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Vaccine Detail

S. neurona SAG1 Protein Vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0004042
  • Type: Subunit vaccine
  • Status: Research
  • SAG1 gene engineering:
    • Type: Recombinant protein preparation
    • Detailed Gene Information: Click Here.
  • Adjuvant: Polygen vaccine adjuvant
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Horse Response

  • Vaccination Protocol: The horses were vaccinated on days 0 and 21 with 1 mL adjuvanted (Polygen; MVP Laboratories, Omaha, Nebraska, USA) rSnSAG1 (50 μg) or 1 mL adjuvant alone by IM injection in the left side of the neck (Ellison and Witonsky, 2009).
  • Challenge Protocol: Horses in all groups were challenged on study day 36 with S. neurona merozoites (Ellison and Witonsky, 2009).
  • Efficacy: Vaccination with rSnSAG-1 produced antibodies in horses that neutralized merozoites when tested by in vitro culture and significantly reduced clinical signs demonstrated by in vivo challenge (Ellison and Witonsky, 2009).
References
Ellison and Witonsky, 2009: Ellison S, Witonsky S. Evidence that antibodies against recombinant SnSAG1 of Sarcocystis neurona merozoites are involved in infection and immunity in equine protozoal myeloencephalitis. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 2009; 73(3); 176-183. [PubMed: 19794889].