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Streptococcus suis |
Table of Contents |
- General Information
- NCBI Taxonomy ID
- Vaccine Information
- rSPV-MRP (Streptococcus suis)
- References
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I. General Information |
1. NCBI Taxonomy ID: |
1307 |
II. Vaccine Information |
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1. rSPV-MRP (Streptococcus suis) |
a. Vaccine Ontology ID: |
VO_0004635 |
b. Type: |
Recombinant vector vaccine |
c. Status: |
Research |
d. Host Species for Licensed Use: |
Mouse |
e. Vector: |
(Huang et al., 2012) |
f. Preparation |
A swinepox virus (SPV) was used as a vector to express truncated muramidase-released protein (MRP) of S. suis type 2 (SS2), designated rSPV-MRP (Huang et al., 2012). |
g. Immunization Route |
Intramuscular injection (i.m.) |
h.
Mouse Response |
- Vaccination Protocol:
Mice were immunized intramuscularly with rSPV-MRP, SS2 inactive vaccine (positive control), wild-type SPV (negative control) and PBS (blank control) (Huang et al., 2012).
- Vaccine Immune Response Type:
VO_0003057
- Challenge Protocol:
All CD1 mice were challenged with a lethal dose or a sublethal dose of SS2 highly virulent strain ZY05719 (Huang et al., 2012).
- Efficacy:
SS2 inactive vaccine protected all mice, immunization with rSPV-MRP resulted in 60% survival and protected mice against a lethal dose of the highly virulent SS2 strain, compared with the negative control (Huang et al., 2012).
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III. References |
1. Huang et al., 2012: Huang D, Zhu H, Lin H, Xu J, Lu C. First insights into the protective effects of a recombinant swinepox virus expressing truncated MRP of Streptococcus suis type 2 in mice. Berliner und Munchener tierarztliche Wochenschrift. 2012; 125(3-4); 144-152. [PubMed: 22515033].
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