VIOLIN: Vaccine Investigation and Online Information Network

cbiA
Gene Name	cbiA
Sequence Strain (Species/Organism)	Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91
NCBI Gene ID	6923268
NCBI Protein GI	205353181
Locus Tag	SG2061
Genbank Accession	AM933173
Protein Accession	YP_002226982
Taxonomy ID	550538
Gene Starting Position	2106950
Gene Ending Position	2108329
Gene Strand (Orientation)	-
Protein Name	cobyrinic acid a,c-diamide synthase
Protein pI	6.59
Protein Weight	47041.13
Protein Length	459
Protein Note	responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid
DNA Sequence	>gi\|205351346:2106950-2108329 Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 chromosome, complete genome GTCATAATACGCGCCTCGCCGCCGCCAGCCAGTGCTGCAACATTTCCGGACGCTGGGCGAAATGGACGTG CAGATAGCTGGCAAACGTGTTGCCTGTCTGCCAGCCGCCAGTCCATTCCTGTAACACGCGGCCATCGCGA ACCTTACGACAGGCCATAACGGCGGGTGTTTCGGGGATAAAATCTGAGTAGTGAAATTCATGGCCGCGCA CTATCTCGCCAAGCGCCGCCAATAGCGTTGGCTGCATAGCCTGCGCCTCACAGTAGCCAAAGCGGGTAAG TCGCTTACCCATTTTGCTGTGACCGGGGATAATATTCGCCATCTGATGAATTTCCCCACCGCTATCCTCC AGAGTGCTCCCCAGATACATCAGACCGCCACACTCCGCGTAAATCGCCACGCCGCGCTGATGCGCCGCCC GCAAATGTTTTAACATCGCCGTATTTGCCGCCAGATCCGCGGCGTATAATTCAGGATATCCACCGCCCAG CCAGATCATCTGACAATCAGGCAATGCGCGGTCATGCAGTGGGCTAAAACGCACAATGTTAACGCCGGCA CGCTCCAGAAAATCGATGTTATCGGGATAATAAAAGTTAAAGGCCTCATCATCCGCCAGAGCAAGCGTCA GCCCTGCCCCCGCTGTGTTATCGGGGCGCTCAGGCCACATTCCCGTCGGAAGCGCTGATAACACGCTCAG CGAGAGTAGCGCATCCACATCCACTGTTTGTTCCAGCGAGGCGGCAAAATCATGCCATGATTGCTGATTG ACGAGGGATTCTCTGGCGGTAATCAACCCCAGGTGGCGTTCAGGTAATGCGACGCCGTCGCAAGGAGGAA CATACCCCAGTACCGGCCGTGAGCAATAATGTTCAATGGCATTTTTGAGGAGCTGATAGTGGGCGTCGCT AGTGACGCGATTCACAATCACGCCCGCGAGGTTGAGGGTCGGGTCGAAGTGCTGAAATCCCATAACGGTA GCCGCAAGCGACGTTGAAACAGCCTTGCCGTCCACCAGTAGGATGACCGGGCAACCAAGCTGTTTGGCCA TCGCGGCTGTGCTGCAGTAATTGGGGTCGACGCCATAGCCGTCATACAGCCCCATGACGCCTTCAATGAC AGCGATATCCGCCTGCCGCATTTGTTCGCAAAATAAGGCGTTGAGAACAGGAGGAGGAAGCATGAAACTG TCAAGATTACGGGACGCCACGCCACAGATAGCGGTATGCCAGCCGGTATCAAGGTAATCTGGCCCAACTT TAAACGGCTGTACGCGCAGCGCGCGTTTTTGCAGCAGCCTCAACAAACCAAGCGTCACCGTGGTTTTGCC GCAACCGCTTCCTGTGCCTGCAAGAATAAATGCGTGATGCCTTGCCGCCA
Protein Sequence	>gi\|205353181\|ref\|YP_002226982.1\| cobyrinic acid a,c-diamide synthase [Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91] MAARHHAFILAGTGSGCGKTTVTLGLLRLLQKRALRVQPFKVGPDYLDTGWHTAICGVASRNLDSFMLPP PVLNALFCEQMRQADIAVIEGVMGLYDGYGVDPNYCSTAAMAKQLGCPVILLVDGKAVSTSLAATVMGFQ HFDPTLNLAGVIVNRVTSDAHYQLLKNAIEHYCSRPVLGYVPPCDGVALPERHLGLITARESLVNQQSWH DFAASLEQTVDVDALLSLSVLSALPTGMWPERPDNTAGAGLTLALADDEAFNFYYPDNIDFLERAGVNIV RFSPLHDRALPDCQMIWLGGGYPELYAADLAANTAMLKHLRAAHQRGVAIYAECGGLMYLGSTLEDSGGE IHQMANIIPGHSKMGKRLTRFGYCEAQAMQPTLLAALGEIVRGHEFHYSDFIPETPAVMACRKVRDGRVL QEWTGGWQTGNTFASYLHVHFAQRPEMLQHWLAAARRVL
Molecule Role	Virmugen
Molecule Role Annotation	A cbiA mutant, in combination with a cobS mutation, is attenuated in chickens and induces significant protection from challenge with wild type S. Gallinarum. This mutant was also able to provide some protection against S. Enteritidis (Penha et al., 2010).
Related Vaccines(s)	Salmonella Gallinarum cbiA/cobS mutant vaccine
References

cbiA