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purM

Gene Name purM
Sequence Strain (Species/Organism) Francisella tularensis subsp. holarctica LVS
NCBI Gene ID 3952575
NCBI Protein GI 89255806
Locus Tag FTL_0395
Genbank Accession AM233362
Protein Accession YP_513168
Taxonomy ID 376619
Gene Starting Position 364623
Gene Ending Position 365666
Gene Strand (Orientation) ?
Protein Name phosphoribosylaminoimidazole synthetase
Protein pI 5.23
Protein Weight 35240.61
Protein Length 347
Protein Note catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis
DNA Sequence 
>gi|89255449:364623-365666 Francisella tularensis subsp. holarctica LVS chromosome, complete genome
AATGGCAGGCTTAAAATATGAAGATGCTGGCGTAAATATCGAAGCTGGTAATCAAGCTGTAGAAAGAATG
AAGCAGCATGTCAAAAAAACTTTTACCCAAGATGTTTTGACAGGTTTGGGTAGCTTTGGTTCTTTATACT
CACTAAAAAATATTATAAATAATTATGATGATCCTGTCTTAGTACAGTCGATTGATGGTGTTGGTACAAA
GACAAAAGTCGCGGTAATGTGTGGTAAGTTTGAAAACCTTGGTTATGATCTTTTCTCAGCTGCGACAAAT
GATATTGTTGTAATGGGTGCCAAGCCAATTACGTTTCTAGATTATGTCGCGCATGATAAGCTTGATCCTG
CAATTATGGAAGAGCTCGTCAAAGGGATGTCAAAAGCTTGTGCTGAGTGTGGGGTTTCGCTGGTAGGTGG
CGAGACTGCGGAAATGCCTGGAGTATATCAAGCTGGTGAGATTGACATGGTTGGAGTTATCACTGGTATC
GTTGGTAGAAAAAGAATTATCAATGGTGAGAATATCAAAGAGGGTGATATTGTCTTTGGGCTTAGTTCAT
CAGGATTACATACAAATGGCTACTCTTTTGCACGTAAACTATTTTTTGATGTAGCAGGCAACAAACATAC
TGATACTTATCCAGAGTTAGAGGGTAAAACTATCGGTGATGTGCTACTTGAACCACATATCAACTATACT
AATATCATCCATGATTTCTTAGATAATGGTGTTGATATCAAAGGTATGGCACATATCACAGGTGGCGGGT
TTATCGAGAATATTCCACGCGTATTACCACAAGGTTTAGGTGCCCAAATTGACAAAGATAGTTTTGCAAC
TCCAGCTATTTTTAAGCTAATGCAGAGAATCGGCGATATAAGCGAGTTTGAAATGTATCGCTCATTTAAT
ATGGGTATTGGTATGACGATAATTGCTAGCCAAGATCAATTTGACAAGATGCAAGAATTAGCTAAAAAAC
ATACTAATACAAAACTATATCAAATTGGTAAAATCACAAATTCAGGAAAGGTAGAAATTATCTA
Protein Sequence 
>gi|89255806|ref|YP_513168.1| phosphoribosylaminoimidazole synthetase [Francisella tularensis subsp. holarctica LVS]
MAGLKYEDAGVNIEAGNQAVERMKQHVKKTFTQDVLTGLGSFGSLYSLKNIINNYDDPVLVQSIDGVGTK
TKVAVMCGKFENLGYDLFSAATNDIVVMGAKPITFLDYVAHDKLDPAIMEELVKGMSKACAECGVSLVGG
ETAEMPGVYQAGEIDMVGVITGIVGRKRIINGENIKEGDIVFGLSSSGLHTNGYSFARKLFFDVAGNKHT
DTYPELEGKTIGDVLLEPHINYTNIIHDFLDNGVDIKGMAHITGGGFIENIPRVLPQGLGAQIDKDSFAT
PAIFKLMQRIGDISEFEMYRSFNMGIGMTIIASQDQFDKMQELAKKHTNTKLYQIGKITNSGKVEII
Molecule Role Virmugen
Molecule Role Annotation A purMCD mutant in Francisella tularensis was attenuated. A low dose of the F. tularensis LVS delta purMCD mutant provided protection against subsequent lethal challenge with the LVS parental strain (Pechous et al., 2006).
Related Vaccines(s) Francisella tularensis purMCD mutant vaccine
References