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IroN

Gene Name IroN
Sequence Strain (Species/Organism) Escherichia coli
VO ID VO_0010988
NCBI Gene ID 7379404
NCBI Protein GI 222104801
Locus Tag MM1_0014
Genbank Accession AF449498
Protein Accession YP_002539290
3D structure: PDB ID 1FEP
Taxonomy ID 562
Plasmid No pAPEC-1
Gene Starting Position 9647
Gene Ending Position 11824
Gene Strand (Orientation) -
Protein Name outer membrane receptor FepA
Protein pI 5.85
Protein Weight 74767.07
Protein Length 725
Protein Note Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space
DNA Sequence 
>NC_011980.1:9647-11824 Escherichia coli chi7122 plasmid pAPEC-1, complete sequence
ATCAGAATGATGCGGTAACTCCGGCATAGTAAGCCCGGCCTGGCTCGTTATAGGTATTCGCCCCTTCAGA
AGATCGGAAGATCTGTTTATTGAGGATATTACTGACGCCGACATTAAGACGCAGATTTTTATTAATATCG
TAATTGAAGTTCGTCCCCACCAGTGAATAAGCGCCCAGCTCTTTACCTGACAGACCGCCAGTATCTTCAC
TGCGGGTTTCCGCATGAGTACGCGGTTTTTGTCTGCCATATAACGTCCAGTTGACGCTGGCAGAAAACGC
CTGGGTGATGGTCCAGTTAAGCGAGTTATTGATAGTATATTTCGGGATGACCGACAGAGGATTACCGGTG
TCTTTTTGCTCCGAAGTGATCATCCATGTGGCATTGGTATTCCAGTTCAGACGATCTTTCACCAGTGGGA
AAGACATACTGGCTTCGATACCGTCCACCAGAGCTTTCCCGCCATTCTGCCACTTGAGGATATATGCGCC
TGAAGCGGTTTGCCCGATAACGTTATCCCCGGCCACGATCTTATTCTGGTAATCATTGCGGAAGTAGGTC
ACACTTGCGTGGTAATCTTCCCAGGTGAACTCCAGCCCAATTTCTTTATTGACGCTGATTTCCGGATCGA
GATCTTTATTACCGATCAGGTAGCACCCGCCTGATGTAATATCTTTTGGACAGCCATTGCCTTTCGAGTA
GAGCAGATAGCCTTCACTGGATTGATACAGGTTTGGGGCTTTAAAGGTTCGGGCAACCCCTGCTTTGACT
TTGAAATAATCGCCCAATTCCTGCGAAAGATTCAGACTGGGGCTGAAGTTCCCGCCGGAGTCGCTGAGAT
AATCAAAGCGCAGGCCGGGAATGATATTCGTGCCAGGAACCGGCTCAATGTTATCTTCAATATACAGCGC
ACTGATTTGAGAATGATTTTTACTGCTGCGATCCGCAGCAGAGCCAGAAATACCGCTGATATCACTGTCA
TTCACCGTCAGGCTGGTAGAGGAAGGATCATCGAGCTTATCGCGGTTCCACTCTGCACCAACGGTCAGCG
TTTGATCAACCATCACATTCAAAGGAATATTAAGCTCGCCGCTGGTTCGCCAGGAACTCAGGCGATTGGT
CGTAAACTTTTCACCCGCTAAAATACGCCCTTCACCACCGCCGGATAATCCTTCATTCATGCGGGTATTA
TTGGTTTTCTCGTAATAAACACCAAAGCGACTTTGTCCCCAGTCCCAGATACCATTATGCGTAATGCCAT
