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guaA

Gene Name guaA
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Enteritidis str. P125109
NCBI Gene ID 6948075
NCBI Protein GI 207857920
Locus Tag SEN2490
Genbank Accession AM933172
Protein Accession YP_002244571
Taxonomy ID 550537
Gene Starting Position 2623837
Gene Ending Position 2625414
Gene Strand (Orientation) -
Protein Name GMP synthase
Protein pI 5.06
Protein Weight 53428.72
Protein Length 525
Protein Note contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
DNA Sequence
>gi|207855516:2623837-2625414 Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 chromosome, complete genome
CTTATTCCCACTCAATGGTAGCTGGTGGTTTACCGCTGATGTCATACACCACACGGGAAATCCCGTTGAC
TTCATTGATGATGCGGTTGGAAACACGACCCAGGAAATCATACGGCAGATGTGCCCAGTGTGCGGTCATA
AAGTCGATGGTTTCGACAGCACGCAGAGAGACAACCCAATCGTACTTACGACCATCGCCCATCACGCCTA
CGGAACGGACCGGCAGGAAGACGGTAAACGCCTGACTGACTTTGTCGTACAGATCCGCTTTGCGCAGCTC
TTCAATGAAGATAGCGTCCGCGCGACGCAGCAGGTCGCAGTACTCTTTCTTCACTTCGCCCAGTACGCGC
ACGCCGAGGCCCGGCCCCGGGAACGGATGGCGATACAGCATGTCGTACGGCAGGCCCAGCTCCAGACCAA
TCTTACGCACTTCGTCTTTGAACAGCTCTTTCAGCGGTTCAACCAGCCCCATCTTCATCTCTTTCGGCAG
GCCGCCGACATTGTGGTGAGATTTGATGACGTGCGCTTTACCGGTTGCAGACGCCGCAGATTCGATAACG
TCAGGGTAGATGGTGCCCTGCGCCAGCCATTTCACGTCTTCCAGTTTCAGCGCTTCTTCGTCGAACACTT
CAACGAAAACGCGGCCGATGATCTTACGCTTGGCTTCCGGATCGTTCTCACCAGCCAGCGCGGACAGGAA
GCGATCTTCTGCCGGTACGTGAACAATGTTCAGACCAAAATGGTCGCCAAACATGTCCATCACCTGCTCG
GCTTCGTTCAGGCGCAACAGGCCGTTGTCGACGAAAACACAGGTCAGATTTTTACCGATCGCGCGGTGCA
GCAGCATGGCGGTGACGGAAGAATCCACGCCGCCGGAGAGACCGAGGATCACTTTATCGTCGCCTACCTG
CTCGCGAATGCGCGCCACGGCGTCATCGATGATCTTCGCCGGCGTCCACAACGCTTCACACTGGCAGATA
TCGCGTACAAAACGCTCCAGCATGCGCATACCCTGGCGGGTGTGAGTCACTTCCGGGTGGAACTGTACGC
CGTAGAAGCGTTTTTCTTCGTTGGCCATAATGGCGAACGGGCAGCTCTCGGTGCTGGCGACGGTCACGAA
GTCGGACGGAATCGCCGTCACTTTATCGCCGTGGCTCATCCACACGTCCAGCAGCGGTTTGCCGTCTGCG
GTCAGGGAATCTTCAATACCGCGAACCAGCGCGCTGTCGGTCAACACTTCGACCTGCGCATAACCAAATT
CACGCTCATTAGAACCTTCTACATGACCGCCAAGCTGCATCGCCATGGTCTGCATACCATAGCAAACGCC
AAATACCGGCACGCCTGCTTCAAAGACATACTGCGGCGCGCGCGGGCTGTTTTCTTCGGTGGTGCTTTCC
GGGCCGCCGGAAAGAATAATGCCGCTTGGGTTGAAGTCACGAATTTGTGCTTCTGTCACATCCCACGCCC
ACAGTTCACAGTAAACACCCAGCTCACGCACGCGGCGCGCAACCAGTTGAGTGTACTGAGAACCGAAGTC
CAGAATGAGGATGCGATGCTTATGAATGTTTTCCGTCA
Protein Sequence
>gi|207857920|ref|YP_002244571.1| GMP synthase [Salmonella enterica subsp. enterica serovar Enteritidis str. P125109]
MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSPR
APQYVFEAGVPVFGVCYGMQTMAMQLGGHVEGSNEREFGYAQVEVLTDSALVRGIEDSLTADGKPLLDVW
MSHGDKVTAIPSDFVTVASTESCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLERFVRDICQCEALWTP
AKIIDDAVARIREQVGDDKVILGLSGGVDSSVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVMDMFGDH
FGLNIVHVPAEDRFLSALAGENDPEAKRKIIGRVFVEVFDEEALKLEDVKWLAQGTIYPDVIESAASATG
KAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEY
CDLLRRADAIFIEELRKADLYDKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPY
DFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
Molecule Role Virmugen
Molecule Role Annotation A guaBA and clpP mutant (CVD 1941) is attenuated in mice after oral immunization. This mutant is also protective in mice and had a vaccine efficacy of 76% against challenge with wild type Salmonella Enteritidis (Tennant et al., 2011).
Related Vaccines(s) Salmonella Enteritidis guaBA/clpP mutant vaccine
References