VIOLIN: Vaccine Investigation and Online Information Network

Newcastle disease virus

Table of Contents

General Information
Vaccine Related Pathogen Genes
1. F (Protective antigen)
2. F fusion protein (Protective antigen)
3. HN hemagglutinin-neuraminidase (Protective antigen)
Vaccine Information
References

I. General Information

1. NCBI Taxonomy ID:

11176

2. Disease:

Newcastle disease

3. Introduction

Newcastle disease virus (NDV) is a negative-sense single-stranded RNA virus. Transmission occurs by exposure to faecal and other excretions from infected birds, and through contact with contaminated feed, water, equipment and clothing. NDV strains can be categorised as velogenic (highly virulent), mesogenic (intermediate virulence) or lentogenic (nonvirulent). Velogenic strains produce severe nervous and respiratory signs, spread rapidly and cause up to 90% mortality. Mesogenic strains cause coughing, affect egg quality and production and result in up to 10% mortality. Lentogenic strains produce mild signs with negligible mortality. In 1999, promising results were reported using an attenuated strain of the Newcastle virus codenamed MTH-68 in cancer patients. Newcastle disease is a contagious bird disease affecting many domestic and wild avian species. Its effects are most notable in domestic poultry due to their high susceptibility and the potential for severe impacts of an epidemic on the poultry industries. It is endemic to many countries (Wiki: Newcastle disease).

4. Host Ranges and Animal Models

Domestic and wild birds are affected by Newcastle virus, Amazon parrots are can be asymptomatic carriers of the disease (Wiki: Newcastle disease).

II. Vaccine Related Pathogen Genes

1. F

Gene Name : F
Sequence Strain (Species/Organism) : Newcastle disease virus strain D26/76
NCBI Protein GI : 549308
Other Database IDs : CDD:278924
Taxonomy ID : 11180
Gene Strand (Orientation) : ?
Protein Name : Fusion glycoprotein F0
Protein pI : 7.35
Protein Weight : 58481.16
Protein Length : 735
Protein Note : {ECO:0000255}.

Protein Sequence : Show Sequence

>sp|P35936.1|FUS_NDVD RecName: Full=Fusion glycoprotein F0; Contains: RecName: Full=Fusion glycoprotein F2; Contains: RecName: Full=Fusion glycoprotein F1; Flags: Precursor
MGSRSSTRIPVPLMLTVRIMLALSCVCPTSSLDGRPLAAAGIVVTGDKAVNIYTSSQTGSIIIKLLPNMP
KDKEACAKAPLEAYNRTLTTLLTPLGDSIRRIQESVTTSGGGKQGRLIGAIIGGVALGVATAAQITAASA
LIQANQNAANILRLKESIAATNEAVHEVTDGLSQLAVAVGKMQQFVNDQFNKTAQELDCIKITQQVGVEL
NLYLTELTTVFGPQITSPALTQLTIQALYNLAGGNMDYLLTKLGVGNNQLSSLIGSGLITGNPILYDSQT
QLLGIQVTLPSVGNLNNMRATYLETLSVSTTKGFASALVPKVVTQVGSVIEELDTSYCIETDLDLYCTRI
VTFPMSPGIYSCLSGNTSACMYSKTEGALTTPYMTLKGSVIANCKMTTCRCADPPGIISQNYGEAVSLID
RQSCNILSLDGITLRLSGEFDATYQKNISIQDSQVIVTGNLDISTELGNVNNSISNALDKLEESNSKLDK
VNVKLTSTSALITYIFLTVISLVCGILSLVLACYLMYKQKAQQKTLLWLGNNTLDQMRATTKM

Molecule Role : Protective antigen

2. F fusion protein

Gene Name : F fusion protein
Sequence Strain (Species/Organism) : Newcastle disease virus B1
VO ID : VO_0011208
NCBI Gene ID : 912271
NCBI Protein GI : 11545723
Locus Tag : NDVgp4
Genbank Accession : AF309418
Protein Accession : NP_071469
3D structure: PDB ID : 3MAW
Taxonomy ID : 139270
Gene Starting Position : 4497
Gene Ending Position : 6278
Gene Strand (Orientation) : +
Protein Name : fusion protein
Protein pI : 8.34
Protein Weight : 55332.07
Protein Length : 553

