|
|
Streptococcus suis |
| Table of Contents |
- General Information
- NCBI Taxonomy ID
- Vaccine Information
- rSPV-MRP (Streptococcus suis)
- References
|
| I. General Information |
| 1. NCBI Taxonomy ID: |
|
1307 |
| II. Vaccine Information |
 |
|
 |
|
|
|
|
1. rSPV-MRP (Streptococcus suis) |
| a. Vaccine Ontology ID: |
| VO_0004635 |
| b. Type: |
| Recombinant vector vaccine |
| c. Status: |
| Research |
| d. Host Species for Licensed Use: |
| Mouse |
| e. Vector: |
| (Huang et al., 2012) |
| f. Preparation |
| A swinepox virus (SPV) was used as a vector to express truncated muramidase-released protein (MRP) of S. suis type 2 (SS2), designated rSPV-MRP (Huang et al., 2012). |
| g. Immunization Route |
| Intramuscular injection (i.m.) |
| h.
Mouse Response |
- Vaccination Protocol:
Mice were immunized intramuscularly with rSPV-MRP, SS2 inactive vaccine (positive control), wild-type SPV (negative control) and PBS (blank control) (Huang et al., 2012).
- Vaccine Immune Response Type:
VO_0003057
- Challenge Protocol:
All CD1 mice were challenged with a lethal dose or a sublethal dose of SS2 highly virulent strain ZY05719 (Huang et al., 2012).
- Efficacy:
SS2 inactive vaccine protected all mice, immunization with rSPV-MRP resulted in 60% survival and protected mice against a lethal dose of the highly virulent SS2 strain, compared with the negative control (Huang et al., 2012).
|
|
|
|
 |
|
 |
|
|
| III. References |
1. Huang et al., 2012: Huang D, Zhu H, Lin H, Xu J, Lu C. First insights into the protective effects of a recombinant swinepox virus expressing truncated MRP of Streptococcus suis type 2 in mice. Berliner und Munchener tierarztliche Wochenschrift. 2012; 125(3-4); 144-152. [PubMed: 22515033].
|
|
