VIOLIN: Vaccine Investigation and Online Information Network

Bovine Respiratory Syncytial Virus

Table of Contents

General Information
Vaccine Related Pathogen Genes
1. F (Protective antigen)
2. M2 (Protective antigen)
3. N (Protective antigen)
4. N (Protective antigen)
5. P (Protective antigen)
6. glycoprotein G (Virmugen)
Vaccine Information
References

I. General Information

1. NCBI Taxonomy ID:

11246

2. Disease:

Respiratory Disease

3. Introduction

Bovine respiratory syncytial virus (BRSV) is an RNA virus classified as a pneumovirus in the paramyxovirus family. This virus was named for its characteristic cytopathic effect—the formation of syncytial cells. In additional to cattle, sheep and goats can also be infected by respiratory syncytial viruses. Human respiratory syncytial virus (HRSV) is an important respiratory pathogen in infants and young children. Antigenic subtypes are known to exist for HRSV, and preliminary evidence suggests that there may be antigenic subtypes of BRSV. BRSV is distributed worldwide, and the virus is indigenous in the cattle population.
BRSV infections associated with respiratory disease occur predominantly in young beef and dairy cattle. Passively derived immunity does not appear to prevent BRSV infections but will reduce the severity of disease. Initial exposures to the virus are associated with severe respiratory disease; subsequent exposures result in mild to subclinical disease. BRSV is an important virus in the bovine respiratory disease complex because of its frequency of occurrence, predilection for the lower respiratory tract, and ability to predispose the respiratory tract to secondary bacterial infection. In outbreaks, morbidity tends to be high, and the case fatality rate can be 0-20% (Merck Vet Manual: BRSV).

4. Host Ranges and Animal Models

Cattle

II. Vaccine Related Pathogen Genes

1. F

Gene Name : F
Sequence Strain (Species/Organism) : Bovine respiratory syncytial virus strain Snook
NCBI Protein GI : 3451386
Other Database IDs : CDD:278924
GOA:O90698
HSSP: 1G2C
InterPro: IPR000776
InterPro: IPR013055
UniProtKB/TrEMBL: O90698
Taxonomy ID : 11246
Gene Strand (Orientation) : ?
Protein Name : F protein
Protein pI : 9.09
Protein Weight : 59125.88
Protein Length : 632
Protein Note : Fusion glycoprotein F0; pfam00523

Protein Sequence : Show Sequence

>CAA76980.1 F protein [Bovine orthopneumovirus]
MATTAMTMIISIIFISTYVTHITLCQNITEEFYQSTCSAVSRGYLSALRTGWYTSVVTIELSKIQKNVCK
STDSKVKLIKQELERYNNAVVELQSLMQNEPASFSRAKRSIPELIHYTRNSTKKFYGLMGKKRKRRFLGF
LLGIGSAIASGVAVSKVLHLEGEVNKIKNALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKELLPKVNNH
DCRISNIATVIEFQQKNNRLLEIAREFSVNAGITTPLSTYMLTNSELLSLINDMPITNDQKKLMSSNVQI
VRQQSYSIMSVVKEEVIAYVVQLPIYGVIDTPCWKLHTSPLCTTDNKEGSNICLTRTDRGWYCDNAGSVS
FFPQAETCKVQSNRVFCDTMNSLTLPTDVNLCNTDIFNTKYDCKIMTSKTDISSSVITSIGAIVSCYGKT
KCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKLEGKALYIKGEPIINYYDPLVFPSDEFDA
SIAQVNAKINQSLAFIRRSDELLHSVDVGKSTTNVVITTIIIVIVVVILMLIAVGLLFYCKTRSTPIMLG
KDQLSGINNLSFSK

Molecule Role : Protective antigen
Related Vaccine(s): BRSV DNA vaccine VCL-Fb

2. glycoprotein G

Gene Name : glycoprotein G
Sequence Strain (Species/Organism) : Bovine respiratory syncytial virus
NCBI Gene ID : 1489813
NCBI Protein GI : 9631274
Locus Tag : BovRSVgp07
Genbank Accession : AF092942
Protein Accession : NP_048054
3D structure: PDB ID : 1BRV
Taxonomy ID : 11246
Gene Starting Position : 4689
Gene Ending Position : 5528
Gene Strand (Orientation) : +
Protein Name : mRNA
Protein pI : 10.63
Protein Weight : 27981.73
Protein Length : 257