DNA Sequence : Show Sequence

>NC_002617.1:4497-6278 Newcastle disease virus B1, complete genome
CACGGGTAGAAGACTCTGGATCCCGGTTGGCGCCCTCCAGGTGCAGGATGGGCTCCAGACCTTTTACCAA
GAACCCAGCACCTATGATGCTGACTATCCGGGTCGCGCTGGTATTGAGTTGCATCTGTCCGGCAAACTCC
ATTGATGGCAGGCCTTTTGCAGCTGCAGGAATTGTGGTTACAGGAGACAAAGCAGTCAACATATACACCT
CATCCCAGACAGGATCAATCATAGTTAAGCTCCTCCCGAATCTGCCCAAGGATAAGGAGGCATGTGCGAA
AGCCCCCTTGGATGCATACAACAGGACATTGACCACTTTGCTCACCCCCCTTGGTGACTCTATCCGTAGG
ATACAAGAGTCTGTGACTACATCTGGAGGGGGGAGACAGGGGCGCCTTATAGGCGCCATTATTGGCGGTG
TGGCTCTTGGGGTTGCAACTGCCGCACAAATAACAGCGGCCGCAGCTCTGATACAAGCCAAACAAAATGC
TGCCAACATCCTCCGACTTAAAGAGAGCATTGCCGCAACCAATGAGGCTGTGCATGAGGTCACTGACGGA
TTATCCCAACTAGCAGTGGCAGTTGGGAAGATGCAGCAGTTTGTTAATGACCAATTTAATAAAACAGCTC
AGGAATTAGACTGCATAAAAATTGCACAGCAAGTTGGTGTAGAGCTCAACCTGTACCTAACCGAATTGAC
TACAGTATTCGGACCACAAATCACTTCACCTGCCTTAAACAAGCTGACTATTCAGGCACTTTACAATCTA
GCTGGTGGGAATATGGATTACTTATTGACTAAGTTAGGTATAGGGAACAATCAACTCAGCTCATTAATCG
GTAGCGGCTTAATCACCGGTAACCCTATTCTATACGACTCACAGACTCAACTCTTGGGTATACAGGTAAC
TCTACCTTCAGTCGGGAACCTAAATAATATGCGTGCCACCTACTTGGAAACCTTATCCGTAAGCACAACC
AGGGGATTTGCCTCGGCACTTGTCCCAAAAGTGGTGACACAGGTCGGTTCTGTGATAGAAGAACTTGACA
CCTCATACTGTATAGAAACTGACTTAGATTTATATTGTACAAGAATAGTAACGTTCCCTATGTCCCCTGG
TATTTACTCCTGCTTGAGCGGCAATACATCGGCCTGTATGTACTCAAAGACCGAAGGCGCACTTACTACA
CCATATATGACTATCAAAGGCTCAGTCATCGCTAACTGCAAGATGACAACATGTAGATGTGTAAACCCCC
CGGGTATCATATCGCAAAACTATGGAGAAGCCGTGTCTCTAATAGATAAACAATCATGCAATGTTTTATC
CTTAGGCGGGATAACTTTAAGGCTCAGTGGGGAATTCGATGTAACTTATCAGAAGAATATCTCAATACAA
GATTCTCAAGTAATAATAACAGGCAATCTTGATATCTCAACTGAGCTTGGGAATGTCAACAACTCGATCA
GTAATGCTTTGAATAAGTTAGAGGAAAGCAACAGAAAACTAGACAAAGTCAATGTCAAACTGACCAGCAC
ATCTGCTCTCATTACCTATATCGTTTTGACTATCATATCTCTTGTTTTTGGTATACTTAGCCTGATTCTA
GCATGCTACCTAATGTACAAGCAAAAGGCGCAACAAAAGACCTTATTATGGCTTGGGAATAATACCCTAG
ATCAGATGAGAGCCACTACAAAAATGTGAACACAGATGAGGAACGAAGGTTTCCCTAATAGTAATTTGTG
TGAAAGTTCTGGTAGTCTGTCAGTTCGGAGAG

Protein Sequence : Show Sequence

>NP_071469.1 fusion protein [Newcastle disease virus B1]
MGSRPFTKNPAPMMLTIRVALVLSCICPANSIDGRPFAAAGIVVTGDKAVNIYTSSQTGSIIVKLLPNLP
KDKEACAKAPLDAYNRTLTTLLTPLGDSIRRIQESVTTSGGGRQGRLIGAIIGGVALGVATAAQITAAAA
LIQAKQNAANILRLKESIAATNEAVHEVTDGLSQLAVAVGKMQQFVNDQFNKTAQELDCIKIAQQVGVEL
NLYLTELTTVFGPQITSPALNKLTIQALYNLAGGNMDYLLTKLGIGNNQLSSLIGSGLITGNPILYDSQT
QLLGIQVTLPSVGNLNNMRATYLETLSVSTTRGFASALVPKVVTQVGSVIEELDTSYCIETDLDLYCTRI
VTFPMSPGIYSCLSGNTSACMYSKTEGALTTPYMTIKGSVIANCKMTTCRCVNPPGIISQNYGEAVSLID
KQSCNVLSLGGITLRLSGEFDVTYQKNISIQDSQVIITGNLDISTELGNVNNSISNALNKLEESNRKLDK
VNVKLTSTSALITYIVLTIISLVFGILSLILACYLMYKQKAQQKTLLWLGNNTLDQMRATTKM

Molecule Role : Protective antigen
Molecule Role Annotation : A recombinant fowlpox virus expressing the fusion protein of Newcastle disease virus strain F48E8 protected chickens against virulent NDV challenge. The protective rate was 96.7% (Wu et al., 2000).
Related Vaccine(s): HVT-ND , Newcastle disease virus DNA vaccine pCAGF encoding the F protein , rAPMV3-F (newcastle disease)

3. HN hemagglutinin-neuraminidase

Gene Name : HN hemagglutinin-neuraminidase
Sequence Strain (Species/Organism) : Newcastle disease virus B1
VO ID : VO_0011209
NCBI Gene ID : 912270
NCBI Protein GI : 11545724
Locus Tag : NDVgp5
Genbank Accession : AF309418
Protein Accession : NP_071470
3D structure: PDB ID : 1USR
Taxonomy ID : 139270
Gene Starting Position : 6320
Gene Ending Position : 8311
Gene Strand (Orientation) : +
Protein Name : hemagglutinin-neuraminidase
Protein pI : 7.24
Protein Weight : 59257.8
Protein Length : 577

