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Crimean-Congo Haemorrhagic Fever (CCHF)

Table of Contents
  1. General Information
    1. NCBI Taxonomy ID
    2. Introduction
  2. Vaccine Information
    1. rMVA-CCHF
  3. References
I. General Information
1. NCBI Taxonomy ID:
11593
2. Introduction
Crimean-Congo Haemorrhagic Fever (CCHF) is a severe tick-borne disease, endemic in many countries in Africa, the Middle East, Eastern Europe and Asia. Between 15-70% of reported cases are fatal. There is no approved vaccine available (Buttigieg et al., 2014).
II. Vaccine Information
1. rMVA-CCHF
a. Vaccine Ontology ID:
VO_0004665
b. Type:
Recombinant vector vaccine
c. Status:
Research
d. Host Species for Licensed Use:
Baboon
e. Preparation
Modified Vaccinia virus Ankara was used to develop a recombinant candidate vaccine expressing the CCHF virus glycoproteins (Buttigieg et al., 2014).
f. Immunization Route
Intramuscular injection (i.m.)
g. Mouse Response
  • Vaccine Immune Response Type: VO_0003057
  • Efficacy: This vaccine protected all recipient animals from lethal disease in a challenge model adapted to represent infection via a tick bite (Buttigieg et al., 2014).
III. References
1. Buttigieg et al., 2014: Buttigieg KR, Dowall SD, Findlay-Wilson S, Miloszewska A, Rayner E, Hewson R, Carroll MW. A novel vaccine against Crimean-Congo Haemorrhagic Fever protects 100% of animals against lethal challenge in a mouse model. PloS one. 2014; 9(3); e91516. [PubMed: 24621656].