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SodB from F. tularensis SCHU S4
Gene Name	SodB from F. tularensis SCHU S4
Sequence Strain (Species/Organism)	Francisella tularensis subsp. tularensis SCHU S4
VO ID	VO_0011077
NCBI Gene ID	3190713
NCBI Protein GI	56707247
Locus Tag	FTT_0068
Genbank Accession	AJ749949
Protein Accession	YP_169143
3D structure: PDB ID	3H1S
Taxonomy ID	177416
Gene Starting Position	70160
Gene Ending Position	70738
Gene Strand (Orientation)	?
Protein Name	superoxide dismutase (Fe)
Protein pI	5.29
Protein Weight	20748.47
Protein Length	192
Protein Note	Similar to SODF_ECOLI (P09157) Superoxide dismutase [Fe] from E. coli (192 aa). FASTA: opt: 896 Z-score: 1143.2 E(): 8.8e-56 Smith-Waterman score: 896; 66.316 identity in 190 aa overlap
DNA Sequence	>gi\|255961454:70160-70738 Francisella tularensis subsp. tularensis SCHU S4, complete genome AATGAAATTTGAATTACCAAAACTACCTTACGCTGTTGATGCATTAGAGTCAACAATATCAAAAGAAACA ATAGAGTATCACTATGGTAAACATCATCAAACATATGTAACTAATCTAAATAATTTAGTTGAGGGTACAG AGCACGATGGCAGAAACCTAGAAGAAATCGTAAAAACTTCTAATGGCGGAATATTTAATAACGCTGCTCA AGTTTTTAATCATACTTTTTACTGGAATTGTTTAACTCCAAACAAAACAGAAGCTTCAAGTCAGTTAAAA GCAGCATTGATCGAGACATTTGGTTCTGTAGAAAATTTTAAAGAACAATTCTCTAAGGCAGCTATTGCAA CATTTGGTTCTGGTTGGGCTTGGTTAGTAAAAAATACTGAAGGTAAACTTGAAATAGTAACTACAAGTAA CGCTGGTTGCCCATTAACAGAGAACAAAAAGCCATTGCTAACTTTTGATGTTTGGGAGCACGCATACTAT ATTGATTATCGTAATGCTAGACCTAAATATGTTGAAGCATTATGGGATATCGTAAACTGGCAATTTGTTT CTGAGCAATTCGCTGATTA
Protein Sequence	>gi\|56707247\|ref\|YP_169143.1\| superoxide dismutase (Fe) [Francisella tularensis subsp. tularensis SCHU S4] MKFELPKLPYAVDALESTISKETIEYHYGKHHQTYVTNLNNLVEGTEHDGRNLEEIVKTSNGGIFNNAAQ VFNHTFYWNCLTPNKTEASSQLKAALIETFGSVENFKEQFSKAAIATFGSGWAWLVKNTEGKLEIVTTSN AGCPLTENKKPLLTFDVWEHAYYIDYRNARPKYVEALWDIVNWQFVSEQFAD
Molecule Role	Virmugen
Molecule Role Annotation	C57BL/6 mice were vaccinated intranasally (i.n.) with the sodB(Ft) mutant and challenged i.n. with lethal doses of F. tularensis SchuS4. SodB(Ft) vaccinated mice following SchuS4 challenge exhibited significantly reduced bacterial burden in lungs, liver, and spleen, regulated production of pro-inflammatory cytokines, and less severe histopathological lesions compared to the LVS vaccinated mice. The sodB(Ft) vaccination induced a potent humoral immune response and protection against SchuS4 required both CD4 and CD8 T cells in the vaccinated mice (Bakshi et al., 2008).
Related Vaccines(s)	sodB(Ft)
References

SodB from F. tularensis SCHU S4