DNA Sequence : Show Sequence

>NC_002617.1:6320-8311 Newcastle disease virus B1, complete genome
TACGGGTAGAACGGTAAGAGAGGCCGCCCCTCAATTGCGAGCCAGACTTCACAACCTCCGTTCTACCGCT
TCACCGACAACAGTCCTCAATCATGGACCGCGCCGTTAGCCAAGTTGCGTTAGAGAATGATGAAAGAGAG
GCAAAAAATACATGGCGCTTGATATTCCGGATTGCAATCTTATTCTTAACAGTAGTGACCTTGGCTATAT
CTGTAGCCTCCCTTTTATATAGCATGGGGGCTAGCACACCTAGCGATCTTGTAGGCATACCGACTAGGAT
TTCCAGGGCAGAAGAAAAGATTACATCTACACTTGGTTCCAATCAAGATGTAGTAGATAGGATATATAAG
CAAGTGGCCCTTGAGTCTCCATTGGCATTGTTAAATACTGAGACCACAATTATGAACGCAATAACATCTC
TCTCTTATCAGATTAATGGAGCTGCAAACAACAGCGGGTGGGGGGCACCTATTCATGACCCAGATTATAT
AGGGGGGATAGGCAAAGAACTCATTGTAGATGATGCTAGTGATGTCACATCATTCTATCCCTCTGCATTT
CAAGAACATCTGAATTTTATCCCGGCGCCTACTACAGGATCAGGTTGCACTCGAATACCCTCATTTGACA
TGAGTGCTACCCATTACTGCTACACCCATAATGTAATATTGTCTGGATGCAGAGATCACTCACACTCATA
TCAGTATTTAGCACTTGGTGTGCTCCGGACATCTGCAACAGGGAGGGTATTCTTTTCTACTCTGCGTTCC
ATCAACCTGGACGACACCCAAAATCGGAAGTCTTGCAGTGTGAGTGCAACTCCCCTGGGTTGTGATATGC
TGTGCTCGAAAGCCACGGAGACAGAGGAAGAAGATTATAACTCAGCTGTCCCTACGCGGATGGTACATGG
GAGGTTAGGGTTCGACGGCCAATATCACGAAAAGGACCTAGATGTCACAACATTATTCGGGGACTGGGTG
GCCAACTACCCAGGAGTAGGGGGTGGATCTTTTATTGACAGCCGCGTATGGTTCTCAGTCTACGGAGGGT
TAAAACCCAATTCACCCAGTGACACTGTACAGGAAGGGAAATATGTGATATACAAGCGATACAATGACAC
ATGCCCAGATGAGCAAGACTACCAGATTCGAATGGCCAAGTCTTCGTATAAGCCTGGACGGTTTGGTGGG
AAACGCATACAGCAGGCTATCTTATCTATCAAAGTGTCAACATCCTTAGGCGAAGACCCGGTACTGACTG
TACCGCCCAACACAGTCACACTCATGGGGGCCGAAGGCAGAATTCTCACAGTAGGGACATCCCATTTCTT
GTATCAGCGAGGGTCATCATACTTCTCTCCCGCGTTATTATATCCTATGACAGTCAGCAACAAAACAGCC
ACTCTTCATAGTCCTTATACATTCAATGCCTTCACTCGGCCAGGTAGTATCCCTTGCCAGGCTTCAGCAA
GATGCCCCAACTCGTGTGTTACTGGAGTCTATACAGATCCATATCCCCTAATCTTCTATAGAAACCACAC
CTTGCGAGGGGTATTCGGGACAATGCTTGATGGTGAACAAGCAAGACTTAACCCTGCGTCTGCAGTATTC
GATAGCACATCCCGCAGTCGCATAACTCGAGTGAGTTCAAGCAGCATCAAAGCAGCATACACAACATCAA
CTTGTTTTAAAGTGGTCAAGACCAATAAGACCTATTGTCTCAGCATTGCTGAAATATCTAATACTCTCTT
CGGAGAATTCAGAATCGTCCCGTTACTAGTTGAGATCCTCAAAGATGACGGGGTTAGAGAAGCCAGGTCT
GGCTAGTTGAGTCAACTATGAAAGAGTTGGAAAGATGGCATTGTATCACCTATCTTCTGCGACATCAAGA
ATCAAACCGAATGCCGGCGCGTGCTCGAATTCCATGTCGCCAGTTGACCACAATCAGCCAGTGCTCATGC
GATCAGATTAAGCCTTGTCAATAGTCTCTTGA

Protein Sequence : Show Sequence

>NP_071470.1 hemagglutinin-neuraminidase [Newcastle disease virus B1]
MDRAVSQVALENDEREAKNTWRLIFRIAILFLTVVTLAISVASLLYSMGASTPSDLVGIPTRISRAEEKI
TSTLGSNQDVVDRIYKQVALESPLALLNTETTIMNAITSLSYQINGAANNSGWGAPIHDPDYIGGIGKEL
IVDDASDVTSFYPSAFQEHLNFIPAPTTGSGCTRIPSFDMSATHYCYTHNVILSGCRDHSHSYQYLALGV
LRTSATGRVFFSTLRSINLDDTQNRKSCSVSATPLGCDMLCSKATETEEEDYNSAVPTRMVHGRLGFDGQ
YHEKDLDVTTLFGDWVANYPGVGGGSFIDSRVWFSVYGGLKPNSPSDTVQEGKYVIYKRYNDTCPDEQDY
QIRMAKSSYKPGRFGGKRIQQAILSIKVSTSLGEDPVLTVPPNTVTLMGAEGRILTVGTSHFLYQRGSSY
FSPALLYPMTVSNKTATLHSPYTFNAFTRPGSIPCQASARCPNSCVTGVYTDPYPLIFYRNHTLRGVFGT
MLDGEQARLNPASAVFDSTSRSRITRVSSSSIKAAYTTSTCFKVVKTNKTYCLSIAEISNTLFGEFRIVP
LLVEILKDDGVREARSG