DNA Sequence : Show Sequence

>gi|9631267:4689-5528 Bovine respiratory syncytial virus, complete genome
TGGGGCAAATACAAGTATGTCCAACCATACCCACCATCTTAAATTCAAGACATTAAAGAGGGCTTGGAAA
GCCTCAAAATACTTCATAGTAGGATTATCATGTTTATATAAGTTCAATTTAAAATCCCTTGTCCAAACGG
CTTTGACCACCTTAGCAATGATAACCTTGACATCACTCGTCATAACAGCCATTATTTACATTAGTGTGGG
AAATGCTAAAGCCAAGCCCACATCCAAACCAACCATCCAACAAACACAACAGCCCCAAAACCATACCTCA
CCATTTTTCACAGAGCACAACTACAAATCAACTCACACATCAATTCAAAGCACCACACTGTCCCAACTAC
CAAACACAGACACCACTAGAGAAACTACATACAGTCACTCAATCAACGAAACCCAAAACAGAAAAATCAA
AAGCCAATCCACTCTACCCGCCACCAGAAAACCACCAATTAACCCATCGGGAAGCAACCCCCCTGAAAAC
CACCAAGACCACAACAACTCCCAAACACTCCCCTATGTGCCTTGCAGTACATGTGAAGGTAATCTTGCTT
GTTTATCACTCTGCCAAATCGGGCCGGAGAGAGCACCAAGCAGAGCCCCTACAATCACCCTCAAAAAGAC
TCCAAAACCCAAAACCACCAAAAAGCCAACCAAGACAACAATCCACCACAGAACCAGCCCTGAAGCCAAA
CTGCAACCCAAAAACAACACGGCAGCTCCACAACAAGGCATCCTCTCTTCACCAGAACACCACACAAATC
AATCAACTACACAGATCTAACAACACACCTCCATATAATATCAATTATGTTCATATATAGTTATTTAAAA

Protein Sequence : Show Sequence

>gi|9631274|ref|NP_048054.1| G [Bovine respiratory syncytial virus]
MSNHTHHLKFKTLKRAWKASKYFIVGLSCLYKFNLKSLVQTALTTLAMITLTSLVITAIIYISVGNAKAK
PTSKPTIQQTQQPQNHTSPFFTEHNYKSTHTSIQSTTLSQLPNTDTTRETTYSHSINETQNRKIKSQSTL
PATRKPPINPSGSNPPENHQDHNNSQTLPYVPCSTCEGNLACLSLCQIGPERAPSRAPTITLKKTPKPKT
TKKPTKTTIHHRTSPEAKLQPKNNTAAPQQGILSSPEHHTNQSTTQI

Molecule Role : Virmugen
Molecule Role Annotation : A glycoprotein G deletion in bovine respiratory syncytial virus(rBRSV) and recombinant rBRSV was attenuated and provided protection against a BRSV challenge infection in calves (Schmidt et al., 2002).
Related Vaccine(s): Bovine respiratory syncytial virus glycoprotein G mutant vaccine , Bovine Respiratory Syncytial Virus recombinant vector vaccine BHVl/BRSVG encoding the G protein

3. M2

Gene Name : M2
Sequence Strain (Species/Organism) : Bovine Respiratory Syncytial Virus
NCBI Protein GI : AAL49411
Other Database IDs : CDD:214632
CDD:283973
Taxonomy ID : 11247
Protein Name : M2-1 protein
Protein pI : 8.79
Protein Weight : 21321.46
Protein Length : 262
Protein Note : original isolate

Protein Sequence : Show Sequence

>AAL49411.1 M2-1 protein [Bovine respiratory syncytial virus ATCC51908]
MSRRNPCKYEIRGHCLNGKKCHFSHNYFEWPPHALLVRQNFMLNKILKSMDRNNDTLSEISGAAELDRTE
EYALGVIGVLESYLSSINNITKQSACVAMSKLLAEINNDDIKRLRNKEVPTSPKIRIYNTVISYIDSNKR
NTKQTIHLLKRLPADVLKKTIKNTIDIHNEINGNNQGDINVDEQNE

