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HAVgp2

Gene Name HAVgp2
Sequence Strain (Species/Organism) Hepatovirus A
VO ID VO_0010906
NCBI Gene ID 1493919
NCBI Protein GI 9626734
Locus Tag HAVgp2
Genbank Accession M14707
Protein Accession NP_041008
Taxonomy ID 12092
Gene Starting Position 740
Gene Ending Position 7417
Gene Strand (Orientation) +
Protein Name hypothetical protein
Protein pI 6.48
Protein Weight 235187.3
Protein Length 2225
DNA Sequence 
>NC_001489.1:740-7417 Hepatitis A virus, complete genome
CATGTCTAGACAAGGTATTTTCCAGACTGTTGGGAGTGGTCTTGACCACATCCTGTCTTTGGCAGACATT
GAGGAAGAGCAAATGATTCAATCAGTTGATAGGACTGCAGTGACTGGTGCTTCTTATTTTACTTCTGTGG
ATCAATCTTCAGTTCATACAGCTGAGGTTGGATCACACCAGGTTGAACCTTTGAGAACCTCTGTTGATAA
ACCCGGTTCAAAGAAGACTCAGGGAGAGAAATTTTTCTTGATTCATTCTGCAGATTGGCTTACTACACAT
GCTCTTTTCCATGAAGTTGCAAAATTGGATGTGGTGAAATTATTATACAATGAGCAGTTTGCTGTTCAAG
GGTTGTTGAGATACCATACATATGCAAGATTTGGCATTGAAATTCAAGTTCAGATAAACCCTACACCTTT
CCAACAGGGGGGATTGATCTGTGCTATGGTTCCTGGTGACCAGAGCTATGGTTCTATAGCATCATTGACT
GTTTATCCTCATGGTTTGTTAAATTGCAATATTAACAATGTGGTTAGAATAAAGGTTCCATTTATTTACA
CAAGAGGTGCTTACCACTTTAAAGATCCACAATACCCAGTTTGGGAATTGACAATTAGAGTTTGGTCAGA
ATTAAATATTGGGACAGGAACTTCAGCTTATACTTCACTCAATGTTTTAGCTAGATTTACAGATTTGGAG
TTGCATGGATTAACTCCTCTTTCTACACAAATGATGAGAAATGAATTTAGGGTCAGTACTACTGAGAATG
TGGTGAATCTGTCAAATTATGAAGATGCAAGAGCAAAGATGTCTTTTGCTTTGGATCAGGAAGATTGGAA
ATCTGATCCGTCCCAGGGTGGTGGGATCAAAATTACTCATTTTACTACTTGGACATCTATTCCAACTTTG
GCTGCTCAGTTTCCATTTAATGCTTCAGACTCAGTTGGTCAACAAATTAAAGTTATTCCAGTTGACCCAT
ATTTTTTCCAAATGACAAATACGAATCCTGACCAAAAATGTATAACTGCTTTGGCTTCTATTTGTCAGAT
GTTTTGTTTTTGGAGAGGAGATCTTGTCTTTGATTTTCAAGTTTTTCCCACCAAATATCATTCAGGTAGA
TTACTGTTTTGTTTTGTTCCTGGCAATGAGCTAATAGATGTTTCTGGAATCACATTAAAGCAAGCAACTA
CTGCTCCTTGTGCAGTAATGGATATTACAGGAGTGCAGTCAACTTTGAGATTTCGTGTTCCCTGGATTTC
TGACACTCCTTACAGAGTGAACAGGTATACAAAGTCAGCACATCAGAAAGGTGAGTACACTGCCATTGGG
AAGCTTATTGTGTATTGTTATAACAGATTGACCTCTCCTTCTAACGTTGCTTCCCATGTCAGAGTGAATG
TTTATCTTTCAGCAATTAACTTGGAATGTTTTGCTCCTCTTTATCATGCTATGGATGTTACTACACAAGT