Molecule Role : Protective antigen
Molecule Role Annotation : Recombinant baculoviruses containing the fusion (F) and hemagglutinin-neuraminidase (HN) glycoprotein gene of the viscerotropic velogenic (vv) Newcastle disease virus (NDV) isolate, Kr-005/00, and a lentogenic La Sota strain of the NDV were constructed. A single dose of rNDHN(V) had a protective effect against mortality (p <0.01) in chickens (Lee et al., 2008).
Related Vaccine(s): Newcastle Disease Virus HN Glycoprotein Subunit Vaccine , rAPMV3-F (newcastle disease)

III. Vaccine Information

1. Bursal Disease-Newcastle Disease Killed Virus Vaccine (USDA: 12G5.10)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002065

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

2. Bursal Disease-Newcastle Disease Killed Virus Vaccine (USDA: 12G5.11)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002066

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

3. Bursal Disease-Newcastle Disease Killed Virus Vaccine (USDA: 12G5.43)

a. Manufacturer:

Lohmann Animal Health International, Biomune Company

b. Vaccine Ontology ID:

VO_0002068

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

4. Bursal Disease-Newcastle Disease Standard & Variant, Killed Virus Vaccine (USDA: 12G5.42)

a. Manufacturer:

Intervet Inc., Biomune Company

b. Vaccine Ontology ID:

VO_0002067

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

5. Bursal Disease-Newcastle Disease-Bronchitis B1 Type, B1 Strain, Mass & Ark Types, Live Virus Vaccine (USDA: 12H1.4M)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002069

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

6. Bursal Disease-Newcastle Disease-Bronchitis B1 Type, B1 Strain, Mass & Ark Types, Live Virus Vaccine (USDA: 12H1.67)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002070

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

7. Bursal Disease-Newcastle Disease-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 12J5.40)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002071

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

8. Bursal Disease-Newcastle Disease-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 12J5.43)

a. Manufacturer:

Lohmann Animal Health International

b. Vaccine Ontology ID:

VO_0002072

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

9. Bursal Disease-Newcastle Disease-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 12J5.62)

a. Manufacturer:

Biomune Company

b. Vaccine Ontology ID:

VO_0002074

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

10. Bursal Disease-Newcastle Disease-Bronchitis Standard & Variant, Mass & Ark Types, Killed Virus Vaccine (USDA: 12D5.45)

a. Manufacturer:

Lohmann Animal Health International, Merial, Inc.

b. Vaccine Ontology ID:

VO_0002060

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

11. Bursal Disease-Newcastle Disease-Bronchitis Standard & Variant, Mass Type, Killed Virus Vaccine (USDA: 12J5.61)

a. Manufacturer:

Intervet Inc., Biomune Company

b. Vaccine Ontology ID:

VO_0002073

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

12. Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Standard & Variant, Mass Type, Killed Virus Vaccine (USDA: 12M5.00)

a. Manufacturer:

Lohmann Animal Health International, Biomune Company

b. Vaccine Ontology ID:

VO_0002075

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

13. Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Standard & Variant, Mass Type, Killed Virus Vaccine (USDA: 12M5.01)

a. Manufacturer:

Intervet Inc., Lohmann Animal Health International, Biomune Company

b. Vaccine Ontology ID:

VO_0002076

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

14. Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Killed Virus Vaccine (USDA: 12M5.40)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002078

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

15. Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Mass Type, Killed Virus Vaccine (USDA: 12M5.11)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002077

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

16. Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Mass Type, Killed Virus Vaccine (USDA: 12M5.43)

a. Manufacturer:

Lohmann Animal Health International

b. Vaccine Ontology ID:

VO_0002081

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

17. Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Mass Type, Killed Virus Vaccine (USDA: 12M5.50)

a. Manufacturer:

Biomune Company

b. Vaccine Ontology ID:

VO_0002082

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

18. Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Mass Type, Killed Virus Vaccine (USDA: 12M5.90)

a. Manufacturer:

Wyeth, Lohmann Animal Health International

b. Vaccine Ontology ID:

VO_0002083

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

19. Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Mass Type, Killed Virus Vaccine (USDA: 12M5.91)

a. Manufacturer:

Wyeth, Lohmann Animal Health International

b. Vaccine Ontology ID:

VO_0002084

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

20. Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Standard & Variant, Mass & Ark Types, Killed Virus Vaccine (USDA: 12M5.41)

a. Manufacturer:

Lohmann Animal Health International, Merial, Inc.

b. Vaccine Ontology ID:

VO_0002079

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

21. Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Standard & Variant, Mass & Ark Types, Killed Virus Vaccine (USDA: 12M5.42)

a. Manufacturer:

Lohmann Animal Health International

b. Vaccine Ontology ID:

