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Vaccine Detail

Influenza virus NS1 mutant vaccine

Vaccine Information

Vaccine Ontology ID: VO_0002981
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Mouse, pig, horse, macaque
NS1 from Influenza virus gene engineering:
- Type: Gene mutation
- Description: This NS1 mutant is from influenza virus (Richt and García-Sastre, 2009).
- Detailed Gene Information: Click Here.
Immunization Route: intranasal immunization

Host Response

Mouse Response

Persistence: An NS1 mutant is attenuated in mice (Richt and García-Sastre, 2009).
Efficacy: An NS1 mutant induces significant protection in mice from challenge with wild type influenza virus (Richt and García-Sastre, 2009).

Pig Response

Persistence: An NS1 mutant is attenuated in pigs (Richt and García-Sastre, 2009).
Efficacy: An NS1 mutant induces significant protection in pigs from challenge with wild type influenza virus (Richt and García-Sastre, 2009).

Horse Response

Persistence: An NS1 mutant is attenuated in horses (Richt and García-Sastre, 2009).
Efficacy: An NS1 mutant induces significant protection in horses from challenge with wild type influenza virus (Richt and García-Sastre, 2009).

Macaque Response

Persistence: An NS1 mutant is attenuated in macaques (Richt and García-Sastre, 2009).
Efficacy: An NS1 mutant induces significant protection in macaques from challenge with wild type influenza virus (Richt and García-Sastre, 2009).

References

Richt and García-Sastre, 2009: Richt JA, García-Sastre A. Attenuated influenza virus vaccines with modified NS1 proteins. Current topics in microbiology and immunology. 2009; 333; 177-195. [PubMed: 19768406].