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Vaccine Detail

BVDV DNA vaccine encoding E2
Vaccine Information
  • Vaccine Ontology ID: VO_0004538
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Calves
  • Antigen: E2 from BVDV Q140 (van et al., 2013)
  • E2 gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • Vector: pMASIA (van et al., 2013)
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Cattle Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Two doses of this vaccine spaced 6 or 12 weeks apart were sufficient to induce significant virus-neutralizing antibody titers, numbers of activated T cells, and reduction in viral shedding and clinical presentations after BVDV-2 challenge. In contrast to the placebo-treated animals, the vaccinated calves did not lose any weight, which is an excellent indicator of the well-being of an animal and has a significant economic impact (van et al., 2013).
References
van et al., 2013: van Drunen Littel-van den Hurk S, Lawman Z, Snider M, Wilson D, van den Hurk JV, Ellefsen B, Hannaman D. Two doses of bovine viral diarrhea virus DNA vaccine delivered by electroporation induce long-term protective immune responses. Clinical and vaccine immunology : CVI. 2013; 20(2); 166-173. [PubMed: 23220999].