VO_0002080

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

22. Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Standard & Variant, Mass Type, Killed Virus Vaccine (USDA: 12M5.E0)

a. Manufacturer:

Biomune Company

b. Vaccine Ontology ID:

VO_0002085

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

23. Bursal Disease-Newcastle Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12P5.40)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002086

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

24. Bursal Disease-Newcastle Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12P5.41)

a. Manufacturer:

Intervet Inc., Biomune Company

b. Vaccine Ontology ID:

VO_0002087

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

25. Bursal Disease-Newcastle Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12P5.E0)

a. Manufacturer:

Biomune Company

b. Vaccine Ontology ID:

VO_0002088

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

26. HVT-ND

a. Vaccine Ontology ID:

VO_0004632

b. Type:

Recombinant vector vaccine

c. Status:

Research

d. Host Species for Licensed Use:

Baboon

e. Gene Engineering of F fusion protein

Type: Recombinant vector construction
Description: A turkey herpesvirus vector Newcastle disease vaccine (HVT/ND) expressing the fusion gene of Newcastle disease virus (NDV) (Esaki et al., 2013).
Detailed Gene Information: Click here.

f. Vector:

(Esaki et al., 2013)

g. Preparation

A turkey herpesvirus vector Newcastle disease vaccine (HVT/ND) expressing the fusion gene of Newcastle disease virus (NDV) (Esaki et al., 2013).

h. Immunization Route

Intramuscular injection (i.m.)

i. Chicken Response

Vaccination Protocol: Chickens were vaccinated by the in ovo route to 18-day-old embryos or by the subcutaneous route to 1-day-old chicks (Esaki et al., 2013).
Vaccine Immune Response Type: VO_0003057
Challenge Protocol: Challenge was conducted using a low-virulence NDV strain (genotype II; pathotype lentogenic) via the respiratory tract each week between 1 and 5 weeks of age, in order to mimic the situation in areas where virulent NDV strains do not normally exist and low-virulence strains cause mild respiratory symptoms leading to economic losses (Esaki et al., 2013).
Efficacy: Partial protection was observed at 3 weeks of age, when 6 out of 10 (60%) chickens were protected. Full protection was obtained at 4 and 5 weeks of age, when 9 out of 10 (90%) and 10 out of 10 (100%) chickens were protected, respectively. Finally, protection against challenge with virulent Texas GB strain at 19 weeks of age was evaluated in commercial female layer chickens vaccinated at 1 day of age with HVT/ND. All of the vaccinated chickens were protected, while all of the challenge controls succumbed to the challenge (Esaki et al., 2013).

27. Marek's Disease-Newcastle Disease Serotype 3, Live Marek's Disease Vector Vaccine (USDA: 16N1.R0)

a. Manufacturer:

Intervet Inc., Biomune Company

b. Vaccine Ontology ID:

VO_0002143

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

28. Marek's Disease-Newcastle Disease Serotypes 1 & 2 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 16N1.R2)

a. Manufacturer:

Biomune Company

b. Vaccine Ontology ID:

VO_0002145

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

29. Marek's Disease-Newcastle Disease Serotypes 1 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 16N1.R1)

a. Manufacturer:

Biomune Company

b. Vaccine Ontology ID:

VO_0002144

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

30. Marek's Disease-Newcastle Disease Serotypes 2 & 3, Live Virus & Live Marek's Disease Vector Vaccine (USDA: 17H1.R1)

a. Manufacturer:

Biomune Company

b. Vaccine Ontology ID:

VO_0002182

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

31. Marek's Disease-Newcastle Disease Serotypes 2 & 3, Live Virus & Live Marek's Disease Vector Vaccine (USDA: 17H1.R2)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002183

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

32. Newcastle Disease B1 Type, B1 Strain, Live Virus Vaccine (USDA: 1711.10)

a. Manufacturer:

Wyeth, Lohmann Animal Health International, Merial, Inc.

b. Vaccine Ontology ID:

VO_0001704

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

33. Newcastle Disease B1 Type, B1 Strain, Live Virus Vaccine (USDA: 1711.12)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0001705

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

34. Newcastle Disease B1 Type, B1 Strain, Live Virus Vaccine (USDA: 1711.14)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0001706

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

35. Newcastle Disease B1 Type, B1 Strain, Live Virus Vaccine (USDA: 1711.18)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0001707

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

36. Newcastle Disease B1 Type, B1 Strain, Live Virus Vaccine (USDA: 17A2.10)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0001708

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

37. Newcastle Disease B1 Type, C2 Strain, Live VirusVaccine (USDA: 17B1.10)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0001709

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

38. Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.0A)

a. Manufacturer:

Lohmann Animal Health International

b. Vaccine Ontology ID:

VO_0001710

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

39. Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.10)

a. Manufacturer:

Wyeth, Lohmann Animal Health International, Biomune Company

b. Vaccine Ontology ID:

VO_0001711

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

40. Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.11)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0001712

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

41. Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.15)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0001713

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

42. Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.16)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0001714

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

43. Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.17)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0001715

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

44. Newcastle Disease Killed Virus Vaccine (USDA: 1705.10)

a. Manufacturer:

Wyeth, Intervet Inc., Biomune Company

b. Vaccine Ontology ID:

VO_0001716

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

45. Newcastle Disease Killed Virus Vaccine (USDA: 1705.11)

a. Manufacturer:

Wyeth, Lohmann Animal Health International

b. Vaccine Ontology ID:

