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Vaccine Detail

Bacillus Calmette-Guérin Danish (BCG)
Vaccine Information
  • Vaccine Ontology ID: VO_0004807
  • Type: Live, attenuated vaccine
  • Status: Licensed
  • Host Species for Licensed Use: Baboon
  • Immunization Route: subcutaneous injection
Host Response

Cattle Response

  • Vaccination Protocol: Two groups of calves (n = 9/group) were vaccinated subcutaneously with a lyophilized BCG Danish vaccine containing either 0.5 (1 × 105 to 4 × 105 CFU) or 5 (1 × 106 to 4 × 106 CFU) human doses of BCG Danish, with an additional group of 10 calves serving as non vaccinated controls (Buddle et al., 2013).
  • Challenge Protocol: Intratracheal challenge with 5 × 103 CFU of virulent M. bovis 15 weeks after vaccination (Buddle et al., 2013).
  • Efficacy: Vaccination of the calves with either 0.5 or 5 equivalent human doses of BCG Danish induced similar levels of protection against challenge with M. bovis, with both groups showing significant reductions in the pathological and microbiological parameters compared to those for the the control group (P < 0.05) (Buddle et al., 2013).
References
Buddle et al., 2013: Buddle BM, Hewinson RG, Vordermeier HM, Wedlock DN. Subcutaneous administration of a 10-fold-lower dose of a commercial human tuberculosis vaccine, Mycobacterium bovis bacillus Calmette-Guerin Danish, induced levels of protection against bovine tuberculosis and responses in the tuberculin intradermal test similar to those induced by a standard cattle dose. Clinical and vaccine immunology : CVI. 2013; 20(10); 1559-1562. [PubMed: 23925885].