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Vaccine Detail

BV-H5/H7/H9
Vaccine Information
  • Vaccine Ontology ID: VO_0004654
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • HA from Influenza A virus (A/Viet Nam/1203/2004(H5N1)) gene engineering:
    • Type: Recombinant vector construction
    • Description: A recombinant virus-like particle (VLP) that co-localizes hemagglutinin (HA) proteins derived from H5N1, H7N2, and H9N2 viruses (Tretyakova et al., 2013).
    • Detailed Gene Information: Click Here.
  • HA gene engineering:
    • Type: Recombinant vector construction
    • Description: A recombinant virus-like particle (VLP) that co-localizes hemagglutinin (HA) proteins derived from H5N1, H7N2, and H9N2 viruses (Tretyakova et al., 2013).
    • Detailed Gene Information: Click Here.
  • Preparation: A baculovirus vector co-expressing the H5, H7, and H9 genes from A/Viet Nam/1203/2004 (H5N1), A/New York/107/2003 (H7N2) and A/Hong Kong/33982/2009 (H9N2) viruses, respectively, as well as neuraminidase (NA) and matrix (M1) genes from A/Puerto Rico/8/1934 (H1N1) virus (Tretyakova et al., 2013).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Ferret Response

  • Vaccination Protocol: Ferrets received two vaccinations i.n. of the H5/H7/H9 triple-subtype VLPs and control animals received PBS in place of vaccine (Tretyakova et al., 2013).
  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: The ferrets were challenged with 106 EID50 challenges with H7N2 or H9N2 (Tretyakova et al., 2013).
  • Efficacy: Intranasal vaccination of ferrets with the VLPs resulted in induction of serum antibody responses and efficient protection against experimental challenges with H5N1, H7N2, and H9N2 viruses (Tretyakova et al., 2013).
References
Tretyakova et al., 2013: Tretyakova I, Pearce MB, Florese R, Tumpey TM, Pushko P. Intranasal vaccination with H5, H7 and H9 hemagglutinins co-localized in a virus-like particle protects ferrets from multiple avian influenza viruses. Virology. 2013; 442(1); 67-73. [PubMed: 23618102].