TGGAGATGATTCTGGAGGTTTTTCAACAACAGTTTCTACAGAACAGAATGTTCCAGATCCCCAAGTTGGT
ATAACAACCATGAAAGATTTGAAAGGAAAAGCTAACAGAGGGAAAATGGATGTTTCAGGAGTACAAGCAC
CTGTGGGAGCTATCACAACAATTGAGGATCCAGTTTTAGCAAAGAAAGTACCTGAGACATTTCCTGAATT
GAAACCTGGAGAATCCAGACATACATCAGATCATATGTCCATCTACAAGTTTATGGGAAGGTCTCATTTC
TTGTGCACTTTTACATTCAATTCAAATAATAAAGAGTACACATTTCCTATAACCTTGTCTTCAACCTCTA
ATCCTCCTCATGGTTTGCCATCAACACTGAGGTGGTTTTTCAACTTGTTTCAGTTGTATAGAGGGCCTTT
AGATCTGACAATTATTATTACAGGAGCAACTGATGTAGATGGCATGGCCTGGTTCACTCCAGTAGGTCTT
GCCGTTGATACTCCTTGGGTAGAGAAGGAGTCAGCTTTGTCTATTGACTACAAAACTGCTCTTGGAGCTG
TCAGATTTAACACAAGGAGAACAGGGAACATTCAGATTAGATTACCATGGTATTCTTATTTATATGCTGT
GTCTGGAGCACTGGATGGTTTGGGTGACAAGACAGATTCTACATTTGGATTGGTTTCTATTCAGATTGCA
AATTACAATCATTCTGATGAATACTTGTCTTTTAGTTGTTATTTGTCTGTCACAGAACAATCAGAGTTTT
ATTTTCCCAGAGCTCCATTGAACTCAAATGCCATGTTATCCACTGAATCAATGATGAGCAGAATTGCAGC
TGGAGACTTGGAGTCATCAGTGGATGATCCTAGATCAGAGGAAGATAAAAGATTTGAGAGTCATATAGAA
TGCAGGAAGCCATATAAAGAACTGAGATTAGAAGTTGGGAAACAAAGACTCAAGTATGCTCAGGAAGAAT
TGTCAAATGAAGTACTTCCACCCCCTAGGAAAATGAAGGGACTGTTTTCACAAGCCAAAATTTCTCTTTT
TTATACTGAGGAGCATGAAATAATGAAGTTTTCCTGGAGAGGTGTGACTGCTGATACTAGAGCTTTAAGG
AGGTTTGGATTCTCTTTGGCCGCAGGCAGAAGTGTGTGGACTCTTGAAATGGATGCTGGGGTTCTTACTG
GGAGACTGATTAGATTGAATGATGAGAAATGGACAGAAATGAAGGATGACAAGATTGTTTCATTGATTGA
AAAGTTTACAAGTAACAAATATTGGTCCAAAGTGAATTTCCCACATGGGATGTTGGATCTTGAAGAAATT
GCTGCCAATTCTAAGGATTTTCCTAACATGTCTGAAACGGATTTGTGTTTCTTGCTGCATTGGTTAAATC
CAAAGAAAATTAATTTAGCAGATAGAATGCTTGGATTGTCTGGAGTTCAGGAAATTAAAGAACAAGGTGT
TGGATTAATAGCAGAGTGTAGAACTTTCTTAGATTCTATTGCTGGAACTTTAAAATCTATGATGTTTGGA
TTTCATCATTCTGTGACTGTTGAAATTATAAACACTGTGCTCTGTTTTGTTAAGAGTGGAATTTTGCTTT
ATGTAATACAACAATTGAATCAGGATGAACATTCTCACATAATTGGTTTGTTGAGAGTCATGAATTATGC
AGATATTGGTTGTTCAGTTATTTCATGTGGCAAAGTTTTTTCCAAAATGCTGGAAACAGTCTTTAATTGG
CAAATGGACTCCAGAATGATGGAGTTAAGGACTCAGAGTTTTTCCAACTGGTTAAGAGATATTTGTTCTG
GGATCACCATTTTTAAAAACTTCAAGGATGCAATTTATTGGCTTTATACAAAATTAAAGGACTTTTATGA
AGTGAATTATGGCAAGAAGAAGGACATTTTAAATATTCTTAAAGATAACCAACAAAAAATAGAGAAAGCC
ATTGAGGAAGCCGATGAATTTTGCATTTTGCAAATCCAAGATGTGGAAAAATTTGAACAGTATCAGAAAG