Molecule Role : Protective antigen
Molecule Role Annotation :

4. N

Gene Name : N
Sequence Strain (Species/Organism) : Bovine Respiratory Syncytial Virus
NCBI Protein GI : ARJ54327
Other Database IDs : CDD:308720
Taxonomy ID : 11246
Protein Name : nucleoprotein
Protein pI : 9.76
Protein Weight : 23680.64
Protein Length : 296
Protein Note : Pneumovirus nucleocapsid protein; pfam03246

Protein Sequence : Show Sequence

>ARJ54327.1 nucleoprotein, partial [Bovine orthopneumovirus]
MLLITEDANHKFTGLIGMLYAMSRLGREDTLKILKDAGYQVRANGVDVITHRQDVNGKEMKFEVLTLVSL
TSEVQGNIEIESRKSYKKMLKEMGEVASEYRHDAPDCGMIVLCVAALVITKLAAGDRSGLTAVIRRANNV
LRNEMKRYKGLIPKDIANSFYEVFEKYPHYIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGAGQVMLR
WGVLAKSVKNIMLGHASVQA

Molecule Role : Protective antigen
Molecule Role Annotation : (Gershwin et al., 2017)

5. N

Gene Name : N
Sequence Strain (Species/Organism) : Bovine Respiratory Syncytial Virus
NCBI Protein GI : AAL49405
Other Database IDs : CDD:281264
Taxonomy ID : 11247
Protein Name : nucleocapsid protein
Protein pI : 7.22
Protein Weight : 41002.61
Protein Length : 478
Protein Note : original isolate

Protein Sequence : Show Sequence

>AAL49405.1 nucleocapsid protein [Bovine respiratory syncytial virus ATCC51908]
MALSKVKLNDTFNKDQLLSTSKYTIQRSTGDNIDIPNYDVQKHLNKLCGMLLITEDANHKFTGLIGILYA
MSRLGREDTLKILKDAGYQVRANGVDVITHRQDVNGKEMKFEVLTLVSLTSEVQGNIEIESRKSYKKMLK
EMGEVAPEYRHDSPDCGMIVLCVAALVITKLAAGDRSGLTAVIRRANNVLRNEMKRYKGLIPKDIANSFY
EVIEKYPHYIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGAGQVMLRWGVLAKSVKNIMLGHASVQAE
MEQVVEVYEYAQKLGGEAGFYHILNNPKASLLSLTQFPNFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAA
KAYAEQLKENGVINYSVLDLTTEELEAIKNQLNPKDNDVEL

Molecule Role : Protective antigen
Molecule Role Annotation :

6. P

Gene Name : P
Sequence Strain (Species/Organism) : Bovine Respiratory Syncytial Virus
NCBI Protein GI : AAL49406
Other Database IDs : CDD:280615
Taxonomy ID : 11247
Protein Name : phosphoprotein
Protein pI : 4.3
Protein Weight : 27092.97
Protein Length : 320
Protein Note : original isolate

Protein Sequence : Show Sequence

>AAL49406.1 phosphoprotein [Bovine respiratory syncytial virus ATCC51908]
MEKFAPEFHGEDANTKATKFLESLKGKFTSSKDSRKKDSIISVNSIDIELPKESPITSTNHNINQPSEIN
DTIAANQVHIRKPLVSFKEELPSSENPFTKLYKETIETFDNNEEESSYSYDEINDQTNDNITARLDRIDE
KLSEIIGMLHTLVVASAGPTAARDGIRDAMVGLREEMIEKIRSEALMTNDRLEAMARLRDEESEKMTKDT
SDEVKLTPTSEKLNMVLEDESSDNDLSLEDF

Molecule Role : Protective antigen
Molecule Role Annotation :

III. Vaccine Information

1. Bovine Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1161.00)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0001875

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

2. Bovine Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1161.20)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0001876

