VIOLIN: Vaccine Investigation and Online Information Network

prtA
Gene Name	prtA
Sequence Strain (Species/Organism)	Streptococcus pneumoniae
NCBI Protein GI	NP_358155
Other Database IDs	CDD:310481 CDD:173801 CDD:240123 CDD:310703 CDD:273478
Taxonomy ID	171101
Gene Strand (Orientation)	?
Protein Name	cell wall-associated serine proteinase PrtA
Protein pI	6.04
Protein Weight	229148.76
Protein Length	2263
Protein Note	Peptidase inhibitor I9; pfam05922
Protein Sequence	>NP_358155.1 cell wall-associated serine proteinase PrtA [Streptococcus pneumoniae R6] MKKSTVLSLTTAAVILAAYAPNEVVLADTSSSEDALSISDKEKVVVDKETENKEKHKDIHNAIETSKDTE EKKTTIIEEKEVVSKNPVIDTKTSNEEAKIKEENSNQSQGDHTDSFVNKNTENPKKEDKVVYIAEFKDKE SGEKAIKGLSNLKNTKVLYTYDRIFNGSAIETTPDNLDKIKQIEGISSIERAQKVQPMMNHARKEIGVEE AIDYLKSINAPFGKNFDGRGMVISNIDTGTDYRHKAMRIDDDAKASMRFKKEDLKGTDKNYWLSDKIPHA FNYYNGGKITVEKYDDGRDYFDPHGMHIAGILAGNDTEQDIKNFNGIDGIAPNAQIFSYKMYSDAGSGFA GDETMFHAIEDSIKHNVDVVSVSSGFTGTGLVGEKYWQAIRALRKAGIPMVVATGNYATSASSSSWDLVA NNHLKMTDTGNVTRTAAHEDAIAVASAKNQTVEFDKVNIGGESFKYRNIGAFFDKNKITTNEDGTKAPSK LKFVYIGKGQDQDLIGLDLRGKIAVMDRIYTKDLKNAFKKAMDKGARAIMVVNTVNYYNRDNWTELPAMG YEADEGTKSQVFSISGDDGVKLWNMINPDKKTEVKRNNKEDFKDKLEQYYPIDMESFNSNKPNVGDEKEI DFKFAPDTDKELYKEDIIVPAGSTSWGPRIDLLLKPDVSAPGKNIKSTLNVINGKSTYGYMSGTSMATPI VAASTVLIRPKLKEMLERPVLKNLKGDDKIDLTSLTKIALQNTARPMMDATSWKEKSQYFASPRQQGAGL INVANALRNEVVATFKNTDSKGLVNSYGSISLKEIKGDKKYFTIKLHNTSNRPLTFKVSASAITTDSLTD RLKLDETYKDEKSPDGKQIVPEIHPEKVKGANITFEHGTFTIGANSSFDLNAVINVGEAKNKNKFVESFI HFESVEEMEALNSNGKKINFQPSLSMPLMGFAGNWNHEPILDKWAWEEGSRSKTLGGYDDDGKPKIPGTL NKGIGGEHGIDKFNPAGVIQNRKDKNTTSLDQNPELFAFNNQGINAPSSSGSKIANIYPLDSNGNPQDAQ LERGLTPSPLVLRSAEEGLISIVNTNKEGENQRDLKVISREHFIRGILNSKSNDAKGIKSSKLKVWGDLK WDGLIYNPRGREENAPESKDNQDPATKIRGQFEPIAEGQYFYKFKYRLTKDYPWQVSYIPVKIDNTAPKI VSVDFSNPEKIKLITKDTYHKVKDQYKNETLFARDQKEHPEKFDEIANEVWYAGAALVNEDGEVEKNLEV TYAGEGQGRNRKLDKDGNTIYEIKGAGDLRGKIIEVIALDGSSNFTKIHRIKFADQADEKGMISYYLVDP DKDASKYEKLGEISEDKLKNAKSPEENTNNNQAKDEDSKPDEKSSVEGEASLEINKTISTIREFENKDLK KLIKKKFREVNDFTSETGKRIEEYDYKYDDKGNIIAYDDGSALQYETEKFDEIKSKIYGVLSPSKDGHFE ILGKISNVSKNAKVYYGNSYKSIEIKATKYDSHSKTMIFDLYANINDIVDGLAFAGDMRLFVKDDNQIKA ETKIRMPEKNKETKAEYPYVSSYGNVIELGEGDLSKNKPDNLTKMESGKIYSDSEKQQYLLKDNIILRKG YALKVTTYNPGKTDMLEGNGVYSKEDIAKIQKANPNLRVLSETTIYADSRNVEDGRSTQAVLMSALDGFN IIRYQVFTFKMNDKGEAIDKDGNLVTDSSKLVLFGKDDKEYTGEDKSNVEAIKEDGSMLFIDTKPVNLSM DKNYFNPSKSNKIYVRNPEFYLRGKISDKGGFNWELRVNESVVDNYLIYGDLHIDNTRDFNIKLNVKDGD IMDWGMKDYKANGFPDKVTDMDGNVYLQTGYSDLNAKAVGVHYQFLYDNVKPEVNIDPKGNTSIEYADGK SVVFNINDKRNNGFDGEIQEQHIYVNGKEYTSFDDIKQITDKTLNIKIVVKDFARNTTVKEFILNKDTGE VSELKPHRVTVTIQNGKEMSSTIVSEEDFILPVYKGELEKGYQFDGWEISGFEGKKDAGYVINLSKDTFI KPVFKKIEEKKEEENKPTFDVSKKKDNPQVNHSQLNESHRKEDLQREDHSQKSDSTKDVTATVLDKNNIS SKSTTNNPNKLPKTGTASGAQTLLAAGIMFIVGIFLGLKKKNQD
Molecule Role	Protective antigen
Molecule Role Annotation	Seven proteins induced protective responses, in terms of reduced lung burdens of the serotype 3 pneumococci. Three of the protective proteins were histidine triad protein family members (PhtB, PhtD and PhtE). Four other proteins, all bearing LPXTG linkage domains, also had activity in this model (PrtA, NanA, PavB and Eng).(Anderson et al., 2016)
References

prtA