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Vaccine Detail

P. falciparum MSA-2 subunit vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0004269
  • Type: Subunit vaccine
  • Status: Research
  • Antigen: merozoite antigen, MSA-2 (Pye et al., 1997).
  • Adjuvant: SAF-1 vaccine adjuvant
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Sheep Response

  • Vaccination Protocol: Sheep were immunized intramuscularly (i.m.) in the left rear leg, with a second immunization in the right rear leg 4 weeks later. A 100 μg antigen dose was delivered in 1.0 ml. Serum was prepared from bleeds taken prior to the first immunization, 3 or 4 weeks later (i.e. prior to the second dose), and a final bleed 2 weeks after the second immunization (Pye et al., 1997).
  • Immune Response: Sheep immunized with MSA-2 and SAF-1 had higher antibody response than sheep immunized with MSA-2 and alhydrogel (Pye et al., 1997).
References
Pye et al., 1997: Pye D, Vandenberg KL, Dyer SL, Irving DO, Goss NH, Woodrow GC, Saul A, Alving CR, Richards RL, Ballou WR, Wu MJ, Skoff K, Anders RF. Selection of an adjuvant for vaccination with the malaria antigen, MSA-2. Vaccine. 1997; 15(9); 1017-1023. [PubMed: 9261951].