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Vaccine Detail

rFP-RPV-H/F
Vaccine Information
  • Vaccine Ontology ID: VO_0004752
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • Preparation: Rinderpest virus (RPV) antigens, expressed in pox virus vectors (Jones et al., 1997).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Ferret Response

  • Vaccination Protocol: Ferrets were inoculated intradermally with recombinant vaccinia viruses expressing the H gene of RPV, the F gene of RPV, the H and F genes of RPV, or fowlpox virus recombinant expressing both genes. Two ferrets were vaccinated s.c. with CDV vaccine as positive controls, and 1 group was left unvaccinated as a negative control (Jones et al., 1997).
  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: The ferrets were challenge exposed with a high dose of CDV (Jones et al., 1997).
  • Efficacy: Partial protection was seen in all groups, with vRVFH vaccination being the most protective (Jones et al., 1997).
References
Jones et al., 1997: Jones L, Tenorio E, Gorham J, Yilma T. Protective vaccination of ferrets against canine distemper with recombinant pox virus vaccines expressing the H or F genes of rinderpest virus. American journal of veterinary research. 1997; 58(6); 590-593. [PubMed: 9185963].