GGGTTGACTTGATACAAAAATTGAGAACTGTTCATTCAATGGCTCAGGTTGATCCAAATTTAATGGTTCA
TTTGTCACCTTTGAGAGATTGTATAGCAAGAGTTCATCAGAAACTTAAAAACCTTGGATCTATAAATCAG
GCAATGGTAACGAGATGTGAGCCAGTTGTTTGTTATTTATATGGCAAAAGAGGGGGAGGAAAGAGCTTAA
CATCAATTGCATTGGCAACCAAAATTTGTAAACATTATGGTGTTGAGCCTGAAAAGAATATCTATACTAA
ACCTGTGGCTTCAGATTACTGGGATGGATATAGTGGACAATTAGTTTGCATCATTGATGATATTGGCCAA
AACACAACAGATGAGGATTGGTCAGATTTTTGTCAGTTAGTGTCAGGATGTCCAATGAGATTAAACATGG
CCTCTCTTGAGGAGAAGGGTAGGCATTTTTCTTCTCCTTTTATAATAGCAACTTCAAATTGGTCAAATCC
AAGTCCAAAAACAGTTTATGTTAAGGAAGCAATTGACCGCAGACTCCATTTCAAGGTTGAAGTTAAACCT
GCTTCATTTTTCAAAAATCCTCACAATGATATGTTGAATGTTAATTTAGCTAAAACAAATGATGCAATCA
AAGATATGTCTTGTGTTGATTTGATAATGGATGGACATAATGTTTCATTGATGGATTTGCTCAGTTCTTT
AGTCATGACAGTTGAAATTAGAAAACAAAACATGACTGAATTCATGGAGTTGTGGTCTCAGGGAATTTCA
GATGATGATAATGATAGTGCAGTAGCTGAGTTTTTCCAGTCTTTTCCATCTGGTGAACCATCGAACTCTA
AATTATCTGGCTTTTTCCAATCTGTTACTAATCACAAGTGGGTTGCTGTGGGAGCTGCAGTTGGCATTCT
TGGAGTGCTCGTTGGAGGATGGTTTGTGTATAAGCATTTCTCCCGCAAAGAGGAGGAACCAATCCCAGCT
GAAGGGGTATATCATGGTGTAACTAAGCCCAAGCAAGTGATTAAATTAGATGCAGATCCAGTAGAATCTC
AGTCAACTTTGGAAATAGCAGGACTGGTTAGGAAGAACTTGGTTCAGTTTGGAGTTGGAGAGAAGAATGG
ATGTGTGAGATGGGTTATGAATGCCTTGGGAGTGAAAGATGATTGGCTGCTTGTGCCTTCCCATGCTTAT
AAATTTGAGAAAGATTATGAAATGATGGAGTTTTATTTTAATAGAGGTGGAACTTACTATTCAATTTCAG
CTGGTAATGTTGTTATTCAATCTTTGGATGTGGGATTCCAGGATGTTGTTCTGATGAAGGTTCCTACAAT
TCCTAAGTTTAGAGATATTACTCAGCATTTTATTAAGAAAGGGGATGTGCCTAGAGCTTTGAATCGCCTG
GCAACATTAGTGACAACTGTAAATGGAACCCCTATGTTAATTTCTGAGGGCCCACTAAAGATGGAAGAGA
AAGCTACTTATGTTCATAAGAAAAATGATGGTACAACAGTTGATTTAACTGTGGATCAGGCATGGAGAGG
AAAAGGCGAAGGTCTTCCTGGAATGTGTGGTGGGGCCTTGGTTTCATCGAATCAATCTATACAGAATGCA
ATCTTGGGCATCCATGTTGCTGGAGGAAATTCAATTCTTGTTGCAAAATTGGTTACTCAAGAAATGTTCC
AAAATATTGATAAGAAAATTGAAAGTCAGAGAATTATGAAAGTGGAGTTTACTCAGTGTTCAATGAATGT
GGTCTCCAAAACGCTTTTTAGAAAGAGTCCCATTTATCATCACATTGATAAAACCATGATTAATTTTCCT
GCAGCTATGCCCTTTTCTAAAGCTGAAATTGATCCAATGGCTGTGATGTTATCTAAGTATTCATTACCTA
TTGTAGAAGAACCAGAGGATTATAAAGAGGCTTCAATTTTTTATCAAAATAAAATAGTGGGTAAGACTCA
