VIOLIN: Vaccine Investigation and Online Information Network

Canine coronavirus

Table of Contents

General Information
Vaccine Related Pathogen Genes
1. S (Protective antigen)
Vaccine Information
References

I. General Information

1. NCBI Taxonomy ID:

11153

2. Disease:

Intestinal disease

3. Introduction

Canine coronavirus is a virus of the family Coronaviridae that causes a highly contagious intestinal disease worldwide in dogs. It was discovered in 1971 in Germany during an outbreak in sentry dogs. The virus invades and replicates in the villi of the small intestine. Intestinal disease may be related to virus-induced apoptosis (programmed cell death) of cells of the epithelial mucosa of the small intestine. Canine coronavirus was originally thought to cause serious gastrointestinal disease, but now most cases are considered to be very mild or without symptoms. A more serious complication of canine coronavirus occurs when the dog is also infected with canine parvovirus. Coronavirus infection of the intestinal villi makes the cells more susceptible to parvovirus infection. This causes a much more severe disease than either virus can separately. However, fatal intestinal disease associated with canine coronavirus without the presence of canine parvovirus is still occasionally reported. This may be related to the high mutation rate of RNA positive stranded viruses, of which canine coronavirus is one.

The incubation period is only one to three days. The disease is highly contagious and is spread through the feces of infected dogs, who usually shed the virus for six to nine days, but sometimes for six months following infection. Symptoms include diarrhea, vomiting, and anorexia. Diagnosis is through detection of virus particles in the feces. Treatment usually only requires medication for diarrhea, but more severely affected dogs may require intravenous fluids for dehydration. Fatalities are rare (Wiki: Canine coronavirus).

II. Vaccine Related Pathogen Genes

1. S

Gene Name : S
Sequence Strain (Species/Organism) : Canine coronavirus
NCBI Protein GI : AGE32061
Taxonomy ID : 11153
Protein Name : spike glycoprotein
Protein pI : 4.39
Protein Weight : 13725.702
Protein Length : 189
Protein Note : pantropic;
biotype: CCoV-IIa; genotype: CCoV-II

Protein Sequence : Show Sequence

>AGE32061.1 spike glycoprotein, partial [Canine coronavirus]
IVLETCILLLCSYHTVXSTTNNDCRQVNVTQLPGNEYLIRDFLFQNFKEEGSEVVGGYYPTEVWYNCSRT
ATTTAYEYFNNIHAFYFDMEAMENSTGNARGKPLLFHVHGDPVSVIIYISAYRDD

Molecule Role : Protective antigen
Molecule Role Annotation : (Qiao et al., 2005)

III. Vaccine Information

1. Canine Coronavirus Killed Virus Vaccine (USDA: 14P5.20)

a. Manufacturer:

Wyeth, Intervet Inc., Pfizer, Inc., VacciCel, Inc.

b. Vaccine Ontology ID:

VO_0001743

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

2. Canine Coronavirus Killed Virus Vaccine (USDA: 14P5.21)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0001744

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

3. Canine Coronavirus Killed Virus Vaccine-Borrelia Burgdorferi Bacterin (USDA: 47A5.20)

a. Manufacturer:

Wyeth, Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0002239

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

4. Canine Coronavirus Killed Virus Vaccine-Borrelia Burgdorferi Bacterin-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 47E5.21)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002244

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

5. Canine Coronavirus Killed Virus Vaccine-Borrelia Burgdorferi Bacterin-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 47E5.20)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002243

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

6. Canine Coronavirus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46E5.21)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002222

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

7. Canine Coronavirus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46E5.24)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002224

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

8. Canine Coronavirus Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46E5.23)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002223

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

9. Canine Coronavirus Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46E5.25)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002225

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

10. Canine Coronavirus Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46E5.20)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002221

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

11. Canine Coronavirus Killed Virus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract (USDA: 46D5.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002220

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

12. Canine Coronavirus Modified Live Virus Vaccine (USDA: 14P1.20)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0001745

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

13. Canine Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14R7.20)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002122

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

14. Canine Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14R7.21)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002123

c. Type:

Live vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

15. Canine Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14R7.22)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002124

c. Type:

Live vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

16. Canine Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14R7.25)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002125

c. Type:

Live vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

17. Canine Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14R7.29)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002126

c. Type:

Live vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

18. Canine Coronavirus-Parvovirus Modified Live Virus Vaccine (USDA: 14R1.20)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002121

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

19. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 1599.20)

a. Manufacturer:

Intervet Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002136

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

20. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 1599.21)

a. Manufacturer:

Wyeth, Intervet Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002137

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

21. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 1599.25)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002138

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

22. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 1599.29)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002139

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

23. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Borrelia Burgdorferi Bacterin (USDA: 47C5.20)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002241

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

24. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Borrelia Burgdorferi Bacterin (USDA: 47C5.29)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002242

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

25. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Borrelia Burgdorferi Bacterin-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46B9.21)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002219

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

26. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46J9.25)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002231

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

27. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46J9.29)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002234

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

28. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterin (USDA: 47L9.20)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002246

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

29. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.21)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002230

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

30. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.26)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002232

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

31. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002233

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

32. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J7.20)

a. Manufacturer:

Intervet Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002226

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

33. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J7.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002227

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

34. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J9.20)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002229

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

35. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract (USDA: 46L9.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002236

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

36. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live Virus, Live Canarypox Vector Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J9.R1)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002235

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

37. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live Virus; Canarypox Vector Vaccine (USDA: 1591.R1)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002135

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

38. Canine Distemper-Adenovirus Type 2-Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract (USDA: 46P9.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002237

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

39. Canine Distemper-Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14D7.20)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002117

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

40. Canine Distemper-Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14D9.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002118

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

41. RECOMBITEK Corona MLV

a. Tradename:

RECOMBITEK Corona MLV

b. Manufacturer:

Merial

c. Vaccine Ontology ID:

VO_0000923

d. Type:

Live, attenuated vaccine

e. Status:

Licensed

f. Host Species for Licensed Use:

Dog

g. Immunization Route

Intramuscular injection (i.m.)

h. Description

Modified live virus(Pardo et al., 1999)

IV. References

1. Pardo et al., 1999: Pardo MC, M. Mackowiak. Efficacy of a new canine-origin, modified-live virus vaccine against canine coronavirus. Canine Practice. 1999; 24; 6-8.

2. Qiao et al., 2005: Qiao J, Xia XZ, Yang ST, Hu GX, Xie ZJ. [Construction of recombinant canine adenovirus type 2 expressing Canine coronavirus spike glycoprotein and its immunogenicity]. Wei sheng wu xue bao = Acta microbiologica Sinica. 2005; 45(4); 588-592. [PubMed: 16245877].

3. Wiki: Canine coronavirus: Canine coronavirus [http://en.wikipedia.org/wiki/Canine_coronavirus]