VO_0001717

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

46. Newcastle Disease Killed Virus Vaccine (USDA: 1705.13)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0001718

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

47. Newcastle Disease Killed Virus Vaccine (USDA: 1705.15)

a. Manufacturer:

Lohmann Animal Health International

b. Vaccine Ontology ID:

VO_0001719

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

48. Newcastle Disease VG/GA Strain, Live Virus Vaccine (USDA: 1701.10)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0001720

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

49. Newcastle Disease VG/GA Strain, Live Virus Vaccine (USDA: 17A2.V1)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0001721

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

50. Newcastle disease virus DNA vaccine pCAGF encoding the F protein

a. Vaccine Ontology ID:

VO_0004324

b. Type:

DNA vaccine

c. Status:

Research

d. Host Species as Laboratory Animal Model:

Chicken

e. Gene Engineering of F fusion protein

Type: DNA vaccine construction
Description: Vector Pcaggs expressed the Newcastle disease virus Fprotein (NDV-F) (Sakaguchi et al., 1996).
Detailed Gene Information: Click here.

f. Vector:

Pcaggs (Sakaguchi et al., 1996)

g. Immunization Route

Intramuscular injection (i.m.)

h. Chicken Response

Vaccine Immune Response Type: VO_0000286
Efficacy: At 9 weeks post-injection, chickens were challenged with the velogenic NDV Sato strain. The chickens that had the antibody against NDV-F from immunization were protected from lethal NDV challenge. The DNA vaccine conferred efficient protection against the disease (Sakaguchi et al., 1996).

51. Newcastle Disease Virus HN Glycoprotein Subunit Vaccine

a. Vaccine Ontology ID:

VO_0011552

b. Type:

Subunit vaccine

c. Status:

Research

d. Antigen

Hemagglutinin-neuraminidase (HN) glycoprotein (Lee et al., 2008).

e. Gene Engineering of HN hemagglutinin-neuraminidase

Type: Recombinant protein preparation
Description:
Detailed Gene Information: Click here.

f. Adjuvant:

VO ID: VO_0001269

g. Vector:

Baculovirus (Lee et al., 2008).

h. Immunization Route

Intramuscular injection (i.m.)

i. Chicken Response

Vaccination Protocol: For vaccination, chickens were inoculated intramuscularly with the Seppic-adjuvanted antigen (Lee et al., 2008).
Challenge Protocol: Each group of vaccinated and unvaccinated chickens was challenged with the vvNDV Kr-005/00 strain through an intraocular inoculation with an 10^5.5 EID50 per bird. vvNDV Kr-005/00 was the representative strain of genotype VII, which is the dominant epizootic genotype in Korea. The chickens were kept under observation for 14 days after infection (Lee et al., 2008).
Efficacy: A single dose of rNDHN(V) had a protective effect against mortality (p <0.01) in chickens (Lee et al., 2008).

52. Newcastle disease virus vaccine by Dow AgroSciences

a. Manufacturer:

Dow AgroSciences

b. Vaccine Ontology ID:

VO_0011474

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Host Species for Licensed Use:

Pig

f. Immunization Route

Intramuscular injection (i.m.)

g. Description

HN recombinant produced in plant cell lines (registered but not on market)(Meeusen et al., 2007)

53. Newcastle Disease-Bronchitis Mass & Ark Types, Killed Virus Vaccine-Salmonella Enteritidis Bacterin (USDA: 48D7.10)

a. Manufacturer:

Lohmann Animal Health International

b. Vaccine Ontology ID:

VO_0002282

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

54. Newcastle Disease-Bronchitis Mass & Ark Types, Killed Virus Vaccine-Salmonella Enteritidis Bacterin (USDA: 48D7.11)

a. Manufacturer:

Lohmann Animal Health International

b. Vaccine Ontology ID:

VO_0002283

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

55. Newcastle Disease-Fowl Pox Live Fowl Pox Vector Vaccine (USDA: 17C1.R0)

a. Manufacturer:

Merial, Inc., Biomune Company

b. Vaccine Ontology ID:

VO_0002181

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

56. Newcastle-Bronchitis B1 Type, B1 Strain, Conn Type, Live Virus Vaccine (USDA: 1761.13)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002150

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

57. Newcastle-Bronchitis B1 Type, B1 Strain, Conn Type, Live Virus Vaccine (USDA: 1761.1A)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002156

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

58. Newcastle-Bronchitis B1 Type, B1 Strain, Conn Type, Live Virus Vaccine (USDA: 1762.13)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002158

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

59. Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Ark Types, Live Virus Vaccine (USDA: 1791.1X)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002176

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

60. Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Ark Types, Live Virus Vaccine (USDA: 17A1.1M)

a. Manufacturer:

Wyeth, Merial, Inc.

b. Vaccine Ontology ID:

VO_0002177

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

61. Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Ark Types, Live Virus Vaccine (USDA: 17A1.1N)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002178

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

62. Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Ark Types, Live Virus Vaccine (USDA: 17A2.1M)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002179

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

63. Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1761.14)

a. Manufacturer:

Wyeth, Intervet Inc., Merial, Inc.

b. Vaccine Ontology ID:

VO_0002151

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

64. Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1761.15)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002152

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

65. Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1761.17)

a. Manufacturer:

Lohmann Animal Health International

b. Vaccine Ontology ID:

VO_0002153

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

66. Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1762.1H)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002159

