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Vaccine Detail

Rabies virus glycoprotein G mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002991
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse, hamster
  • Glycoprotein G gene engineering:
    • Type: Gene mutation
    • Description: This glycoprotein G mutant is from Rabies virus (Wu et al., 2011).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Persistence: A glycoprotein G mutant is attenuated in mice (Wu et al., 2011).
  • Efficacy: A glycoprotein G mutant induces protection in mice from challenge with wild type rabies virus (Wu et al., 2011).

Hamster Response

  • Persistence: A glycoprotein G mutant is attenuated in hamsters (Wu et al., 2011).
  • Efficacy: A glycoprotein G mutant induces significant protection in hamsters from challenge with wild type rabies virus (Wu et al., 2011).
References
Wu et al., 2011: Wu X, Franka R, Henderson H, Rupprecht CE. Live attenuated rabies virus co-infected with street rabies virus protects animals against rabies. Vaccine. 2011; ; . [PubMed: 21514343].