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Vaccine Detail
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S. neurona SAG1 Protein Vaccine |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004042
- Type: Subunit vaccine
- Status: Research
- SAG1
gene engineering:
- Type: Recombinant protein preparation
- Detailed Gene Information: Click Here.
- Adjuvant:
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Horse Response
- Vaccination Protocol: The horses were vaccinated on days 0 and 21 with 1 mL adjuvanted (Polygen; MVP Laboratories, Omaha, Nebraska, USA) rSnSAG1 (50 μg) or 1 mL adjuvant alone by IM injection in the left side of the neck (Ellison and Witonsky, 2009).
- Challenge Protocol: Horses in all groups were challenged on study day 36 with S. neurona merozoites (Ellison and Witonsky, 2009).
- Efficacy: Vaccination with rSnSAG-1 produced antibodies in horses that neutralized merozoites when tested by in vitro culture and significantly reduced clinical signs demonstrated by in vivo challenge (Ellison and Witonsky, 2009).
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| References |
Ellison and Witonsky, 2009: Ellison S, Witonsky S. Evidence that antibodies against recombinant SnSAG1 of Sarcocystis neurona merozoites are involved in infection and immunity in equine protozoal myeloencephalitis. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 2009; 73(3); 176-183. [PubMed: 19794889].
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