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aroA

Gene Name aroA
Sequence Strain (Species/Organism) Aeromonas salmonicida subsp. salmonicida A449
NCBI Gene ID 4997369
NCBI Protein GI 145298842
Locus Tag ASA_1859
Genbank Accession CP000644
Protein Accession YP_001141683
Taxonomy ID 382245
Gene Starting Position 1959933
Gene Ending Position 1961216
Gene Strand (Orientation) +
Protein Name 3-phosphoshikimate 1-carboxyvinyltransferase
Protein pI 6.3
Protein Weight 43170.95
Protein Length 427
Protein Note catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
DNA Sequence 
>gi|145297124:1959933-1961216 Aeromonas salmonicida subsp. salmonicida A449, complete genome
TATGAATTCGTTGCGTTTGGAACCCATTTCTCGTGTGGCCGGTGAGGTCAATCTGCCCGGCTCCAAGAGC
GTATCCAATCGGGCTTTGTTGCTGGCGGCCCTTGCCCGTGGCACCACCCGGCTGACCAATCTGCTCGACA
GCGATGATATTCGTCATATGCTGGCGGCGCTGACCCAGCTCGGGGTCAAGTACAAGCTTTCCGCCGACAA
GACAGAGTGCACAGTGCACGGTCTGGGTCGCAGCTTTGCGGTATCGGCACCGGTCAACCTGTTCCTCGGC
AATGCCGGTACTGCCATGCGTCCCCTCTGTGCGGCCCTGTGTCTGGGATCCGGTGAATACATGCTGGGCG
GTGAACCCAGGATGGAAGAGCGTCCCATCGGCCATCTGGTGGATGCCTTGCGTGAAGCGGGCGCCCATAT
CCAGTACCTGAAAAAAGATGGCTACCCGCCGCTGGTGGTGGATGCCAAGGGTCTCTGGGGCGGTGACGTA
CACGTCGATGGGTCCGTCTCCAGCCAGTTCCTGACGGCGTTTTTGATGGCGGCGCCCATGGCGGCCGGTG
ATACCCGTATCCACATCAAGGGTGAGCTGGTCTCCAAGCCCTACATCGACATCACGTTGCACATCATGAA
ACAGTTCGGGGTGGTCATCGAGCACGACAACTACAAGCTGTTCTACATCAAGGGCAACCAGAGCTATGTC
AGCCCGGGTGACTTCCTGGTGGAAGGGGACGCCTCCAGCGCTTCTTACTTCCTCGCGGCAGGTGCCATCA
AGGGCAAGGTGCGGGTGACCGGCATCGGCAAGCACAGTATTCAGGGCGATATCCACTTCGCCGACGTGCT
GGAGAGGATGGGCGCCCGCATCACCTGGGGTGACGACTTCATCGAGGCAGAGCAAGGCCCGCTGCACGGC
GTCGACATGGACATGAACCATATTCCGGATGCGGCCATGACCATAGCGGTCGCGGCACTGTTTGCCGAGG
GGCCCACCTCCATTCGCAACATCTACAACTGGCGGGTGAAGGAGACGGATCGTCTGCACGCCATGGCCAC
CGAGCTGCGCAAGCTGGGTGTGGAGGTGGAAGAGGGGCACGACTTCATTACCGTGACGCCGCCGACCCAG
CTCAAGCACGCCGAGATCGACACCTACAACGATCACCGCATCGCCATGTGCTTCTCGCTGGTGGCGCTGT
CCGATATCGCCGTCACCATCAATGATCCGGGTTGTACTTCCAAGACCTTCCCGGACTACTTCGATAAATT
GGCCAGCGTCAGCCAGGCCGTTTG
Protein Sequence 
>gi|145298842|ref|YP_001141683.1| 3-phosphoshikimate 1-carboxyvinyltransferase [Aeromonas salmonicida subsp. salmonicida A449]
MNSLRLEPISRVAGEVNLPGSKSVSNRALLLAALARGTTRLTNLLDSDDIRHMLAALTQLGVKYKLSADK
TECTVHGLGRSFAVSAPVNLFLGNAGTAMRPLCAALCLGSGEYMLGGEPRMEERPIGHLVDALREAGAHI
QYLKKDGYPPLVVDAKGLWGGDVHVDGSVSSQFLTAFLMAAPMAAGDTRIHIKGELVSKPYIDITLHIMK
QFGVVIEHDNYKLFYIKGNQSYVSPGDFLVEGDASSASYFLAAGAIKGKVRVTGIGKHSIQGDIHFADVL
ERMGARITWGDDFIEAEQGPLHGVDMDMNHIPDAAMTIAVAALFAEGPTSIRNIYNWRVKETDRLHAMAT
ELRKLGVEVEEGHDFITVTPPTQLKHAEIDTYNDHRIAMCFSLVALSDIAVTINDPGCTSKTFPDYFDKL
ASVSQAV
Molecule Role Virmugen
Molecule Role Annotation The aroA gene was inactivated by inserting a fragment expressing kanamycin resistance within the coding sequence and challenged in fish. The LD50 for unvaccinated
fish was 7.1 x 101. In contrast, the LD50 was 1.8 x 104 in fish vaccinated once and 3 x 105 in fish vaccinated twice (Vaughan et al., 1993).
Related Vaccines(s) A. salmonicida live-attenuated vaccine encoding AroA
References