VIOLIN: Vaccine Investigation and Online Information Network

ompP1
Gene Name	ompP1
Sequence Strain (Species/Organism)	Haemophilus influenzae strain 4-H-1093
VO ID	VO_0012406
NCBI Protein GI	9716645
Other Database IDs	CDD:224978
Taxonomy ID	727
Gene Strand (Orientation)	?
Protein Name	outer membrane protein P1
Protein pI	9.25
Protein Weight	46882.94
Protein Length	521
Protein Note	Long-chain fatty acid transport protein [Lipid transport and metabolism]; COG2067
Protein Sequence	>AAF97590.1 outer membrane protein P1 [Haemophilus influenzae] MKKFNQSLLATAMLLAAGGANAAAFQLAEVSTSGLGRAYAGEAAIADNASVVATNPALMSLFKTAQFSTG GVYIDSRINMSGDVDASIKATAMARTKYGSASQRNVVPGAFVPNLYFVAPVNDKFALGAGMNVNFGLKSE YGDSYDAGIFGGKTDLSAINLNLSGAYRVTEGLSLGLGVNAVYANAQIERNAGIIADSIQDNQIQQALKA VDPQTKIHEYLTSKDKSVVSLQDRAAWGFGWNAGVMYQFNEANRIGLAYHSKVDIDFTDRTATSLGKKDI VAGKTGDLTLTLPDYLELSGFHQLTDKLAVHYSYKYTHWSRLTKLYASYENGEKAFDKELQYSNNSRIAL GASYNLYEKLTLRAGIAYDQAASRHQRSAAIPDTDRTWYSLGATYKFTPNLSVDLGYAYLKGKKVHFKEV KTIGAHIITNANYTSQAHANLYGLNLNYSF
Molecule Role	Protective antigen
Molecule Role Annotation	When chinchillas were immunized with recombinant P1 (rP1) obtained from one of these isolates (BCH-3), all animals developed antibodies specific for rP1. Immunized animals were protected against disease when challenged with BCH-3, but not with an ompP1 mutant of BCH-3 or a strain (BCH-2) possessing a heterologous P1 (91% identity). We conclude that (i) while P1 induces protection against NTHI-mediated otitis media, development of a polyvalent vaccine reflecting the variability of P1 would be necessary to construct an efficacious vaccine (Bolduc et al., 2000).
Related Vaccines(s)	Nontypeable H. influenzae Outer Membrane Protein P1 vaccine
References

ompP1