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Vaccine Comparison

African Swine Fever Virus 9GL mutant vaccine BacMam-sHAPQ
Vaccine Information Vaccine Information
  • Vaccine Ontology ID: VO_0004284
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Swine
  • 9GL gene engineering:
    • Type: Gene mutation
    • Description: This 9GL mutant is from African Swine Fever Virus Mal (Lewis et al., 2000).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
  • Vaccine Ontology ID: VO_0004655
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • Immunization Route: Intramuscular injection (i.m.)
Host Response Host Response

Pig Response

  • Persistence: A 9GL mutant is attenuated in swine (Lewis et al., 2000).
  • Efficacy: A 9GL mutant induces significant protection in swine from challenge with wild type ASFV (Lewis et al., 2000).

Pig Response

  • Vaccine Immune Response Type: VO_0003057
  • Efficacy: The protective potential of this recombinant vaccine candidate was tested by a homologous sublethal challenge with ASFV following immunization. Four out of six immunized pigs remained viremia-free after ASFV infection, while the other two pigs showed similar viremic titres to control animals (Argilaguet et al., 2013).
References References
Lewis et al., 2000: Lewis T, Zsak L, Burrage TG, Lu Z, Kutish GF, Neilan JG, Rock DL. An African swine fever virus ERV1-ALR homologue, 9GL, affects virion maturation and viral growth in macrophages and viral virulence in swine. Journal of virology. 2000; 74(3); 1275-1285. [PubMed: 10627538].
Argilaguet et al., 2013: Argilaguet JM, Pérez-Martín E, López S, Goethe M, Escribano JM, Giesow K, Keil GM, Rodríguez F. BacMam immunization partially protects pigs against sublethal challenge with African swine fever virus. Antiviral research. 2013; 98(1); 61-65. [PubMed: 23428670].