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FopA

Gene Name FopA
Sequence Strain (Species/Organism) Francisella tularensis subsp. holarctica OSU18
VO ID VO_0011078
NCBI Gene ID 4306351
NCBI Protein GI 115315051
Locus Tag FTH_1293
Genbank Accession CP000437
Protein Accession YP_763774
Taxonomy ID 393011
Gene Starting Position 1267837
Gene Ending Position 1269018
Gene Strand (Orientation) -
Protein Name outer membrane protein FopA
Protein pI 5.43
Protein Weight 39079.73
Protein Length 393
DNA Sequence 
>NC_008369.1:1267837-1269018 Francisella tularensis subsp. holarctica OSU18, complete genome
ATTAGTTAGCTTCTTTAAGTGGAGCTGATACGCTAGCTTCTACACGCTGGTTACGCGGATCAGACTTATG
AATACCACCTAAAGTATCATTATAGCCAAAACCTTTAGTAATTATTTTCTCACTATCTAAACCTAATTGC
TTCATGTAATCAGCAACAGCTTGTGCTCTCTTCTCAGAAAGTTTTTGGTTATATATATCAAACTCACTAC
CAGTTTGACCTTGAGAAGCATAACCTTTAACTGTTACAGAGCTAATGTTACTATCCTTGATAAAATTAAC
AAAAGATGCAATAGCTTTTTTACCTTTAGCATTTAAAGTAGCTTTATCATAAGCAAACTTAGTATCTAGG
TAAACTGTTACATCATCACCATTTACTGTATAGCACGCGACACCATCTTCAGTTAGATTAAAGTTGCCTT
CACATTGCTTAATACCAGCAGGTAAAACATACTTAGACTCATCAATAGTTGGCATAGCAACAGTTTGAGC
AGCTGTAGTCGCACCATTATCCTGAATATTACCAGTGTCATTATTAGTAGTATCTTTGCCACCAAAGAAC
CATGTTAAACCAGCACCAATCATGTTAGTACCCGCTCTGCCATTAGCACCAGAAATATTACTAGGTGCCA
TTGTTTGGATATATCTGTAGTCAACACTTGCTTGAACATTTCTAGATAGTTCAAACTTAAGACCACCACC
CACATCCCAAGCACCTGTTGCTTGACCTGCTAGATTTGCCCAACCAGCACCACCTGCAGCATATGGAGTA
AACATAGTATTATTACTAAAGTTTACAACACCTTCACCTAAACCAGCAAATACTCTACCAACTAATTGGT
TGTACTGTACAGCGAAGTATTTATTGATGTTATAACCGATTGTGAAGTTAGCACCAGCACCTGATGGAGA
GTTAGGAGTTCCAGCTAGACCGTTAGCATCTACACCTAAGTACCACTGGCCAGTTCTATCTTGAGGACCC
CAAGTATTGTCCTTGTTAGTCAAAGCGCTATAAGTATTTGCAAAAGGAGCAATGAAATTATTAGCTGCAA
AACCACTGCTTTGTGTAGTAGCTGAATTAGAGTTTGCTGACGTATCGATATTATCTGAACCTGCAGCGAT
AGATGCTGTAGCTGAACCTAATAATACAGTTGTAGCTATAACAATACTTTTTAATCTCATCA
Protein Sequence 
>YP_763774.1 outer membrane protein FopA [Francisella tularensis subsp. holarctica OSU18]
MMRLKSIVIATTVLLGSATASIAAGSDNIDTSANSNSATTQSSGFAANNFIAPFANTYSALTNKDNTWGP
QDRTGQWYLGVDANGLAGTPNSPSGAGANFTIGYNINKYFAVQYNQLVGRVFAGLGEGVVNFSNNTMFTP
YAAGGAGWANLAGQATGAWDVGGGLKFELSRNVQASVDYRYIQTMAPSNISGANGRAGTNMIGAGLTWFF
GGKDTTNNDTGNIQDNGATTAAQTVAMPTIDESKYVLPAGIKQCEGNFNLTEDGVACYTVNGDDVTVYLD
TKFAYDKATLNAKGKKAIASFVNFIKDSNISSVTVKGYASQGQTGSEFDIYNQKLSEKRAQAVADYMKQL
GLDSEKIITKGFGYNDTLGGIHKSDPRNQRVEASVSAPLKEAN
Molecule Role Protective antigen
Molecule Role Annotation Anti-FopA MAbs protected 90% of naïve C3H/HeN mice from lethal challenge with F. tularensis LVS when administered prophylactically as well as therapeutically (Savitt et al., 2009).
References