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Vaccine Detail

rAd-P97c
Vaccine Information
  • Vaccine Ontology ID: VO_0004697
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • P97 gene engineering:
    • Type: Recombinant vector construction
    • Description: a P97 recombinant replication-defective adenovirus (rAdP97c) subunit vaccine (Okamba et al., 2010).
    • Detailed Gene Information: Click Here.
  • Preparation: P97 recombinant replication-defective adenovirus (rAdP97c) subunit vaccine (Okamba et al., 2010).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Pig Response

  • Vaccination Protocol: The pigs in the rAdP97c vaccinated group, animals were vaccinated with 2 × 1010 TCID50 of rAdP97c twice, (at days 0 and 14) by intranasal (i.n.) route (Okamba et al., 2010).
  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: The challenge was performed at day 28 after the first vaccination with 106 CCU of the 232 M. hyopneumoniae strain by intratracheal route (Okamba et al., 2010).
  • Efficacy: The rAdP97c vaccinated pigs developed a lower amount of macroscopic lung lesions (18.5 + or - 9.6%) compared to the unvaccinated and challenged animals (45.8 + or - 11.5%). rAdP97c vaccine reduced significantly the severity of inflammatory response and the amount of M. hyopneumoniae in the respiratory tract. Furthermore, the average daily weight gain was slightly improved in the rAdP97c vaccinated pigs (0.672 + or - 0.068 kg/day) compared to the unvaccinated and challenged animals (0.568 + or - 0.104 kg/day (Okamba et al., 2010).
References
Okamba et al., 2010: Okamba FR, Arella M, Music N, Jia JJ, Gottschalk M, Gagnon CA. Potential use of a recombinant replication-defective adenovirus vector carrying the C-terminal portion of the P97 adhesin protein as a vaccine against Mycoplasma hyopneumoniae in swine. Vaccine. 2010; 28(30); 4802-4809. [PubMed: 20472025].