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

3. Bovine respiratory syncytial virus glycoprotein G mutant vaccine

a. Vaccine Ontology ID:

VO_0002951

b. Type:

Live, attenuated vaccine

c. Status:

Research

d. Host Species as Laboratory Animal Model:

Cow

e. Gene Engineering of glycoprotein G

Type: Gene mutation
Description: This glycoprotein G mutant is from Bovine respiratory syncytial virus (Schmidt et al., 2002).
Detailed Gene Information: Click here.

f. Immunization Route

intranasal immunization

g. Cattle Response

Persistence: A glycoprotein G mutant is attenuated in calves (Schmidt et al., 2002).
Efficacy: A glycoprotein G mutant induces significant protection in calves from challenge with wild type BRSV (Schmidt et al., 2002).

4. Bovine Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1095.20)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc., Merial, Inc.

b. Vaccine Ontology ID:

VO_0001558

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

5. Bovine Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1095.21)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0001559

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

6. Bovine Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 40A5.20)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0002205

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

7. Bovine Respiratory Syncytial Virus recombinant vector vaccine BHVl/BRSVG encoding the G protein

a. Vaccine Ontology ID:

VO_0004289

b. Type:

Recombinant vector vaccine

c. Status:

Licensed

d. Host Species as Laboratory Animal Model:

Calves

e. Gene Engineering of glycoprotein G

Type: Recombinant vector construction
Description: The gE gene was replaced by a gene encoding the G protein of BRSV in a BHVI vector (Schrijver et al., 1997).
Detailed Gene Information: Click here.

f. Vector:

BHVI (Schrijver et al., 1997)

g. Immunization Route

intranasal immunization

h. Cattle Response

Vaccine Immune Response Type: VO_0000286
Efficacy: Flow cytometric analysis showed a significant relative increase of gamma/delta+ T cells in peripheral blood after BRSV challenge-infection of the calves of the control group but not in the vaccinated groups. These results indicate that the G protein of BRSV can induce significant protection against BRSV infection in cattle, and that the BHV1/BRSV-G vaccine protects effectively against a subsequent BRSV and BHV1 infection (Schrijver et al., 1997).

8. Bovine Respiratory Syncytial Virus Vaccine Modified Live Virus (USDA: 1091.20)

a. Manufacturer:

Pfizer, Inc., Heska Corporation

b. Vaccine Ontology ID:

VO_0001560

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

9. Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.00)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0001895

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

10. Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.20)

a. Manufacturer:

Wyeth, Pfizer, Inc., Heska Corporation, Texas Vet Lab, Inc.

b. Vaccine Ontology ID:

VO_0001896

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

11. Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.21)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001897

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

12. Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001898

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

13. Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.23)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001899

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

14. Bovine Rhinotracheitis-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 11B5.20)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0001900

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

15. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.00)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0001939

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

16. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.20)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc., Intervet Inc., Heska Corporation, Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0001940

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

17. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.21)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001941

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

18. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.22)

a. Manufacturer:

Wyeth, Intervet Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001942

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

19. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.23)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001943

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

20. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.24)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0001944

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

21. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.25)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001945

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

22. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.26)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001946

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

23. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.28)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001947

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

24. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.30)

a. Manufacturer:

Intervet Inc., Heska Corporation

b. Vaccine Ontology ID:

VO_0001948

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

25. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1185.20)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc., Merial, Inc., Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0001949

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

26. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1185.22)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0001950

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

27. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44M5.20)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0001951

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

28. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44M5.22)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0001952

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

29. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B5.20)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0001953

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

30. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B6.20)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0001954

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

31. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B6.21)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0001955

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

32. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.20)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0001968

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

33. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.21)

a. Manufacturer:

Wyeth, Pfizer, Inc., Merial, Inc.

b. Vaccine Ontology ID:

VO_0001969

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

34. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.22)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0001970

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

35. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.25)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001971

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

36. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1189.00)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0001972

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

37. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1189.21)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0001973

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

38. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1189.30)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0001974

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

39. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B9.21)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0001975

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

40. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B9.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001976

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

41. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.20)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc., Intervet Inc.