GTTAGTTGATGATTTTTTAGATCTTGATATGGCCATTACAGGGGCCCCAGGAATTGATGCTATCAACATG
GATTCATCTCCTGGATTTCCTTATGTCCAGGAGAAGTTGACCAAAAGAGATTTAATTTGGTTGGATGAAA
ATGGTTTATTGCTGGGAGTTCATCCAAGATTGGCTCAGAGAATCTTATTCAATACTGTCATGATGGAAAA
TTGTTCTGATTTGGATGTTGTTTTTACAACCTGTCCAAAAGATGAATTGAGACCATTAGAGAAAGTGTTG
GAATCAAAAACAAGAGCTATTGATGCTTGTCCTCTGGATTACTCAATTTTGTGCCGAATGTATTGGGGTC
CAGCTATTAGTTATTTTCATTTGAATCCAGGTTTCCATACAGGTGTTGCTATTGGCATAGATCCTGATAG
ACAGTGGGATGAATTATTTAAAACAATGATAAGATTCGGAGATGTTGGTCTTGATTTAGATTTCTCTGCT
TTTGATGCTAGTCTTAGTCCATTTATGATTAGAGAAGCAGGTAGAATCATGAGTGAACTATCTGGAACTC
CATCCCATTTTGGCACAGCTCTTATCAATACTATCATTTATTCCAAGCATTTGCTGTATAACTGTTGTTA
CCATGTCTGTGGTTCAATGCCCTCTGGGTCTCCTTGTACAGCTTTGCTAAATTCAATTATTAATAATGTC
AATTTGTATTATGTGTTTTCCAAGATATTTGGAAAGTCTCCAGTTTTCTTTTGTCAGGCTTTGAAGATTC
TCTGTTATGGAGATGATGTTTTAATAGTTTTCTCTCGAGATGTTCAGATTGATAATCTTGATTTGATTGG
ACAAAAAATTGTAGATGAGTTTAAGAAACTTGGCATGACAGCTACTTCTGCTGACAAGAATGTACCTCAG
CTGAAACCAGTTTCGGAATTGACTTTTCTCAAAAGATCTTTCAATTTGGTAGAGGATAGAATTAGACCTG
CAATTTCGGAAAAAACAATTTGGTCTTTAATAGCATGGCAGAGAAGTAACGCTGAGTTTGAGCAGAATTT
AGAAAATGCTCAGTGGTTTGCTTTTATGCATGGCTATGAGTTTTATCAGAAATTTTATTATTTTGTTCAG
TCCTGTTTGGAGAAAGAGATGATAGAATACAGACTTAAATCTTATGATTGGTGGAGAATGAGATTTTATG
ACCAGTGTTTCATTTGTGACCTTTCATG
Protein Sequence 
>NP_041008.1 hypothetical protein HAVgp2 [Hepatovirus A]
MSRQGIFQTVGSGLDHILSLADIEEEQMIQSVDRTAVTGASYFTSVDQSSVHTAEVGSHQVEPLRTSVDK
PGSKKTQGEKFFLIHSADWLTTHALFHEVAKLDVVKLLYNEQFAVQGLLRYHTYARFGIEIQVQINPTPF
QQGGLICAMVPGDQSYGSIASLTVYPHGLLNCNINNVVRIKVPFIYTRGAYHFKDPQYPVWELTIRVWSE
LNIGTGTSAYTSLNVLARFTDLELHGLTPLSTQMMRNEFRVSTTENVVNLSNYEDARAKMSFALDQEDWK
SDPSQGGGIKITHFTTWTSIPTLAAQFPFNASDSVGQQIKVIPVDPYFFQMTNTNPDQKCITALASICQM
FCFWRGDLVFDFQVFPTKYHSGRLLFCFVPGNELIDVSGITLKQATTAPCAVMDITGVQSTLRFRVPWIS
DTPYRVNRYTKSAHQKGEYTAIGKLIVYCYNRLTSPSNVASHVRVNVYLSAINLECFAPLYHAMDVTTQV
GDDSGGFSTTVSTEQNVPDPQVGITTMKDLKGKANRGKMDVSGVQAPVGAITTIEDPVLAKKVPETFPEL
KPGESRHTSDHMSIYKFMGRSHFLCTFTFNSNNKEYTFPITLSSTSNPPHGLPSTLRWFFNLFQLYRGPL
DLTIIITGATDVDGMAWFTPVGLAVDTPWVEKESALSIDYKTALGAVRFNTRRTGNIQIRLPWYSYLYAV
