VIOLIN: Vaccine Investigation and Online Information Network

hbpA
Gene Name	hbpA
Sequence Strain (Species/Organism)	Actinobacillus pleuropneumoniae
NCBI Protein GI	ABN75084
Other Database IDs	CDD:223818 CDD:173858
Taxonomy ID	416269
Protein Name	Heme-binding protein A
Protein pI	6.89
Protein Weight	57811.6
Protein Length	643
Protein Note	ABC-type transport system, periplasmic component [Amino acid transport and metabolism]; COG0747
Protein Sequence	>ABN75084.1 Heme-binding protein A [Actinobacillus pleuropneumoniae serovar 5b str. L20] MKLANLTKVSAAVLAVLALAACDDKNADGKTTAKPAAEKTFVNCVSRSPQYFSPALAMDGISYNASSQQV YNRLVEFKRGSTEIEPALAESWDISEDGLTYTFHLRKGVKFHSNKEFTPSRDFNADDVVFSFNRQLDPNH PYHTVSKATYPYFKAMKFPTLLKSVEKVDDHTVKFTLTKRDATFVSSLGMDFTSIYSAEYADAMLKAGKP ETIDTTPIGTGPFAFTGYVLDQASRYVAYKDYWKGKADFDRLIFEIVPDATARYAKLQAGQCDLIDFPNA TDIEKMKTDPKVQLLSQPGLNIAYVAFNTEKAPFDNVKVRQALNLAVDKKAIIDVVYQGAGIAAKNPLPP TIWGYNDSLAESEFNIEKAKQLLAEAGYPNGFETELWVQPVVRASNPNPRRMSEIIQADWAKIGVKAKLV TYEWGDYIKRTKAGELTAGTYGWSGDNGDPDNFLSPLFGSANVGNSNYARFNSPELDALLDKALGLSDKA ERTKLYEQAQALLREQAPWINVAHSINFAPTSKRVQDYKQSPFGYTYLYGTKLAD
Molecule Role	Protective antigen
Molecule Role Annotation	Three of these proteins (APJL_0126, HbpA and OmpW) were further tested in the natural host (swine) by homologous and heterologous challenges. The results showed that these proteins could induce high titers of antibodies(Chen et al., 2012)
Related Vaccines(s)	A. pleuropneumoniae HbpA vaccine
References