VIOLIN Logo
VO Banner
Search: for Help
About
Introduction
Statistics
VIOLIN News
Your VIOLIN
Register or Login
Submission
Tutorial
Vaccine & Components
Vaxquery
Vaxgen
VBLAST
Protegen
VirmugenDB
DNAVaxDB
CanVaxKB
Vaxjo
Vaxvec
Vevax
Huvax
Vaccine Mechanisms
Vaximmutordb
Vaxism
Vaxar
Vaccine Literature
VO-SciMiner
Litesearch
Vaxmesh
Vaxlert
Vaccine Design
Vaxign
Community Efforts
Vaccine Ontology
ICoVax 2012
ICoVax 2013
Advisory Committee
Vaccine Society
Vaxperts
VaxPub
VaxCom
VaxLaw
VaxMedia
VaxMeet
VaxFund
VaxCareer
Data Exchange
V-Utilities
VIOLINML
Help & Documents
Publications
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

Streptococcus suis

Table of Contents
  1. General Information
    1. NCBI Taxonomy ID
  2. Vaccine Information
    1. rSPV-MRP (Streptococcus suis)
  3. References
I. General Information
1. NCBI Taxonomy ID:
1307
II. Vaccine Information
1. rSPV-MRP (Streptococcus suis)
a. Vaccine Ontology ID:
VO_0004635
b. Type:
Recombinant vector vaccine
c. Status:
Research
d. Host Species for Licensed Use:
Mouse
e. Vector:
(Huang et al., 2012)
f. Preparation
A swinepox virus (SPV) was used as a vector to express truncated muramidase-released protein (MRP) of S. suis type 2 (SS2), designated rSPV-MRP (Huang et al., 2012).
g. Immunization Route
Intramuscular injection (i.m.)
h. Mouse Response
  • Vaccination Protocol: Mice were immunized intramuscularly with rSPV-MRP, SS2 inactive vaccine (positive control), wild-type SPV (negative control) and PBS (blank control) (Huang et al., 2012).
  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: All CD1 mice were challenged with a lethal dose or a sublethal dose of SS2 highly virulent strain ZY05719 (Huang et al., 2012).
  • Efficacy: SS2 inactive vaccine protected all mice, immunization with rSPV-MRP resulted in 60% survival and protected mice against a lethal dose of the highly virulent SS2 strain, compared with the negative control (Huang et al., 2012).
III. References
1. Huang et al., 2012: Huang D, Zhu H, Lin H, Xu J, Lu C. First insights into the protective effects of a recombinant swinepox virus expressing truncated MRP of Streptococcus suis type 2 in mice. Berliner und Munchener tierarztliche Wochenschrift. 2012; 125(3-4); 144-152. [PubMed: 22515033].