SGALDGLGDKTDSTFGLVSIQIANYNHSDEYLSFSCYLSVTEQSEFYFPRAPLNSNAMLSTESMMSRIAA
GDLESSVDDPRSEEDKRFESHIECRKPYKELRLEVGKQRLKYAQEELSNEVLPPPRKMKGLFSQAKISLF
YTEEHEIMKFSWRGVTADTRALRRFGFSLAAGRSVWTLEMDAGVLTGRLIRLNDEKWTEMKDDKIVSLIE
KFTSNKYWSKVNFPHGMLDLEEIAANSKDFPNMSETDLCFLLHWLNPKKINLADRMLGLSGVQEIKEQGV
GLIAECRTFLDSIAGTLKSMMFGFHHSVTVEIINTVLCFVKSGILLYVIQQLNQDEHSHIIGLLRVMNYA
DIGCSVISCGKVFSKMLETVFNWQMDSRMMELRTQSFSNWLRDICSGITIFKNFKDAIYWLYTKLKDFYE
VNYGKKKDILNILKDNQQKIEKAIEEADEFCILQIQDVEKFEQYQKGVDLIQKLRTVHSMAQVDPNLMVH
LSPLRDCIARVHQKLKNLGSINQAMVTRCEPVVCYLYGKRGGGKSLTSIALATKICKHYGVEPEKNIYTK
PVASDYWDGYSGQLVCIIDDIGQNTTDEDWSDFCQLVSGCPMRLNMASLEEKGRHFSSPFIIATSNWSNP
SPKTVYVKEAIDRRLHFKVEVKPASFFKNPHNDMLNVNLAKTNDAIKDMSCVDLIMDGHNVSLMDLLSSL
VMTVEIRKQNMTEFMELWSQGISDDDNDSAVAEFFQSFPSGEPSNSKLSGFFQSVTNHKWVAVGAAVGIL
GVLVGGWFVYKHFSRKEEEPIPAEGVYHGVTKPKQVIKLDADPVESQSTLEIAGLVRKNLVQFGVGEKNG
CVRWVMNALGVKDDWLLVPSHAYKFEKDYEMMEFYFNRGGTYYSISAGNVVIQSLDVGFQDVVLMKVPTI
PKFRDITQHFIKKGDVPRALNRLATLVTTVNGTPMLISEGPLKMEEKATYVHKKNDGTTVDLTVDQAWRG
KGEGLPGMCGGALVSSNQSIQNAILGIHVAGGNSILVAKLVTQEMFQNIDKKIESQRIMKVEFTQCSMNV
VSKTLFRKSPIYHHIDKTMINFPAAMPFSKAEIDPMAVMLSKYSLPIVEEPEDYKEASIFYQNKIVGKTQ
LVDDFLDLDMAITGAPGIDAINMDSSPGFPYVQEKLTKRDLIWLDENGLLLGVHPRLAQRILFNTVMMEN
CSDLDVVFTTCPKDELRPLEKVLESKTRAIDACPLDYSILCRMYWGPAISYFHLNPGFHTGVAIGIDPDR
QWDELFKTMIRFGDVGLDLDFSAFDASLSPFMIREAGRIMSELSGTPSHFGTALINTIIYSKHLLYNCCY
HVCGSMPSGSPCTALLNSIINNVNLYYVFSKIFGKSPVFFCQALKILCYGDDVLIVFSRDVQIDNLDLIG
QKIVDEFKKLGMTATSADKNVPQLKPVSELTFLKRSFNLVEDRIRPAISEKTIWSLIAWQRSNAEFEQNL
ENAQWFAFMHGYEFYQKFYYFVQSCLEKEMIEYRLKSYDWWRMRFYDQCFICDLS
Molecule Role Protective antigen
Molecule Role Annotation A recombinant vaccinia virus containing most of the P1 region of hepatitis A virus (HAV) was constructed bearing epitopes from structural polypeptides VP4, -3 and -2, and the N terminus of VP. Inoculation of tamarin monkeys with the recombinant virus resulted in the development of a specific anti-HAV immune response which was protective against challenge with a virulent strain of HAV (Karayiannis et al., 1991).
References