VIOLIN Logo
VO Banner
Search: for Help
About
Introduction
Statistics
VIOLIN News
Your VIOLIN
Register or Login
Submission
Tutorial
Vaccine & Components
Vaxquery
Vaxgen
VBLAST
Protegen
VirmugenDB
DNAVaxDB
CanVaxKB
Vaxjo
Vaxvec
Vevax
Huvax
Vaccine Mechanisms
Vaximmutordb
Vaxism
Vaxar
Vaccine Literature
VO-SciMiner
Litesearch
Vaxmesh
Vaxlert
Vaccine Design
Vaxign
Community Efforts
Vaccine Ontology
ICoVax 2012
ICoVax 2013
Advisory Committee
Vaccine Society
Vaxperts
VaxPub
VaxCom
VaxLaw
VaxMedia
VaxMeet
VaxFund
VaxCareer
Data Exchange
V-Utilities
VIOLINML
Help & Documents
Publications
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

Vaccine Detail

T. parva Subunit p67 Protein Vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0011494
  • Type: Subunit vaccine
  • Status: Research
  • p67 gene engineering:
    • Type: Recombinant protein preparation
    • Detailed Gene Information: Click Here.
  • Adjuvant: saponin vaccine adjuvant
  • Immunization Route: Subcutaneous Injection
Host Response

Cattle Response

  • Vaccination Protocol: The immunization regimen consisted of five inoculations in 2-ml vol containing 1 mg of recombinant p67 emulsified in 3% saponin (Merck) and administered subcutaneously at monthly intervals (Musoke et al., 1992).
  • Challenge Protocol: Immunized groups were challenged 10 days after the final inoculation along with four nonimmunized control animals. In both experiments, the nonimmunized controls served to test the infectivity of the sporozoite stabilate (Musoke et al., 1992).
  • Efficacy: Immunization with p67 induced protection in 70% of the immunized cattle (Musoke et al., 1992).
References
Musoke et al., 1992: Musoke A, Morzaria S, Nkonge C, Jones E, Nene V. A recombinant sporozoite surface antigen of Theileria parva induces protection in cattle. Proceedings of the National Academy of Sciences of the United States of America. 1992; 89(2); 514-518. [PubMed: 1731322].