VIOLIN Logo
VO Banner
Search: for Help
About
Introduction
Statistics
VIOLIN News
Your VIOLIN
Register or Login
Submission
Tutorial
Vaccine & Components
Vaxquery
Vaxgen
VBLAST
Protegen
VirmugenDB
DNAVaxDB
CanVaxKB
Vaxjo
Vaxvec
Vevax
Huvax
Vaccine Mechanisms
Vaximmutordb
Vaxism
Vaxar
Vaccine Literature
VO-SciMiner
Litesearch
Vaxmesh
Vaxlert
Vaccine Design
Vaxign
Community Efforts
Vaccine Ontology
ICoVax 2012
ICoVax 2013
Advisory Committee
Vaccine Society
Vaxperts
VaxPub
VaxCom
VaxLaw
VaxMedia
VaxMeet
VaxFund
VaxCareer
Data Exchange
V-Utilities
VIOLINML
Help & Documents
Publications
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

phtE

Gene Name phtE
Sequence Strain (Species/Organism) Streptococcus pneumoniae
NCBI Protein GI CKA60496
Other Database IDs CDD:331999
CDD:309414
Taxonomy ID 1313
Gene Strand (Orientation) ?
Protein Name pneumococcal histidine triad protein E
Protein pI 5.25
Protein Weight 125033.92
Protein Length 1276
Protein Note Streptococcal histidine triad protein; cl27178
Protein Sequence
>CKA60496.1 pneumococcal histidine triad protein E [Streptococcus pneumoniae]
MKFSKKYIAAGSAVIVSLSLCAYALNQHRSQENKDNNRVSYVDGSQSSQKSENLTPDQVSQKEGIQAEQI
VIKITDQGYVTSHGDHYHYYNGKVPYDALFSEELLMKDPNYQLKDGDIVNEVKGGYIIKVDGKYYVYLKD
AAHADNVRTKDEINRQKQEHVKDNEKVSSDVAVARSQGRYTTDDGYVFNPADIIEDTGDAYIVPHGGHYH
YIPKSDLSASELAAAKAHLAGKNTQPSQLSYSSAASDNNTQSVAQGSTSKPESKVENLQSLLKELYDLPS
DQRYSESDGLVFDPAKIISRTPNGVAIPHGDHYHFIPYSKLSALEEKIARMVPIGGTGSTVSTNAKPNAV
ASSLGSLSNNPSSLTTSRELSSTSDGYIFNPKDIVEETATAYIVRHGDHFHYIPKSNQIGQPTLPNNGLT
TPSPSLPINPGTSHEEHEEDGHGFDANRIIAEDAAGFIMTHGNHNHYFFKKDLTADQIKAAQDHLKGANT
ATPNPAHDDDHDEDHHGHHHGHHHDEDHDHGFDADRVISEDDQGFVMTHGNHNHYFFKKDLTAEQIKAAQ
DHLKAHHGAEPVKPLAKTVESFSRDASDEEKIAYISKTYGVPLEAIRISNGFFVFGNPDQAYDPTHIHPY
AVRKEHVRLPLQTGNPELDFLNELYTTALRDGVSPYSLQVENGSFVIPHGDHNHYIKVQTKGYEVALKNK
IPALQSNYQPGAFDEKGVLAKVDQLLAESRNVYKDDPIKQRQIELALGQFTENMKKLATNSTAGYLKTLD
LFDKQYIHIDESVKPVETSALDKKYQALIDKINTLDTDSYGLPKKDLLVRLQEAKLAKDEAALAAVESQL
QALQDFNDRTGDTSVEYIKYFYEHVNDSRLSDELRNKVANLTFTLYQSQSFRKAVDLNKLFPSIYQTKQE
VEEALKNQPATAKVNETVLDKEKVDNQSAKQAIYEFLKDLYPDLKKEEHVNHVSKEEVESLLSKASQLLE
QIHEEGIRQSLAEEVENLKAATNKADADLDEVNSQVKDVLTRIASALQQEKENAEQDPQTLVLYQKLYDI
LISLHSYLENNKGSDEDFDKVDALLDQLSAKSKDKAALLELTKAILVLNHQIQSKASASEETSPARNAEA
NGDNSSAENQPNATAESNSETASDENKPSNTRDSKPTEPALENETTESSTTTGNQAKPAE
Molecule Role Protective antigen
Molecule Role Annotation Seven proteins induced protective responses, in terms of reduced lung burdens of the serotype 3 pneumococci. Three of the protective proteins were histidine triad protein family members (PhtB, PhtD and PhtE). Four other proteins, all bearing LPXTG linkage domains, also had activity in this model (PrtA, NanA, PavB and Eng).(Anderson et al., 2016)
References