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Vaccine Detail

Pasteurella multocida aroA mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002862
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Cow
  • aroA gene engineering:
    • Type: Gene mutation
    • Description: This aroA mutant is from Pasteurella multocida (Dagleish et al., 2007).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Cattle Response

  • Persistence: An aroA mutant is highly attenuated in calves (Dagleish et al., 2007).
  • Efficacy: An aroA mutant induces significant protection in calves from challenge with wild type Pasteurella multocida (Dagleish et al., 2007).
  • Host IgG response
    • Description: After second vaccination, serum IgG titers rose. Groups receiving 109 and 108 CFU of the mutant had significantly higher titer of IgG than those receiving 107 CFU, and all vaccinated groups had significantly higher titers than the unvaccinated challenge control group of calves (Dagleish et al., 2007).
    • Detailed Gene Information: Click Here.
  • Host IgM response
    • Description: After the second vaccination, serum IgM titers rose. Groups receiving 109 and 108 CFU of the mutant had significantly higher titer of IgM than those receiving 107 CFU, and all vaccinated groups had significantly higher titers than the unvaccinated challenge control group of calves (Dagleish et al., 2007).
    • Detailed Gene Information: Click Here.
References
Dagleish et al., 2007: Dagleish MP, Hodgson JC, Ataei S, Finucane A, Finlayson J, Sales J, Parton R, Coote JG. Safety and protective efficacy of intramuscular vaccination with a live aroA derivative of Pasteurella multocida B:2 against experimental hemorrhagic septicemia in calves. Infection and immunity. 2007; 75(12); 5837-5844. [PubMed: 17875632].