VIOLIN: Vaccine Investigation and Online Information Network

Tir
Gene Name	Tir
Sequence Strain (Species/Organism)	Escherichia coli O157:H7 str. EDL933
VO ID	VO_0010940
NCBI Gene ID	960860
NCBI Protein GI	15804222
Locus Tag	Z5112
Genbank Accession	AE005174
Protein Accession	NP_290261
Taxonomy ID	155864
Gene Starting Position	4668912
Gene Ending Position	4670588
Gene Strand (Orientation)	-
Protein Name	translocated intimin receptor protein
Protein pI	4.78
Protein Weight	54549.01
Protein Length	558
DNA Sequence	>NC_002655.2:4668912-4670588 Escherichia coli O157:H7 str. EDL933 genome TTTAGACGAAACGATGGGATCCCGGCGCTGGTGGGTTATTCGAAGTATTCACAGCGCTATTACTCCCCCC CGTTAATCCTCCCATGTCATGGCGTAATCCACCACTTAGCGCCAGACGCGCATAAGTGCTTTGAATCCCC GCACTTGGATTTCCTAATAACCGTGCGCCGTTATCAGTAGTATCCCGGGGAGGATGTTGAATGGTGCTAT ATACAACAGAATCTGTATTCCCCATATTCTGAACAGACGTATTAGAATTAGAAGTCGGCACCTGCGAATC ATGCAGCGATGTTTTAACATCAGCATACGGATTCTGCACGGTCCCTATGCTGGAAGTGTCAAAGAAAGTC GACGAGGTGCTAGCCATCGAGCTACGTCTGCTCTCCATGGTATCTTCTGACCCAGGGGTATCTACATTGC CCTGTGCAGGTGTATTATTTGCAGGCTTATTCTCTACCGTACGTGCGCTTGTAGTTGTAGTTGTAGTAGT TGTTGTTGTTGTTTGTTCTACCGGCTGATTTTTTCGATGAAGCGCAGCGGTGACGGCAACACCAATTCCC CCACCAAGAATCAATGCGCCACTAAGACCGTAGCCAGCCCCCGATGAAACTTTCAGCTCCTCCTGGCGTT TAGCTTGTTGTTCATCATATTTTTTTTGCGCCTGAGCATTATTTTCAATGGCTTGCTGTTTGGCCTCTTC GCCTGCTGCTTTAGCCTGCTCTTCTATATTCGCAACAACATCATCTTTCAATACCCCTGACGGAATCGCA TTTCCGAGCTCATCGATATTAACTTTTTGATTATCTGGGTTCTGGAACGCTTCTTTCGTTAACTGATCTC TTGTCGCAGTTTCAGTTGCACTTGCAGCTGCATCAGGGTCGGTCGTGGTTGGGCTATCCGGCTCCGGCGT CAATGCAAGCGCCTGTACAATACCCGTCGCCGCCAACCCTATCAGACCTGTAGCAACAGTCCCCAACGCC AACCAAAGTTTAGGATCTGAACGAAGGCTGGAAGTTGAGGTTGAGGTCTGAGTTTCTGTGGTGTTTTCCG CACCGCTATTTGACTCCCTCAACTCCCCAACGCCTTTTGACTCCCCAGCACCTTTGGACTCCCCGGTCCC TTTGGGCTCTAACAGCTCCAGTATCCTTTGGCGGGCTTCCGTGATATCTGAAGCAACGGTGACCATAGCA TGCCCAGCACCACCACGGCCTCCAGTAAATACAAATTTGTCTTTACCTTCAGGATCAATGGACTGCAAGC GAGCGTACTCTTGATCACTTAAAACAACAGAGGTCTCAACACCATTCCTCTGACCGACAGCAATATGTTT ACCATCTTCCTGAGTTTCAACTCGAAATACCGAAGAGCCAATCTGCCTGTTAAGAGTATCGAGCGGACCA TGATCATGAAGAACTTCAAATCCATCATTCAGTGTTATCTCAGACGCCGCCAGGCGCATCGGATTTACAG GAAGTCCAGGAACATCACTGGCACGATTGTCGCCAGAATCAGCCATAGAATTCCTTACAGGCGTAAATAG CGCACGAGATCCCAACGGCCCCGTAGAGTTAATGAGCTGACCACGCCCCCCTGCACCGTCGGTTTGTGAA GGTAATGGAGGTGCAGGAGGAATTGAATTATTCACATTGGGATTATGACCAAGATTACCAATAGGCA
Protein Sequence	>NP_290261.1 translocated intimin receptor protein [Escherichia coli O157:H7 str. EDL933] MPIGNLGHNPNVNNSIPPAPPLPSQTDGAGGRGQLINSTGPLGSRALFTPVRNSMADSGDNRASDVPGLP VNPMRLAASEITLNDGFEVLHDHGPLDTLNRQIGSSVFRVETQEDGKHIAVGQRNGVETSVVLSDQEYAR LQSIDPEGKDKFVFTGGRGGAGHAMVTVASDITEARQRILELLEPKGTGESKGAGESKGVGELRESNSGA ENTTETQTSTSTSSLRSDPKLWLALGTVATGLIGLAATGIVQALALTPEPDSPTTTDPDAAASATETATR DQLTKEAFQNPDNQKVNIDELGNAIPSGVLKDDVVANIEEQAKAAGEEAKQQAIENNAQAQKKYDEQQAK RQEELKVSSGAGYGLSGALILGGGIGVAVTAALHRKNQPVEQTTTTTTTTTTTSARTVENKPANNTPAQG NVDTPGSEDTMESRRSSMASTSSTFFDTSSIGTVQNPYADVKTSLHDSQVPTSNSNTSVQNMGNTDSVVY STIQHPPRDTTDNGARLLGNPSAGIQSTYARLALSGGLRHDMGGLTGGSNSAVNTSNNPPAPGSHRFV
Molecule Role	Protective antigen
Molecule Role Annotation	Mice immunized intranasally with recombinant Tir protein had a survival rate of 92.9% after challenge with EHEC 0157:H7 (Fan et al., 2011). Immunization of calves with recombinant EHEC O157 EspA, intimin and Tir resulted in the generation of antibodies capable of cross-reacting with antigens from non-O157 EHEC serotypes, suggesting that immunization with these antigens may provide a degree of cross-protection against other EHEC serotypes (McNeilly et al., 2015)
Related Vaccines(s)	E. coli O157:H7 intimin vaccine , E. coli O157:H7 subunit vaccine expressing Esps and Tir , Recombinant Tir Protein Vaccine
References

Tir