b. Vaccine Ontology ID:

VO_0001982

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

42. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001983

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

43. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.23)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001984

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

44. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.25)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001985

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

45. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Hardjo Bacterin (USDA: 4L49.20)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002003

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

46. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus-Mannheimia Haemolytica-Pasteurella Multocida Modified Live Virus, Avirulent Live Culture Vaccine (USDA: 11A8.22)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002008

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

47. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 11A5.20)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002009

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

48. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 11A1.20)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0002010

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

49. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 11A1.26)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002011

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

50. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 11A1.30)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0002012

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

51. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.20)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0002013

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

52. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.26)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002014

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

53. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.30)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0002015

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

54. Bovine Virus Diarrhea-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 12A5.20)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0002028

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

55. BRSV DNA vaccine VCL-Fb

a. Vaccine Ontology ID:

VO_0004574

b. Type:

DNA vaccine

c. Status:

Research

d. Host Species as Laboratory Animal Model:

Calves

e. Gene Engineering of F

Type: DNA vaccine construction
Description:
Detailed Gene Information: Click here.

f. Vector:

pVCL1012 (Taylor et al., 2005)

g. Immunization Route

Intramuscular injection (i.m.)

h. Cattle Response

Vaccine Immune Response Type: VO_0003057
Immune Response: Seven days after BRSV challenge, BRSV-specific serum IgA titres in calves vaccinated i.m. with VCL-Fb were significantly greater than those in calves vaccinated by the i.d. route (P < 0.05) (Taylor et al., 2005).
Efficacy: Vaccination with DNA encoding the BRSV F protein can induce a significant reduction in BRSV excretion in young calves. At slaughter, 7 days after challenge, BRSV was isolated from the lungs of three out of four calves vaccinated with control plasmid, two out of six calves vaccinated i.d. with VCL-Fb, but none of the calves vaccinated i.m. with VCL-Fb (Taylor et al., 2005).

IV. References

1. Blod�rn et al., 2014: Blod�rn K, H�gglund S, Fix J, Dubuquoy C, Makabi-Panzu B, Thom M, Karlsson P, Roque JL, Karlstam E, Pringle J, El�ou�t JF, Riffault S, Taylor G, Valarcher JF. Vaccine safety and efficacy evaluation of a recombinant bovine respiratory syncytial virus (BRSV) with deletion of the SH gene and subunit vaccines based on recombinant human RSV proteins: N-nanorings, P and M2-1, in calves with maternal antibodies. PloS one. 2014; 9(6); e100392. [PubMed: 24945377].

2. Gershwin et al., 2017: Gershwin LJ, Behrens NE, McEligot HA, Carvallo-Chaigneau FR, Crum LT, Gunnarson BM, Corbeil LB. A recombinant subunit vaccine for bovine RSV and Histophilus somni protects calves against dual pathogen challenge. Vaccine. 2017; 35(15); 1954-1963. [PubMed: 28274639].

3. Merck Vet Manual: BRSV: Merck Veterinary Manual-Bovine Respiratory Syncytial Virus [http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/121211.htm]

4. Schmidt et al., 2002: Schmidt U, Beyer J, Polster U, Gershwin LJ, Buchholz UJ. Mucosal immunization with live recombinant bovine respiratory syncytial virus (BRSV) and recombinant BRSV lacking the envelope glycoprotein G protects against challenge with wild-type BRSV. Journal of virology. 2002; 76(23); 12355-12359. [PubMed: 12414977].

5. Schrijver et al., 1997: Schrijver RS, Langedijk JP, Keil GM, Middel WG, Maris-Veldhuis M, Van Oirschot JT, Rijsewijk FA. Immunization of cattle with a BHV1 vector vaccine or a DNA vaccine both coding for the G protein of BRSV. Vaccine. 1997; 15(17-18); 1908-1916. [PubMed: 9413101].

6. Taylor et al., 2005: Taylor G, Bruce C, Barbet AF, Wyld SG, Thomas LH. DNA vaccination against respiratory syncytial virus in young calves. Vaccine. 2005; 23(10); 1242-1250. [PubMed: 15652666].