VIOLIN: Vaccine Investigation and Online Information Network

TK
Gene Name	TK
Sequence Strain (Species/Organism)	Equid herpesvirus 1 Ab4
NCBI Protein GI	59214
3D structure: PDB ID	1P73
Other Database IDs	CDD:177537 GOA:P69185 InterPro: IPR001889 UniProtKB/UniProt: P69185
Taxonomy ID	10326
Gene Strand (Orientation)	?
Protein Name	thymidine kinase
Protein Length	352
Protein Note	thymidine kinase; Provisional
Protein Sequence	>gi\|59214\|emb\|CAA48144.1\| thymidine kinase [Equid herpesvirus 1] MAARVPSGEARRSASGAPVRRQVTIVRIYLDGVYGIGKSTTGRVMASAASGGSPTLYFPEPMAYWRTLFE ADVISGIYDTQNRKQQGDLAADDAASITAHYQSRFTTPYLILHDHTFGLFGGDSLQRGTRPDLTVVFDRH PVASAVCFPAARYLIGDMSMCALIAMVATLPREPQGGNIVVTTLNVDEHVRRLRTRARIGEQIDMKLIAT LRNVYSMLANTSNFLRSGRVWRDGWGELPLSCETYKHRATQMDAFQERESPELSDTLFAMFKTPELLDDR GVILEVHAWALDALMLKLRNLSVFCADLSGTPRQCAATVESLIPLMSSTLSDSESASSLERAARTFNAEM GV
Molecule Role	Virmugen
Molecule Role Annotation	A thymidine kinase-deficient mutant (PR1) is attenuated in mice and induced significant protection from challenge with wild type EHV-1 5 weeks after vaccination. In foals, PR1 also showed attenuation; however, the mutant induced only partial protection from challenge with EHV-1 (Slater et al., 1993).
Related Vaccines(s)	Equid herpesvirus TK mutant vaccine
References