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AroC

Gene Name AroC
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhi Ty2
NCBI Gene ID 1069415
NCBI Protein GI 29140996
Locus Tag t0480
Genbank Accession NC_004631.1
Protein Accession NP_804338.1
Taxonomy ID 28901
Gene Starting Position 554066
Gene Ending Position 555151
Gene Strand (Orientation) +
Protein Name chorismate synthase
Protein pI 6.68
Protein Weight 39122.2
Protein Length 361
Protein Note catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
DNA Sequence 
>GeneID|1069415 [Salmonella enterica subsp. enterica serovar Typhi Ty2 ] 554066..555151
tggcaggaaacacaattggacaactctttcgcgtaaccactttcggcgaatcacacgggctggcgcttgg
gggtatcgtcgatggcgtgccgcccggcatcccgttgacggaggccgatctgcagcacgatctcgacaga
cgccgccctggcacctcgcgctatactactcagcgccgcgaaccggaccaggtaaaaattctctccggcg
tgtttgatggcgtgacgaccggcaccagtattggcctgctgattgaaaacaccgatcagcgctcgcagga
ctacagcgcgattaaagatgtttttcgcccgggacacgcggattacacctatgagcagaaatacggcctg
cgcgattaccgcggcggtggacgttcttccgcgcgtgaaaccgcgatgcgcgtagcggcaggggcgatcg
ccaagaaatacttggcggaaaagttcggcatcgaaatccgcggctgcctgacccagatgggcgacattcc
gctggagattaaagactggcgtcaggttgagcttaatccgttcttttgccccgatgcggacaaacttgac
gcgctggacgaactgatgcgcgcgctgaaaaaagagggtgactccatcggcgcgaaagtgacggtgatgg
cgagcggcgtgccggcagggcttggcgaaccggtatttgaccgactggatgcggacatcgcccatgcgct
gatgagcatcaatgcggtgaaaggcgtggagatcggcgaaggatttaacgtggtggcgctgcgcggcagc
cagaatcgcgatgaaatcacggcgcagggttttcagagcaaccacgctggcggcatcctcggtggcatca
gtagtgggcaacacattgtggcgcatatggcgctgaaacctacctccagcattaccgtgccgggacgtac
gatcaaccggatgggtgaagaggtcgagatgatcaccaaagggcgccacgatccgtgtgtggggattcgc
gcagtgccgatcgcagaagccatgctggcgatcgtactgatggatcacctgctgcgccatcgggcacaga
atgcggatgtaaagacagagattccacgctggtaag
Protein Sequence 
>gi|29140996|ref|NP_804338.1| chorismate synthase [Salmonella enterica subsp. enterica serovar Typhi Ty2 ]
MAGNTIGQLFRVTTFGESHGLALGGIVDGVPPGIPLTEADLQHDLDRRRPGTSRYTTQRREPDQVKILSG
VFDGVTTGTSIGLLIENTDQRSQDYSAIKDVFRPGHADYTYEQKYGLRDYRGGGRSSARETAMRVAAGAI
AKKYLAEKFGIEIRGCLTQMGDIPLEIKDWRQVELNPFFCPDADKLDALDELMRALKKEGDSIGAKVTVM
ASGVPAGLGEPVFDRLDADIAHALMSINAVKGVEIGEGFNVVALRGSQNRDEITAQGFQSNHAGGILGGI
SSGQHIVAHMALKPTSSITVPGRTINRMGEEVEMITKGRHDPCVGIRAVPIAEAMLAIVLMDHLLRHRAQ
NADVKTEIPRW
Molecule Role Virmugen
Molecule Role Annotation Inactivation of AroC results in attenuation in humans, and the deletions of both AroC and AroD provide a high level of safety against restoration of pathogenicity by recombination. An aroC/aroD-deleted derivative of S. Typhi strain Ty2 (the parent strain of Ty21a) is designated the strain "CVD 908" (Tacket and Levine, 2007).
Related Vaccines(s) Aro-deleted S. Typhi , CVD 908-htrA
References