VIOLIN: Vaccine Investigation and Online Information Network

hpaA
Gene Name	hpaA
Sequence Strain (Species/Organism)	Helicobacter pylori
NCBI Protein GI	WP_000855917
Other Database IDs	CDD:310078
Taxonomy ID	210
Gene Strand (Orientation)	?
Protein Name	neuraminyllactose-binding hemagglutinin
Protein pI	8.62
Protein Weight	28131.12
Protein Length	343
Protein Note	Neuraminyllactose-binding hemagglutinin precursor (NLBH); pfam05211
Protein Sequence	>WP_000855917.1 neuraminyllactose-binding hemagglutinin [Helicobacter pylori] MKTNGHFKDFAWKKCFLGASVVALLVGCSPHIIETNEVALKLNYHPASEKVQALDEKILLLRPAFQYSDN IAKEYENKFKNQTTLKVEEILQNQGYKVINVDSSDKDDFSFAQKKEGYLAVAMNGEIVLRPDPKRTIQKK SEPGLLFSTGLDKMEGVLIPAGFVKVTILEPMSGESLDSFTMDLSELDIQEKFLKTTHSSHSGGLVSTMV KGTDNSNDAIKSALNKIFASIMQEMDKKLTQRNLESYQKDAKELKNKRNR
Molecule Role	Protective antigen
Molecule Role Annotation	Oral therapeutic immunization with CWAE significantly reduced the number of H. pylori colonies in the stomach of Mongolian gerbils, compared with oral immunization using CTB-UE or H. pylori urease. The protection of CWAE was associated with higher levels of mixed CD4+ T cell (Th cell) response, IgG, and secretory IgA (sIgA) antibodies to H. pylori (Guo et al., 2017).
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