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MDV040

Gene Name MDV040
Sequence Strain (Species/Organism) Gallid alphaherpesvirus 2
VO ID VO_0011164
NCBI Gene ID 4811501
NCBI Protein GI 125745079
Locus Tag MD5V_040
Genbank Accession AF147806
Protein Accession YP_001033956
Taxonomy ID 10390
Gene Starting Position 61024
Gene Ending Position 63651
Gene Strand (Orientation) -
Protein Name envelope glycoprotein B
Protein pI 8.4
Protein Weight 92434.87
Protein Length 865
Protein Note glycoprotein BALF4; the Herpesviridae are non-segmented dsDNA viruses with genomes ranging from 120-230kbp; although herpes viruses vary greatly in sequence identity and homology, they all share four common elements: an envelope, a tegument which is composed of viral enzymes, a capsid of 162 capsomers, and a core composed of genomic DNA; BALF4 is a transmembrane glycoprotein found in the lipid envelope of several herpesviruses
DNA Sequence 
>NC_002229.3:61024-63651 Gallid herpesvirus 2, complete genome
TTTTATTCAGTTCAAATATAATAGTGCCCACTTACACAGCATCATCTTCTGAGTCTGAATATGTAGTAGG
TAACTTATCATATTTAGGGTTACTATTTTTAATCCTCATTTTTGCCAGGTGGTCCGATAGAACGGCGGTA
GTGCCTCGCCTCTTTCTCCGCAGTTTTTTCTCGTGGCGTTCTTCCGCGGAGACTAACGCCATATATTTTA
TCATTTCTCTAGCTTCTTCTAATTTTCTTTCATCAATAGATGTTCGTTCCAAATCATCTGATTCCTCGCC
ATGCAACTCACGCGTTGCCTGTGCCTTAAGCACTTCTGTTGTCATAGGATAAAGGGCTTTCATTGGATTG
CTTTTAAGCTTGTTTACATAACGATATGCTAAAAATGCAGCCACGAGTCCTGCTATAATGATTAAACCGA
TTGCCAAAGCCCCAAAGGGATTTGACATGAAAGCAGAGACACCAGATATGGTAGATACGATTGCACCGGC
AGCCCCTACTACAACTTTGCCTATAGCTTGCCCTACCTGACCCATACCGTTAAACAATTCGGCCAAACCG
TTCATAAACGCGTAATTTGTATCCACTTCTATTACTTTGTTTATGTCATAAAATTTAAGTTCATGTAGTT
GATTGCGGCGAGCTACTTCTGCATAATCCAATACACCAACATCACGCAACTCTTCTTTTGTGTAAACGGA
TAAAGGCAAAATTTCCCGATCTTCTAGCAGGGTTAGATTAAGCTCGACAAATGTGCTAGCAATCTGTATA
TCGGCAGCGTCTACCATCTTAACAAAATTATAGTTTTCAAATAAAGCATAACCGGATCCAAACAGAAAAT
ATCTACGATGATTAGCCGAGCATGGCTCTACAGCCTCTAGCGTTGGAAGCAACTCGTTGTTTTCACCGAG
TTGTCCCTGTATGTTTCCTTGGTTTTCTCCATATGAAAATAGAACCAATGGTCGGCTATAACATGTATTA
GTGGATGTGATAACTCGCATAGAATTTTGCAAAGTGACGGATTCCGCATCTATAGCAGTGCAGCTCGATA
CAGCAGCGACATCCCCCAACATCTTTGCAGCCACTCTCCTTCCTAATGTTGCACTCGCTGTAGCGCTAGG
ATTAATCTTTATCCCTTCGTGCCATAAAACAAGTTCTCTATTCTGCAATTCGCACCAAGCTGTGGCAATC
CTACTAAACATATCATTAATATGGGTTTGTATATGATCATAAAGAAATTGGAGCATGGCGAATTGAACAG
ACGATGTCGATTTAATAGCTGTGGTGTCGTCTAATGTTATTTTTCTATTTGGTGCATTTCGAATATCTCG
CCGCAATCGTGACAATGAGGTAGCATTTTTCTTATAAATTGCATGCTTATTGTTTACCAGGTCGAGCATC
TCATCGGTCCTGTTGTCTCTCATCAATTCTCTGAGGTACATATGAGCCAGGGATTTGGATAGAACAGGCT
GATATGCTACAATAAATCCCCCGAGAGCCAAGAAATATTGTACATGTCCAACCTTGACGTGACTGTCATT
