VIOLIN: Vaccine Investigation and Online Information Network

Il25
Gene Name	Il25
Sequence Strain (Species/Organism)	Mus musculus
NCBI Gene ID	140806
NCBI Protein GI	18141561
Genbank Accession	CH466535
Protein Accession	NP_542767
Taxonomy ID	10090
Chromosome No	14
Gene Starting Position	54930309
Gene Ending Position	54935840
Gene Strand (Orientation)	+
Protein Name	transcript variant X1
Protein pI	7.9
Protein Weight	18018.88
Protein Length	169
DNA Sequence	>NC_000080.6:54930309-54935840 Mus musculus strain C57BL/6J chromosome 14, GRCm38.p4 C57BL/6J TCCTCTGGCGTTGGGTACAGAGGCAGAGAAAGAAACCCCAAATGTCTCCTATGAAAAACAATGTCCCCGT CATCCAGGCCAGATCATTCTGCAGTGTCAACAGTTGAGACAAGAAGCTGGGGTCATTTTCTGTGCCTAAG AGTGCCTGTTCTGCACTGGCCAAGGTCTGCTTCCTAGGTTGTGCTGGGAGGCAGGGGGGTGGGGGGACTT ATAGGAATCCTTCTCTTTGAAACAGCACTGCCTGCTAAAGGACCCTACTCTGGGCTTGGGGTTGCTAAGG AACACCACAAGCCACCTGAGACCACGTGCCAGACAAAAGGCTGGGGAACAGGAAGCTGGAACAATGGATC CCAGCCAGTGGGGCTGGATGCCAAAGAGGACTGGGATGCCCTGTGGTTTTAGGCAGGTGCAAATGAAACA CATCCAGTGCCAGTCCGGGGGGGGGGGGGAGCACTGGAGCAAGGGTGGGAGCACTGAGGCAAGGATGGGT ATGGCACTGGCTGAAGATATTAATGGCCTTATTATTCTTCCCAGGGGAACAGGAACACATTTTCTCTGGG GGCTCTCCTTCCATTCATAGCCACCTGAGGATTGGCTCATGCTAGAAGCTTATGTTTGGAGTTACTGAGG GCTGGAATGGAAAAGCCAGCTCAGGTTTTTTTTTTCTAACTACCTAACCCTGAGTAGATGATTGGGGTTG GGTCTCACTTTCCTCGACCTCAACATGAGGATTTTAGGTTTCATGTCATGGTTTTAGTGTCAGGATAATA AGAGGATGTGTCTAGGGCTCAGCACCAAGTCTGGCACACTCAAGTGCACAGGAACAAGACCAGCAATGCA TAAAGGGAAATGGTTTCCAGGAGCACGGGGGGGGGGGGGGCGGGCAGGGCGGGGGGAGCACTGGAGCAAG GATGGGTGGGAGCACTGGAGCAAGGGTGGGAGCACTGGAGCAAGGGTGGGAGCACTGAGGCAAGGATGGG TATGACACTGGCTAAAGATACTCCTGGCCTTATTAGTCTTCCCAAGTGTCCTAACGGTGGCCACCAATGG TTTCTTCTCAGTGCCTCCCACTGTTCCAGGCCCCTAAGATTCACCCAAAGTAGTTTCTTCCAACTTTTGA GAATGCCCTCTGTCGTCATGACACCGCTGCCTCCAGACTGTGTTGTCCCACAGCGGTCCTGTATGATATG CATTATTCCTGGCTCCCTTTGTTTACTTTCTGATCCCTTGGTTACTTCAGGAGTATTTTCTGAGGGAAAG CACATGCAAATCAGCACACATTATTCTAGAGACAGTGTGTATGAGTGTGTTGGGGTGGGGCAGAAGGTCC CTGGGCAAACAGAGAAAGACCTGGAGGAAGCACACTGGCCGGTCTCTGCACAGTCGTCCCCTGCAGGCTG GACCTTGATTGGCCTGTGTCTTTGTAATCTGTCTTCTGGAGTATACACACACCCACCTGGCTAATAGGGC CCCATGAGAGTGCAGAAGCTGAATGGGCCCCCTATGGCTGGAGAGTAGCAGCTATCCTTGTTGTGAGTTT TGTTCCTGGGGCTCTATGAACAGGAGTGAAACCTCCTGCTGGGTCTTAGAGACCTCAGTGTCCTCTTCTC CATGTTCCACTCTCATTTGTGCAGTATAGACAGTCACCCACAGCTTCTTCCATCACTCTTGCCCACCCAA GCAGACAACTCCTTCAGGCATATCCTGGTAGCATGGTAGGGCGAGAGCTGCCTTCTCATCCCAGGAAGAG