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

67. Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1791.14)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002173

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

68. Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1791.15)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002174

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

69. Newcastle-Bronchitis B1 Type, B1 Strain, Mass Type, Live Virus Vaccine (USDA: 1761.11)

a. Manufacturer:

Wyeth, Merial, Inc.

b. Vaccine Ontology ID:

VO_0002148

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

70. Newcastle-Bronchitis B1 Type, B1 Strain, Mass Type, Live Virus Vaccine (USDA: 1761.12)

a. Manufacturer:

Intervet Inc., Lohmann Animal Health International, Merial, Inc.

b. Vaccine Ontology ID:

VO_0002149

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

71. Newcastle-Bronchitis B1 Type, B1 Strain, Mass Type, Live Virus Vaccine (USDA: 1761.18)

a. Manufacturer:

Wyeth, Intervet Inc.

b. Vaccine Ontology ID:

VO_0002154

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

72. Newcastle-Bronchitis B1 Type, B1 Strain, Mass Type, Live Virus Vaccine (USDA: 1761.19)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002155

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

73. Newcastle-Bronchitis B1 Type, B1 Strain, Mass Type, Live Virus Vaccine (USDA: 1762.11)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002157

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

74. Newcastle-Bronchitis B1 Type, B1 Strain, Mass Type, Live Virus Vaccine (USDA: 1791.19)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002175

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

75. Newcastle-Bronchitis B1 Type, B1 Strain, Mass Type, Live Virus Vaccine (USDA: 1791.1X)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0004207

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

76. Newcastle-Bronchitis B1 Type, C2 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1XC1.10)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002204

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

77. Newcastle-Bronchitis B1 Type, C2 Strain, Mass Type, Live Virus Vaccine (USDA: 1XB1.10)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002203

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

78. Newcastle-Bronchitis B1 Type, LaSota Strain, Mass & Conn Types Vaccine (USDA: 17B1.17)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002180

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

79. Newcastle-Bronchitis B1 Type, LaSota Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1771.14)

a. Manufacturer:

Intervet Inc., Merial, Inc.

b. Vaccine Ontology ID:

VO_0002162

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

80. Newcastle-Bronchitis B1 Type, LaSota Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1771.17)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002163

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

81. Newcastle-Bronchitis B1 Type, LaSota Strain, Mass Type, Live Virus Vaccine (USDA: 1771.11)

a. Manufacturer:

Wyeth, Lohmann Animal Health International, Merial, Inc.

b. Vaccine Ontology ID:

VO_0002160

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

82. Newcastle-Bronchitis B1 Type, LaSota Strain, Mass Type, Live Virus Vaccine (USDA: 1771.12)

a. Manufacturer:

Wyeth, Merial, Inc.

b. Vaccine Ontology ID:

VO_0002161

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

83. Newcastle-Bronchitis B1 Type, LaSota Strain, Mass Type, Live Virus Vaccine (USDA: 1771.18)

a. Manufacturer:

Intervet Inc., Lohmann Animal Health International

b. Vaccine Ontology ID:

VO_0002164

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

84. Newcastle-Bronchitis B1 Type, LaSota Strain, Mass Type, Live Virus Vaccine (USDA: 1771.19)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002165

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

85. Newcastle-Bronchitis B1 Type, LaSota Strain, Mass Type, Live Virus Vaccine (USDA: 1771.1A)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002166

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

86. Newcastle-Bronchitis Mass & Ark Types, Killed Virus Vaccine (USDA: 1785.10)

a. Manufacturer:

Lohmann Animal Health International

b. Vaccine Ontology ID:

VO_0002170

c. Status:

Licensed

d. Location Licensed:

USA

e. Host Species for Licensed Use:

Chicken

87. Newcastle-Bronchitis Mass & Ark Types, Killed Virus Vaccine (USDA: 1785.12)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002172

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

88. Newcastle-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 1775.10)

a. Manufacturer:

Wyeth, Biomune Company

b. Vaccine Ontology ID:

VO_0002167

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

89. Newcastle-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 1775.11)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002168

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

90. Newcastle-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 1776.10)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002169

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

91. Newcastle-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 1785.11)

a. Manufacturer:

Lohmann Animal Health International

b. Vaccine Ontology ID:

VO_0002171

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

92. Newcastle-Bronchitis Mass Type, Killed Virus Vaccine-Mycoplasma Gallisepticum Bacterin (USDA: 48B5.10)

a. Manufacturer:

Lohmann Animal Health International

b. Vaccine Ontology ID:

VO_0002275

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

93. Newcastle-Bronchitis Mass Type, Killed Virus Vaccine-Mycoplasma Gallisepticum Bacterin (USDA: 48B6.10)

a. Manufacturer:

Wyeth, Intervet Inc.

b. Vaccine Ontology ID:

VO_0002276

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

94. Newcastle-Bronchitis Mass Type, Killed Virus Vaccine-Salmonella Enteritidis Bacterin (USDA: 48D6.10)

a. Manufacturer:

Wyeth, Intervet Inc., Biomune Company

b. Vaccine Ontology ID:

VO_0002281

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

95. Newcastle-Bronchitis VG/GA Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 17V1.10)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002185

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

96. Newcastle-Bronchitis VG/GA Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 17V1.11)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002186

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

97. Newcastle-Paramyxovirus Type 3, Killed Virus Vaccine (USDA: 17P5.10)

a. Manufacturer:

