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Vaccine Detail

C. trachomatis DNA vaccine pWRG7079::MOMP
Vaccine Information
  • Vaccine Ontology ID: VO_0004554
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Pig
  • Antigen: ompA of C. trachomatis serovar E strain 468 (Schautteet et al., 2011)
  • ompA gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • Vector: pWRG7079 (Schautteet et al., 2011)
  • Immunization Route: Intravaginal injection
Host Response

Pig Response

  • Vaccine Immune Response Type: VO_0003057
  • Efficacy: A good level of protection against C. trachomatis genital infection was observed in the immunized group. This group had no or only mild macroscopic lesions in comparison with the control group. The infection was mainly localized in the lower genital tract while in the placebo-primed group, C. trachomatis was spread throughout the lower and upper genital tract. The scores for chlamydial presence were significantly higher for the corpus uteri, the uterine tubes and the oviducts of the control group. No replication was detected outside the urogenital tract, which is in accordance with the literature. Induction of immune mechanisms that limited infection and replication also resulted in a decreased shedding by the vaccinated pigs in comparison with the control ones. Significant differences were seen at some time points from 10 days post infection until euthanasia (Schautteet et al., 2011).
References
Schautteet et al., 2011: Schautteet K, Stuyven E, Beeckman DS, Van Acker S, Carlon M, Chiers K, Cox E, Vanrompay D. Protection of pigs against Chlamydia trachomatis challenge by administration of a MOMP-based DNA vaccine in the vaginal mucosa. Vaccine. 2011; 29(7); 1399-1407. [PubMed: 21195805].