGRWMRELVLYDKEEIRRIWRQANNGDDATAGLTHMMIWH
SNLNDTTYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGIGTMVMELIRMIKRGINDRNFWRGE
NGRKTRSAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFSARSALILRGSVAHKSCLPACV
YGPAVSSGYNFEKEGYSLVGIDPFKLLQNSQVYSLIRPNENPAHKSQLVWMACHSAAFEDLRLLSFIRGT
KVSPRGKLSTRGVQIASNENMDNMESSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPF
EKSTVMAAFTGNTEGRTSDMRAEIIRMMEGAKPEEVSFRGRGVFELSDEKATNPIVPSFDMSNEGSYFFG
DNAEEYDN

Molecule Role : Protective antigen
Molecule Role Annotation : BALB/c mice were immunized intranasally with an adjuvant (cholera toxin B subunit containing 0.2% of the whole toxin)-combined with A or B virus recombinant NP. The NP-immune mice, when challenged intranasally with a sublethal dose of the virus 3 wk after immunization, had accelerated virus clearance from the nasal site in both an influenza type-specific and a nonspecific manner, as shown by the protection from high morbidity from the second day after challenge (Tamura et al., 1996).

37. NP from Influenza B virus

Gene Name : NP from Influenza B virus
Sequence Strain (Speices/Organism) : Influenza B virus
VO ID : VO_0011110
NCBI Gene ID : 956539
NCBI Protein GI : 8486155
Locus Tag : FLUBVsRNA-5gp1
Genbank Accession : K01395
Protein Accession : NP_056661
Taxonomy ID : 11520
Segment No : RNA 5
Gene Starting Position : 57
Gene Ending Position : 1739
Gene Strand (Orientation) : +
Protein Name : nucleoprotein
Protein pI : 9.94
Protein Weight : 58594.17
Protein Length : 560

DNA Sequence : Show Sequence

>gi|8486154:57-1739 Influenza B virus RNA 5, complete sequence
AATGTCCAACATGGATATTGACAGTATAAATACCGGAACAATCGATAAAACACCAGAAGAACTGACTCCC
GGAACCAGTGGGGCAACCAGACCAATCATCAAGCCAGCAACCCTTGCTCCGCCAAGCAACAAACGAACCC
GAAATCCATCTCCAGAAAGGACAACCACAAGCAGTGAAACCGATATCGGAAGGAAAATCCAAAAGAAACA
AACCCCAACAGAGATAAAGAAGAGCGTCTACAAAATGGTGGTAAAACTGGGTGAATTCTACAACCAGATG
ATGGTCAAAGCTGGACTTAATGATGACATGGAAAGGAATCTAATTCAAAATGCACAAGCTGTGGAGAGAA
TCCTATTGGCTGCAACTGATGACAAGAAAACTGAATACCAAAAGAAAAGGAATGCCAGAGATGTCAAAGA
AGGGAAGGAAGAAATAGACCACAACAAGACAGGAGGCACCTTTTATAAGATGGTAAGAGATGATAAAACC
ATCTACTTCAGCCCTATAAAAATTACCTTTTTAAAAGAAGAGGTGAAAACAATGTACAAGACCACCATGG
GGAGTGATGGTTTCAGTGGACTAAATCACATTATGATTGGACATTCACAGATGAACGATGTCTGTTTCCA
AAGATCAAAGGGACTGAAAAGGGTTGGACTTGACCCTTCATTAATCAGTACTTTTGCCGGAAGCACACTA
CCCAGAAGATCAGGTACAACTGGTGTTGCAATCAAAGGAGGTGGAACTTTAGTGGATGAAGCCATCCGAT
TTATAGGAAGAGCAATGGCAGACAGAGGGCTACTGAGAGACATCAAGGCCAAGACGGCCTATGAAAAGAT
TCTTCTGAATCTGAAAAACAAGTGCTCTGCGCCGCAACAAAAGGCTCTAGTTGATCAAGTGATCGGAAGT
AGGAACCCAGGGATTGCAGACATAGAAGACCTAACTCTGCTTGCCAGAAGCATGGTAGTTGTCAGACCCT
CTGTAGCGAGCAAAGTGGTGCTTCCCATAAGCATTTATGCTAAAATACCTCAACTAGGATTCAATACCGA
AGAATACTCTATGGTTGGGTATGAAGCCATGGCTCTTTATAATATGGCAACACCTGTTTCCATATTAAGA
ATGGGAGATGACGCAAAAGATAAATCTCAACTATTCTTCATGTCGTGCTTCGGAGCTGCCTATGAAGATC
TAAGAGTGTTATCTGCACTAACGGGCACCGAATTTAAGCCTAGATCAGCACTAAAATGCAAGGGTTTCCA
TGTCCCGGCTAAGGAGCAAGTAGAAGGAATGGGGGCAGCTCTGATGTCCATCAAGCTTCAGTTCTGGGCC
CCAATGACCAGATCTGGAGGGAATGAAGTAAGTGGAGAAGGAGGGTCTGGTCAAATAAGTTGCAGCCCTG
TGTTTGCAGTAGAAAGACCTATTGCTCTAAGCAAGCAAGCTGTAAGAAGAATGCTGTCAATGAACGTTGA
AGGACGTGATGCAGATGTCAAAGGAAATCTACTCAAAATGATGAATGATTCAATGGCAAAGAAAACCAGT
GGAAATGCTTTCATTGGGAAGAAAATGTTTCAAATATCAGACAAAAACAAAGTCAATCCCATTGAGATTC
CAATTAAGCAGACCATCCCCAATTTCTTCTTTGGGAGGGACACAGCAGAGGATTATGATGACCTCGATTA
TTA

Protein Sequence : Show Sequence

>gi|8486155|ref|NP_056661.1| nucleoprotein [Influenza B virus]
MSNMDIDSINTGTIDKTPEELTPGTSGATRPIIKPATLAPPSNKRTRNPSPERTTTSSETDIGRKIQKKQ
TPTEIKKSVYKMVVKLGEFYNQMMVKAGLNDDMERNLIQNAQAVERILLAATDDKKTEYQKKRNARDVKE
GKEEIDHNKTGGTFYKMVRDDKTIYFSPIKITFLKEEVKTMYKTTMGSDGFSGLNHIMIGHSQMNDVCFQ
RSKGLKRVGLDPSLISTFAGSTLPRRSGTTGVAIKGGGTLVDEAIRFIGRAMADRGLLRDIKAKTAYEKI
LLNLKNKCSAPQQKALVDQVIGSRNPGIADIEDLTLLARSMVVVRPSVASKVVLPISIYAKIPQLGFNTE
EYSMVGYEAMALYNMATPVSILRMGDDAKDKSQLFFMSCFGAAYEDLRVLSALTGTEFKPRSALKCKGFH
VPAKEQVEGMGAALMSIKLQFWAPMTRSGGNEVSGEGGSGQISCSPVFAVERPIALSKQAVRRMLSMNVE
GRDADVKGNLLKMMNDSMAKKTSGNAFIGKKMFQISDKNKVNPIEIPIKQTIPNFFFGRDTAEDYDDLDY

Molecule Role : Protective antigen
Molecule Role Annotation : BALB/c mice were immunized intranasally with an adjuvant (cholera toxin B subunit containing 0.2% of the whole toxin)-combined with A or B virus recombinant NP. The NP-immune mice, when challenged intranasally with a sublethal dose of the virus 3 wk after immunization, had accelerated virus clearance from the nasal site in both an influenza type-specific and a nonspecific manner, as shown by the protection from high morbidity from the second day after challenge (Tamura et al., 1996).

II. References

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