AATTCTGTCGGTACAGGCGGTTCGTCTCTTTGCCGGATTTTGCCAGGCTTTCGGTAACTGCACTGGAAGA
ACTGTTTTGCGTATCGCCCGCATAGATATTCCCCTGGCGGCTATATCCGGCTTCGAAATCGAGAATCTGC
TGCGGATTTAATTTCCACGAGACAACGCCGTTAATATCTTTGTTACGTACCCCTTCATGCCCGGCTGCGT
TTTTCGTACCGACCGGAGAATTAATATCCCAACTGTCAGCATCCGTTTTATTCAGGTTACCATACAAACG
CGTGGTAAGAGCATTACCAGCCAGAGGCCCACTAAGGCTGAAATTGGCGCGACGCGTAGCGCCCTCATCG
CTACTTTCCGGCTGATTGGTGTATAACGACAGCGAACCGTGCCAGTCGTTGGTGGGACGTTTGGTAATGA
TGTTCACCACCCCCCCGGCTGCCCCCGAACCGTAGCGCGCCGCCGCAGGGCCGCGGATCACTTCAATACG
CTCAACCTGTTCCGGTGGCACCCAGTTGGTGTCACCGCGGGTATCACGCTCTCCACGCCAGCTATAACGC
ACGGAGTTACGTGACGTCACCGGTACACCATCAATTAAAATTAAGGTGTTTTCCGGCCCCATACCACGAA
TATCGATCTGGCGGTTGTTACCGCGTGTGCCCGAGGCGCTATTGCCGGTAAGATTGACGCCAGGCATTTT
ACGAATAATATCTGAAAGGTCGTTTACCGGAGGGGTCTTTTTAATATCCTCGCTGGTAATAACCGACACG
CCCGGCTGCTGTTTTAATACCTGCTCAGCGGTGGCTTCCACCACCAGAGTCTCGTCATTATCATCGTCGG
AGGATTTGGCTACTGATACCTGGCTATTCAACCCAACCAGGAGCACAGTTAGCGACCAGAGGATTTTGTT
AATTCTCA
Protein Sequence 
>YP_002539290.1 IroN, siderophore receptor (plasmid) [Escherichia coli chi7122]
MRINKILWSLTVLLVGLNSQVSVAKSSDDDNDETLVVEATAEQVLKQQPGVSVITSEDIKKTPPVNDLSD
IIRKMPGVNLTGNSASGTRGNNRQIDIRGMGPENTLILIDGVPVTSRNSVRYSWRGERDTRGDTNWVPPE
QVERIEVIRGPAAARYGSGAAGGVVNIITKRPTNDWHGSLSLYTNQPESSDEGATRRANFSLSGPLAGNA
LTTRLYGNLNKTDADSWDINSPVGTKNAAGHEGVRNKDINGVVSWKLNPQQILDFEAGYSRQGNIYAGDT
QNSSSSAVTESLAKSGKETNRLYRQNYGITHNGIWDWGQSRFGVYYEKTNNTRMNEGLSGGGEGRILAGE
KFTTNRLSSWRTSGELNIPLNVMVDQTLTVGAEWNRDKLDDPSSTSLTVNDSDISGISGSAADRSSKNHS
QISALYIEDNIEPVPGTNIIPGLRFDYLSDSGGNFSPSLNLSQELGDYFKVKAGVARTFKAPNLYQSSEG
YLLYSKGNGCPKDITSGGCYLIGNKDLDPEISVNKEIGLEFTWEDYHASVTYFRNDYQNKIVAGDNVIGQ
TASGAYILKWQNGGKALVDGIEASMSFPLVKDRLNWNTNATWMITSEQKDTGNPLSVIPKYTINNSLNWT
ITQAFSASVNWTLYGRQKPRTHAETRSEDTGGLSGKELGAYSLVGTNFNYDINKNLRLNVGVSNILNKQI
FRSSEGANTYNEPGRAYYAGVTASF
Molecule Role Protective antigen
Molecule Role Annotation Active immunization of BALB/c mice with IroN antigen in Freund's adjuvant protects mice from lethal challenge with ExPEC strain S26 (Durant et al., 2007).
References