GTCAGGGAAAATCTGGGGACAGGGATGGGAACAGGGTGGCAAAGTGAGAAGGCAAAGGGAAATTGGGGGT GGTAATGGACAGCAAGGAGAAGTCATGCTCAAAATGGCTGGGTTTAGCCAACAAAAGGGGATGGCGGCCC AAGAGGCTGAAGAGAAGGCCAGTGTTTATTAAGACAGGTGGTCAGAGACATCTAAGAAGAAGAGCGACAG CCAGAGGTCAGATCCTAGGTAGGAAGTCTTGGAAATGGTGCCCTTGGAAAGGAGACCACAGAACATTCTT TAATTTGAGGTAGCACACACACATCAGGGAAATTCCCATCATGCCATCCCACAGAGACAGAATTGCAGAT GCTATTACTACGACCCCCGCCCGGAAAGTGCAAGGAACAAAGTTTACCCAATCAGCTGCCAGGCTGATAA TGATGATCATTACAACTTCCATGAGGGTAGCATTTAATCAGCTTTTGGGAACACTTTCAGGGTTGGGTTT TTTTGGTTGTTGTTATTGGTTTTATTTTTTTTTTCTTTTGGTTTTTCTTTTCTTTTTTTTTAATCTCAAG TCACTCCCTCTAAAAGATAGTGGAAATAAATTTGAATAAACAAAACAGGTTTGCTGAAAATAAAACCAGG ACACCTCAGCTGCTCCAGTCAGCCTCTCTCAGAAGGCCTGTCAGGCAGGGGTAGTACCTGTGACTGGTGA GCAGTGTCCGGCATGTACCAGGTGAGTGGCCCTGATGTCTGACAGAGGAATGGCTGAGAGAGAAAGGAGT AGAGATGGTATTGAGTGTGTAGGAAGGCTAGGCTTCCAGGCTTCCAGGCTTCTGGTCTCAGGGAGCTGCA GGAGGTAGGGGGTGGGGCTTGTATAGTATGGGGGAACTGCAAGTGACCTGCGAGTAGCTTTCTCATTGGC TTTTGCTCATAGGCTGTTGCATTCTTGGCAATGATCGTGGGAACCCACACCGTCAGCTTGCGGATCCAGG AGGGCTGCAGTCACTTGCCCAGCTGCTGCCCCAGCAAAGAGCAAGAACCCCCGGAGGAGTGGCTGAAGTG GAGCTCTGCATCTGTGTCCCCCCCAGAGCCTCTGAGCCACACCCACCACGCAGAATCCTGCAGGGCCAGC AAGGATGGCCCCCTCAACAGCAGGGCCATCTCTCCTTGGAGCTATGAGTGAGTGTCCGTAGTCCCCTCCT CAATGTTCTCATGGATCCCCCAGGGCATGGATGAGGGGCCGGGGGAGTTCCACCCAATTTGACCTATTTT AATTAATTAAACAGACCAGATAGGTTTGGGAGCTACACAGGCCTGAATTTGACTCTCAGCTCTGTCCTCA TTGTGTTGGGTGATGTTTTCAAAGTTCCTTCCTTCCTTCTTTCCTCTAGATTATATTCTAGAGGCTAATA CATAGGTCAAATGCAACAATGTATGTAAAGCCTGTATTTATATTGATTCTGTTTCTTGTTTAGTCTCCAC CATAACTCATATGTCTCTAAAGTATCAGGTGACATAGACACAAAGCACCACTATGCCAAATGCTGTCACT CGACCCTGGTGGGGCAGGTGGGAGGCCAGATCCCTAGGTTTCTCATCTTTAATTAAAACCCCAGCTCTCT TAATCTTTTACACAGCGTGTCACATACACATTGTAACTCTTTATTTATGACATGATATGAAACTGGGACA GAGAAACCATTTACAAATTAGGGTCTTAGGGATTCCAAACATGTGATTTCATTCCTGTATACTCACATGG TTATACAGCCCCCCCCCCGTGTGTCTCAGTTTCTTAGCCTTATCTTTGAGGGGTTATGAAGGGATTCCTG GTATAGGGAGCTGGTCAGCTTTAACTGATATTGTGTCTAAGACACCAGTTCATAATGCCTTGGAGTTGTC TCAGAGGCTACGTGGAAGATCTGCTTGGGGAGTGGGGGTCTCAGCTACACCTGTCCACTTTTTGGAAAGG CAGTAATAACCCTTGATGACCACTTAGCAGACCCTTTGACATATGCTCTCACAACACTGGTCCCACACGC TGTTTCTCAGGAAAAAAAAAAGTAATGGTGTCAAGTTAAATTTGTGAAAGGTTACAGAGCCCCATCCCTT GAAGATTCATTGCTCTCCATACATTACAATTGGCAAGAAGTCTACAAAAAGAAGCCGTTAGTGTCCCCCA AACTTGTTAGATCGCAGAAGCTTTTGTTTTACAGACAGACAGGCAGACAAATAACAAAAACAAAACCTCA AGGTATTTATTATGGACGCTTGCGGCAGTTGGACCCCAATTTCCCAGGGCTCATATGGGAAATGGTTCTA