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Vaccine Comparison

Bovine respiratory syncytial virus glycoprotein G mutant vaccine Bovine Respiratory Syncytial Virus recombinant vector vaccine BHVl/BRSVG encoding the G protein BRSV DNA vaccine VCL-Fb
Vaccine Information Vaccine Information Vaccine Information
  • Vaccine Ontology ID: VO_0002951
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Cow
  • glycoprotein G gene engineering:
    • Type: Gene mutation
    • Description: This glycoprotein G mutant is from Bovine respiratory syncytial virus (Schmidt et al., 2002).
    • Detailed Gene Information: Click Here.
  • Immunization Route: intranasal immunization
  • Vaccine Ontology ID: VO_0004289
  • Type: Recombinant vector vaccine
  • Status: Licensed
  • Host Species as Laboratory Animal Model: Calves
  • glycoprotein G gene engineering:
    • Type: Recombinant vector construction
    • Description: The gE gene was replaced by a gene encoding the G protein of BRSV in a BHVI vector (Schrijver et al., 1997).
    • Detailed Gene Information: Click Here.
  • Vector: BHVI (Schrijver et al., 1997)
  • Immunization Route: intranasal immunization
  • Vaccine Ontology ID: VO_0004574
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Calves
  • F gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • Vector: pVCL1012 (Taylor et al., 2005)
  • Immunization Route: Intramuscular injection (i.m.)
Host Response Host Response Host Response

Cattle Response

  • Persistence: A glycoprotein G mutant is attenuated in calves (Schmidt et al., 2002).
  • Efficacy: A glycoprotein G mutant induces significant protection in calves from challenge with wild type BRSV (Schmidt et al., 2002).

Cattle Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Flow cytometric analysis showed a significant relative increase of gamma/delta+ T cells in peripheral blood after BRSV challenge-infection of the calves of the control group but not in the vaccinated groups. These results indicate that the G protein of BRSV can induce significant protection against BRSV infection in cattle, and that the BHV1/BRSV-G vaccine protects effectively against a subsequent BRSV and BHV1 infection (Schrijver et al., 1997).

Cattle Response

  • Vaccine Immune Response Type: VO_0003057
  • Immune Response: Seven days after BRSV challenge, BRSV-specific serum IgA titres in calves vaccinated i.m. with VCL-Fb were significantly greater than those in calves vaccinated by the i.d. route (P < 0.05) (Taylor et al., 2005).
  • Efficacy: Vaccination with DNA encoding the BRSV F protein can induce a significant reduction in BRSV excretion in young calves. At slaughter, 7 days after challenge, BRSV was isolated from the lungs of three out of four calves vaccinated with control plasmid, two out of six calves vaccinated i.d. with VCL-Fb, but none of the calves vaccinated i.m. with VCL-Fb (Taylor et al., 2005).
References References References
Schmidt et al., 2002: Schmidt U, Beyer J, Polster U, Gershwin LJ, Buchholz UJ. Mucosal immunization with live recombinant bovine respiratory syncytial virus (BRSV) and recombinant BRSV lacking the envelope glycoprotein G protects against challenge with wild-type BRSV. Journal of virology. 2002; 76(23); 12355-12359. [PubMed: 12414977].
Schrijver et al., 1997: Schrijver RS, Langedijk JP, Keil GM, Middel WG, Maris-Veldhuis M, Van Oirschot JT, Rijsewijk FA. Immunization of cattle with a BHV1 vector vaccine or a DNA vaccine both coding for the G protein of BRSV. Vaccine. 1997; 15(17-18); 1908-1916. [PubMed: 9413101].
Taylor et al., 2005: Taylor G, Bruce C, Barbet AF, Wyld SG, Thomas LH. DNA vaccination against respiratory syncytial virus in young calves. Vaccine. 2005; 23(10); 1242-1250. [PubMed: 15652666].