ATATTTTGTCCTAAATATCTGCTCGATTGCTGCTTCTGCCTCGCGTTTAATACATTGTCCTAATATGATG
CGATTTGGATCAAACTCAGTCGTATTACTGATAAACGTTGCCGAAAGTTCACGGGCCATAAATCTGTATC
TCCCATTAACTGTTGCACGCAACATTTCAGTCACCTCTTTCCACTTAGTCATTGAACATACACGAGTAGT
TTTTGGAGCCCAGTCCCACCCAACTGTGAAGTGTGATGTGATGAGAAAGTTACGCTTGACTGGAAGGCTT
GCTTTTCGACGCTTGTCCAAATCCATTGAAAAATAGCTATCTAGTTGTTTGAAATTATCCTGGGGATATC
CCATGGGTTCTGCGGCAGCCTCTGGTGGGGATAGACCATAAAATGGAGATATGTTCGCGATGTCGCCATT
GGCCATTGCAAAATATGAATACGGAAACACAGAGCGGGCATCCATTTCCTCTACTATACAATTGACGGAG
GTTCCCGTTCGATATATCCATGGTGATCCCCACACGGTATACGTCTCATTAGTCGTGTGCCATGCCCTAG
ATTCGGGCGTGTTGAATTTTGATGGTTTTAGAAGTACTTGTTTTTCTCCCGCATCCCTGTCAAACGCTTC
AACATATACATTGTTTCTAAGGTATCTTGCTTTAGATGAGCATCTTCCTTTGCCGTCGATTAGATCCGTG
ATCTCTTCAATGGAAACGGGCGTCCTATCTGTATATCGATTAGTGATCTGTCTATATGTCGTCCCCGTCC
ATGTCGTCGTCTGAATGATATTTTTATAATAAAGCGTCACTTTAAATTTATATGGACTGATATTCTCTTT
AAATAATATCGCGATTCCTTCACCCCATTCGGTGGCTTTTCTAGGTTCGGGACATTTTCGCGGCGGTTCT
AGACGGATCACGGTTGAACCCACTGGTGGGGGACAAAGATAAAACGTAGACTCTTCCTCAGACAACTGGA
CGCTCGAAACAACTTCTCTTGATGTCACATTTTGGGTACTCGGAGATGAGTTCGTACCATATAGAATAAC
TATAAGGAAAAAAATGCAATTCCGCCTAAAATAGTGCA
Protein Sequence 
>YP_001033956.1 envelope glycoprotein B [Gallid alphaherpesvirus 2]
MHYFRRNCIFFLIVILYGTNSSPSTQNVTSREVVSSVQLSEEESTFYLCPPPVGSTVIRLEPPRKCPEPR
KATEWGEGIAILFKENISPYKFKVTLYYKNIIQTTTWTGTTYRQITNRYTDRTPVSIEEITDLIDGKGRC
SSKARYLRNNVYVEAFDRDAGEKQVLLKPSKFNTPESRAWHTTNETYTVWGSPWIYRTGTSVNCIVEEMD
ARSVFPYSYFAMANGDIANISPFYGLSPPEAAAEPMGYPQDNFKQLDSYFSMDLDKRRKASLPVKRNFLI
TSHFTVGWDWAPKTTRVCSMTKWKEVTEMLRATVNGRYRFMARELSATFISNTTEFDPNRIILGQCIKRE
AEAAIEQIFRTKYNDSHVKVGHVQYFLALGGFIVAYQPVLSKSLAHMYLRELMRDNRTDEMLDLVNNKHA
IYKKNATSLSRLRRDIRNAPNRKITLDDTTAIKSTSSVQFAMLQFLYDHIQTHINDMFSRIATAWCELQN
RELVLWHEGIKINPSATASATLGRRVAAKMLGDVAAVSSCTAIDAESVTLQNSMRVITSTNTCYSRPLVL
FSYGENQGNIQGQLGENNELLPTLEAVEPCSANHRRYFLFGSGYALFENYNFVKMVDAADIQIASTFVEL
NLTLLEDREILPLSVYTKEELRDVGVLDYAEVARRNQLHELKFYDINKVIEVDTNYAFMNGLAELFNGMG
QVGQAIGKVVVGAAGAIVSTISGVSAFMSNPFGALAIGLIIIAGLVAAFLAYRYVNKLKSNPMKALYPMT
TEVLKAQATRELHGEESDDLERTSIDERKLEEAREMIKYMALVSAEERHEKKLRRKRRGTTAVLSDHLAK
MRIKNSNPKYDKLPTTYSDSEDDAV
Molecule Role Protective antigen
Molecule Role Annotation Recombinant fowl poxviruses (rFPVs) were constructed to express genes from serotype 1 Marek's disease virus (MDV, Gallid herpesvirus 2). rFPV/gB1 expressing MDV040 conferred 42% protection in maternal antibody-positive chickens when challenged with highly virulent MDV isolates (Lee et al., 2003).
Related Vaccines(s) Marek's Disease Virus Vaccine rFPV/gB1
References