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Vaccine Detail

ALVAC-AHSV
Vaccine Information
  • Vaccine Ontology ID: VO_0004725
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • Preparation: Recombinant canarypox virus vector (ALVAC-AHSV) co-expressing synthetic genes encoding the outer capsid proteins (VP2 and VP5) of AHSV serotype 4 (AHSV-4) (Guthrie et al., 2009).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Horse Response

  • Vaccination Protocol: Two groups of four horses each (two males and two females) were inoculated intramuscularly with 107.1 or 106.4 TCID50, respectively, of ALVAC–AHSV in approximately 1 ml of diluent containing a Carbopol® 974P adjuvant (BF Goodrich) (Guthrie et al., 2009).
  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: All nine horses were challenged by intravenous inoculation of 105.5 TCID50 of AHSV-4 at 28 days after the second vaccination (week 8) (Guthrie et al., 2009).
  • Efficacy: Post challenge, all horses remained healthy and showed no adverse effects after vaccination (Guthrie et al., 2009).
References
Guthrie et al., 2009: Guthrie AJ, Quan M, Lourens CW, Audonnet JC, Minke JM, Yao J, He L, Nordgren R, Gardner IA, Maclachlan NJ. Protective immunization of horses with a recombinant canarypox virus vectored vaccine co-expressing genes encoding the outer capsid proteins of African horse sickness virus. Vaccine. 2009; 27(33); 4434-4438. [PubMed: 19490959].