VIOLIN: Vaccine Investigation and Online Information Network

efa1
Gene Name	efa1
Sequence Strain (Species/Organism)	Escherichia coli O157:H7
NCBI Gene ID	916316
NCBI Protein GI	WP_001239095
Locus Tag	ECs3860
Genbank Accession	NC_002695
Protein Accession	NP_311887
Other Database IDs	CDD:315573 CDD:327708
Taxonomy ID	562
Gene Starting Position	3867200
Gene Ending Position	3868501
Gene Strand (Orientation)	+
Protein Name	cytotoxin
Protein pI	9.61
Protein Weight	49129.25
Protein Length	486
Protein Note	TcdB toxin N-terminal helical domain; pfam12918
DNA Sequence	>gi\|916316\|gb\|H40264.1\|H40264 yp59e12.s1 Soares fetal liver spleen 1NFLS Homo sapiens cDNA clone IMAGE:191758 3', mRNA sequence NATNTATCAATGAAGATTTTTATTCAAGCTTAAAGTAAAAAGTAATTTTAGTTAAGAAAAATGAAGTACC AGATAAACTGTAACATATATTTTAACTTAGAAGTATCAAAACAGGAATTTTTTGATTCTCTAAGTGGTGG TCTCTGCAAAATGGAGCTTGAAGAAATCTTTTACATACCAATTTGATAAGAGTCTGCTGACCACGATCTG TCATTTTCTTTACTATGGGCTTCTGGGAGAATGAATGCTATTTTAAGGCCAAATGTGTTTTTCTTTCTTC TCCCCTTTCCCTGACTTTTCCCTTTCTCCCATCCCCGACCACCTACCCCACAATGGGNAGGAATTTTTGA CATC
Protein Sequence	>WP_001239095.1 cytotoxin [Escherichia coli] MRLPEKVLFPPVTSGLSGQEKQKKPKSITGFQENYQRNIRPIKTASEARLRFFDKMVSKENSLEDVVSLG EMIQKEIYGHEQRTFSPVHHTGNWKSSLLHNALLGLANVYNGLRETEYPNTFNRDGIKSTNSFRDNLLTK TRTPRDNFEEGIKHPEHATIPYDNDNESNKLLKAGKIAGNNNELLMEIKKESQSDHQIPLSDKFLKRKKR SPVAEDKVQNSLTPENFVQKISLSDELKTKYANEILEIKRIMGEYNLLPDKNSRNGLKLLQKQADLLKII MEDTSVTENTFKNIEMAIADIKREYYSHTVDIEKNIHAIWVAGSPPESISDYIKTFLKTYKEFTYYLWVD EKAFGAAKFTSVLKQIAFDLACRTIQQNTPQKNIDFINLYNEIRKKYNNNPSGQQEYLNKLRELYATYQK ISTPLKHMFNSFF
Molecule Role	Protective antigen
Molecule Role Annotation	Efa-1 is a factor for adherence that influences colonisation of the bovine intestines. Non-O157 EHEC, including serotype O26:H-, contain a full-length copy of efa-1 while EHEC O157:H7 contains a truncated form which is predicted to encode the amino-terminal 433 amino acids of the protein (efa-1) (van et al., 2007).
References

efa1