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Vaccine Detail

Foot and mouth disease DNA vaccine pWRMHX encoding a minimal self-cleaving ribozyme
Vaccine Information
  • Vaccine Ontology ID: VO_0004320
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse, pig
  • FMDV A12 genome gene engineering:
    • Type: DNA vaccine construction
    • Description: This vaccine encoded the genome of FMDV strain A12 and a minimal self-cleaving ribozyme from hepatitis delta virus (Ward et al., 1997),
    • Detailed Gene Information: Click Here.
  • Vector: pWRM (Ward et al., 1997)
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Pig Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Swine inoculated with pWRMHX did not show any signs of disease and produced neutralizing antibodies to FMDV, and 20% of the vaccinated animals were protected from FMDV challenge (Ward et al., 1997).
References
Ward et al., 1997: Ward G, Rieder E, Mason PW. Plasmid DNA encoding replicating foot-and-mouth disease virus genomes induces antiviral immune responses in swine. Journal of virology. 1997; 71(10); 7442-7447. [PubMed: 9311823].