CCACACTGGGGCTTCCCGCTAGGCTACTGGATGCAATATATATATTTCTTTCCAGTTTTTGTTTTGATCT GGGCTTTGTTGTTGTTGCCACAAATCTTTTCTGAATTGGTAAGAAAAAAAAGTCTTTCCCATGACCTAAA TGTGCCTGTAATCCACTCTTGGGCTGTGACTGGAGAGTGGACATGAAGCAGCTCTCCCTGGGGAGTACAT AGAACAAAAGGAAACACTTGTTCTCTGTGTATTCTTTTATATGTGCCTGTCGACTGTGTGGCACAGGTTA GCCTCAAACTTATGGCTGTCTTTGCCTCGGCCTCTCAAGTGCTAGGGTTACAGGCACGTGCCACCTCACA GCAGTTTTTAATTTTGTAATAGCTGTAATTTAGATAAACATCATAAAACGGAATACCTTCCTAAGAAGCC TCATGCATATCAGACCGGTCTGCATTGGTCTGGTGGAGGCTGGCAGGACAGTCTTCGCCTTCCCCTGTGC TGTAAGAAGCTGTCATGTCTATGGCCTGGCATTGAGAGCCACTAGGAAAGCCACGTTTTTGTTGCCTACC TAAATTAATAGTGGGAGGAAATATTTCTCAGAGAGAAAGGGGTAGCAAAGTTACACAGTATTGGGTGCCA GAACAGATTTAAGAAGTTGAGTCCCCCAACCACGCCATTTGCTCCCTCCAGCGTCTCTACCCCACCTGCC CCTTGCTTCTGGCCTAATCAGCTCTGTCCCCACAGGTTGGACAGGGACTTGAATCGGGTCCCCCAGGACC TGTACCACGCTCGATGCCTGTGCCCACACTGCGTCAGCCTACAGACAGGCTCCCACATGGACCCGCTGGG CAACTCCGTCCCACTTTACCACAACCAGACGGTCTTCTACCGGCGGCCATGCCATGGCGAGGAAGGTACC CATCGCCGCTACTGCTTGGAGCGCAGGCTCTACCGAGTCTCCTTGGCTTGTGTGTGTGTGCGGCCCCGGG TCATGGCTTAGTCATGCTCACCACCTGCCTGAGGCTGATGCCCGGTTGGGAGAGAGGGCCAGGTGTACAA TCACCTTGCCAATGCGGGCCGGGTTCAAGCCCTCCAAAGCCCTACCTGAAGCAGCAGGCTCCCGGGACAA GATGGAGGACTTGGGGAGAAACTCTGACTTTTGCACTTTTTGGAAGCACTTTTGGGAAGGAGCAGGTTCC GCTTGTGCTGCTAGAGGATGCTGTTGTGGCATTTCTACTCAGGAACGGACTCCAAAGGCCTGCTGACCCT GGAAGCCATACTCCTGGCTCCTTTCCCCTGAATCCCCCAACTCCTGGCACAGGCACTTTCTCCACCTCTC CCCCTTTGCCTTTTGTTGTGTTTGTTTGTGCATGCCAACTCTGCGTGCAGCCAGGTGTAATTGCCTTGAA GGATGGTTCTGAGGTGAAAGCTGTTATCGAAAGTGAAGAGATTTATCCAAATAAACATCTGTGTTTAAAG TG
Protein Sequence	>NP_542767.1 interleukin-25 [Mus musculus] MYQAVAFLAMIVGTHTVSLRIQEGCSHLPSCCPSKEQEPPEEWLKWSSASVSPPEPLSHTHHAESCRASK DGPLNSRAISPWSYELDRDLNRVPQDLYHARCLCPHCVSLQTGSHMDPLGNSVPLYHNQTVFYRRPCHGE EGTHRRYCLERRLYRVSLACVCVRPRVMA
Molecule Role	Protective antigen
Molecule Role Annotation	Administration of anti-IL-25 mAb during the sensitization phase of a mouse model of allergic airway disease resulted in significantly reduced levels of IL-5 and IL-13 production, eosinophil infiltration, goblet cell hyperplasia, and serum IgE secretion, and prevented allergenic hyper-responsiveness. Even more striking was the ability of anti-IL-25 mAb, administered only during the challenge phase of the response, specifically to prevent AHR even during an ongoing type 2 inflammatory response in the lungs (Ballantyne et al., 2007).
References

Il25