Lohmann Animal Health International

b. Vaccine Ontology ID:

VO_0002184

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Chicken

98. rAPMV3-F (newcastle disease)

a. Vaccine Ontology ID:

VO_0004684

b. Type:

Recombinant vector vaccine

c. Status:

Research

d. Host Species for Licensed Use:

Baboon

e. Gene Engineering of F fusion protein

Type: Recombinant protein preparation
Description: Recombinant viruses, rAPMV3-F and rAPMV3-HN, were generated expressing the NDV fusion (F) and hemagglutinin-neuraminidase (HN) proteins (Kumar et al., 2011).
Detailed Gene Information: Click here.

f. Gene Engineering of HN hemagglutinin-neuraminidase

Type: Recombinant vector construction
Description: Recombinant viruses, rAPMV3-F and rAPMV3-HN, were generated expressing the NDV fusion (F) and hemagglutinin-neuraminidase (HN) proteins (Kumar et al., 2011).
Detailed Gene Information: Click here.

g. Preparation

Recombinant virus, rAPMV3-F generated expressinv the NDV fusion protein (Kumar et al., 2011).

h. Immunization Route

Intramuscular injection (i.m.)

i. Chicken Response

Vaccination Protocol: 2-week-old chickens were immunized by the oculonasal route in order to evaluate the contribution of each protein to the induction of NDV-specific neutralizing antibodies and protective immunity (Kumar et al., 2011).
Vaccine Immune Response Type: VO_0003057
Challenge Protocol: The immunized birds were challenged 21 days after vaccination with virulent NDV via the oculonasal, intramuscular, or intravenous route (Kumar et al., 2011).
Efficacy: With oculonasal or intramuscular challenge, all three recombinant viruses (rAPMV3, rAPMV3-F, and rAPMV3-HN) were protective, while all unvaccinated birds succumbed to death. However, with intravenous challenge, birds immunized with rAPMV3 were not protected, whereas birds immunized with rAPMV3-F alone or in combination with rAPMV3-HN were completely protected, and birds immunized with rAPMV3-HN alone were partially protected. These results indicate that the NDV F and HN proteins are independent neutralization and protective antigens, but the contribution by F is greater (Kumar et al., 2011).

99. rFPV-NDV-H/F

a. Vaccine Ontology ID:

VO_0004751

b. Type:

Recombinant vector vaccine

c. Status:

Research

d. Host Species for Licensed Use:

Baboon

e. Preparation

(Boursnell et al., 1990)

f. Immunization Route

Intramuscular injection (i.m.)

100. Vectormune FP-ND

a. Tradename:

Vectormune FP-ND

b. Manufacturer:

Biomune

c. Vaccine Ontology ID:

VO_0001016

d. Type:

Recombinant vector vaccine

e. Status:

Licensed

f. Host Species for Licensed Use:

Pig

g. Immunization Route

Intramuscular injection (i.m.)

h. Description

Fowlpox virus vectored

IV. References

1. Boursnell et al., 1990: Boursnell ME, Green PF, Samson AC, Campbell JI, Deuter A, Peters RW, Millar NS, Emmerson PT, Binns MM. A recombinant fowlpox virus expressing the hemagglutinin-neuraminidase gene of Newcastle disease virus (NDV) protects chickens against challenge by NDV. Virology. 1990; 178(1); 297-300. [PubMed: 2167557].

2. Esaki et al., 2013: Esaki M, Godoy A, Rosenberger JK, Rosenberger SC, Gardin Y, Yasuda A, Dorsey KM. Protection and antibody response caused by turkey herpesvirus vector Newcastle disease vaccine. Avian diseases. 2013; 57(4); 750-755. [PubMed: 24597117].

3. Kumar et al., 2011: Kumar S, Nayak B, Collins PL, Samal SK. Evaluation of the Newcastle disease virus F and HN proteins in protective immunity by using a recombinant avian paramyxovirus type 3 vector in chickens. Journal of virology. 2011; 85(13); 6521-6534. [PubMed: 21525340].

4. Lee et al., 2008: Lee YJ, Sung HW, Choi JG, Lee EK, Yoon H, Kim JH, Song CS. Protection of chickens from Newcastle disease with a recombinant baculovirus subunit vaccine expressing the fusion and hemagglutininneuraminidase proteins. Journal of veterinary science. 2008; 9(3); 301-308. [PubMed: 18716451].

5. Meeusen et al., 2007: Meeusen EN, Walker J, Peters A, Pastoret PP, Jungersen G. Current status of veterinary vaccines. Clinical microbiology reviews. 2007; 20(3); 489-510. [PubMed: 17630337].

6. Sakaguchi et al., 1996: Sakaguchi M, Nakamura H, Sonoda K, Hamada F, Hirai K. Protection of chickens from Newcastle disease by vaccination with a linear plasmid DNA expressing the F protein of Newcastle disease virus. Vaccine. 1996; 14(8); 747-752. [PubMed: 8817820].

7. Wiki: Newcastle disease: Newcastle disease [http://en.wikipedia.org/wiki/Newcastle_disease_virus]

8. Wu et al., 2000: Wu YT, Peng DX, Liu XF, Liu WZ, Zhang RK. [A recombinant fowlpox virus expressing the fusion protein of Newcastle disease virus strain F48E8 and its protective efficacy]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2000; 16(5); 591-594. [PubMed: 11191764].