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Vaccine Detail

BoHV-4-A-gD(cp)gD(106)ΔTK
Vaccine Information
  • Vaccine Ontology ID: VO_0004685
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • Preparation: The bovine herpesvirus 4 (BoHV-4) based vector derived from an apathogenic isolate of BoHV-4 was used to express the immunodominant CpHV-1 glycoprotein D (BoHV-4-A-gD(cp)gD(106)ΔTK) (Donofrio et al., 2013).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Goat Response

  • Vaccination Protocol: Goats were vaccinated with BoHV-4-A-gD(cp)gD(106)ΔTK (Donofrio et al., 2013).
  • Vaccine Immune Response Type: VO_0003057
  • Immune Response: No clinical signs were evident but a good titer of serum neutralizing antibodies was produced in all inoculated animals (Donofrio et al., 2013).
  • Challenge Protocol: A challenge experiment was performed in a new group of animals using a highly pathogenic dose of CpHV-1 (Donofrio et al., 2013).
  • Efficacy: All the vaccinated goats with BoHV-4-A-gD(cp)gD(106)ΔTK were protected toward CpHV-1 induced genital disease respect to the unvaccinated control goat who showed typical vaginal lesions with a high grade of clinical score as well as a long lasting viral shedding (Donofrio et al., 2013).
References
Donofrio et al., 2013: Donofrio G, Franceschi V, Lovero A, Capocefalo A, Camero M, Losurdo M, Cavirani S, Marinaro M, Grandolfo E, Buonavoglia C, Tempesta M. Clinical protection of goats against CpHV-1 induced genital disease with a BoHV-4-based vector expressing CpHV-1 gD. PloS one. 2013; 8(1); e52758. [PubMed: 23300989].