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FimH/MrpH fusion protein

Gene Name FimH/MrpH fusion protein
Sequence Strain (Species/Organism) Escherichia coli
NCBI Protein GI AHW46359
Other Database IDs CDD:198456
CDD:286270
CDD:294848
Taxonomy ID 32630
Gene Strand (Orientation) ?
Protein Name FimH/MrpH fusion protein
Protein pI 8.73
Protein Weight 55910.91
Protein Length 644
Protein Note Escherichia coli/Proteus mirabilis fusion
Protein Sequence 
>AHW46359.1 FimH/MrpH fusion protein [synthetic construct]
MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPAVNVGQNLVVDLSTQIFCHNDYP
ETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVA
IKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAK
SQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYART
GGQVTAGNVKSIIGVTFVYQMFIFKRFPAIFILIAGLFSAPAMASIFSYITESTGTPSNATYTYVIERWD
PETSGILNPCYGWPVCYVTVNHKHTVNGTGGNPAFQIARIEKLRTLAEVRDVVLKNRSFPIEGQTTHRGP
SLNSNQECVGLFYQPNSSGISPRGKLLPGSLCGIAPPPVGACKISEGAVNLNYGDIDEASLSGAKRSETI
NVTCNLAMKVLVIASGSDSGRVPLRADKSLYADLYLNNYPGEKGVTVNVPAGGSAPVSVSSTLRTNGRVA
PGRFSGSGSIILTMP
Molecule Role Protective antigen
Molecule Role Annotation Immunization of mice with MrpH.FimH fusion with MPL or a mixture of FimH, MrpH and MPL conferred the highest protection of the bladder and kidneys when challenged with UPEC and P. mirabilis in a UTI mouse model (Habibi et al., 2015)
References