VIOLIN: Vaccine Investigation and Online Information Network

phtE
Gene Name	phtE
Sequence Strain (Species/Organism)	Streptococcus pneumoniae
NCBI Protein GI	CKA60496
Other Database IDs	CDD:331999 CDD:309414
Taxonomy ID	1313
Gene Strand (Orientation)	?
Protein Name	pneumococcal histidine triad protein E
Protein pI	5.25
Protein Weight	125033.92
Protein Length	1276
Protein Note	Streptococcal histidine triad protein; cl27178
Protein Sequence	>CKA60496.1 pneumococcal histidine triad protein E [Streptococcus pneumoniae] MKFSKKYIAAGSAVIVSLSLCAYALNQHRSQENKDNNRVSYVDGSQSSQKSENLTPDQVSQKEGIQAEQI VIKITDQGYVTSHGDHYHYYNGKVPYDALFSEELLMKDPNYQLKDGDIVNEVKGGYIIKVDGKYYVYLKD AAHADNVRTKDEINRQKQEHVKDNEKVSSDVAVARSQGRYTTDDGYVFNPADIIEDTGDAYIVPHGGHYH YIPKSDLSASELAAAKAHLAGKNTQPSQLSYSSAASDNNTQSVAQGSTSKPESKVENLQSLLKELYDLPS DQRYSESDGLVFDPAKIISRTPNGVAIPHGDHYHFIPYSKLSALEEKIARMVPIGGTGSTVSTNAKPNAV ASSLGSLSNNPSSLTTSRELSSTSDGYIFNPKDIVEETATAYIVRHGDHFHYIPKSNQIGQPTLPNNGLT TPSPSLPINPGTSHEEHEEDGHGFDANRIIAEDAAGFIMTHGNHNHYFFKKDLTADQIKAAQDHLKGANT ATPNPAHDDDHDEDHHGHHHGHHHDEDHDHGFDADRVISEDDQGFVMTHGNHNHYFFKKDLTAEQIKAAQ DHLKAHHGAEPVKPLAKTVESFSRDASDEEKIAYISKTYGVPLEAIRISNGFFVFGNPDQAYDPTHIHPY AVRKEHVRLPLQTGNPELDFLNELYTTALRDGVSPYSLQVENGSFVIPHGDHNHYIKVQTKGYEVALKNK IPALQSNYQPGAFDEKGVLAKVDQLLAESRNVYKDDPIKQRQIELALGQFTENMKKLATNSTAGYLKTLD LFDKQYIHIDESVKPVETSALDKKYQALIDKINTLDTDSYGLPKKDLLVRLQEAKLAKDEAALAAVESQL QALQDFNDRTGDTSVEYIKYFYEHVNDSRLSDELRNKVANLTFTLYQSQSFRKAVDLNKLFPSIYQTKQE VEEALKNQPATAKVNETVLDKEKVDNQSAKQAIYEFLKDLYPDLKKEEHVNHVSKEEVESLLSKASQLLE QIHEEGIRQSLAEEVENLKAATNKADADLDEVNSQVKDVLTRIASALQQEKENAEQDPQTLVLYQKLYDI LISLHSYLENNKGSDEDFDKVDALLDQLSAKSKDKAALLELTKAILVLNHQIQSKASASEETSPARNAEA NGDNSSAENQPNATAESNSETASDENKPSNTRDSKPTEPALENETTESSTTTGNQAKPAE
Molecule Role	Protective antigen
Molecule Role Annotation	Seven proteins induced protective responses, in terms of reduced lung burdens of the serotype 3 pneumococci. Three of the protective proteins were histidine triad protein family members (PhtB, PhtD and PhtE). Four other proteins, all bearing LPXTG linkage domains, also had activity in this model (PrtA, NanA, PavB and Eng).(Anderson et al., 2016)
References

phtE