VIOLIN: Vaccine Investigation and Online Information Network

hpd
Gene Name	hpd
Sequence Strain (Species/Organism)	Haemophilus influenzae
VO ID	VO_0011081
NCBI Protein GI	148971
Other Database IDs	CDD:236859
Taxonomy ID	727
Gene Strand (Orientation)	?
Protein Name	protein D
Protein pI	6.85
Protein Weight	40003.95
Protein Length	418
Protein Note	glycerophosphodiester phosphodiesterase; Provisional; PRK11143
Protein Sequence	>AAA24998.1 protein D [Haemophilus influenzae] MKLKTLALSLLAAGVLAGCSSHSSNMANTQMKSDKIIIAHRGASGYLPEHTLESKALAFAQQADYLEQDL AMTKDGRLVVIHDHFLDGLTDVAKKFPHRHRKDGRYYVIDFTLKEIQSLEMTENFETKDGKQAQVYPNRF PLWKSHFRIHTFEDEIEFIQGLEKSTGKKVGIYPEIKAPWFHHQNGKDIAAETLKVLKKYGYDKKTDMVY LQTFDFNELKRIKTELLPQMGMDLKLVQLIAYTDWKETQEKDPKGYWVNYNYDWMFKPGAMAEVVKYADG VGPGWYMLVNKEESKPDNIVYTPLVKELAQYNVEVHPYTVRKDALPEFFTDVNQMYDALLNKSGATGVFT DFPDTGVEFLKGIK
Molecule Role	Protective antigen
Molecule Role Annotation	Rats vaccinated with PD (hpd) cleared NT H. influenzae better after middle ear and pulmonary bacterial challenge, and chinchillas vaccinated with PD showed significant protection against NT H. influenzae-dependent acute otitis media. In a clinical trial involving children, PD was used as an antigenically active carrier protein in an 11-valent pneumococcal conjugate investigational vaccine; significant protection was achieved against acute otitis media not only caused by pneumococci but also caused by NT H. influenzae (Forsgren et al., 2008). Protein D (PD) from NTHi is included as a carrier protein in the 10-valent pneumococcal polysaccharide conjugate vaccine (PHiD10-CV), and other promising protein vaccine candidates exist, including outer membrane protein 4 (P4) and protein 6 (P6). (Thornton et al., 2017)
References

hpd